Article
Medicine, General & Internal
Filippo Mariano, Consuelo De Biase, Zsuzsanna Hollo, Ilaria Deambrosis, Annalisa Davit, Alberto Mella, Daniela Bergamo, Stefano Maffei, Francesca Rumbolo, Alberto Papaleo, Maurizio Stella, Luigi Biancone
Summary: The study found that burn patients treated with CRRT had a long-term expectation of preserved renal function, but were more predisposed to microalbuminuria, diabetes, and the presence of risk factors for intercurrent comorbidities and chronic renal disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Urology & Nephrology
Diego Aguilar Palacios, Brigid Wilson, Mustafa Ascha, Rebecca A. Campbell, Sunah Song, Molly E. DeWitt-Foy, Steven C. Campbell, Robert Abouassaly
Summary: The study developed and validated a simplified equation to predict new baseline glomerular filtration rate in patients with renal cell carcinoma undergoing radical nephrectomy or partial nephrectomy. The equation demonstrated high correlation and accuracy in both internal and external validation cohorts, accurately predicting postoperative glomerular filtration rate above a certain threshold.
JOURNAL OF UROLOGY
(2021)
Article
Physiology
Carlos Hernando, Carla Hernando, Nayara Panizo, Eladio Collado-Boira, Ana Folch-Ayora, Ignacio Martinez-Navarro, Barbara Hernando
Summary: Long distance races have physiological impacts on runners, with the use of elliptical machines for marathon recovery delaying renal function recovery. Light-intensity continuous running might be a better strategy for recovery after finishing a marathon.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Analytical
Jun Wang, Menglei Zha, Hui Zhao, Wentong Yue, Decheng Wu, Kai Li
Summary: This research successfully synthesized a class of renal-clearable gadolinium nanoparticles and achieved the diagnosis of kidney dysfunction in a mice model with a damaged kidney through noninvasive magnetic resonance imaging. This provides a new tool for exploring translational strategies for kidney dysfunction.
ANALYTICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Nori J. L. Smeets, Oliver Hartmann, Janin Schulte, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study aimed to investigate the relationship between a novel GFR marker, PENK, and age in children, as well as its correlation with traditional markers. The study found that PENK levels were higher in young children and decreased to adult levels around two years of age. The correlation between PENK and mGFR was similar to the correlation between SCr-based eGFR and mGFR.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment is associated with unfavorable outcomes following intracerebral hemorrhage, and there may be safety concerns for intensive blood pressure control in patients with renal impairment.
Article
Multidisciplinary Sciences
Shinhyeung Kwak, Jeong Yeon Kim, Heeyeon Cho
Summary: This retrospective study conducted at Samsung Medical Center in Seoul, South Korea, aimed to investigate the prevalence and risk factors of vancomycin-induced nephrotoxicity in non-ICU pediatric patients. The study found that a longer hospital stay, concomitant use of piperacillin-tazobactam, and a serum trough level of vancomycin above 24.35 mu g/mL were independently associated with VIN. The study suggests that measuring serum trough level of vancomycin can help clinicians prevent VIN in pediatric patients.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Evgeniia V. Garbuzova, Alyona D. Khudiakova, Lilia V. Shcherbakova, Elena V. Kashtanova, Yana V. Polonskaya, Ekaterina M. Stakhneva, Yulia I. Ragino
Summary: This study found that in young people with dyslipidemia, abdominal obesity and increased resistin and GIP levels are associated with the presence of renal dysfunction.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Mayumi Fukuda-Doi, Haruko Yamamoto, Masatoshi Koga, Yohei Doi, Adnan I. Qureshi, Sohei Yoshimura, Kaori Miwa, Akiko Ishigami, Masayuki Shiozawa, Katsuhiro Omae, Masafumi Ihara, Kazunori Toyoda
Summary: Renal impairment may lead to unfavorable outcomes following intracerebral hemorrhage, and there is a significant interaction between decreased eGFR and treatment assignment in intensive blood pressure control therapy, raising safety concerns.
Article
Infectious Diseases
Silvijus Abramavicius, Vaidotas Galaune, Agile Tunaityte, Astra Vitkauskiene, Gintautas Gumbrevicius, Aurelija Radzeviciene, Romaldas Maciulaitis
Summary: The study found that current eGFR estimators for patients with acute kidney injury (AKI) pose risks of inaccuracy in renal function assessment and drug dosing, with the exception of the Cockcroft-Gault estimator, which is more appropriate.
Article
Urology & Nephrology
Ghazal Z. Quinn, Amin Abedini, Hongbo Liu, Ziyuan Ma, Andrew Cucchiara, Andrea Havasi, Jon Hill, Matthew B. Palmer, Katalin Susztak
Summary: The study discovered that histologic analysis is an important complementary method for evaluating kidney disease, especially in the early stages. Some individuals exhibit relatively severe structural damage despite having preserved eGFR.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Hassan N. Ibrahim, Dina N. Murad, Sean A. Hebert, Horacio E. Adrogue, Hana Nguyen, Duc T. Nguyen, Arthur J. Matas, Edward A. Graviss
Summary: The study found that obese kidney donors were more likely to develop diabetes, hypertension, and proteinuria compared to nonobese donors. Obese donors had a higher increase in eGFR in the first 10 years post-donation, but this trend became comparable to nonobese donors thereafter. The absolute risk of developing ESKD was small for obese donors, and their risk of death was similar to that of nonobese donors.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Noppawit Aiumtrakul, Puvanant Wiputhanuphongs, Ouppatham Supasyndh, Bancha Satirapoj
Summary: A prospective cohort study in a Southeast Asian community-based population found an independent association of serum uric acid levels with impaired renal function, with higher incidence observed in males than females. Linear regression analysis showed a negative correlation between eGFR and serum uric acid levels.