Editorial Material
Biochemistry & Molecular Biology
Ilona C. Grunwald Kadow, David Owald
Summary: Animals constantly evaluate their options based on new experiences, and something considered bad initially can become better when compared to something worse. A new study demonstrates how flies re-evaluate between better and worse choices.
Article
Genetics & Heredity
Andriy S. Yatsenko, Halyna R. Shcherbata
Summary: This study reveals that multiple modes of Notch signaling activation contribute to the specification of spatial cellular interactions necessary for stem cell niche assembly in Drosophila. It demonstrates the trans-activation of Notch signaling among non-equipotent cells through distant induction, as well as a secondary security mechanism controlled by the soma to ensure the formation of the stem cell niche. These findings advance our understanding of Notch signaling and stem cell niche formation, with implications for stem cell biology and regenerative medicine.
Review
Immunology
Christine Gaboriaud, Marie Lorvellec, Veronique Rossi, Chantal Dumestre-Perard, Nicole M. Thielens
Summary: Our immune system responds to infectious and tissue damage signals, with the complement system and HMGB1 playing important roles. These systems involve molecular cascades and amplification loops, initially acting as alarm systems but eventually contributing to inflammation resolution and homeostasis. However, when these defense systems go out of control, they can cause serious cellular and tissue damage. The interaction between complement and HMGB1 pathways, as well as their traditional and non-canonical roles, functioning, and impact in different systems are described.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Milagros N. Wong, Pierre-Louis Tharaux, Florian Grahammer, Victor G. Puelles
Summary: Crescentic glomerulonephritis involves rapid kidney function loss and the formation of glomerular crescents. Recent studies show that parietal epithelial cells play a crucial role in crescent formation even without immune modulation. Understanding the biology of these cells and their physiological and pathological roles in glomerular lesions, particularly in the context of crescentic glomerulonephritis, is highlighted in this review.
CELL AND TISSUE RESEARCH
(2021)
Review
Behavioral Sciences
Tim L. Emmerzaal, Gerben Nijkamp, Marin Veldic, Shamima Rahman, Ana Cristina Andreazza, Eva Morava, Richard J. Rodenburg, Tamas Kozicz
Summary: Medications used to treat neuropsychiatric disorders can have either positive or mixed effects on mitochondrial function, with only a few showing exclusively adverse effects. The preclinical studies discussed in this review may inform medication prescribing practices for individuals with psychopathology and impaired mitochondrial function.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Juthatip Wiwattanapantuwong, Arunya Tuicomepee, Panrapee Suttiwan, Rewadee Watakakosol, Menachem Ben-Ezra, Robin Goodwin
Summary: This study found that the novel infectious disease in Thailand has a certain impact on interpersonal relationships. Married individuals without children had fewer improvements in partner, friendship, and neighbor relationships. Those with lower perceived control over the infection reported declines in relationships, while single individuals reported fewer positive changes in partnership or family relations. The prioritization of security was associated with relationship decline, while the value of universalism was associated with positive changes in family, friendship, and neighborly relations.
Article
Geography
Chrystal Jaye, Geoff Noller, Mark Bryan, Fiona Doolan-Noble
Summary: The 2017 outbreak of Mycoplasma bovis in New Zealand had a significant impact on rural communities, particularly cattle farmers. The Ministry for Primary Industries implemented an eradication programme in 2018, but affected farmers felt that the bureaucracy was not attentive to their needs and practical knowledge. They believed that biosecurity threats like M. bovis could be better managed by being more responsive to rural lifeworld and farmers' situated knowledge.
JOURNAL OF RURAL STUDIES
(2021)
Article
Engineering, Manufacturing
Can Sun, Yonghua Ji
Summary: The application of IoT technology in the e-commerce environment has complex effects on manufacturers and channel performance, and sometimes increasing the value of IoT technology may harm both manufacturers and channel performance.
PRODUCTION AND OPERATIONS MANAGEMENT
(2022)
Review
Oncology
Shuai Zhao, Ling Lv, Kai Zheng, Yu Tian, Jian-Chun Zheng, Cheng-Gang Jiang
Summary: The prognosis of SRC is better at early stage compared to other types of gastric cancer, while it is relatively poorer at advanced stage.
FRONTIERS IN ONCOLOGY
(2021)
Review
Neurosciences
Sandra Zivkovic, Maryam Ayazi, Grace Hammel, Yi Ren
Summary: Neutrophils are crucial components of the innate immune system, playing a key role in defense against infections and tissue injuries by recognizing and neutralizing pathogens. They are proficient in various immune response mechanisms, such as phagocytosis, granule release, and formation of NETs. In the pathologic changes in injured spinal cord, neutrophils play a significant role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Arthur W. Lambert, Christopher Fiore, Yogesh Chutake, Elisha R. Verhaar, Patrick C. Strasser, Mei Wei Chen, Daneyal Farouq, Sunny Das, Xin Li, Elinor Ng Eaton, Yun Zhang, Joana Liu Donaher, Ian Engstrom, Ferenc Reinhardt, Bingbing Yuan, Sumeet Gupta, Bruce Wollison, Matthew Eaton, Brian Bierie, John Carulli, Eric R. Olson, Matthew G. Guenther, Robert A. Weinberg
Summary: This study isolated highly enriched populations of human breast cancer stem cells (CSCs) using cell-surface expression of integrin b4 (ITGB4), and identified the gene regulatory network operating in ITGB4+ CSCs. The transcriptional program controlled by DNp63 in CSCs was found to be distinct from that in normal basal mammary stem cells, and instead resembled a regenerative epithelial stem cell response to wounding. Additionally, the quasi-mesenchymal CSCs repurpose this program to drive metastatic colonization via autocrine EGFR signaling.
DEVELOPMENTAL CELL
(2022)
Review
Food Science & Technology
Maria Dimopoulou, Marguerite Dols-Lafargue
Summary: Research has shown that lactic acid bacteria produce a variety of exopolysaccharides in fermented beverages through multiple biosynthetic pathways, crucial for bacterial adaptation to human intervention. LAB polysaccharides have been widely studied in the food industry, but research in wine, beer and cider is limited. This review summarizes information on the structure, biosynthetic pathways, and physiology of LAB polysaccharides in these beverages.
Article
Cardiac & Cardiovascular Systems
Jagadish Ramasamy, Victoria Job, Thenmozhi Mani, Molly Jacob
Summary: The study found that LDL-C values calculated using the modified formula showed better agreement with directly measured values and had less bias and percentage total error than those calculated using the Friedewald formula. However, the total percentage error of LDL-C values calculated using the modified formula exceeded the recommended limit.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Joyita Bharati, Praveen N. N. Chander, Pravin C. C. Singhal
Summary: Glomerular parietal epithelial cells (PECs) play crucial roles in both repair and pathogenesis of kidney diseases. Recent studies have shown that microRNA-193a (miR193a) is involved in the modulation of PEC behavior and its role in diseases such as focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (CrescGN), where PECs exhibit abnormal proliferation. Inhibition of miR193a reduces crescent lesions in a mouse model of CrescGN, while its induction leads to dedifferentiation of podocytes in a mouse model of primary FSGS.
Article
Biochemistry & Molecular Biology
Yusuke Mori, Naoka Shiratsuchi, Nanami Sato, Azusa Chaya, Nobuyuki Tanimura, Susumu Ishikawa, Mugihiko Kato, Ikumi Kameda, Shunsuke Kon, Yukinari Haraoka, Tohru Ishitani, Yasuyuki Fujita
Summary: This study found that reactive oxygen species (ROS) are elevated in the surrounding epithelial layers during cell extrusion, and reducing ROS levels inhibits the extrusion process. Additionally, extruding cells release ATP, which promotes ROS levels and cell extrusion. The extracellular ATP and ROS pathways also regulate the movement of surrounding cells towards the extruding cells. These findings highlight the important role of extracellular ATP in cell extrusion.
Article
Urology & Nephrology
Ghazal Z. Quinn, Amin Abedini, Hongbo Liu, Ziyuan Ma, Andrew Cucchiara, Andrea Havasi, Jon Hill, Matthew B. Palmer, Katalin Susztak
Summary: The study discovered that histologic analysis is an important complementary method for evaluating kidney disease, especially in the early stages. Some individuals exhibit relatively severe structural damage despite having preserved eGFR.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Josyf C. Mychaleckyj, Erkka Valo, Takaharu Ichimura, Tarunveer S. Ahluwalia, Christian Dina, Rachel G. Miller, Ivan G. Shabalin, Beata Gyorgy, JingJing Cao, Suna Onengut-Gumuscu, Eiichiro Satake, Adam M. Smiles, Jani K. Haukka, David-Alexandre Tregouet, Tina Costacou, Kristina O'Neil, Andrew D. Paterson, Carol Forsblom, Hillary A. Keenan, Marcus G. Pezzolesi, Marlon Pragnell, Andrzej Galecki, Stephen S. Rich, Niina Sandholm, Ronald Klein, Barbara E. Klein, Katalin Susztak, Trevor J. Orchard, Ron Korstanje, George L. King, Samy Hadjadj, Peter Rossing, Joseph V. Bonventre, Per-Henrik Groop, James H. Warram, Andrzej S. Krolewski
Summary: Rare protein coding variants in the HSD17B14 gene were found to have a protective effect against the onset of ESKD in individuals with type 1 diabetes. However, gene and protein expression were attenuated in diabetic proximal tubules and mouse kidney injury models.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Barry Freedman, Jeffrey B. Kopp, Matthew G. Sampson, Katalin Susztak
Summary: APOL1 kidney risk variants have been identified as major drivers of kidney disease in individuals with sub-Saharan African ancestry. Future research aims to focus on characterizing different APOL1 RV phenotypes, further dissecting APOL1-mediated pathways, and developing new therapies.
KIDNEY INTERNATIONAL
(2021)
Article
Genetics & Heredity
Xin Sheng, Yuting Guan, Ziyuan Ma, Junnan Wu, Hongbo Liu, Chengxiang Qiu, Steven Vitale, Zhen Miao, Matthew J. Seasock, Matthew Palmer, Myung K. Shin, Kevin L. Duffin, Steven S. Pullen, Todd L. Edwards, Jacklyn N. Hellwege, Adriana M. Hung, Mingyao Li, Benjamin F. Voight, Thomas M. Coffman, Christopher D. Brown, Katalin Susztak
Summary: This study generated cell-type-specific eQTL maps in the human kidney using over 600 microdissected kidney samples, highlighting the cell types influencing kidney function, hypertension, and other traits.
Review
Genetics & Heredity
Melina Claussnitzer, Katalin Susztak
Summary: Large-scale genetic association studies have identified thousands of genetic risk loci with sequence variations more common in patients with metabolic diseases. While the molecular and cellular mechanisms affected by these common genetic variations remain mostly unknown, new genome-wide data types and analytical methodologies are paving the way for systematic variant-to-function studies, improving mechanistic understanding of disease biology.
TRENDS IN GENETICS
(2021)
Editorial Material
Urology & Nephrology
Daigoro Hirohama, Katalin Susztak
Summary: In 2021, significant progress was made in understanding the genetics of kidney function and disease, with key advances in genome-wide association studies and multi-omics methods identifying key genes and cell types involved in disease development.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Urology & Nephrology
Xiujie Liang, Tamas Aranyi, Jianfu Zhou, Yuting Guan, Hailong Hu, Hongbo Liu, Katalin Susztak
Summary: This study shows that Tet2 and Tet3 play key roles in kidney development and nephron endowment. These proteins regulate gene expression by catalyzing active DNA hydroxymethylation and also have important functions in signaling pathways. The loss of Tet2 and Tet3 leads to defective nephron formation, resulting in kidney failure and perinatal death.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Poonam Dhillon, Kelly Ann Mulholland, Hailong Hu, Jihwan Park, Xin Sheng, Amin Abedini, Hongbo Liu, Allison Vassalotti, Junnan Wu, Katalin Susztak
Summary: Inflammation is a common feature in chronic kidney disease, and endogenous retroviruses can activate cytosolic nucleotide sensors causing renal fibroinflammation.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Urology & Nephrology
Katalin Susztak
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Amin Abedini, Konstantin A. Kloetzer, Katalin Susztak
Article
Endocrinology & Metabolism
Tomohito Doke, Sarmistha Mukherjee, Dhanunjay Mukhi, Poonam Dhillon, Amin Abedini, James G. Davis, Karthikeyani Chellappa, Beishan Chen, Joseph A. Baur, Katalin Susztak
Summary: Doke et al. found that NMN and NR supplementation can protect against kidney injury caused by cisplatin, by inhibiting the release of mitochondrial RNA and the subsequent activation of the RIG-I pathway and inflammation. It is discovered that NAD(+) deficiency plays a role in mitochondrial dysfunction and the development of kidney disease. Supplementing with nicotinamide riboside or nicotinamide mononucleotide can restore NAD(+) levels and improve kidney function.
Article
Urology & Nephrology
Farah Lizotte, Marina Rousseau, Benoit Denhez, Dominique Levesque, Andreanne Guay, Hongbo Liu, Julie Moreau, Sarah Higgins, Robert Sabbagh, Katalin Susztak, Francois-Michel Boisvert, Anne Marie Cote, Pedro Geraldes
Summary: Clinical and experimental data suggest that podocyte injury is involved in the onset and progression of diabetic kidney disease. The protein tyrosine phosphatase SHP-1 plays a major role in the survival and function of podocytes, and its expression is increased in diabetes. The podocyte-specific deletion of SHP-1 can prevent DKD progression and preserve podocyte function.
KIDNEY INTERNATIONAL
(2023)
Review
Medicine, Research & Experimental
Samer Mohandes, Tomohito Doke, Hailong Hu, Dhanunjay Mukhi, Poonam Dhillon, Katalin Susztak
Summary: Kidney disease is a leading cause of death in diabetes patients, with diabetic kidney disease (DKD) accounting for nearly half of all chronic kidney disease cases. Podocytes and endothelial cells are found to play a crucial role in the development of albuminuria and early kidney disease in diabetes. Hyperglycemia induces cellular stress in the kidney, leading to changes in cellular metabolism and an excessive workload for proximal tubule cells. Later, mitochondrial defects result in increased oxidative stress and activation of inflammatory pathways, causing progressive decline in kidney function and fibrosis. Blocking the renin-angiotensin system or the sodium-glucose cotransporter can protect cells and slow down the decline in kidney function. Newly identified molecular pathways may pave the way for the development of much-needed novel therapeutics.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Medicine, Research & Experimental
Junnan Wu, Archana Raman, Nathan J. Coffey, Xin Sheng, Joseph Wahba, Matthew J. Seasock, Ziyuan Ma, Pazit Beckerman, Dorottya Laczko, Matthew B. Palmer, Jeffrey B. Kopp, Jay J. Kuo, Steven S. Pullen, Carine M. Boustany-Kari, Andreas Linkermann, Katalin Susztak
Summary: Coding variants in APOL1, especially G1 and G2, are key factors contributing to excess kidney disease risk in African Americans. The study reveals that expression of G2 APOL1 induces activation of STING and NLRP3 inflammasome in podocytes, leading to kidney dysfunction. Inhibition of NLRP3, GSDMD, and STING shows promising therapeutic potential for APOL1-associated kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Urology & Nephrology
Barak Rosenzweig, Pedro Recabal, Caroline Gluck, Jonathan A. Coleman, Katalin Susztak, A. Ari Hakimi, Edgar A. Jaimes, Robert H. Weiss
Summary: Nephrectomy type, gender, blood lipids, and metabolites from benign kidney parenchyma at nephrectomy were found to be significantly associated with long-term kidney function. Some of these metabolites overlapped with previously reported processes related to chronic kidney disease.
CLINICAL KIDNEY JOURNAL
(2021)
