Article
Chemistry, Multidisciplinary
Daniel A. Ferreira, Mario Rothbauer, Joao P. Conde, Peter Ertl, Carla Oliveira, Pedro L. Granja
Summary: A streamlined approach for fabricating organ-on-a-chip devices using an adaptation of xurography is proposed, allowing rapid and low-cost generation of multilayered, membrane-integrated biochips suitable for organ-on-a-chip applications without cytotoxic effects on cells.
Article
Chemistry, Analytical
Yao Chen, Lin Jiang, Xiaozhe Zhang, Zhonghua Ni, Nan Xiang
Summary: This article introduces an efficient label-free sorting and mechanical phenotyping method for tumor cells, which utilizes a viscoelastic-sorting integrated deformability cytometer (VSDC) to sort, extract, and analyze the mechanical properties of tumor cells. Machine learning algorithms are used to distinguish tumor cells from white blood cells.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Hedan Bai, Shuo Li, Robert F. Shepherd
Summary: The article explores the development and challenges of virtual and augmented reality technologies, particularly in the field of haptics. It suggests that soft robotics may offer potential solutions to overcome the difficulties in developing soft haptic output and input devices.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Analytical
Navya Rastogi, Pranjal Seth, Ramray Bhat, Prosenjit Sen
Summary: The novel orthogonal vortex chip enables size-based cell separation at lower velocities to avoid cell damage caused by high flow speeds. The device utilizes shear-gradient lift, centrifugal, and Dean flow drag forces to selectively trap particles of different sizes, showing promising results for gentle isolation of rare cells from blood.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
Jiaxing Jansen Lin, Dimeng Yang, Sean Jun Leong Ou, Ying Yuan Mak, Delia Pei Shan Lee, Ker Li Lim, E. Shyong Tai, Mei Hui Liu, Saif A. Khan
Summary: This study demonstrates the design and prototyping of novel food assemblies using hydrocolloids through microfluidic processing, showcasing their impact and performance in both in vitro and in vivo contexts. The food assemblies exhibit potential in appetite control and satiety regulation, while being a functional platform for nutrient delivery tailored to specific nutritional needs.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Physical
Caffiyar Mohammed Yousuff, Vineet Tirth, Mohamed Zackria Ansar Babu Irshad, Kashif Irshad, Ali Algahtani, Saiful Islam
Summary: Through investigating the effects of electrode configuration, this study found that electrodes with triangular arrangements produce less heating effect even at 30V without compromising device performance and separation efficiency. It also identified that certain electrode materials erode channels quickly, affecting device reliability, and predicted the optimal medium conductivity for cell survival inside the channel.
Article
Chemistry, Physical
Linshan Wu, Zhiguang Guo, Weimin Liu
Summary: This article discusses the development of microfluidic technology and the importance of droplet control. The balance between droplet driving force and fluid resistance is crucial for achieving selective droplet transport. The article also explores the effects of external fields on droplet transport and the applications and challenges of microfluidics in various fields.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Kaiming Zhang, Sheng Chen, Yanglei Chen, Liangying Jia, Can Cheng, Shuli Dong, Jingcheng Hao
Summary: The research team developed a solvent-free elastic ionic conductor with stretchable and self-healing capabilities using cross-linked polyTA and lithium bis(trifluoromethane sulfonamide) as the matrix and electrolyte, respectively. This conductor can be used as a stable strain sensor and maintained good working ability under extreme conditions. The team also created a sustainable triboelectric nanogenerator with outstanding performance.
Article
Chemistry, Analytical
Kazem Akbarnataj, Sasan Maleki, Masoud Rezaeian, Mohammad Haki, Amir Shamloo
Summary: This study proposes novel microfluidic devices based on size-dependent cell-sorting for label-free, ultra-fast enrichment of circulating tumor cells (CTCs). The devices were evaluated through numerical simulation and demonstrated optimal separation efficiency at a flow rate of 2.5 mL/min, achieving CTC purity values between 88% and 90%.
Article
Pharmacology & Pharmacy
Wing-Fu Lai, Wing-Tak Wong
Summary: This study explores the use of Gelatine Methacryloyl (GM) in fabricating microgels for bioactive agent delivery. The microfluidic approach used in this study generates highly monodisperse microgels with tunable size. Tetracycline hydrochloride was used as a model agent to demonstrate prolonged release capabilities of the microgels, which showed potential for applications in food and pharmaceutical industries.
Article
Multidisciplinary Sciences
Naotomo Tottori, Takasi Nisisako
Summary: Deterministic lateral displacement (DLD) is a promising technology for high-resolution separation of suspended particles based on size. Conventional DLD has a fixed critical diameter (D-c) determined by device geometry, but we propose a novel DLD that uses thermo-responsive hydrogel pillars to flexibly tune the D-c value. By adjusting temperature, the pillers can shrink or swell, allowing continuous switching of particle trajectories and on/off separation of particles.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Seyong Kwon, Jieung Oh, Min Seok Lee, Eujin Um, Joonwoo Jeong, Joo H. Kang
Summary: A hemolysis-free and highly efficient plasma separation platform has been developed using enhanced diamagnetic repulsion of blood cells. By supplementing blood with superparamagnetic iron oxide nanoparticles, complete removal of blood cells from blood plasma is achieved, allowing for successful collection of plasma without losing plasma proteins, platelets, or exosomes.
Article
Nanoscience & Nanotechnology
Deepika Sharma, Roderick Y. H. Lim, Thomas Pfohl, Yasin Ekinci
Summary: The focus of this work is on the development of simple and effective nanofluidic devices for trapping single charged nanoparticles in an aqueous environment. By modifying the surface of the device to change its charge properties and reducing the surface modification time, the study demonstrates the successful enhancement in device performance.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Engineering, Chemical
Rohollah Nasiri, Amir Shamloo, Javad Akbari
Summary: The separation of cancer cells is crucial for cancer research and treatment. This paper presents the design and investigation of two microfluidic devices for efficient cancer cell separation, demonstrating their effectiveness through numerical modeling and experimental study.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Chemistry, Analytical
Noor Abdulhussain, Suhas H. Nawada, Sinead A. Currivan, Peter J. Schoenmakers
Summary: This study focuses on devices for two-dimensional separations, utilizing monolithic frits fabricated through photo-masking to connect the first-dimension channel and the second-dimension outlets. The effectiveness of the monolithic frits was demonstrated by successfully separating a mixture of five standard peptides and connecting the outlet to a mass spectrometer.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Analytical
Bao D. Ho, Jason P. Beech, Jonas O. Tegenfeldt
Summary: By combining deterministic lateral displacement (DLD) with electrokinetics, this study demonstrates the sorting of cells based on differences in membrane and/or internal structures, and successfully separates different cell types in experiments. The significant change in zeta potential or dielectrophoretic mobility at different frequencies is utilized to achieve cell separation.
Article
Physics, Applied
Yang Chen, Lukas Hrachowina, Enrique Barrigon, Jason P. Beech, David Alcer, Roman Lyttleton, Reza Jafari Jam, Lars Samuelson, Heiner Linke, Magnus Borgstrom
Summary: The use of transparent solar cells as windows in buildings can greatly increase the surface area available for Building Integrated Photovoltaics. The challenge lies in capturing energy while maintaining transparency. InP nanowire arrays have been shown to have good transparency in the visible region and high absorption in the near-infrared region, meeting the requirements of functioning as windows.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Analytical
David W. Inglis, Robert E. Nordon, Jason P. Beech, Gary Rosengarten
Summary: Research shows that red blood cells undergo reversible deformation under certain shear stress, taking on characteristic shapes not previously seen in physiological buffers. The rates of deformation and recovery are negatively correlated with flow rates, while the degree of deformation saturates with increasing shear stress.
Article
Biology
Carlos Arellano-Caicedo, Pelle Ohlsson, Martin Bengtsson, Jason P. Beech, Edith C. Hammer
Summary: This study used microfluidic devices to investigate how spatial distortion of pore spaces affects fungal and bacterial growth, interactions, and substrate degradation. Results showed that sharper angles reduced fungal and bacterial biomass, especially when angles were repeated. Modifications to fungal habitats were identified as a potential cause for this effect.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Vibha Kumra Ahnlide, Johannes Kumra Ahnlide, Sebastian Wrighton, Jason P. Beech, Pontus Nordenfelt
Summary: Antibodies play a crucial role in the immune system by targeting harmful pathogens, but identifying specific binding sites can be challenging. The SiteLoc method developed by Kumra Ahnlide et al. uses fluorescent probes to measure nanoscale distances between antibodies and cell surfaces, overcoming previous limitations and offering potential applications in therapeutic development and research.
Article
Chemistry, Analytical
Oskar E. Strom, Jason P. Beech, Jonas O. Tegenfeldt
Summary: The length-based separation of DNA remains an important technique in modern scientific research. Microfluidics has the potential to automate sample preparation and analysis, but there is a need for more versatile and powerful separation methods. This study demonstrates a highly efficient DNA separation technique using microfluidics, with orders of magnitude greater throughput than other techniques. The study also explores the challenges of separating high concentrations of DNA.
Article
Biochemical Research Methods
Oskar E. Stroem, Jason P. Beech, Jonas O. Tegenfeldt
Summary: Regular patterns emerge in high-concentration DNA solutions in microfluidic pillars at low Reynolds numbers and high Deborah numbers. Interacting vortices between pillars lead to long-range traveling waves consisting of DNA. The position of the pillars in each unit cell plays a role in the formation of waves. Elastic effects are identified as central to the origin of these waves, and this research may contribute to improving sample processing in microfluidics and understanding viscoelastic mechanisms.
Article
Chemistry, Multidisciplinary
Jason P. Beech, Oskar E. Strom, Enrico Turato, Jonas O. Tegenfeldt
Summary: Solutions of macromolecules exhibit viscoelastic properties and may break time-reversal symmetry, resulting in elastic turbulence and wave variations. Altering the symmetry of individual pillars can influence the symmetry of waves and control instabilities and mixing in high-concentration DNA solutions.
Article
Chemistry, Multidisciplinary
Mercy Lard, Bao D. Ho, Jason P. Beech, Jonas O. Tegenfeldt, Christelle N. Prinz
Summary: Nanostraw substrates have the potential to achieve minimally invasive cell transfection, but leakage of current limits the effectiveness of cell coverage. This issue can be addressed by covering the nanostraw substrate with an insulating layer containing pores of similar size to cells.
Meeting Abstract
Respiratory System
Rehnberg Emil, Sinem Tas, Deniz Bolukbas, Jason Beech, Hani N. Alsafadi, Isak Sveningsson, Martin Arvidsson, Axel Sandberg, Kajsa A. Dahlgren, Alexander Edthofer, Anna Gustafsson, Hanna Isaksson, Jeffrey A. Wood, Jonas O. Tegenfeldt, Darcy E. Wagner
EUROPEAN RESPIRATORY JOURNAL
(2021)
