Review
Biology
Antonio Tundo, Sophia Betro', Rocco de Filippis, Fulvia Marchetti, Daniele Nacca, Roberta Necci, Marica Iommi
Summary: This study reviewed the effectiveness and safety of pramipexole augmentation in the treatment of treatment-resistant depression. The results showed that pramipexole augmentation had a treatment response rate of 62.5% for both unipolar and bipolar depression, with good safety. However, further confirmation is needed.
Article
Clinical Neurology
Rodrigo Simonini Delfino, Jose Alberto Del-Porto, Juliana Surjan, Eduardo Magalhaes, Lorena Catarina Del Sant, Ana Cecilica Lucchese, Marco Aurelio Tuena, Carolina Nakahira, Victor Augusto Rodoalho Fava, Matheus Souza Steglich, Matheus Ghossain Barbosa, Luciana Maria Sarin, Acioly Luiz Tavares Lacerda
Summary: This study aimed to evaluate the anti-anhedonic effect of esketamine in patients with unipolar and bipolar depression. Results showed a significant reduction in anhedonia severity after multiple subcutaneous esketamine infusions, indicating effectiveness in both types of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Filippo Cantu, Giandomenico Schiena, Domenico Sciortino, Lorena Di Consoli, Giuseppe Delvecchio, Eleonora Maggioni, Paolo Brambilla
Summary: Accelerated intermittent theta-burst stimulation (iTBS) protocol of transcranial magnetic stimulation (TMS) in a real-world six-patient population with treatment-resistant depression (TRD) did not show significant effect, indicating further studies on larger samples are needed to fully understand its potential.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Gordon Parker, Michael J. Spoelma, Gabriela Tavella, Martin Alda, David L. Dunner, Claire O'Donovan, Janusz K. Rybakowski, Adam Bayes, Verinder Sharma, Philip Boyce, Vijaya Manicavasagar
Summary: The study developed a new measure for identifying bipolar disorder, comparing the classification accuracy of a weighting rating scale with equivalent weightings for each item. Results showed that both methods had extremely high classificatory accuracy, and identified optimal cut-off scores for diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Melody J. Y. Kang, Gustavo H. Vazquez
Summary: This study evaluated the efficacy of acute intravenous ketamine treatment for treatment-resistant depression (TRD) and explored the peripheral blood-based biomarkers associated with treatment response. The results showed that ketamine significantly improved depressive symptoms and was well tolerated. In addition, baseline BDNF levels were found to be predictive of treatment response to ketamine.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Diana Bogdanova
Summary: Recent studies compare psychomotor reactivity disorders and gait activity in unipolar and bipolar depression, and find significant differences among the three groups. Bipolar patients exhibit more inhibited psychomotor skills than unipolar patients and healthy controls. The simplified variant of the equilibriometric task is the most sensitive and psychomotor reactivity is a more precise marker than psychomotor activity. These findings are important for distinguishing similar psychiatric conditions and developing new diagnostic and therapeutic approaches.
Article
Psychology, Multidisciplinary
Ma Ruihua, Zhao Meng, Chen Nan, Liu Panqi, Guo Hua, Liu Sijia, Shi Jing, Zhao Ke, Tan Yunlong, Tan Shuping, Yang Fude, Tian Li, Wang Zhiren
Summary: This study aimed to investigate differences in facial emotion recognition among patients with UD, BD, and normal controls. It found that UD patients performed poorly in recognizing negative expressions and had longer recognition times, while BD patients had lower accuracy in recognizing positive expressions and longer recognition times. Rapid facial expression recognition may serve as a potential endophenotype for early identification of unipolar and BD.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Yen-Yue Lin, Chuan-Chia Chang, Cathy Chia-Yu Huang, Nian-Sheng Tzeng, Yu-Chen Kao, Hsin-An Chang
Summary: Bifrontal tDCS shows rapid and lasting improvement in depression symptoms for both unipolar and bipolar depression patients. Patients also experience enhancements in cognitive performance, anxiety, and psychosocial functioning post-treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Shuqi Kong, Zhiang Niu, Dongbin Lyu, Lvchun Cui, Xiaohui Wu, Lu Yang, Hong Qiu, Wenjie Gu, Yiru Fang
Summary: This study investigates the seasonal symptoms and non-enzymatic oxidative stress in first hospitalized patients with bipolar and unipolar depression, aiming to differentiate between the two disorders and reduce misdiagnosis. The study finds that patients with bipolar depression have distinct seasonal characteristics compared to those with unipolar depression. Clinical symptoms and indicators of oxidative stress may serve as factors for distinguishing between seasonal unipolar depression and bipolar depression. Young individuals aged 15-35 are more likely to develop bipolar depression in winter.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
HaoFei Wang, Shui Tian, Rui Yan, Hao Tang, Jiabo Shi, RongXin Zhu, Yu Chen, YingLin Han, Zhilu Chen, HongLiang Zhou, Shuai Zhao, ZhiJian Yao, Qing Lu
Summary: This study investigated the neural oscillation patterns and cognitive impairments in patients with unipolar depression (UD) and bipolar depression (BD) using magnetoencephalography (MEG). The results showed that BD patients had more severe cognitive impairments in different dimensions compared to UD patients, and these impairments were associated with disrupted beta power modulations.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Joshua D. Di Vincenzo, Orly Lipsitz, Nelson B. Rodrigues, Brett D. M. Jones, Hartej Gill, Yena Lee, Leanna M. W. Lui, Kayla M. Teopiz, Roger Ho, Kangguang Lin, Flora Nasri, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This study conducted a retrospective analysis of symptomatic worsening rates during IV ketamine therapy for treatment-resistant depression in patients with unipolar and bipolar TRD. The findings suggest that the rates of symptomatic worsening associated with IV ketamine therapy for TRD are very low and similar to conventional antidepressants.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Victor M. Tang, Daniel M. Blumberger, Alanah Throop, Shawn M. McClintock, Daphne Voineskos, Jonathan Downar, Yuliya Knyahnytska, Benoit H. Mulsant, Paul B. Fitzgerald, Zafiris J. Daskalakis
Summary: Continuation magnetic seizure therapy (MST) can sustain improvements in depressive symptoms for most participants without adverse cognitive effects. During the study period, MST showed good control of suicidal ideation and no significant changes in neurocognitive test scores were observed.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Computer Science, Information Systems
Huifeng Zhang, Zhen Zhou, Lei Ding, Chuangxin Wu, Meihui Qiu, Yueqi Huang, Feng Jin, Ting Shen, Yao Yang, Li-Ming Hsu, Jinhong Wang, Han Zhang, Dinggang Shen, Daihui Peng
Summary: Machine learning and the whole-brain high-order functional connectivity network can be used to effectively differentiate bipolar depression from unipolar depression, expanding our understanding of these two mental disorders.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Psychiatry
Sandeep Grover, Himani Adarsh
Summary: This study aimed to evaluate the prevalence of mixed specifier in patients with unipolar and bipolar depression in India. The results showed that about one-fifth of patients with both types of depression exhibited mixed features during the acute phase of the illness, with no significant difference in the prevalence between the two groups.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Thomas T. Kim, Jay D. Amsterdam
Summary: This study compared the safety and effectiveness of MAOI therapy in patients with bipolar depression versus unipolar depression. The results showed that patients with bipolar depression had lower post-treatment clinical global impressions/severity scores compared to patients with unipolar depression.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Neurosciences
G. Fond, C. Boulangeat, M. Messiaen, A. Duba, M. Boucekine, P. Auquier, C. Lancon, L. Boyer
Summary: This study investigated the prevalence of anxiety and depression in a national sample of young physicians and their associated factors. The results showed that almost one third of medical students suffered from anxiety disorder or major depression, and less than one fifth of them received the recommended treatment. The study also identified moral harassment, alcohol and coffee consumption, and poor quality of initial training in dealing with disease as modifiable factors associated with poor mental health. These findings are important for improving the prevention and treatment of psychiatric disorders among medical students.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Letter
Neurosciences
A. Garosi, R. Richieri, L. Boyer, C. Lancon, G. Fond
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Article
Neurosciences
G. Fond, M. Masson, R. Richieri, T. Korchia, D. Etchecopar-Etchart, P-L Sunhary de Verville, C. Lancon, L. Boyer
Summary: Psychiatric patients are at risk of vitamin D deficiency and Covid-19-related mortality. Vitamin D supplementation, in addition to its mental health benefits, may be effective in preventing severe forms of Covid-19 infections. However, it is currently not considered necessary and is not reimbursed for this purpose in France. A monthly dose of 50,000 IU may be sufficient for most cases, with double the dose recommended for obese patients. The risk of kidney stones is not increased at these doses, even in patients without vitamin D deficiency. The Covid-19 crisis provides an opportunity to promote vitamin D supplementation in psychiatric patients, as it has been shown to be effective in other respiratory diseases.
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guillaume Fond, Alexandra Garosi, Melanie Faugere, Jacques-Yves Campion, Christophe Lancon, Laurent Boyer, Raphaelle Richieri, Eric Guedj
Summary: Peripheral inflammation in stabilized patients with schizophrenia is associated with changes in brain perfusion, which are correlated with the persistence of psychotic symptoms.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Psychiatry
Theo Korchia, Maud Tastevin, Pierre-Louis Sunhary De Verville, Ridha Joober, Christelle Andrieu-Haller, Melanie Faugere, Ophelia Godin, Damien Etchecopar-Etchart, Fabrice Berna, Bruno Aouizerate, Delphine Capdevielle, Isabelle Chereau, Julie Clauss-Kobayashi, Nathalie Coulon, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Jasmina Mallet, David Misdrahi, Christine Passerieux, Romain Rey, Frank Schurhoff, Andrei Szoke, Mathieu Urbach, Marion Leboyer, Pierre-Michel Llorca, Christophe Lancon, Raphaelle Richieri, Laurent Boyer, Guillaume Fond
Summary: Motivation deficits are common in individuals with schizophrenia and are associated with impaired functioning and quality of life. Factors such as alcohol use disorder, severe nicotine dependence, history of suicide attempt, positive symptoms, current major depressive episode, sleep disorders, and lower medication adherence contribute to motivation deficits in schizophrenia.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Laurent Boyer, Sara Fernandes, Melanie Faugere, Raphaelle Richieri, Pascal Auquier, Guillaume Fond, Christophe Lancon
Summary: This study validates the S-QoL 18 for use in individuals with bipolar and depressive disorders, confirming its reliability and validity. The S-QoL 18 proves to be a valid and reliable instrument for assessing quality of life in patients with bipolar and depressive disorders.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Neurosciences
V. Achour, M. Masson, C. Lancon, L. Boyer, G. Fond
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2022)
Article
Medicine, General & Internal
Sara Fernandes, Laurent Boyer, Xavier Zendjidjian, Anderson Loundou, Jeremie Riedberger, Pierre-Michel Llorca, Pascal Auquier, Guillaume Fond
Summary: This study aimed to calibrate an item bank to measure patients' experience of drug therapy for adult patients with SMIs and develop computerized adaptive testing to improve its use in routine practice. The resulting item bank showed strong psychometric properties and the use of computerized adaptive testing facilitated widespread use in clinical settings. Practical information and information about the side effects of psychotropic treatments and how to cope with them should be targeted as a priority to improve patients' experience of drug therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Environmental Sciences
Minh Ngoc Le Vu, Anh Linh Do, Laurent Boyer, Quy Chi Tran, Stefan Kohler, Syed Ishtiaque Ahmed, Andreea Molnar, Tung Son Vu, Nhan Trong Huynh Vo, Linh Mai Vu Nguyen, Linh Gia Vu, Vu Anh Trong Dam, Thomy Duong, Dan Linh Nguyen Do, Ngoc Minh Do, Roger S. Mclntyre, Carl Latkin, Roger Chun Man Ho, Cyrus Su Hui Ho
Summary: This study reviewed the effectiveness, feasibility, and acceptability of art therapy on children and adolescents during the COVID-19 pandemic and past epidemics. The results showed that art therapy can improve children's mental health, sleep quality, and psychological well-being in epidemic contexts, and it is widely accepted by children, adolescents, and their families.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Editorial Material
Neurosciences
Theo Korchia, Ridha Joober, Raphaelle Richieri, Priyadharshini Sabesan, Lena Palaniyappan
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Clinical Neurology
Julia Maruani, Fanny Moliere, Ophelia Godin, Antoine Yrondi, Djamila Bennabi., Raphaelle Richieri., Wissan El-Hage, Etienne Allauze, Loic Anguill, Alexandra Bouvard, Vincent Camus, Jean-Michel Dorey, Bruno Etain, Guillaume Fond, Jean-Baptiste Genty, Emmanuel Haffen, Jerome Holtzmann, Mathilde Horn, Francois Kazour, Anne-Sophie Nguon, Jean Petrucci, Romain Rey, Florian Stephan, Guillaume Vaiva, Michel Walter, Michel Lejoyeux, Marion Leboyer, Pierre-Michel Llorca, Philippe Courtet, Bruno Aouizerate, Pierre A. Geoffroy
Summary: Patients with treatment-resistant depression (TRD) are at risk of suicide. Sleep and circadian rhythm alterations, including excessive daytime sleepiness and daytime dysfunction, are predictors of suicidal ideations. Hypnotics intake is associated with a reduced risk of suicidal ideations in TRD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Letter
Neurosciences
Theo Korchia, Ridha Joober, Raphaelle Richieri, Priyadharshini Sabesan, Lena Palaniyappan
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2023)
Article
Medicine, General & Internal
Julien Coelho, Jacques Taillard, Adele Bernard, Regis Lopez, Guillaume Fond, Laurent Boyer, Guillaume Lucas, Francois Alla, Daniel J. Buysse, Meredith L. Wallace, Catherine Verdun-Esquer, Pierre-Alexis Geoffroy, Emmanuel d'Incau, Pierre Philip, Jean-Arthur Micoulaud-Franchi
Summary: This study investigated good sleep health among healthcare workers and its relationship with burnout. The results showed that good sleep health was associated with a reduced risk of burnout among healthcare workers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Laurent Boyer, Pascal Auquier, Dong Keon Yon, Pierre-Michel Llorca, Guillaume Fond
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Obstetrics & Gynecology
Mathilde Gibier, Vanessa Pauly, Veronica Orleans, Cyprien Fabre, Laurent Boyer, Julie Blanc
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
