期刊
KNEE
卷 20, 期 2, 页码 113-119出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.knee.2012.10.018
关键词
Osteoarthritis; Cartilage lesions; T1rho; Magnetic resonance imaging
资金
- NIH [RO1 AR46905]
Background: The purpose of this investigation is to evaluate the T-1p relaxation times of articular cartilage surrounding focal defects in the tibiofemoral joint. Methods: Quantitative cartilage assessment was performed using 3 T MRI with T-1p mapping in 19 healthy individuals and 44 OA patients. Sagittal T-2-weighted fast spin echo (FSE) images were acquired for lesion assessment. Differences were determined using analysis of variance (ANOVA). Results: Cartilage lesions were found in 37% of controls, and 93% of OA patients. Meniscal tears were found in 16% of controls and 57% of OA patients. We observed no difference in T-1p relaxation times when comparing cartilage immediately surrounding a focal defect, and the remaining cartilage within that compartment. The medial femoral condyle (MFC) had the highest incidence of cartilage defects. MFC and medial meniscus posterior horn T1p were higher in subjects having multiple focal lesions (p = 0.048, pb0.001 respectively) and extensive full thickness lesions (p = 0.009, pb0.001 respectively) compared to subjects with no MFC defects. Significant elevations in T-1p, of the adjacent compartment (medial tibia) and medial meniscus were observed in subjects with MFC lesions. Conclusion: Increased relaxation times in the involved compartment as well as the adjacent compartment and associated meniscus underscore the interdependence of these structures at bearing load. However, no differences in cartilage composition immediately surrounding a defect were noted. Finally, an association was observed between cartilage defects and meniscal damage in advanced disease. Clinical Relevance: Cartilage defects were not associated with degeneration in the immediately adjacent cartilage. (C) 2012 Elsevier B.V. All rights reserved.
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