期刊
LAB ON A CHIP
卷 9, 期 2, 页码 251-256出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b806003g
关键词
-
类别
资金
- National Science Foundation [CMS-0509723, ECS-9731293]
- National Institute of Health [DK77302]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K25DK077302] Funding Source: NIH RePORTER
We report a microfluidic chip that is capable of measuring volume changes in single cells in real-time. Single eukaryotic cells were immobilized in the sensing area and changes in volume in response to hypotonic challenges and drugs were measured using the electrical impedance method. Experiments on MDCK cells showed that the maximum swelling and the time course of swelling vary between individual cells following hypotonic stimulation. The microfluidic chip allows, rapid and convenient change of solutions, enabling detailed studies of various drugs and chemicals that may play important role in cell physiology at the single cell level.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据