Article
Medicine, General & Internal
Heng-Chi Pan, Hsing-Yu Chen, Hui-Ming Chen, Yu-Tung Huang, Ji-Tseng Fang, Yung-Chang Chen
Summary: This study aimed to identify the risk factors for the occurrence of acute kidney disease (AKD) and determine its predictive value for 180-day mortality in critically ill patients. The study found that AKI severity, underlying early CKD, chronic liver disease, malignancy, and use of emergency hemodialysis were independent risk factors of AKD, while male gender, higher lactate levels, use of ECMO, and admission to surgical ICU were negatively correlated with AKD. The occurrence of AKD adds limited additional prognostic information for risk stratification of survivors among critically ill patients with AKI but could predict prognosis in survivors without prior AKI.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Letter
Medicine, General & Internal
Dominique Vodovar, Bruno Megarbane, Stephane Gaudry, Didier Dreyfuss, Paul M. Palevsky
Summary: This article discusses the importance and effectiveness of using extracorporeal kidney-replacement therapy in poisonings, even in the absence of acute kidney injury, to rapidly remove toxicants and save lives.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Urology & Nephrology
Huiting Luo, Xiaolin Li, Qidong Ren, Yangzhong Zhou, Gang Chen, Bin Zhao, Xuemei Li
Summary: This study investigates the occurrence of acute kidney injury (AKI) after COVID-19 vaccinations. The Pfizer-BNT vaccine appears to have a stronger correlation with AKI compared to the MODERNA and JANSSEN vaccines. The main cause of post-vaccine AKI is volume depletion. Elderly patients are more likely to experience AKI, with the highest mortality rate observed in patients who received the Pfizer-BNT vaccine.
Article
Oncology
Nuttha Lumlertgul, Pietro Vassallo, Florence Tydeman, Natasha Lewis, Abigail Hobill, Kittisak Weerapolchai, Nurul Zaynah Nordin, Nina Seylanova, Luke Martin, Armando Cennamo, Yanzhong Wang, Anne Rigg, Nisha Shaunak, Marlies Ostermann
Summary: This study investigated the incidence of immune-related acute kidney injury (ICPi-AKI) and non-immune-related acute kidney injury (non-ICPi-AKI) in cancer patients treated with immune checkpoint inhibitors (ICPi). Among 1037 patients, 18.2% developed AKI, with 3.6% being ICPi-AKI. Patients with ICPi-AKI had worse kidney outcomes compared to non-ICPi-AKI, but non-ICPi-AKI was associated with a higher risk of death.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Simon Sawhney, Samira Bell, Corri Black, Christian Fynbo Christiansen, Uffe Heide-Jorgensen, Simon Kok Jensen, Paul E. Ronksley, Zhi Tan, Marcello Tonelli, Heather Walker, Matthew T. James
Summary: Using a consistent analytical approach and KDIGO criteria, the study found that the incidence and prognosis of AKI and AKD are consistent in three high-income countries. The age-standardized incidence rates were similar across regions and years, and the standardized 1-year mortality varied among patients meeting different creatinine criteria.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Huizhen Ma, Xiaoning Zhang, Ling Liu, You Huang, Si Sun, Ke Chen, Qi Xin, Pengfei Liu, Yuxing Yan, Yili Wang, Yuan Li, Haile Liu, Ruoli Zhao, Kexin Tan, Xinzhu Chen, Xun Yuan, Yonghui Li, Ying Liu, Haitao Dai, Changlong Liu, Hao Wang, Xiao-Dong Zhang
Summary: To address the issue of low bioactivity in most near-infrared-II (NIR-II) fluorophores, researchers have developed atomically precise Au-22 clusters with strong NIR-II fluorescence and high catalytic activities. The newly developed Au21Cu1 clusters show significantly higher antioxidant, catalase-like, and superoxide dismutase-like activities than Au-22 clusters, with negligible fluorescence loss. These clusters can be used for three-dimensional imaging of cisplatin-induced renal injury and inhibit oxidative stress and inflammation in a mouse model.
Article
Pharmacology & Pharmacy
Yu Zhou, Jianbin Li, Linyao Wang, Xinyan Zhu, Meilian Zhang, Jiaping Zheng
Summary: This study examined the occurrence of drug-induced acute kidney injury (AKI) in COVID-19 patients, particularly those with diabetes mellitus (DM), using the FDA Adverse Event Reporting System (FAERS) database. The results showed that remdesivir and tocilizumab were associated with an increased risk of AKI in COVID-19 patients, especially those with DM.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Filipe Marques, Joana Gameiro, Joao Oliveira, Jose Agapito Fonseca, Ines Duarte, Joao Bernardo, Carolina Branco, Claudia Costa, Carolina Carreiro, Sandra Braz, Jose Antonio Lopes
Summary: The study retrospectively analyzed COVID-19 patients with AKI admitted at Centro Hospitalar Universitario Lisboa Norte between March and August 2020. It found that factors such as hypertension, CKD, lower hemoglobin and CRP levels, as well as nephrotoxin exposure were independent risk factors for the development of AKD. Older age, higher serum ferritin levels at admission, and development of AKD were independent predictors of in-hospital mortality in COVID-19-AKI patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Orestis Katsoulis, Athina Georgiadou, Aubrey J. Cunnington
Summary: Acute kidney injury is a common complication of severe malaria and an independent risk factor for death. Different aspects of malaria pathology interact to amplify the damaging effects of the host inflammatory response on the kidneys.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Critical Care Medicine
Nan Cai, Min Jiang, Chao Wu, Fei He
Summary: This study investigated the association between red cell distribution width (RDW) at admission and the frequency of acute kidney injury (AKI) and 28-day mortality in acute respiratory distress syndrome (ARDS) patients. The results showed that RDW levels were significantly higher in the AKI group and increased RDW was a significant predictor of AKI. RDW was also associated with 28-day mortality in ARDS patients, with a higher RDW level leading to a lower survival rate.
Article
Chemistry, Multidisciplinary
Jiajia Li, Qijia Duan, Xiaona Wei, Jianping Wu, Qiongqiong Yang
Summary: This study developed a nanoparticle for targeted delivery of rosmarinic acid (RA) in the treatment of acute kidney injury (AKI). The nanoparticle showed excellent antioxidative and antiapoptotic effects, improved renal function, and repaired damaged renal tissue in vivo.
Review
Biochemistry & Molecular Biology
Naomi Pode-Shakked, Prasad Devarajan
Summary: Acute kidney injury (AKI) is a common and serious problem affecting people of all ages, with a lack of understanding in its pathobiology hindering the development of new diagnostics and therapeutics. Recent advancements in using human stem cells, organoids, and in silico approaches have been made in studying human AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Urology & Nephrology
Josee Bouchard, Ravindra L. Mehta
Summary: The optimal timing of kidney support therapy in critically ill patients with acute kidney injury (AKI) without life-threatening complications related to AKI is controversial. This article reviews the concept of timing of dialysis in AKI, performs a critical assessment of the most important clinical trials in this topic, discusses ongoing research and knowledge gaps, and defines key research issues to address in the future.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Multidisciplinary Sciences
Raul Lombardi, Alejandro Ferreiro, Daniela Ponce, Rolando Claure-Del Granado, Gustavo Aroca, Yanissa Venegas, Mariana Pereira, Jonathan Chavez-Iniguez, Nelson Rojas, Ana Villa, Marcos Colombo, Cristina Carlino, Caio Guimaraes, Mauricio Younes-Ibrahim, Lilia Maria Rizo, Gisselle Guzman, Carlos Varela, Guillermo Rosa-Diez, Diego Janiques, Roger Ayala, Galo Coronel, Eric Roessler, Serena Amor, Washington Osorio, Natalia Rivas, Benedito Pereira, Caroline de Azevedo, Adriana Flores, Jose Ubillo, Julieta Rano, Luis Yu, Emmanuel A. Burdmann, Luis Rodriguez, Gianny Galagarza-Gutierrez, Jesus Curitomay-Cruz
Summary: This study describes the characteristics of acute kidney disease associated with COVID-19 infection. The study found that kidney injury was mainly caused by COVID-19 MODS and volume depletion, and some patients exhibited proteinuria. The study also highlighted the importance of proteinuria detection in monitoring disease progression.
Article
Multidisciplinary Sciences
Farid Samaan, Elisa Carneiro de Paula, Fabrizzio Batista Guimaraes de Lima Souza, Luiz Fernando Cardoso Mendes, Paula Regina Gan Rossi, Rafaela Andrade Penalva Freitas, Fernando Takahashi Nakagawa, Alexandre Toledo Maciel, Sylvia Aranha, Eduardo Osawa, Henrique Pinheiro Konigsfeld, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Tales Dantas Vieira, Karina De Bonis Thomaz, Elias Marcos Silva Flato, Renata Cristina da Silva, Lucas Vicente Andrade, Muna Badaoui, Eduardo Pogetti Badaoui, Miguel Angelo Goes, Sergio Henrique do Amaral, Karlla Cunha, Ines Marin Muniz, Jacqueline Siqueira Sampaio, Marcelino de Souza Durao Junior, Dirce M. Trevisan Zanetta, Emmanuel A. Burdmann
Summary: AKI-RRT associated with COVID-19 occurred in patients with a heavy burden of comorbidities and had a high mortality rate. The number of organ dysfunctions at admission and RRT efficiency were independent factors associated with mortality. A significant proportion of survivors were discharged while still dependent on RRT.
Letter
Urology & Nephrology
Veronica T. Costa e Silva, Lesley A. Inker, Emmanuel A. Burdmann, Andrew S. Levey
KIDNEY INTERNATIONAL
(2022)
Letter
Urology & Nephrology
Precil D. Neves, Renato A. Caires, Manoel P. Guimaraes, Elerson C. Costalonga, Livia B. Cavalcante, Veronica T. Costa e Silva, Francisco Z. Mattedi, Leonardo F. Santana, Antonio A. Teixeira-Junior, Orlando V. Gomes, Gyl E. Silva, Emmanuel A. Burdmann, Luiz F. Onuchic
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria Dp Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
Summary: This study compares the performance of different equations for glomerular filtration rate (GFR) evaluation in cancer patients. The results show that the Cockcroft-Gault equation is the least accurate, while the CKD-EPI equation and eGFRcr-cys equation perform better. Therefore, it is recommended to adopt guideline-recommended methods for GFR evaluation in oncology practice and clinical trials.
KIDNEY INTERNATIONAL
(2022)
Article
Psychology, Clinical
Geraldo F. Busatto, Adriana Ladeira de Araujo, Joao Mauricio Castaldelli-Maia, Rodolfo Furlan Damiano, Marta Imamura, Bruno F. Guedes, Fabio de Rezende Pinna, Marcio Valente Yamada Sawamura, Marcio C. Mancini, Katia R. da Silva, Michelle L. Garcia, Nairo Sumita, Andre Russowsky Brunoni, Alberto J. da Silva Duarte, Emmanuel A. Burdmann, Esper G. Kallas, Giovanni G. Cerri, Ricardo Nitrini, Ricardo F. Bento, Vanderson Geraldo Rocha, Heraldo Possolo de Souza, Euripedes C. Miguel, Carlos R. R. de Carvalho, Orestes Forlenza, Linamara Rizzo Batistella
Summary: A study was conducted to investigate the patterns of symptom co-occurrence and their biological correlates in individuals with post-acute sequelae of SARS-CoV-2 infection. The results showed that fatigue, psychiatric, and cognitive symptoms were highly discriminative and associated with physical disability and persistent systemic inflammation.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Urology & Nephrology
Heitor S. Ribeiro, Emmanuel A. Burdmann, Edilene A. Vieira, Mateus L. Ferreira, Aparecido P. Ferreira, Antonio J. Inda-Filho
Summary: This study found that hypomagnesemia at ICU admission was associated with the development of acute kidney injury (AKI), while hypermagnesemia was not significantly associated with AKI. Both hypomagnesemia and hypermagnesemia were associated with higher mortality risks.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Correction
Psychology, Clinical
Geraldo F. Busatto, Adriana Ladeira de Araujo, Joao Mauricio Castaldelli-Maia, Rodolfo Furlan Damiano, Marta Imamura, Bruno F. Guedes, Fabio de Rezende Pinna, Marcio Valente Yamada Sawamura, Marcio C. Mancini, Katia R. da Silva, Michelle L. Garcia, Nairo Sumita, Andre Russowsky Brunoni, Alberto J. da Silva Duarte, Emmanuel A. Burdmann, Esper G. Kallas, Giovanni G. Cerri, Ricardo Nitrini, Ricardo F. Bento, Vanderson Geraldo Rocha, Heraldo Possolo de Souza, Euripedes C. Miguel, Carlos R. R. de Carvalho, Orestes V. Forlenza, Linamara Rizzo Batistella
PSYCHOLOGICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Juliana Carvalho Ferreira, Tiana C. Lopes Moreira, Adriana Ladeira de Araujo, Marta Imamura, Rodolfo F. Damiano, Michelle L. Garcia, Marcio V. Y. Sawamura, Fabio R. Pinna, Bruno F. Guedes, Fabio A. Rodrigues Goncalves, Marcio Mancini, Emmanuel A. Burdmann, Demostenes Ferreira da Silva Filho, Jefferson Lordello Polizel, Ricardo F. Bento, Vanderson Rocha, Ricardo Nitrini, Heraldo Possolo de Souza, Anna S. Levin, Esper G. Kallas, Orestes Forlenza, Geraldo F. Busatto, Linamara R. Batistella, Carlos R. Ribeiro de Carvalho, Thais Mauad, Nelson Gouveia
Summary: This study aimed to describe the persistent symptoms among COVID-19 survivors and identify factors associated with post-COVID-19 syndrome. The study found a high frequency of persistent symptoms, including pain, fatigue, and posttraumatic stress disorder, which were associated with the severity of COVID-19, individual characteristics, and environmental factors. These findings suggest that most COVID-19 recovering patients will require post-discharge care and pose an additional burden to healthcare systems.
JOURNAL OF GLOBAL HEALTH
(2022)
Article
Urology & Nephrology
Farid Samaan, Danilo Aoike, Ricardo Pagrion-Neto, Thiago Cesar Pons, Rafaela Bracci Lisboa, Emmanuel A. Burdmann
Summary: This study evaluated the knowledge of non-nephrologists, undergraduate medical students, and health professionals regarding acute kidney injury (AKI). The results showed knowledge gaps and highlighted the need for professional training programs.
Editorial Material
Critical Care Medicine
Marlies Ostermann, Rajit K. Basu, Ravindra L. Mehta
INTENSIVE CARE MEDICINE
(2023)
Letter
Urology & Nephrology
Veronica T. Costa e Silva, Luiz A. Gil Jr, Lesley A. Inker, Renato A. Caires, Elerson Costalonga, George Coura-Filho, Marcelo T. Sapienza, Gilberto Castro Jr, Maria D. P. Estevez-Diz, Dirce Maria T. Zanetta, Leila Antonangelo, Lia Marcal, Hocine Tighiouart, Shiyuan Miao, Paul Mathew, Andrew S. Levey, Emmanuel A. Burdmann
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Review
Urology & Nephrology
Alexander Zarbock, Lui G. Forni, Marlies Ostermann, Claudio Ronco, Sean M. Bagshaw, Ravindra L. Mehta, Rinaldo Bellomo, John A. Kellum
Summary: Acute kidney injury (AKI) is a common clinical condition associated with increased mortality and the risk of developing chronic kidney disease and kidney failure. Currently, there is no specific therapy for AKI and novel interventions targeting the underlying pathophysiology are needed. Well-designed clinical trials with appropriate end points are crucial to evaluate the efficacy of these new interventions and improve outcomes.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Farid Samaan, Rafaela Andrade Penalva Freitas, Renata Viana, Livia Gambaro, Karlla Cunha, Tales Dantas Vieira, Valkercyo Feitosa, Eric Aragao Correa, Alexandre Toledo Maciel, Sylvia Aranha, Eduardo Atsushi Osawa, Roberta Pillar, Elias Marcos da Silva Flato, Renata Cristina da Silva, Elisa Carneiro, Fabrizzio Batista Guimaraes de Lima Souza, Paula Regina Gan Rossi, Munira Bittencourt Abud, Henrique Pinheiro Konigsfeld, Riberto Garcia da Silva, Ricardo Barbosa Cintra de Souza, Saurus Mayer Coutinho, Miguel angelo Goes, Barbara Antunes Bruno da Silva, Dirce Maria Trevisan Zanetta, Emmanuel Almeida Burdmann
Summary: In the megalopolis of Sao Paulo, Brazil, the lethality of critically ill patients with COVID-19-associated AKI treated with KRT was higher in the second wave of the pandemic, despite these patients being younger and having fewer comorbidities. Potential factors related to this poor outcome were difficulties in health care access, lack of intra-hospital resources, delay vaccination and virus variants.