Article
Neurosciences
Laura Wade-Bohleber, Niklaus Zolch, Mick Lehmann, Jutta Ernst, Andre Richter, Erich Seifritz, Heinz Boeker, Simone Grimm
Summary: This study investigated the neurobiological changes associated with psychodynamic psychotherapy in patients with major depressive disorder. The results showed that the levels of glutamine in the pregenual anterior cingulate cortex were related to the severity of symptoms before treatment. However, after 6 months of psychotherapy, the correlation between glutamine levels and symptom severity reversed.
NEUROPSYCHOBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Daniel C. Javitt
Summary: Cognitive impairment is a prominent feature of schizophrenia, and its assessment methods are well established. The role of social cognitive impairment and sensory-level dysfunction in functional outcomes has also been recognized. Treatment development targeting N-methyl-d-aspartate receptor (NMDAR) and its associated impairments has become encouraging. Mismatch negativity has emerged as a promising biomarker for early-stage drug development in schizophrenia.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Clinical Neurology
Xu Ding, Huihua Fang, Yutong Liu, Lin Zheng, Xiangru Zhu, Hongxia Duan, Jianhui Wu
Summary: This study aimed to explore the relationship between trait resilience and bottom-up automatic information processing in healthy adults. The results showed that higher resilience was associated with slower automatic detection speed and lower sensory sensitivity.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Athina C. Tsili, Loukas Astrakas, Nikolaos Sofikitis, Maria I. Argyropoulou
Summary: Proton magnetic resonance spectroscopy provides information on testicular metabolism and pathological changes. It has been used in conjunction with scrotal MRI to gain insights into the biochemical environment of normal and abnormal testes.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Alice B. Van Derveer, Jordan M. Ross, Jordan P. Hamm
Summary: Context modulates how information is processed in the mammalian brain. This study investigates the manifestation of neural deviance detection in the cortex, specifically in the parietal associative area and primary visual cortex, when exposed to unisensory and multisensory deviants. The results suggest that deviance detection signals in the cortex can be conceptualized as prediction errors, exhibiting a hierarchical distribution across cortical networks.
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Yang Fan, Yan-Wei Lin, Ruo-Yang Shi, Ling-Zhan Yu, Rui Wu, Qiu-Ying Yao, Luke D. Wesemann, Jiani Hu, Qi Liu, Yan Zhou, Sheng Chen, Lian-Ming Wu
Summary: Creatine distribution in myocardial segments of idiopathic inflammatory myopathy (IIM) patients was measured using cardiovascular magnetic resonance (CMR) chemical exchange saturation transfer (CEST) creatine mapping. CEST showed increased sensitivity in detecting subclinical myocardial changes compared to conventional CMR mapping sequences, making it a promising CMR sequence for screening subclinical myocardial damage.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Aisling O'Neill, Luciano Annibale, Grace Blest-Hopley, Robin Wilson, Vincent Giampietro, Sagnik Bhattacharyya
Summary: The study found that treatment with a single oral dose of cannabidiol in patients with psychosis resulted in a significant increase in hippocampal glutamate levels and a significant decrease in symptom severity, with a negative correlation between the two. These findings suggest a potential link between the antipsychotic effects of cannabidiol and changes in hippocampal glutamate levels.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Shiori Honda, Yoshihiro Noda, Karin Matsushita, Ryosuke Tarumi, Natsumi Nomiyama, Sakiko Tsugawa, Yui Tobari, Nobuaki Hondo, Keisuke Saito, Masaru Mimura, Shinya Fujii, Shinichiro Nakajima
Summary: This study investigated the relationship between rhythm processing abilities and glutamatergic neurometabolites in the caudate. The results showed a negative correlation between glutamate and glutamine levels in the caudate and the production part of the Beat Saliency Test. This suggests that higher levels of glutamatergic neurometabolites in the caudate may contribute to rhythm processing, particularly the ability to produce meter in music precisely.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Nickie N. Andescavage, Subechhya Pradhan, Alexis C. Gimovsky, Kushal Kapse, Mary T. Donofrio, Jenhao Jacob Cheng, Yushuf Sharker, David Wessel, Adre J. du Plessis, Catherine Limperopoulos
Summary: The study found that fetuses with complex congenital heart disease (CHD) have altered cerebral metabolites, particularly in the third trimester of pregnancy. These alterations are associated with survival to hospital discharge and warrant further study on the long-term neurodevelopmental consequences.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Almir Bitencourt, Varadan Sevilimedu, Elizabeth A. Morris, Katja Pinker, Sunitha B. Thakur
Summary: Altered metabolism, including lipid metabolism, is an emerging hallmark of breast cancer. Results of this study showed that breast tumors have significantly lower concentrations of lipid metabolites and PUFA compared to normal fibroglandular tissue. The measure best separating normal and tumor tissues was L21 + L23, indicating the potential of MRS- based lipid measurements in increasing the specificity of breast cancer characterization.
Article
Psychiatry
Jiayue Chen, Shaohong Zou, Yuan Qu, Cheng Zhang, Yi Zhang, Xiaoxiao Tang, Yongfang Ren
Summary: The study analyzed brain biochemical metabolism in BD patients with and without anxiety symptoms using 1H-MRS, finding higher levels of inositol metabolism in the right PWM of BD patients with anxiety symptoms and decreased membrane phospholipid catabolism in the left PWM with increasing age and onset age.
PSYCHIATRY RESEARCH
(2021)
Article
Psychology, Clinical
Xin-lu Cai, Cheng-cheng Pu, Shu-zhe Zhou, Yi Wang, Jia Huang, Simon S. Y. Lui, Arne Moller, Eric F. C. Cheung, Kristoffer H. Madsen, Rong Xue, Xin Yu, Raymond C. K. Chan
Summary: This study found that schizophrenia patients have sensory integration deficits which are positively correlated with anterior cingulate cortex (ACC) glutamate levels. Multimodal analysis showed that in a specific network, blood oxygenation level dependent (BOLD) activation and task-dependent functional connectivity (FC) have opposite correlations between schizophrenia patients and healthy controls.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Tine Maria Hansen, Jens Brondum Frokjaer, Esben Bolvig Mark, Asbjorn Mohr Drewes
Summary: Research shows that both tapentadol and oxycodone can modulate the glutamatergic system at the supraspinal level in humans, leading to decreased glutamate/creatine levels in the brain regions studied.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Oncology
Ruikun Liao, Zhuoyue Tang, Xiaojiao Li, Liang Lv, Chao Yang, Hua Xiong, Bi Zhou, Jiayi Yu, Dan Zhang
Summary: This study investigated the diagnostic performance of Cho peak area, Cho peak amplitude, and the combined approach in detecting early-stage liver cancer using hydrogen-1 proton magnetic resonance spectroscopy. The results showed that these approaches were effective in diagnosing VX2 liver cancer. Additionally, a positive correlation was observed between Cho peak area and amplitude with tumor diameter and volume.
FRONTIERS IN ONCOLOGY
(2022)
Article
Psychiatry
Tiffany C. Ho, Giana I. Teresi, Jillian R. Segarra, Amar Ojha, Johanna C. Walker, Meng Gu, Daniel M. Spielman, Matthew D. Sacchet, Fei Jiang, Yael Rosenberg-Hasson, Holden Maecker, Ian H. Gotlib
Summary: This study found that peripheral inflammation in adolescents with depression can affect glutamate levels in the brain, and antioxidants like ascorbate may help mitigate the impact of inflammation on glutamate metabolism. The results underscore the importance of considering both immune and neural factors in studying depression, and highlight the potential role of anti-inflammatory compounds in alleviating the adverse effects of inflammation.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Rehabilitation
Elizabeth Stratton, Nick Glozier, Alix Woolard, Vicki Gibbs, Eleni A. Demetriou, Kelsie A. Boulton, Ian Hickie, Elizabeth Pellicano, Adam J. Guastella
Summary: The employment rates for autistic individuals are low, and mental health symptoms and disabilities are associated with vocational functioning. The association between anxiety and stress with vocational outcomes is attenuated in a multivariable model. Depression and disabilities are independent factors associated with vocational outcomes.
DISABILITY AND REHABILITATION
(2023)
Article
Psychiatry
Phillip Aouad, Ashlea Hambleton, Peta Marks, Danielle Maloney, Shannon Calvert, Belinda Caldwell, Sian A. McLean, Beth Shelton, Katherine Cowan, John Feneley, Genevieve Pepin, Susan Paxton, Michelle Williams, Thy Meddick, Sarah Squire, Ian Hickie, Frances Kay Lambkin, Stephen Touyz, Sarah Maguire
Summary: This study aimed to identify Australia's top 10 consensus-derived research and translation priorities for eating disorders, in order to address the current issues of limited resources, disjointed vision, and limited uptake of research findings.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Ian B. B. Hickie, Kathleen R. R. Merikangas, Joanne S. S. Carpenter, Frank Iorfino, Elizabeth M. M. Scott, Jan Scott, Jacob J. J. Crouse
Summary: Circadian dysrhythmia is implicated in the switch between activation states in bipolar I disorder. Natural or environmental exposures that disrupt circadian rhythms are related to the switch into high-/low-activation states. Interventions that affect the circadian system can also reduce the switch into high-/low-activation states.
Article
Biology
Zoe Menczel Schrire, Christopher J. Gordon, Jake R. Palmer, Jade Murray, Ian Hickie, Naomi L. Rogers, Simon J. G. Lewis, Zoe Terpening, Jonathon E. Pye, Sharon L. Naismith, Camilla M. Hoyos
Summary: This study explored the association between clinical markers and circadian rhythms in older adults, finding that factors such as chronotype and light exposure were predictive of dim light melatonin onset (DLMO) time and phase angle. The use of clinical variables, such as actigraphy-derived light, as circadian markers in aging could be easily implemented into existing clinical practice and could potentially guide chronotherapeutic interventions.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Psychiatry
Chloe E. Wilson, Joanne S. Carpenter, Jacob J. Crouse, Shin Park, Dagmar Koethe, Elizabeth M. Scott, Ian B. Hickie
Summary: This retrospective cohort study aimed to identify the cardiometabolic characteristics, cross-sectionally and longitudinally, associated with clinical stage in youth accessing early intervention mental health services. Cardiometabolic data were collected in 511 young people receiving mental health care at the early intervention services in Sydney. The results showed that there was no cross-sectional relationship between clinical stage and demographic or cardiometabolic variables at entry, but an increased BMI over time was associated with clinical stage transition longitudinally.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Lina Gomez, Santiago Diaz-Torres, Lucia Colodro-Conde, Luis M. Garcia-Marin, Chloe X. Yap, Enda M. Byrne, Loic Yengo, Penelope A. Lind, Naomi R. Wray, Sarah E. Medland, Ian B. Hickie, Michelle K. Lupton, Miguel E. Renteria, Nicholas G. Martin, Adrian Campos
Summary: The study finds that samples used in genetic research may be subject to ascertainment and attrition biases. The Australian Genetics of Depression Study reveals that older, male participants with higher education are more likely to donate saliva samples, while self-reported mental disorders are associated with lower odds of sample donation. Furthermore, male and younger participants are more likely to agree to record linkage, and participants with higher neuroticism scores and a history of bipolar disorder are also more likely to agree, whereas those with a diagnosis of anorexia are less likely to agree.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Catherine Vacher, Adam Skinner, Jo-An Occhipinti, Sebastian Rosenberg, Nicholas Ho, Yun Ju Christine Song, Ian B. Hickie
Summary: This study simulated the impact of allowing direct access to some Medicare-subsidised mental health care sessions and increasing the growth rate of mental health care capacity on population mental health indicators. The results showed that direct access increased the numbers of emergency department presentations, hospitalisations with self-harm, and deaths by suicide, while increased capacity growth reduced these adverse outcomes. The optimal combination was achieved by combining direct access and increased service capacity growth.
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Psychiatry
Adam Skinner, Jo-An Occhipinti, Ante Prodan, Yun Ju Christine Song, Ian B. Hickie
Summary: The study finds that delayed initiation and early discontinuation of treatment due to limited availability and accessibility of services can lead to more severe mental disorders. Increasing services capacity can lead to a qualitative shift in services system functioning and promote long-term sustainability and resilience in mental health care systems.
INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS
(2023)
Article
Pediatrics
Jacob J. Crouse, Haley M. LaMonica, Yun Ju Christine Song, Kelsie A. Boulton, Cathrin Rohleder, Marilena M. DeMayo, Chloe E. Wilson, Victoria Loblay, Gabrielle Hindmarsh, Tina Stratigos, Michael Krausz, Nathanael Foo, Melissa Teo, Andrew Hunter, Adam J. Guastella, Richard B. Banati, Jakelin Troy, Ian B. Hickie
Summary: Recent years have witnessed significant advancements in understanding early childhood development and the dissemination of health information through digital technologies. The development of a new parenting app called "Thrive by Five" aims to provide evidence-based information and collective actions to caregivers globally, with the potential for improved outcomes in children. This ongoing global project incorporates a scientific framework, including domains to organize content, targeted neurobiological systems, anthropological and cultural considerations, and collaboration with experts in various fields.
JMIR PEDIATRICS AND PARENTING
(2023)
Article
Health Care Sciences & Services
E. Bryant, N. Koemel, J. A. Martenstyn, P. Marks, I. Hickie, S. Maguire
Summary: Eating disorders, one of the deadliest mental disorders, are consistently underfunded in research and treatment, leading to a lack of innovation. Despite high mortality rates, eating disorders receive disproportionately low funding compared to other mental health disorders, with the majority being allocated to basic research.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Editorial Material
Public, Environmental & Occupational Health
Jo-An Occhipinti, William Hynes, Patricia Geli, Harris A. Eyre, Yun Song, Ante Prodan, Adam Skinner, Goran Ujdur, John Buchanan, Roy Green, Sebastian Rosenberg, Allan Fels, Ian B. Hickie
Review
Psychology, Clinical
Haley Russell, Phillip Aouad, Anvi Le, Peta Marks, Danielle Maloney, Stephen Touyz, Sarah Maguire
Summary: This review examines the efficacy of psychotherapy for treating eating disorders, with a focus on behavioral and cognitive-behavioral interventions. The findings suggest that these therapies are effective, although there is variation in outcomes across studies. Further research and investment in novel psychotherapies are needed to improve treatment outcomes and address the full range of eating disorder presentations and populations.
JOURNAL OF EATING DISORDERS
(2023)
Review
Health Care Sciences & Services
Adam Poulsen, Yun J. C. Song, Eduard Fosch-Villaronga, Haley M. Lamonica, Olivia Iannelli, Mafruha Alam, Ian B. Hickie
Summary: This scoping review aims to identify digital rights topics in the 2022 literature on mHealth in low- and middle-income countries (LMICs). The results are expected to highlight the importance of patient empowerment, data protection, and inclusion in mHealth research and policies in LMICs.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Health Care Sciences & Services
Sarah McKenna, Sarah Piper, William Capon, Alison Crowley, Lucas Lira, Haley M. LaMonica, Min Kyung Chong, Elizabeth Scott, Ian Hickie, Frank Iorfino
Summary: This study aimed to monitor the implementation of a health information technology (HIT) platform in real-world mental health service settings. Results showed that staff attitudes towards the HIT improved after implementation, but there were also differing opinions. The HIT was found to enable collaborative decision-making, proactive work on mental health care, and improved response to suicidal risk. The study highlights the influence of clinician beliefs and attitudes towards technology and clinical practice on the adoption of HIT.
JMIR HUMAN FACTORS
(2023)
Article
Substance Abuse
Sue M. Cotton, Sonia Sharmin, Caroline X. Gao, Ellie Brown, Jana M. Menssink, Debra Rickwood, Gillinder Bedi, Ian Hickie, Sarah E. Hetrick, Alexandra G. Parker, Helen Herrman, Nic Telford, Patrick D. McGorry, Kate M. Filia
Summary: This study aimed to investigate the rates and correlates of tobacco use in Australian youth with mental illness at their first presentation to primary mental health services. The results showed that nearly a quarter of young people with mental illness had used tobacco in the past 3 months. Age, gender, relationship status, and poorer functioning were predictors of tobacco use in adolescents, whereas living in a regional location and not studying were predictors in young adults. Having a diagnosed mental illness other than depression and/or anxiety predicted tobacco use in both age groups.
NICOTINE & TOBACCO RESEARCH
(2023)
