Article
Orthopedics
Giulio Maria Marcheggiani Muccioli, Giada Lullini, Eugenio Cammisa, Alberto Leardini, Stefano Zaffagnini
Summary: 10 years post-surgery, a former professional soccer player achieved full-knee functional recovery and successful return to professional soccer activity with an arthroscopically implanted Collagen Meniscus Implant.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
Ju-Ho Song, Seong-Il Bin, Jong-Min Kim, Bum-Sik Lee, Jun-Gu Park, Sang-Min Lee
Summary: This study evaluates the effect of age on joint survivorship after arthroscopic partial meniscectomy for degenerative medial meniscus tears. The results suggest that age itself does not significantly affect joint survival, but other factors related to cartilage status and meniscal tear pattern have a greater impact. For older patients, arthroscopic treatment can still be a viable option if performed with caution.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Veterinary Sciences
Margaret E. Gruen, Jamie A. E. Myers, B. Duncan X. Lascelles
Summary: The study demonstrated significant improvement in pain management for cats treated with frunevetmab compared to placebo, with the majority of adverse events related to activity-monitor collars.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Orthopedics
Siyuan Zhu, Xinning Li, Zhenfei Lu, Jason L. Koh, Chenglong Wang, Peng Wang, Xiexiang Shao, Jianhua Wang
Summary: This study investigated the clinical and radiological outcomes of arthroscopic repair for isolated medial degenerative meniscus tears in patients over 45 years old. The results showed that arthroscopic repair had good clinical outcomes with low clinical failure rates, although unhealed menisci were observed on MRI in approximately 41% of patients.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Genetics & Heredity
Gisel Padula, Gabriela Rudd Garces, Maria Elena Fernandez, Rosario Vercellini, Daniel Osvaldo Arias, Pilar Peral Garcia, Guillermo Giovambattista
Summary: This study aimed to identify potential diagnostic biomarkers for DJD in German Shepherd dogs by investigating the transcriptomic profile of peripheral blood. The study found that THBS4 gene is correlated with DJD severity and long noncoding RNA LOC106559235 may be involved in the DJD process. THBS4 gene should be considered a good biomarker for DJD in dogs.
Article
Orthopedics
K. Magnusson, A. Turkiewicz, B. Snoeker, V. Hughes, M. Englund
Summary: The study estimates the genetic contribution to traumatic and degenerative meniscus tears and finds that environmental risk factors play a more important role than genetic factors in both men and women.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Orthopedics
Balazs K. Kovacs, Rolf Huegli, Dorothee Harder, Luca Cedro, Roger Berbig, Felix Amsler, Susanne Bensler, Michael T. Hirschmann, Anna Hirschmann
Summary: The study aimed to evaluate the MR morphological characteristics and volume of CMI at early, mid, and long-term follow-up, revealing that abnormal SI and irregular margins of CMI in the early postoperative period tend to improve over time in patients with good clinical outcomes.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Review
Orthopedics
Filippo Migliorini, Francesco Oliva, Joerg Eschweiler, Francesco Cuozzo, Frank Hildebrand, Nicola Maffulli
Summary: This systematic review compared the efficacy of arthroscopic partial meniscectomy (APM) with structured physical therapy (PT) in middle-aged patients with symptomatic meniscal damages. The results showed that there was no significant difference in functional PROMs, clinical PROMs, pain, quality of life, physical performance measures, and OA progression between APM and PT. Further research is needed to investigate the long-term effects and optimal indications and outcomes of APM and PT.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Tao Xu, Liuhai Xu, Xinzhi Li, You Zhou
Summary: This study aimed to identify predictors of unfavorable outcomes after arthroscopic partial meniscectomy (APM) for degenerative medial meniscus lesions (DMMLs) and to improve treatment efficacy. The results showed that advancing age, varus alignment, and large medial meniscus extrusion were found to predict a poor prognosis after APM for DMMLs. The preoperative extent of medial meniscal extrusion can be used as a predictive factor for osteoarthritis in APM.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ye Sun, Yuxin Zhang, Qiang Wu, Feng Gao, Yongzhong Wei, Yimin Ma, Wenbo Jiang, Kerong Dai
Summary: The disruption of anisotropic phenotypes of the meniscus in OA patients was confirmed, and 3D-bioprinted anisotropic TCM meniscus constructs were generated to recapitulate healthy meniscus phenotypes. Transplantation of these constructs into rabbit knees replicated native healthy meniscus phenotypes and provided long-term protection against secondary joint degeneration. This approach not only restored the anisotropy of the native healthy meniscus, but also maintained joint function and prevented secondary joint degeneration, offering a new strategy for treating meniscus injury-related joint degenerative diseases.
Article
Orthopedics
Gian Andrea Lucidi, Alberto Grassi, Belal Bashar Hamdan Al-zu'bi, Luca Macchiarola, Piero Agostinone, Maurilio Marcacci, Stefano Zaffagnini
Summary: The study evaluated the long-term clinical results of medial CMI scaffolds, showing satisfactory outcomes and low failure rate. However, mild osteoarthritis progression can still be expected.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Anthropology
Marta Yustos, Marina Lozano, Juan I. Morales, Javier Iglesias-Bexiga, Josep M. Verges
Summary: The study evaluated DJD of the vertebral column from a Chalcolithic collective burial in El Mirador cave, Spain, showing a higher prevalence of DJD in the lumbar region and more manifestation in the adult age group. The results are consistent with other studies and suggest a strong correlation between DJD and age.
INTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY
(2021)
Review
Sport Sciences
Michael D. Bedrin, Katina Kartalias, Bobby G. Yow, Jonathan F. Dickens
Summary: The meniscus plays a crucial role in stabilizing the knee joint and protecting the articular cartilage. Meniscus tears can increase the risk of articular cartilage damage and osteoarthritis, making appropriate treatment and consideration of meniscus repair important.
SPORTS MEDICINE AND ARTHROSCOPY REVIEW
(2021)
Review
Medicine, General & Internal
Denise O'Connor, Renea Johnston, Romina Brignardello-Petersen, Rudolf W. Poolman, Sheila Cyril, Per O. Vandvik, Rachelle Buchbinder
Summary: Arthroscopic knee surgery shows minimal to no clinically important benefit in pain or function, probably does not provide significant improvement in knee-specific quality of life, and may not enhance treatment success compared to placebo surgery. The evidence also suggests that serious and total adverse events may not differ significantly or may slightly increase with arthroscopic surgery, but the certainty of this evidence is low. The impact of arthroscopic surgery on subsequent knee surgery compared to control remains uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Review
Cell Biology
Kai Sun, Xingzhi Jing, Jiachao Guo, Xudong Yao, Fengjing Guo
Summary: Mitochondrial dysfunction is crucial in the development of intervertebral disc degeneration and osteoarthritis. Targeting mitophagy pathways may offer promising therapeutic strategies for degenerative joint diseases.
Article
Surgery
Mario Cherubino, Martina Corno, Salvatore D'Arpa, Pietro Di Summa, Igor Pellegatta, Luigi Valdatta, Mario Ronga
JOURNAL OF RECONSTRUCTIVE MICROSURGERY
(2017)
Article
Orthopedics
Corrado Bait, Pietro Randelli, Riccardo Compagnoni, Paolo Ferrua, Rocco Papalia, Filippo Familiari, Andrea Tecame, Paolo Adravanti, Ezio Adriani, Enrico Arnaldi, Franco Benazzo, Massimo Berruto, Giovanni Bonaspetti, Gian Luigi Canata, Pier Paolo Cane, Araldo Causero, Giancarlo Coari, Matteo Denti, Maristella Fare, Andrea Ferretti, Marco Fravisini, Francesco Giron, Alberto Gobbi, Vincenzo Madonna, Andrea Manunta, Pier Paolo Mariani, Claudio Mazzola, Giuseppe Milano, Luigi Pederzini, Flavio Quaglia, Mario Ronga, Herbert Schonhuber, Giacomo Stefani, Piero Volpi, Giacomo Zanon, Raul Zini, Claudio Zorzi, Stefano Zaffagnini
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2019)
Article
Orthopedics
G. Giannicola, G. Bullitta, R. Rotini, L. Murena, D. Blonna, M. Iapicca, G. Restuccia, G. Merolla, M. Fontana, A. Greco, M. Scacchi, G. Cinotti
BONE & JOINT JOURNAL
(2018)
Article
Nutrition & Dietetics
Michela Zanetti, Gianluca Gortan Cappellari, Chiara Ratti, Giuliano Ceschia, Luigi Murena, Paolo De Colle, Rocco Barazzoni
CLINICAL NUTRITION
(2019)
Article
Critical Care Medicine
Giuseppe Rollo, Gabriele Falzarano, Mario Ronga, Michele Bisaccia, Predrag Grubor, Rocco Erasmo, Guido Rocca, Felix Tome-Bermejo, David Gomez-Garrido, Paolo Pichierri, Giuseppe Rinonapoli, Luigi Meccariello
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2019)
Article
Orthopedics
Mario Ronga, Mario Cherubino, Katia Corona, Alessandro Fagetti, Barbara Bertani, Luigi Valdatta, Redento Mora, Paolo Cherubino
INTERNATIONAL ORTHOPAEDICS
(2019)
Article
Pharmacology & Pharmacy
Michela Abrami, Samuel Golob, Fabio Pontelli, Gianluca Chiarappa, Gabriele Grassi, Beatrice Perissutti, Dario Voinovich, Nadia Halib, Luigi Murena, Gesmi Milcovich, Mario Grassi
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Medicine, Legal
Marta Licata, Silvia Iorio, Piergiorgio Benaglia, Adelaide Tosi, Melania Borgo, Giuseppe Armocida, Mario Ronga, Alessandra Ruspi, Andrea Verzeletti, Chiara Rossetti
JOURNAL OF FORENSIC AND LEGAL MEDICINE
(2019)
Letter
Surgery
Zoran Marij Arnez, Vittorio Ramella, Giovanni Papa, Silvia Galici, Luigi Murena, Stefano Gulli, Chiara Stocco
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2019)
Article
Orthopedics
Gianluca Canton, Federico Santolini, Marco Stella, Antonio Moretti, Michele Francesco Surace, Luigi Murena
EUROPEAN JOURNAL OF ORTHOPAEDIC SURGERY AND TRAUMATOLOGY
(2020)
Article
Orthopedics
Cecile Toanen, Aad Dhollander, Paolo Bulgheroni, Giuseppe Filardo, Stefano Zaffagnini, Tim Spalding, Joan Carles Monllau, Pablo Gelber, Rene Verdonk, Philippe Beaufils, Nicolas Pujol, Erica Bulgheroni, Laura Asplin, Peter Verdonk
AMERICAN JOURNAL OF SPORTS MEDICINE
(2020)
Article
Orthopedics
Stefan Zaffagnini, Alberto Grassi, Paolo Adravanti, Giuseppe Milano, Alfredo Schiavone Panni, Massimo Berruto, Francesco Giron, Mario Ronga, Vincenzo Madonna, Vincenzo Condello, Roberto Rossi, Gian Luigi Canata, Franco Benazzo, Giacomo Zanon, Claudio Mazzola, Luigi Pederzini, Auro Caraffa, Agostino Tucciarone, Giagomo Stefan, Pietro Randelli
ACTA ORTHOPAEDICA BELGICA
(2019)
Review
Surgery
Francesco Kostoris, Stefania Bassini, Emiliano Longo, Luigi Murena
JOURNAL OF HAND SURGERY-ASIAN-PACIFIC VOLUME
(2019)
Article
Orthopedics
Simone Cerciello, Katia Corona, Brent Joseph Morris, Enrico Visona, Giulio Maccauro, Nicola Maffulli, Mario Ronga
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2018)
Article
Orthopedics
Luigi Murena, Antonio Moretti, Francesca Meo, Enrico Saggioro, Giulia Barbati, Chiara Ratti, Gianluca Canton
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2018)
Article
Orthopedics
Jack Zhong, Nathan J. Lee, Ajay Padaki, Connor Crutchfield, Christopher S. Ahmad, David Trofa, Sean Lynch
Summary: This study aimed to evaluate if age is associated with the risk of short-term complications after ACL reconstruction. The results showed that older patients had higher fragility index scores, shorter operative times, and lower use of general anesthesia. Older age was an independent risk factor for VTE, while younger age was associated with prolonged surgeries.
Article
Orthopedics
Ignacio Pasqualini, Michael Mariorenzi, Alison K. Klika, Pedro J. Rullan, Chao Zhang, Trevor G. Murray, Robert M. Molloy, Nicolas S. Piuzzi
Summary: This study aimed to determine the minimal clinically important difference (MCID) and the patient acceptable symptoms state (PASS) threshold for the knee injury and osteoarthritis outcome score (KOOS) pain subscore, KOOS physical short form (PS), and KOOS joint replacement (JR) following medial unicompartmental knee arthroplasty (mUKA). The study identified useful values for the MCID and PASS thresholds at 1 year following medial UKA of KOOS pain, KOOS PS, and KOOS JR scores. These values may be used as targets for surgeons when evaluating PROMS using KOOS to determine whether patients have achieved successful outcomes after their surgical intervention.