Article
Endocrinology & Metabolism
Aaron Douglas, Brenneth Stevens, Lydia Lynch
Summary: In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, IL-17 family is evolutionarily conserved and has a fundamental role beyond typical host defense. IL-17 plays a major function in homeostatic maintenance at barrier sites and is increasingly recognized for its role in regulating cellular metabolism, neuroimmunology, and tissue physiology. It acts as a key player in neuroimmunometabolism, coordinating the cross-talk among the nervous, endocrine, and immune systems for whole-body energy homeostasis.
Review
Biochemistry & Molecular Biology
Anca Hermenean, Daniela Oatis, Hildegard Herman, Alina Ciceu, Giovanbattista D'Amico, Maria Consiglia Trotta
Summary: This article highlights the role of Gal-1 in wound healing and fibrotic diseases, suggesting its potential as a therapeutic target and biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ying Liu, Xiaoge Li, Xuehao Zhou, Jianxun Wang, Xiang Ao
Summary: This review summarizes the recent findings on the structure, functions, and regulatory mechanisms of FADD, focusing on its role in cancer progression. The dysregulation of FADD has been associated with the pathogenesis of various types of cancer, but the detailed mechanisms are not fully understood. The clinical implications of FADD as a biomarker and therapeutic target for cancer patients are also discussed, providing potential insight for the development of FADD-based therapeutic strategies.
MOLECULAR MEDICINE
(2022)
Review
Immunology
Liyun Xu, Wen Liu, Fuxiang Bai, Yong Xu, Xiaohong Liang, Chunhong Ma, Lifen Gao
Summary: Non-alcoholic fatty liver disease is becoming increasingly common worldwide, with hepatic macrophages, specifically Kupffer cells, playing a key role in its progression. Understanding the diverse roles of hepatic macrophages in the development of fatty liver disease may lead to more promising therapeutic strategies for inflammatory liver diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Chenyang Qi, Faten Alsomali, Jinyong Zhong, Raymond C. Harris, Valentina Kon, Haichun Yang, Agnes B. Fogo
Summary: DAAM2 expression is upregulated in human and mouse glomeruli, possibly associated with glomerular hypertrophy. Knockdown of DAAM2 enhances adhesion, slows migration, and influences cell signaling pathways.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Plant Sciences
Biyu Hou, Peng Ma, Xinyu Yang, Xiaoyue Zhao, Li Zhang, Yuerong Zhao, Ping He, Li Zhang, Guanhua Du, Guifen Qiang
Summary: This study demonstrates that Puerarin (PUR) can protect against type 2 diabetic nephropathy by regulating iron homeostasis and mitigating ferroptosis. The results show that PUR significantly improves glucose and lipid metabolism, alleviates renal dysfunction, and inhibits excessive extracellular matrix (ECM) accumulation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Endocrinology & Metabolism
Paramita Paul, Leena Chacko, Tarun K. Dua, Pratik Chakraborty, Udita Paul, Vishwakarma Vishal Phulchand, Niraj K. Jha, Saurabh K. Jha, Ramesh Kandimalla, Saikat Dewanjee
Summary: Diabetic nephropathy is a serious complication of diabetes mellitus, and early detection and effective treatment are crucial. Nanosystems have shown promise in the diagnosis and treatment of diabetic nephropathy, offering advantages such as early and accurate diagnosis, site-specific delivery, and improved pharmacokinetic profile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Yawen Shao, Shujun Deng, Wei Tang, Lingzhi Huang, Yongsheng Xie, Siming Yuan, Liqin Tang
Summary: Diabetic nephropathy (DN) is the most common microvascular complication associated with diabetes, leading to end-stage renal disease. Glomerular endothelial cells (GECs) are susceptible to damage from glucose, lipids, and inflammatory factors, and their injury through the nonclassical caspase-11/GSDMD pathway contributes to the progression of DN. This study highlights the potential of GSDMD as a therapeutic target for DN treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T. Heneka, Christina Ising
Summary: The highest risk factor for the development of tauopathies is aging. Senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. Exposure to tau can lead to microglial senescence, suggesting the presence of a vicious circle.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Baiyu Feng, Yu Lu, Lin Ye, Lijun Yin, Yingjun Zhou, Anqun Chen
Summary: This study used Mendelian randomization analysis to determine the causal relationship between cystatin C and diabetic nephropathy. The study found that cystatin C is an independent risk factor for diabetic nephropathy in patients with diabetes, regardless of BMI and SBP.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Summary: This study identified the pdx1 mutant as a novel model for the study of DKD, showing signs of the early disease progression already in the larval stage and several selective features of later DKD in adult mutants.
Article
Biochemistry & Molecular Biology
Natalia Navarro, Carla Molist, Julia Sansa-Girona, Patricia Zarzosa, Gabriel Gallo-Oller, Guillem Pons, Ainara Magdaleno, Gabriela Guillen, Raquel Hladun, Marta Garrido, Miguel F. Segura, Lourdes Hontecillas-Prieto, Enrique de Alava, Berta Ponsati, Jimena Fernandez-Carneado, Ana Almazan-Moga, Mariona Valles-Miret, Josep Farrera-Sinfreu, Josep Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: Current cancer therapies focus on reducing tumor growth but lack effective options to reduce metastasis. This study reveals the importance of ITGA9 in metastasis and demonstrates the possibility of reducing metastasis by inhibiting ITGA9 with a synthetic peptide.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Hongyan Yao, Zijing Li
Summary: This study analyzed retinal vessel density and thickness characteristics in patients with diabetic nephropathy (DN) and preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA). The findings suggest that DN individuals have more severe microvascular and microstructural impairment compared to individuals without DN. Additionally, estimated glomerular filtration rate (eGFR) may serve as an indicator for retinal microvascular impairment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Sunanda Margrett Williams, Dipankar Chatterji
Summary: Iron plays a vital role in various cellular processes, and the iron storage protein Dps is important for iron storage, DNA binding, and protection against oxidative stress. Understanding the multifarious properties of Dps and its potential role as an iron donor to Fe-S clusters is crucial for studying iron homeostasis.
Article
Medicine, General & Internal
Xiaobo Li, Ishwarya Venkatesh, Veronica Villanueva, Huiting Wei, Terese Geraghty, Anugraha Rajagopalan, Richard W. Helmuth, Mehmet M. Altintas, Hafeez M. Faridi, Vineet Gupta
Summary: This study demonstrates the protective role of podocyte-specific miR-146a in preventing glomerular damage. By modulating ErbB4/EGFR, TGF-β, and associated downstream signaling, miR-146a can alleviate proteinuria and kidney dysfunction caused by diabetic nephropathy and other glomerulopathies.
FRONTIERS IN MEDICINE
(2022)
Letter
Urology & Nephrology
Raina D. Ramnath, Matthew J. Butler, Rebecca R. Foster, Simon C. Satchell
KIDNEY INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Abigail C. Lay, A. Fern Barrington, Jennifer A. Hurcombe, Raina D. Ramnath, Mark Graham, Philip A. Lewis, Marieangela Wilson, Kate J. Heesom, Matthew J. Butler, Rebecca M. Perrett, Chris R. Neal, Eleanor Herbert, Edward Mountjoy, Denize Atan, Viji Nair, Wenjun Ju, Robert G. Nelson, Matthias Kretzler, Simon C. Satchell, Craig A. McArdle, Gavin Welsh, Richard J. M. Coward
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Pharmacology & Pharmacy
Aldy Aliyandi, Simon Satchell, Ronald E. Unger, Birke Bartosch, Romain Parent, Inge S. Zuhorn, Anna Salvati
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Microbiology
Magnus Hansson, Rasmus Gustafsson, Chloe Jacquet, Nedia Chebaane, Simon Satchell, Therese Thunberg, Clas Ahlm, Anne-Marie Fors Connolly
Article
Urology & Nephrology
Baptiste Lamarthee, Carole Burger, Charlotte Leclaire, Emilie Lebraud, Aniela Zablocki, Lise Morin, Xavier Lebreton, Beatrice Charreau, Renaud Snanoudj, Soeli Charbonnier, Tifanie Blein, Melanie Hardy, Julien Zuber, Simon Satchell, Morgan Gallazzini, Fabiola Terzi, Christophe Legendre, Jean Luc Taupin, Marion Rabant, Claire Tinel, Dany Anglicheau
Summary: The study demonstrates that using human glomerular endothelial cells with all HLA antigens deleted as targets and recapitulating a large array of potential non-HLA antibodies in a single test can confirm the detrimental impact of non-HLA antibodies on microvascular inflammation and graft outcome after kidney transplantation, independent of HLA antibodies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Immunology
Aleksandra Urban, Daria Kowalska, Grzegorz Stasilojc, Alicja Kuzniewska, Anna Skrobinska, Emilia Arjona, Eugenia Castellote Alonso, Maria Angeles Fenollosa Segarra, Ilse Jongerius, Robbert Spaapen, Simon Satchell, Marcel Thiel, Stanislaw Oldziej, Santiago Rodriguez de Cordoba, Marcin Okroj
Summary: The impairment of the alternative complement pathway contributes to rare kidney diseases such as aHUS and C3G. Mutations in the classical complement pathway component C2, specifically the R249C and S250C variants, were found to stabilize classical C3 convertases and increase complement-dependent cytotoxicity. The study suggests CRP as a potential trigger for excessive complement activation in carriers of GoF mutations in complement C2.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Jack Tuffin, Musleeha Chesor, Valeryia Kuzmuk, Tim Johnson, Simon C. Satchell, Gavin Welsh, Moin A. Saleem
Summary: Tuffin et al. demonstrate a method for culturing conditionally immortalized human podocytes and GEnCs in 3D by forming spheroid cultures termed GlomSpheres, which are found to segregate in an organized manner. These are shown to establish a GBM-like extracellular matrix with increased cell differentiation and maturity when compared to 2D cultures and their use demonstrated in pharmaceutical screening using rapid imaging approaches.
COMMUNICATIONS BIOLOGY
(2021)
Review
Neurosciences
Patrice Stoddart, Simon C. Satchell, Raina Ramnath
Summary: The socio-economic impact of diseases associated with cognitive impairment is increasing. Research into the cerebral endothelial glycocalyx (CeGC) could offer effective treatments. The CeGC plays a vital role in protecting parenchymal tissue and maintaining the blood-brain barrier (BBB), and its degradation is linked to several cognitive impairment conditions. Further research is needed to fully understand the diagnostic and therapeutic potential of CeGC.
Article
Endocrinology & Metabolism
Yan Qiu, Stanley Buffonge, Raina Ramnath, Sophie Jenner, Sarah Fawaz, Kenton P. Arkill, Chris Neal, Paul Verkade, Stephen J. White, Melanie Hezzell, Andrew H. J. Salmon, M-Saadeh Suleiman, Gavin Welsh, Rebecca R. Foster, Paolo Madeddu, Simon C. Satchell
Summary: Diabetic cardiomyopathy is a serious complication of diabetes that is characterized by diastolic dysfunction and can progress to heart failure. This study suggests that damage to the endothelial glycocalyx in the coronary microcirculation may contribute to increased microvascular permeability and impaired cardiac function in diabetes.
Article
Urology & Nephrology
Natalie C. Finch, Sarah S. Fawaz, Chris R. Neal, Matthew J. Butler, Vivian K. Lee, Andrew J. Salmon, Abigail C. Lay, Megan Stevens, Lusyan Dayalan, Hamid Band, Harry H. Mellor, Steven J. Harper, David T. Shima, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Summary: This study comprehensively characterized the fenestrations of glomerular endothelial cells (GEnC) and investigated their changes in diabetes and their impact on renal filtration function. The study identified EHD3 as a potential regulator of fenestration formation and suggested that its loss may contribute to decreased fenestration density and declining glomerular filtration function. Therefore, EHD3 may be a novel therapeutic target for restoring filtration function in disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Veterinary Sciences
Sara J. Lawrence-Mills, Chris R. Neal, Simon C. Satchell, Gavin I. Welsh, Rebecca R. Foster, Natalie Finch
Summary: The endothelial glycocalyx (eGlx) is a substance that lines the luminal surface of endothelial cells and is crucial for maintaining vascular health. Studying eGlx, especially its direct visualization in clinical samples, is technically challenging. Further research is needed to develop more clinically applicable techniques for assessing eGlx health.
VETERINARY JOURNAL
(2022)
Article
Veterinary Sciences
Sara J. Lawrence-Mills, Melanie J. Hezzell, Sophie E. Adamantos, Iris Chan, Kieran Borgeat, Jessie Rosie Payne, Simon Satchell, Gavin I. Welsh, Rebecca R. Foster, Natalie Finch
Summary: This study investigated the damage of endothelial glycocalyx (eGlx) in dogs with myxomatous mitral valve disease (MMVD) and in dogs with a hypercoagulable state through measuring serum hyaluronan concentrations. The results showed that serum hyaluronan concentrations could serve as a clinically applicable marker of eGlx health and indicate the presence of eGlx damage in dogs with MMVD and dogs in a hypercoagulable state.
VETERINARY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Michael Crompton, Joanne K. Ferguson, Raina D. Ramnath, Karen L. Onions, Anna S. Ogier, Monica Gamez, Colin J. Down, Laura Skinner, Kitty H. Wong, Lauren K. Dixon, Judit Sutak, Steven J. Harper, Paola Pontrelli, Loreto Gesualdo, Hiddo L. Heerspink, Robert D. Toto, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell, Matthew J. Butler
Summary: In diabetic patients, MR antagonists can reduce the progression of albuminuria and preserve the integrity of glomerular endothelial glycocalyx by reducing MMP activity.
Article
Medicine, Research & Experimental
Emily E. Bowen, Jennifer A. Hurcombe, Fern Barrington, Lindsay S. Keir, Louise K. Farmer, Matthew D. Wherlock, Carolina G. Ortiz-Sandoval, Valentina Brun, Arlette Bohorquez-Hernandez, Daniel Diatlov, Niyousha Rostam-Shirazi, Sara Wells, Michelle Stewart, Lydia Teboul, Abigail C. Lay, Matthew J. Butler, Robert J. P. Pope, Eva M. S. Larkai, B. Paul Morgan, John Moppett, Simon C. Satchell, Gavin I. Welsh, Patrick D. Walker, Christoph Licht, Moin Saleem, Richard J. M. Coward
Summary: This study elucidates the pathogenesis of STEC-HUS and suggests the early use of terminal complement pathway inhibitors as a treatment option.
Review
Physiology
Natalie C. Finch, Chris R. Neal, Gavin I. Welsh, Rebecca R. Foster, Simon C. Satchell
Summary: The fenestrations of glomerular endothelial cells (GEnCs) are crucial for the function of the glomerular filtration barrier. This review provides an update on the current understanding of the regulation and biogenesis of fenestrations and discusses the diseases in which loss of GEnC fenestrations may contribute to loss of glomerular filtration function. The literature reviewed includes studies on GEnCs as well as other cell types with similar fenestration structures, such as liver sinusoidal endothelial cells.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
