Review
Clinical Neurology
Pierre A. Geoffroy, Laura Palagini
Summary: Depressive syndromes are common brain conditions with sleep complaints in over 90% of patients, and using chronotherapeutics such as light therapy and sleep deprivation can effectively treat depression. It is important to combine chronotherapeutics with behavioral measures to ensure healthy sleep.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Alessandro Sarzetto, Maria Cristina Cavallini, Lorenzo Fregna, Federico Pacchioni, Francesco Attanasio, Barbara Barbini, Linda Franchini, Cristina Colombo
Summary: This study aims to evaluate the impact of chronotherapeutics on sleep architecture in bipolar depressive patients. The results show significant changes in sleep architecture, which are correlated with the reduction of depressive symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Physiology
Francesco Benedetti, Sara Dallaspezia, Elisa Maria Teresa Melloni, Cristina Lorenzi, Raffaella Zanardi, Barbara Barbini, Cristina Colombo
Summary: The study found that the TSD+LT treatment could decrease peripheral inflammation levels in patients with Bipolar Disorder, leading to antidepressant effects. The reduction in inflammatory biomarkers correlated with the severity of depression, suggesting a potential mechanism for the therapeutic action of TSD+LT.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Helle Ostergaard Madsen, Ida Hageman, Klaus Martiny, Maria Faurholt-Jepsen, Miriam Kolko, Tone E. G. Henriksen, Lars Vedel Kessing
Summary: This study aims to evaluate the acute and long-term stabilizing effects of blue blocking glasses in the outpatient treatment of bipolar disorder. Patients will be randomly assigned to wear glasses with high or low filtration of short wavelength light, and the treatment effects will be observed through continuous assessments and self-monitoring.
ANNALS OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Chen Song, Melanie Boly, Enzo Tagliazucchi, Helmut Laufs, Giulio Tononi
Summary: We identified signatures of sleep in brain hemodynamic activity using simultaneous fMRI and EEG. These signatures can be used to monitor the occurrence of sleep or wakefulness, track the regions that fall asleep or wake up first at the wake-sleep transitions, and investigate local homeostatic sleep processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neuroimaging
Joseph J. Shaffer, Virginia Willour, Jess G. Fiedorowicz, Gary E. Christensen, Jeffrey D. Long, Casey P. Johnson, Samantha L. Schmitz, Aislinn J. Williams, John Wemmie, Vincent A. Magnotta
Summary: This study explored the relationship between suicide attempts and brain imaging measures in bipolar disorder, finding differences in brain activation and metabolism associated with suicide attempts. The study also revealed that the number of suicide attempts was related to differences in brain regions, indicating different neurobiological underpinnings for suicide history and number of attempts.
BRAIN IMAGING AND BEHAVIOR
(2022)
Review
Clinical Neurology
Lisa S. Furlong, Susan L. Rossell, Georgia F. Caruana, Vanessa L. Cropley, Matthew Hughes, Tamsyn E. Van Rheenen
Summary: The review found abnormalities in both the activity and connectivity of facial emotion processing neural circuitry in individuals with bipolar disorder, which may contribute to social cognitive impairments. Future research should further investigate the connectivity and spatiotemporal course of these neural events.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Hanne Lie Kjaerstad, Viktoria Damgaard, Gitte M. Knudsen, Maj Vinberg, Lars Vedel Kessing, Julian Macoveanu, Kamilla W. Miskowiak
Summary: This study aims to assess the neural underpinnings of potential subgroups of bipolar disorder patients and found two distinct patient subgroups with different patterns of neural activity and relapse risk. Heightened amygdala reactivity was associated with increased risk of relapse.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Rif S. El-Mallakh, Yonglin Gao, Michael Roberts, John Hamlyn
Summary: The study demonstrated that sleep disturbance can increase endogenous ouabain levels in control mice, but animals exhibiting manic behaviors are unable to increase ouabain production.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Akua F. Nimarko, Adina S. Fischer, Kelsey E. Hagan, Aaron J. Gorelik, Yvonne Lu, Caroline J. Young, Manpreet K. Singh
Summary: Adolescents at risk for familial bipolar disorder and major depressive disorder show significant neural differences in activation and connectivity during positive emotion processing, particularly in the activation and connectivity of the putamen. These differences may potentially serve as markers of vulnerability for the development of mood or anxiety disorders.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2021)
Article
Psychiatry
Hiroshi Okamoto, Toshiaki Onitsuka, Hironori Kuga, Naoya Oribe, Naho Nakayama, Shou Fukushima, Tomohiro Nakao, Takefumi Ueno
Summary: In this study, we found a significant decrease in ASSR-BOLD signals in the right Brodmann areas 41 and 42 of patients with bipolar disorder in response to 40-Hz stimuli. The BOLD change in these areas showed significant negative correlations with depression scores and negative symptom scores.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Pamina Mitter, Franco De Crescenzo, Kimberley Loo Yong Kee, Jun Xia, Samantha Roberts, Wenjie Chi, Ayse Kurtulumus, Simon D. Kyle, John R. Geddes, Andrea Cipriani
Summary: Sleep deprivation, either alone or in combination with pharmacological treatment, may have potential benefits for people with major depressive episodes. However, the current evidence regarding its clinical effects is conflicting.
SLEEP MEDICINE REVIEWS
(2022)
Review
Neurosciences
Mohammad Amini, Zahra Yousefi, Sayed Soran Ghafori, Gholamreza Hassanzadeh
Summary: Sleep deprivation is a common health problem in the modern era and can stimulate inflammatory responses. The NLRP3 inflammasome plays a crucial role in the detrimental consequences of sleep deprivation, but further research is needed to support this causal claim.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Silvia U. Maier, Todd A. Hare
Summary: By combining emotion regulation and dietary choice tasks, along with fMRI, our study explored the behavioral and neural connections in self-regulation in human participants. We discovered that increased brain activity during the successful reappraisal of emotions was associated with dietary self-control success. This correlation was observed in the prefrontal cortex and striatum, suggesting that processes used in emotion regulation also play a role in making healthy food choices that prioritize health over taste.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Hanne Lie Kjaerstad, Julian Macoveanu, Gitte Moos Knudsen, Sophia Frangou, K. Luan Phan, Maj Vinberg, Lars Vedel Kessing, Kamilla Woznica Miskowiak
Summary: This study compared the neural responses during voluntary down-regulation of negative emotions in bipolar disorder patients, their unaffected first-degree relatives, and healthy controls. The results showed hypo-activity in the prefrontal cortex and deficient connectivity between the prefrontal cortex and amygdala in patients and their relatives, indicating impaired emotion regulation. This study highlights the importance of understanding aberrant emotion regulation in bipolar disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Odile A. van den Heuvel, Premika S. W. Boedhoe, Sara Bertolin, Willem B. Bruin, Clyde Francks, Iliyan Ivanov, Neda Jahanshad, Xiang-Zhen Kong, Jun S. Kwon, Joseph O'Neill, Tomas Paus, Yash Patel, Fabrizio Piras, Lianne Schmaal, Carles Soriano-Mas, Gianfranco Spalletta, Guido A. van Wingen, Je-Yeon Yun, Chris Vriend, H. Blair Simpson, Daan van Rooij, Marcelo Q. Hoexter, Martine Hoogman, Jan K. Buitelaar, Paul Arnold, Jan C. Beucke, Francesco Benedetti, Irene Bollettini, Anushree Bose, Brian P. Brennan, Alessander S. De Nadai, Kate Fitzgerald, Patricia Gruner, Edna Gruenblatt, Yoshiyuki Hirano, Chaim Huyser, Anthony James, Kathrin Koch, Gerd Kvale, Luisa Lazaro, Christine Lochner, Rachel Marsh, David Mataix-Cols, Pedro Morgado, Takashi Nakamae, Tomohiro Nakao, Janardhanan C. Narayanaswamy, Erika Nurmi, Christopher Pittenger, Y. C. Janardhan Reddy, Joao R. Sato, Noam Soreni, S. Evelyn Stewart, Stephan F. Taylor, David Tolin, Sophia I. Thomopoulos, Dick J. Veltman, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Paul M. Thompson, Dan J. Stein
Summary: Neuroimaging has significantly advanced our understanding of OCD's neurobiology, with ENIGMA consortium's collaborative efforts enhancing statistical power. Their work involves samples from multiple countries and regions, utilizing machine learning techniques for research, contributing to the development of neurobiological models of OCD and global scientific collaboration.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Stefano Comai, Elisa Melloni, Cristina Lorenzi, Irene Bollettini, Benedetta Vai, Raffaella Zanardi, Cristina Colombo, Flavia Valtorta, Francesco Benedetti, Sara Poletti
Summary: Bipolar disorder (BD) patients showed higher levels of kynurenine (Kyn) and Kyn/tryptophan (Trp) ratio than major depression (MDD) patients, along with lower fractional anisotropy (FA) in several white matter tracts. Lower Trp levels were associated with more severe depressive symptoms and lower FA in specific brain regions, regardless of diagnosis. In BD patients, immune/inflammatory markers were selectively associated with Kyn/Trp ratio, suggesting a potential role of cytokines and Trp conversion into Kyn in affecting white matter microstructure.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Mario Gennaro Mazza, Mariagrazia Palladini, Rebecca De Lorenzo, Beatrice Bravi, Sara Poletti, Roberto Furlan, Fabio Ciceri, Patrizia Rovere-Querini, Francesco Benedetti
Summary: A study on COVID-19 survivors in Italy one year after infection found a high prevalence of psychiatric sequelae at six and 12 months, with 33% experiencing pathological fatigue at 12 months. An interaction effect of sex and time was observed for depression and anxiety, with males showing an increasing trend of symptoms while females showed an opposite course.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Asad Jamal, Tian Yuan, Stefano Galvan, Antonella Castellano, Marco Riva, Riccardo Secoli, Andrea Falini, Lorenzo Bello, Ferdinando Rodriguez Y. Baena, Daniele Dini
Summary: This article focuses on the application of infusion-based targeted drug delivery in the treatment of brain diseases such as glioblastoma multiforme. The author emphasizes the biomechanical and biochemical aspects of drug delivery and discusses the challenges and advances in medical robotics in targeted drug delivery in the brain. Additionally, the critical overview of current research and its clinical implications is provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Serena Borroni, Linda Franchini, Silvia Brioschi, Giulia Vassena, Elisabetta Masci, Chiara Franzoni, Giulia Ruotolo, Cristina Colombo, Andrea Fossati
Summary: This study examines the role of sociodemographic and clinical variables as well as personality pathological features in predicting high lethality suicide attempts. The results indicate that previous suicide attempts and current suicide ideation play a role in predicting serious suicide attempts. Specifically, the Detachment domain is associated with high lethality suicide attempts and remains a significant predictor even when considering the effects of previous attempts and ideation.
PERSONALITY AND MENTAL HEALTH
(2023)
Article
Clinical Neurology
Elena Mazza, Federico Calesella, Marco Paolini, Camilla di Pasquasio, Sara Poletti, Cristina Lorenzi, Andrea Falini, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: Our study investigated the effects of insulin and its derived measures on white matter microstructure and neural functional connectivity in patients with bipolar disorder (BD). The results showed that insulin was negatively associated with fractional anisotropy and positively influenced radial diffusivity and mean diffusivity. Additionally, insulin resistance had a significant effect on radial diffusivity, while insulin sensitivity was positively associated with fractional anisotropy and negatively associated with radial diffusivity and mean diffusivity. These findings suggest that insulin may play a role in the pathophysiology of BD by affecting white matter microstructure and functional connectivity.
Article
Clinical Neurology
Marco Paolini, Mariagrazia Palladini, Mario Gennaro Mazza, Federica Colombo, Benedetta Vai, Patrizia Rovere-Querini, Andrea Falini, Sara Poletti, Francesco Benedetti
Summary: Cognitive impairment is a common residual symptom in COVID-19 survivors and is associated with various brain changes. This study investigated the neural correlates of subjective cognitive decline using multimodal imaging in a sample of 58 COVID-19 survivors. The findings revealed widespread white matter disruption and abnormal functional connectivity in the brains of individuals with cognitive complaints. These results suggest a potential brain signature of cognitive decline in COVID-19 survivors and may aid in the identification of therapeutic targets for mitigating long-term cognitive dysfunction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Sigrid Breit, Elena Mazza, Sara Poletti, Francesco Benedetti
Summary: Major depressive disorder (MDD) is a complex and serious mental disorder that can result in chronic recurrent symptoms, treatment resistance, and suicidal behavior. Immune dysregulation and brain volume changes, particularly in white matter (WM), are associated with MDD. Neuroimaging markers and blood markers, such as inflammation-related cytokines, may serve as predictors of treatment response in MDD, but the relationship between peripheral inflammation, WM integrity, and antidepressant response is still not clearly understood. This review aims to explore the association between inflammation and WM integrity, and their impact on MDD pathophysiology and progression, as well as the potential role of novel biomarkers in improving MDD prevention and treatment strategies.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Benedetta Vai, Federico Calesella, Claudia Lenti, Lidia Fortaner-Uya, Elisa Caselani, Paola Fiore, Sigrid Breit, Sara Poletti, Cristina Colombo, Raffaella Zanardi, Francesco Benedetti
Summary: Suicide attempts in Bipolar Disorder are characterized by high levels of lethality and impulsivity. Reduced rates of amygdala and cortico-limbic habituation can identify a fMRI phenotype of suicidality in the disorder related to internal over-arousing states. This study found that bipolar suicide attempters have lower habituation levels in several cortico-limbic areas, suggesting that reduced habituation in the cortico-limbic system may serve as a biomarker for suicidality. Machine learning techniques achieved high accuracy in differentiating suicide attempters from non-attempters.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2023)
Article
Medicine, General & Internal
Mariagrazia Palladini, Mario Gennaro Mazza, Andrea Scalabrini, Patrizia Rovere Querini, Sara Poletti, Francesco Benedetti
Summary: COVID-19 survivors experience intense depressive and post-traumatic symptoms in the sub-acute stages. Survivor guilt may contribute to the development of post-COVID psychiatric implications. This study aims to uncover the affective mechanism behind these implications by examining the association between survivor guilt, psychopathology, and maladaptive attributional style. The study evaluated symptoms of depression, post-traumatic distress, and sleep disturbances in 195 COVID-19 survivors one month after discharge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Laura Raffaelli, Sara Poletti, Raffaella Zanardi, Cristina Colombo, Francesco Benedetti
Summary: This study investigated the impact of Neutrophil-to-lymphocyte ratio (NLR) on treatment response in Major Depressive Disorder (MDD) patients, and the influence of sex and hippocampal volume on this relationship. The results showed that NLR had a different effect on treatment response in females compared to males. Additionally, NLR negatively affected hippocampal volume in females, and hippocampal volume partially mediated the effect of NLR on treatment response in females.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Marco Paolini, Yasmin Harrington, Federica Colombo, Valentina Bettonagli, Sara Poletti, Matteo Carminati, Cristina Colombo, Francesco Benedetti, Raffaella Zanardi
Summary: A study found that there is a correlation between MRI imaging and treatment response in patients with major depressive disorder (MDD). The study analyzed MRI scans of 100 patients and found that lower grey matter volumes, particularly in the hippocampus and temporal lobe-related areas, were associated with worse treatment outcomes. Functional connectivity patterns were also found to be related to treatment response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Letter
Criminology & Penology
Lorenzo Fregna, Francesco Attanasio, Guido Travaini, Cristina Colombo
VIOLENCE AND GENDER
(2023)