期刊
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
卷 14, 期 5, 页码 345-352出版社
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
DOI: 10.4196/kjpp.2010.14.5.345
关键词
Erythropoietin; Memory; Scopolamine; Streptozotocin; Morris water-maze
The present study was undertaken to explore the potential of erythropoietin in memory deficits of mice Memory impairment was produced by scopolamine (0 5 mg/kg, i p) and intracerebroventricular streptozotocin (i c.v STZ, 3 mg/kg, 10 mu l, 1(st) and 3(rd) day) in separate groups of animals Morris water-maze test was employed to assess learning and memory The levels of brain thio-barbituric acid reactive species (TBARS) and reduced glutathione (GSH) were estimated to assess degree of oxidative stress Brain acetylcholinesterase enzyme (AChE) activity was also measured Scopolamine/streptozotocin administration induced significant impairment of learning and memory in mice as indicated by marked decrease in Morris water-maze performance Scopolamine/streptozotocin administration also produced a significant enhancement of brain AChE activity and brain oxidative stress (an increase in TBARS and a decrease in GSH) levels Treatment of erythropoietin (500 and 1,000 IU/Kg i p) significantly reversed scopolamine- as well as streptozotocin-induced learning and memory deficits along with attenuation of those-induced rise in brain AChE activity and brain oxidative stress levels It may be concluded that erythropoietin exerts a beneficial effect in memory deficits of mice possibly through its multiple actions including potential anti-oxidative effect
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