Article
Medicine, General & Internal
Aaron Waxman, Ricardo Restrepo-Jaramillo, Thenappan Thenappan, Ashwin Ravichandran, Peter Engel, Abubakr Bajwa, Roblee Allen, Jeremy Feldman, Rahul Argula, Peter Smith, Kristan Rollins, Chunqin Deng, Leigh Peterson, Heidi Bell, Victor Tapson, Steven D. Nathan
Summary: In patients with pulmonary hypertension due to interstitial lung disease, inhaled treprostinil significantly improved exercise capacity and clinical outcomes compared to placebo in a 16-week trial. Adverse events such as cough, headache, dyspnea, dizziness, nausea, fatigue, and diarrhea were commonly reported.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Medicine, General & Internal
Abdullah A. Alqarni, Abdulelah M. Aldhahir, Heba M. Bintalib, Jaber S. Alqahtani, Rayan A. Siraj, Mansour Majrshi, Abdulkareem A. Algarni, Abdallah Y. Naser, Sara A. Alghamdi, Hassan Alwafi
Summary: Inhaled prostaglandin I2 analogue does not improve lung function and exercise capacity in patients with COPD-related pulmonary hypertension. However, short-term use of inhaled prostaglandin I2 analogue has the potential to reduce mean pulmonary artery pressure and pulmonary vascular resistance without impairing ventilation-perfusion mismatch. Further studies with larger sample sizes are warranted.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
Li Wang, Li-li Zhao, Jia-ju Xu, Yong-hui Yu, Zhong-liang Li, Feng-juan Zhang, Hui-min Wen, Hai-huan Wu, Li-ping Deng, Hui-yu Yang, Li Li, Lan-lan Ding, Xiao-kang Wang, Cheng-yuan Zhang, Hui Wang
Summary: This multicenter case-control study aimed to analyze the perinatal risk factors and morbidity of pulmonary hemorrhage (PH) among very preterm infants. The results showed that CPAP failure was significantly associated with PH, and PH increased the risk of death and bronchopulmonary dysplasia.
FRONTIERS IN PEDIATRICS
(2022)
Review
Oncology
Kai Liu, Huan Wang, Shen-Ji Yu, Guo-Wei Tu, Zhe Luo
Summary: Pulmonary hypertension is a severe disease that affects people of all ages, and inhaled pulmonary vasodilators can reduce pulmonary vascular resistance, improve cardiac function, and have additional benefits such as improving oxygenation and reducing inflammation. Inhaled nitric oxide is widely used across different age groups, but further research is needed to determine acceptable inclusion criteria, long-term outcomes, and management strategies.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Critical Care Medicine
Samuel J. Gentle, Colm P. Travers, Arie Nakhmani, Premananda Indic, Waldemar A. Carlo, Namasivayam Ambalavanan
Summary: Early identification of infants with bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) is crucial due to the higher risk of death. We investigated the intermittent hypoxemia (IH) patterns in infants with BPD-PH and compared them with infants with BPD alone. Our findings showed that infants with BPD-PH had longer duration of hypoxemic events, which was associated with both the diagnosis of BPD-PH and death in these infants.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Beate Stubbe, Christian F. Opitz, Michael Halank, Dirk Habedank, Ralf Ewert
Summary: Intravenous prostacyclin analogues therapy for PAH patients has a long history and is now a crucial part of current guidelines. The development of fully implantable pump systems has improved convenience and reduced infection rates.
RESPIRATORY MEDICINE
(2021)
Article
Pediatrics
Irina Branescu, Sandeep Shetty, Justin Richards, Simona Vladareanu, Anay Kulkarni
Summary: This study aimed to describe the clinical characteristics of pulmonary hypertension (PH) associated with moderate to severe bronchopulmonary dysplasia (MSBPD) in premature infants. The incidence of BPD-associated PH (BPD PH) was 12.6%, with 41% of infants having severe PH. The need for positive pressure respiratory support at 36 weeks post menstrual age (PMA) was independently associated with PH. Babies with MSBPD and PH had a higher mortality rate.
Review
Biochemistry & Molecular Biology
Ronni Baran, Daniela Grimm, Manfred Infanger, Markus Wehland
Summary: OSA is a common disease affecting millions worldwide, with CPAP therapy being a common treatment method to prevent complications such as hypertension by improving airway patency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Yalin Lin, Elena K. Amin, Roberta L. Keller, David F. Teitel, Hythem M. Nawaytou
Summary: This study aimed to identify Doppler waveform features and Doppler systolic and diastolic velocity cutoff values associated with a diagnosis of pulmonary vein stenosis (PVS) by cardiac catheterization. The results showed that systolic and diastolic Doppler velocities and features of the waveform can discriminate stenosed pulmonary veins confirmed by cardiac catheterization in ex-preterm children. This provides reference for screening PVS in ex-preterm children.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Pediatrics
Chenhong Wang, Xiaolu Ma, Yanping Xu, Zheng Chen, Liping Shi, Lizhong Du
Summary: The study aimed to establish a prediction model for bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) in preterm infants. Four independent predictive factors were identified, and a prediction model was developed with high accuracy in predicting the development of BPD-PH.
FRONTIERS IN PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
Hosan Hasan, Klea Hysko, Thomas Jack, Jens Dingemann, Martin Wetzke, Georg Hansmann
Summary: This article describes a case of extremely low birth weight premature female infant with severe pulmonary hypertension receiving multiple drug treatments in the neonatal intensive care unit. The use of oral prostacyclin mimetic selexipag as a therapeutic option shows potential benefits in stabilizing the cardiopulmonary condition of the patient.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pediatrics
Ida Jeremiasen, Karin Tran-Lundmark, Mikaela Dolk, Estelle Naumburg
Summary: This study explored the prescription patterns of pulmonary vasodilators in children with bronchopulmonary dysplasia in Sweden. It found that single therapy was most common, with sildenafil being the most frequently prescribed drug. Further evaluation of diagnostic tools, effects, and drug safety is needed.
Article
Cardiac & Cardiovascular Systems
Asli Okbay Gunes, Murat Ciftel, Mehmet Emcet Timur, Ceren Dedebali, Betul Zehra Pirdal
Summary: The study found that endotracheal instillation of iloprost is an effective and safe therapy for persistent pulmonary hypertension unresponsive to conventional treatment.
CARDIOLOGY IN THE YOUNG
(2022)
Article
Pediatrics
Tessa Martherus, Kristel L. A. M. Kuypers, Stefan Boehringer, Janneke Dekker, Ruben S. G. M. Witlox, Stuart B. Hooper, Arjan B. te Pas
Summary: The study showed that using physiological-based CPAP (PB-CPAP) in preterm infants increased heart rate and shortened ventilation duration, but implementation was challenging. However, PB-CPAP did not result in higher oxygen saturation levels.
FRONTIERS IN PEDIATRICS
(2021)
Review
Medicine, General & Internal
Karim El-Kersh, Bilal A. Jalil
Summary: The treatments for pulmonary hypertension (PH) are constantly evolving with the approval of new therapies. Currently, FDA approved inhaled PH therapies include iloprost for group 1 PAH, treprostinil solution and treprostinil dry powder inhaler for both group 1 PAH and group 3 PH-ILD. There are promising molecules in the pipeline for inhaled PH therapies that can improve the current treatment era and minimize systemic side effects.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Article
Critical Care Medicine
Zeynep Fuchs, Martin Scaal, Heinz Haverkamp, Friederike Koerber, Thorsten Persigehl, Frank Eifinger
Article
Anesthesiology
J. Schmitz, T. Battenberg, H. Drinhaus, F. Eifinger, C. Ries, J. Hinkelbein
Article
Medicine, Legal
Katharina Feld, Marcel Bonni, Friederike Koerber, Frank Eifinger, Sibylle Banaschak
FORENSIC SCIENCE INTERNATIONAL
(2020)
Article
Pediatrics
Philipp Jung, Sebastian Brenner, Iris Bachmann, Christian Both, Francesco Cardona, Christian Dohna-Schwake, Christoph Eich, Frank Eifinger, Ralf Huth, Ellen Heimberg, Bernd Landsleitner, Martin Olivieri, Michael Sasse, Thomas Weisner, Michael Wagner, Gert Warnke, Bernhard Ziegler, Bernd W. Boettiger, Vinay Nadkarni, Florian Hoffmann
FRONTIERS IN PEDIATRICS
(2020)
Article
Public, Environmental & Occupational Health
Jochen Hinkelbein, Jan Schmitz, Steffen Kerkhoff, Frank Eifinger, Anatolij Truhlar, Volker Schick, Christoph Adler, Steffen Kalina
Summary: Most European airlines provide the minimum required material for medical emergencies according to European aviation regulations, but there are significant differences in the availability of additional material. The equipment of airlines may not be sufficient for treating specific emergencies according to published in-flight medical guidelines.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Critical Care Medicine
Frank Eifinger, Martin Scaal, Lukas Wehrle, Stien Maushake, Zeynep Fuchs, Friederike Koerber
Summary: The study aimed to find alternative IO puncture sites in neonates by investigating the proximal humeral head and distal femoral end as potential sites. Results showed promising drainage of contrast medium into the central venous system within seconds, suggesting potential for further IO puncture sites.
Article
Immunology
Meike Meyer, Esra Ruebsteck, Frank Eifinger, Florian Klein, Andre Oberthuer, Silke Van Koningsbruggen-Rietschel, Christoph Huenseler, Lutz Thorsten Weber
Summary: This retrospective analysis compares the symptoms, clinical course, outcome, and utilization of hospital care between children infected with respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study found that symptomatic children with RSV infection were hospitalized significantly longer than those infected with SARS-CoV-2. Moreover, RSV-infected patients put higher pressure on the hospital and utilized more hospital resources.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Pediatrics
Patricia Lengua Hinojosa, Frank Eifinger, Michael Wagner, Jochen Herrmann, Monika Wolf, Chinedu Ulrich Ebenebe, Axel von der Wense, Philipp Jung, Aram Mai, Bettina Bohnhorst, Ann Carolin Longardt, Georg Hillebrand, Susanne Schmidtke, Florian Guthmann, Martina Aderhold, Ida Schwake, Maria Sprinz, Dominique Singer, Philipp Deindl
Summary: The study found significant deviations in physiological properties of very low birth weight infant simulators compared to patient reference values, with high airway resistance and low compliance. Expert ratings varied, with three simulators scoring well and one scoring unfavorably.
PEDIATRIC RESEARCH
(2022)
Article
Health Care Sciences & Services
Jost Kaufmann, Stefanie Uhl, Eva Singer, Frank Eifinger, Tobias Klein, Alex Lechleuthner, Thomas Engelhardt, Frank Wappler, Andreas Boehmer
Summary: The use of the PaedER tool combined with educational measures can significantly reduce medication error rates in emergency medical services, especially in avoiding severe dosing errors of important medications like epinephrine. Additionally, the increased documentation of patient weights during drug administration processes has proven to be effective in reducing errors.
JOURNAL OF PATIENT SAFETY
(2021)
Article
Pediatrics
Nora Bruns, Lea Willemsen, Andreas Stang, Bernd Kowall, Katharina Holtkamp, Oliver Kamp, Marcel Dudda, Florian Hey, Florian Hoffmann, Judith Blankenburg, Frank Eifinger, Hans Fuchs, Roland Haase, Jan Baier, Clemens Andree, Michael Heldmann, Vanessa Maldera, Jenny Potratz, Daniel Kurz, Nadine Mand, Claus Doerfel, Tobias Rothoeft, Michel Schultz, Manuel Ohlert, Katrin Silkenbaeumer, Thomas Boesing, Fithri Indraswari, Frank Niemann, Peter Jahn, Michael Merker, Nicole Braun, Francisco Brevis Nunez, Matthias Engler, Konrad Heimann, Milian Brasche, Gerhard Wolf, Holger Freymann, Martin Dercks, Marc Hoppenz, Ursula Felderhoff-Mueser, Christian Dohna-Schwake
Summary: This study examines the number of suicide attempts among adolescents during the COVID-19 pandemic in Germany. The findings show a decrease in suicide attempts during the first lockdown and an increase during the second lockdown. Further research is needed to understand the relationship between pandemic prevention measures and adolescent mental health.
Article
Pediatrics
Nora Bruns, Lea Y. Willemsen, Katharina Holtkamp, Oliver Kamp, Marcel Dudda, Bernd Kowall, Andreas Stang, Florian Hey, Judith Blankenburg, Hemmen Sabir, Frank Eifinger, Hans Fuchs, Roland Haase, Clemens Andree, Michael Heldmann, Jenny Potratz, Daniel Kurz, Anja Schumann, Merle Mueller-Knapp, Nadine Mand, Claus Doerfel, Peter Dahlem, Tobias Rothoeft, Manuel Ohlert, Katrin Silkenbaeumer, Frank Dohle, Fithri Indraswari, Frank Niemann, Peter Jahn, Michael Merker, Nicole Braun, Francisco Brevis Nunez, Matthias Engler, Konrad Heimann, Gerhard K. Wolf, Dominik Wulf, Saskia Hankel, Holger Freymann, Nicolas Allgaier, Felix Knirsch, Martin Dercks, Julia Reinhard, Marc Hoppenz, Ursula Felderhoff-Mueser, Christian Dohna-Schwake
Summary: During the COVID lockdown in Germany, the admission of children and adolescents to pediatric intensive care units due to accidents and injuries experienced some changes. While there was an increase in trauma-related admissions, accidents at traffic and school/kindergarten decreased, but household and leisure accidents increased. Suicide attempts increased among adolescent boys, but decreased among adolescent girls.
Article
Pediatrics
Philipp Jung, Sebastian Brenner, Iris Bachmann, Christian Both, Francesco Cardona, Christian Dohna-Schwake, Christoph Eich, Frank Eifinger, Ralf Huth, Ellen Heimberg, Bernd Landsleitner, Martin Olivieri, Michael Sasse, Thomas Weisner, Michael Wagner, Gert Warnke, Bernhard Ziegler, Bernd W. Boettiger, Vinay Nadkarni, Florian Hoffmann
Summary: Physical and mental disabilities resulting from a child's cardiac arrest are a major concern for families and society. Recent studies have shown that the quality of pediatric resuscitation often falls below recommended standards. Implementing the 10 evidence-based measures outlined here can improve survival rates and morbidity in resuscitated children. These theses focus on prevention, recognition, consistent training, learning from each patient, and evaluating and measuring the quality of resuscitation to identify areas for improvement.
MONATSSCHRIFT KINDERHEILKUNDE
(2023)
Article
Anatomy & Morphology
Ida Schwake, Maria Sprinz, Martin Scaal, Frank Eifinger
Summary: This study investigates the upper airway anatomy of (pre-)term infants to improve airway management and device development. The angles of the ventilation pathway of (pre-)term infants do not depend systematically on gestational age, suggesting laryngeal masks may be suitable for preterm infants.
Letter
Critical Care Medicine
Frank Eifinger, Bernhard Dorweiler, Moritz Wegner
RESUSCITATION PLUS
(2023)
Article
Pediatrics
Philipp Jung, Sebastian Brenner, Iris Bachmann, Christian Both, Francesco Cardona, Christian Dohna-Schwake, Christoph Eich, Frank Eifinger, Ralf Huth, Ellen Heimberg, Bernd Landsleitner, Martin Olivieri, Michael Sasse, Thomas Weisner, Michael Wagner, Gert Warnke, Bernhard Ziegler, Bernd W. Boettiger, Vinay Nadkarni, Florian Hoffmann
Summary: Physical and mental disabilities resulting from a child's cardiac arrest are a major concern for families and society. However, recent studies have shown that the quality of pediatric resuscitation often falls short of recommended standards. Implementing these 10 evidence-based measures can help improve survival rates and minimize long-term effects on resuscitated children. These theses and basic principles are backed by the Austrian, German, and Swiss Resuscitation Councils and have already been published in Frontiers in Pediatrics.
MONATSSCHRIFT KINDERHEILKUNDE
(2022)
