Article
Radiology, Nuclear Medicine & Medical Imaging
Seung Myeon Choi, Hyun Joo Shin, Haesung Yoon, Myeongjee Lee, Yong Seung Lee, Sang Won Han, Mi-Jung Lee
Summary: This study aimed to analyze renal growth slope in children with congenital and acquired solitary functioning kidneys. Significant changes in growth slope were found before and after 24 months of age, without significant difference between congenital and acquired solitary functioning kidneys.
Article
Biochemistry & Molecular Biology
Nicole E. Weaver, Allison Healy, Rebecca A. Wingert
Summary: This study describes a zebrafish model of gldc deficiency that recapitulates phenotypes seen in humans and mice. gldc deficiency leads to abnormal development of the kidney and craniofacial morphology, and regulates renal progenitor development by modulating glycine levels.
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Selene Torrico, Georgina Hotter, Soraya Jativa
Summary: The incidence of renal disease is increasing worldwide and has become a significant public health issue. Cell therapies have been used in experimental models to induce regeneration and treat acute and chronic kidney diseases. Efforts have been made to apply these treatments in a clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Tulin Gungor, Fatma Yazilitas, Evrim Kargin Cakici, Ayse Secil Eksioglu, Evra Celikkaya, Deniz Karakaya, Esra Baglan, Mehmet Bulbul
Summary: This study evaluated the long-term prognosis and clinical characteristics of children with unilateral renal agenesis (URA), finding a higher incidence in males and a subset of patients with other urinary system anomalies. Proteinuria, hyperfiltration, hypertension, and CKD were observed in some patients, with higher incidence in those with other urinary system anomalies. The study highlights the importance of periodic evaluation for urine protein, blood pressure, and kidney functions in patients with a single functional kidney, as well as the use of ambulatory blood pressure monitoring for detecting masked hypertension.
PEDIATRIC NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mathias Hohl, Simina-Ramona Selejan, Jan Wintrich, Ulrike Lehnert, Thimoteus Speer, Clara Schneider, Muriel Mauz, Philipp Markwirth, Dickson W. L. Wong, Peter Boor, Andrey Kazakov, Martin Mollenhauer, Benedikt Linz, Barbara Mara Klinkhammer, Ulrich Huebner, Christian Ukena, Julia Moellmann, Michael Lehrke, Stefan Wagenpfeil, Christian Werner, Dominik Linz, Felix Mahfoud, Michael Boehm
Summary: In patients with chronic kidney disease, renal denervation (RDN) has been found to inhibit atrial fibrillation susceptibility, reducing the risk of stroke and death. This study highlights the potential therapeutic use of RDN in reducing atrial fibrillation risk in CKD patients, independent of renal function and blood pressure.
CIRCULATION RESEARCH
(2022)
Review
Biology
Ewa Kwiatkowska, Sebastian Kwiatkowski, Violetta Dziedziejko, Izabela Tomasiewicz, Leszek Domanski
Summary: Acute kidney injury (AKI) can occur due to reduced renal perfusion, with the kidneys being susceptible to ischemia because of the anatomical microcirculation around the renal tubules. Impaired blood flow causes damage to the endothelium and thrombosis, leading to the destruction of small vessels. This peritubular rarefaction is believed to be the main cause of irreversible changes in the damaged kidney and the development of chronic kidney disease. This article discusses the structure of renal microcirculation, its regulation, and the mechanisms of acute ischemic damage, with a focus on preventing it through the inhibition of the renin-angiotensin-aldosterone system.
Article
Urology & Nephrology
Veronica Arora, Suliman Khan, Ayman W. El-Hattab, Ratna Dua Puri, Maria Eugenia Rocha, Rijad Merdzanic, Omid Paknia, Christian Beetz, Arndt Rolfs, Aida M. Bertoli-Avella, Peter Bauer, Ishwar C. Verma
Summary: A study identified the causal role of GFRA1 gene variants in bilateral renal agenesis, potentially manifesting as an autosomal recessive, nonsyndromic form. This finding will facilitate early genetic diagnosis and improved genetic counseling for families at risk of BRA.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Pediatrics
Douglas G. Matsell, Carol Bao, Teagan Po White, Ella Chan, Eli Matsell, Dan Cojocaru, Marisa Catapang
Summary: The study revealed that in patients with solitary functioning kidney, unilateral renal agenesis (URA) is more commonly associated with syndromes or anomalies, and has worse outcomes over time compared to multicystic dysplastic kidney (MCDK). Patients with URA are more likely to experience hypertension, proteinuria, and chronic kidney injury.
PEDIATRIC NEPHROLOGY
(2021)
Article
Urology & Nephrology
Lei Dai, Jingzhi Li, Liangqun Xie, Weinan Wang, Yang Lu, Mingkun Xie, Jingrui Huang, Kuifang Shen, Hui Yang, Chenlin Pei, Yanhua Zhao, Weishe Zhang
Summary: This study identified a novel genetic cause of bilateral renal agenesis, potentially offering a new target for genetic diagnosis and prenatal diagnosis for families affected by the condition.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Pharmacology & Pharmacy
Jianjun Yu, Chao Yu, Georgia Bayliss, Shougang Zhuang
Summary: Protein arginine methyltransferases (PRMTs) regulate gene transcription and post-translational modifications by methylating a range of histone and non-histone substrates, participating in multiple biological processes. While most studies have focused on their roles in tumors and other organs, there is emerging evidence that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. This review summarizes the role and mechanisms of PRMTs in regulating these renal processes and provides a perspective for future clinical applications.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fernando Carton-Garcia, Cassondra Jeanette Saande, Daniel Meraviglia-Crivelli, Rafael Aldabe, Fernando Pastor
Summary: The global burden of chronic kidney disease (CKD) is increasing, prompting the urgent need for new therapies. Oligonucleotide-based drugs are emerging as a promising alternative, but challenges remain in efficient kidney delivery and potential side effects. The use of nanotechnological platforms could offer potential for more specific and effective treatments.
Article
Genetics & Heredity
Mohamed H. Al-Hamed, Norah Altuwaijri, Nada Alsahan, Wafaa Ali, Firdous Abdulwahab, Fatema Alzahrani, Nada Majrashi, Fowzan S. Alkuraya
Summary: Congenital anomalies of the kidney and urinary tract (CAKUT) are a range of abnormalities affecting the development of the kidneys and urinary tract. This study confirms the role of Nephronectin in renal agenesis in humans and shows that even complete loss of function can result in the formation of a single kidney.
Article
Biochemistry & Molecular Biology
Caizhen Li, Yanting Shen, Liuwei Huang, Chongbin Liu, Jun Wang
Summary: The study confirmed that eliminating senescent cells through pharmacological intervention can reduce renal aging and improve renal fibrosis, providing a new therapeutic approach for treating CKD post-AKI.
Article
Urology & Nephrology
Hao Liu, Chitkale Hiremath, Quinten Patterson, Saumya Vora, Zhiguo Shang, Andrew R. Jamieson, Reto Fiolka, Kevin M. Dean, Michael T. Dellinger, Denise K. Marciano
Summary: Defects in renal lymphatics occur in various kidney diseases, but the role of lymphatics in maintaining kidney structure and function is unknown. Using novel techniques, researchers found that reduced renal lymphatic density does not impair renal function at baseline and results in only modest histologic changes after mild injury. The study introduced a new method for quantifying renal lymphatics in 3D and emphasized the importance of assessing changes in cortical volume for accurate measurement of lymphatic density in chronic kidney disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Transplantation
Martijn van den Broek, Bart Smeets, Michiel F. Schreuder, Jitske Jansen
Summary: Glucocorticoids have been found to directly affect podocytes, promoting their recovery and limiting inflammatory responses, potentially having a positive impact on the treatment of nephrotic syndrome. Current research is primarily conducted using animal and cell models, but there are still limitations in fully replicating the human condition. New and promising models such as glomerulus-on-a-chip and kidney organoids have the potential to be developed into functional models for nephrotic syndrome in the future.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
S. J. A. Hazen, I Vogel, W. A. A. Borstlap, J. W. T. Dekker, J. B. Tuynman, P. J. Tanis, M. Kusters
Summary: This study aimed to analyze stoma-related reinterventions, complications, and readmissions after anterior resection for rectal cancer. The results showed that stoma-related complications were more common after Hartmann's procedure. Even after 1 year post-surgery, a significant number of reinterventions were required.
TECHNIQUES IN COLOPROCTOLOGY
(2022)
Article
Developmental Biology
Jitske Jansen, Bartholomeus T. van den Berge, Martijn van den Broek, Rutger J. Maas, Deniz Daviran, Brigith Willemsen, Rona Roverts, Marit van der Kruit, Christoph Kuppe, Katharina C. Reimer, Gianluca Di Giovanni, Fieke Mooren, Quincy Nlandu, Helmer Mudde, Roy Wetzels, Dirk den Braanker, Naomi Parr, James S. Nagai, Vedran Drenic, Ivan G. Costa, Eric Steenbergen, Tom Nijenhuis, Henry Dijkman, Nicole Endlich, Nicole C. A. J. van de Kar, Rebekka K. Schneider, Jack F. M. Wetzels, Anat Akiva, Johan van der Vlag, Rafael Kramann, Michiel F. Schreuder, Bart Smeets
Summary: Using organoid podocytes as a model, this study investigated idiopathic nephrotic syndrome and found that repaired organoids exhibited improved functionality, providing a valuable tool for disease modeling and therapy development.
Article
Infectious Diseases
Stan J. F. Hartman, Parth J. Upadhyay, Ron A. A. Mathot, Michiel van der Flier, Michiel F. Schreuder, Roger J. Bruggemann, Catherijne A. Knibbe, Saskia N. de Wildt
Summary: The study aimed to characterize cefotaxime pharmacokinetics in critically ill children and evaluate exposures achieved by different dosing regimens. Higher cefotaxime doses were found to be necessary for adequate exposure in most pathogens, with different dosing strategies recommended based on the pathogen's minimum inhibitory concentration (MIC). Increasing dose frequency or using continuous infusion may improve target attainment for intermediately susceptible pathogens.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Urology & Nephrology
Nori J. L. Smeets, Joanna IntHout, Maurice J. P. van der Burgh, George J. Schwartz, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study establishes reference values for GFR in healthy, term-born neonates through an analysis of individual participant data (IPD). The study also optimizes the estimation of GFR using creatinine levels. The findings reveal a biphasic increase in GFR in neonates, with the largest increase occurring between days 1 and 5 after birth.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Zoe McArdle, Reetu R. Singh, Helle Bielefeldt-Ohmann, Karen M. Moritz, Michiel F. Schreuder, Kate M. Denton
Summary: Brief and early ACEi treatment in SFK is associated with reduced glomerular hyperfiltration-mediated kidney disease up to 8 months of age in a sheep model.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Stefania Drovandi, Beata S. Lipska-Zietkiewicz, Fatih Ozaltin, Francesco Emma, Bora Gulhan, Olivia Boyer, Agnes Trautmann, Hong Xu, Qian Shen, Jia Rao, Korbinian M. Riedhammer, Uwe Heemann, Julia Hoefele, Sarah L. Stenton, Alexey N. Tsygin, Kar-Hui Ng, Svitlana Fomina, Elisa Benetti, Manon Aurelle, Larisa Prikhodina, Michiel F. Schreuder, Mansoureh Tabatabaeifar, Maciej Jankowski, Sergey Baiko, Jianhua Mao, Chunyue Feng, Cuihua Liu, Shuzhen Sun, Fang Deng, Xiaowen Wang, Stephanie Clave, Malgorzata Stanczyk, Irena Balasz-Chmielewska, Marc Fila, Anne M. Durkan, Tanja Kersnik Levart, Ismail Dursun, Nasrin Esfandiar, Dorothea Haas, Anna Bjerre, Ali Anarat, Marcus R. Benz, Saeed Talebi, Nakysa Hooman, Gema Ariceta, Franz Schaefer
Summary: This study analyzed the effects of Coenzyme Q10 (CoQ(10)) supplementation on patients with primary CoQ(10) deficiency, showing a significant reduction in proteinuria and better preservation of kidney function.
KIDNEY INTERNATIONAL
(2022)
Article
Pediatrics
Lieke A. Hoogenboom, A. Titia Lely, Matthew W. Kemp, Masatoshi Saito, Alan H. Jobe, Tim G. A. M. Wolfs, Michiel F. Schreuder
Summary: This study investigated the impact of premature birth and chorioamnionitis on kidney development using a sheep model. The findings suggest that chorioamnionitis induced by LPS leads to inflammation, podocyte injury, and potential fibrotic changes in the glomerular mesangium.
FRONTIERS IN PEDIATRICS
(2022)
Article
Transplantation
Stefan Kohl, Fred E. Avni, Peter Boor, Valentina Capone, William L. Clapp, Diego De Palma, Tess Harris, Laurence Heidet, Alina C. Hilger, Helen Liapis, Marc Lilien, Gianantonio Manzoni, Giovanni Montini, Susanna Negrisolo, Marie-Jeanne Pierrat, Ann Raes, Heiko Reutter, Michiel F. Schreuder, Stefanie Weber, Paul J. D. Winyard, Adrian S. Woolf, Franz Schaefer, Max C. Liebau
Summary: Kidney dysplasia is a common cause of chronic kidney failure in children, but the lack of clear clinical parameters leads to imprecise communication among healthcare professionals and patients. Suggestions based on structured literature search have been made to improve disease understanding and treatment.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Pediatrics
Nori J. L. Smeets, Esther M. M. Teunissen, Kim van der Velden, Maurice J. P. van der Burgh, Demi E. Linders, Elodie Teesselink, Dirk-Jan A. R. Moes, Camilla Tondel, Rob Ter Heine, Arno van Heijst, Michiel F. Schreuder, Saskia N. de Wildt
Summary: This study aimed to compare the prevalence of AKI and ARC in critically ill children using iohexol-based mGFR and SCr-based eGFR methods, and investigate the performance of different SCr-based eGFR methods. The results showed that AKI prevalence was higher and ARC prevalence was lower when using mGFR, and age- and sex-dependent equations had the highest accuracy for diagnosing AKI and ARC.
PEDIATRIC NEPHROLOGY
(2022)
Letter
Urology & Nephrology
Juergen Floege, Keisha L. Gibson, Manuel Praga, Jai Radhakrishnan, Heather N. Reich, Michiel F. Schreuder, Jack F. Wetzels, Vladimir Tesar, Marina Vivarelli, Steffen Biechele, Marcello Tonelli
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Oncology
Jennifer Eymael, Martijn van den Broek, Laura Miesen, Valerie Villacorta Monge, Bartholomeus T. van den Berge, Fieke Mooren, Vicky Luna Velez, Jelmer Dijkstra, Meyke Hermsen, Peter Bandi, Michiel Vermeulen, Saskia de Wildt, Brigith Willemsen, Sandrine Florquin, Roy Wetzels, Eric Steenbergen, Rafael Kramann, Marcus Moeller, Michiel F. Schreuder, Jack Fm Wetzels, Johan van der Vlag, Jitske Jansen, Bart Smeets
Summary: Scattered tubular cells (STCs) in the proximal tubule increase in number after acute kidney injury. STCs are preferentially located within the inner bends of the tubule and their number increases with age. STCs represent a transient state of dedifferentiated proximal tubule epithelial cells (PTECs) showing metabolic shift towards glycolysis, facilitating cellular survival after kidney injury.
JOURNAL OF PATHOLOGY
(2023)
Letter
Urology & Nephrology
Michiel F. Schreuder
KIDNEY INTERNATIONAL
(2023)
Article
Pediatrics
Sander Groen In 't Woud, Nel Roeleveld, Iris A. L. M. van Rooij, Wout F. J. Feitz, Michiel Schreuder, Loes F. M. van der Zanden
Summary: This case-control study identified maternal stress as a new risk factor for congenital solitary functioning kidney (CSFK), and confirmed associations with in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI), maternal infections, smoking during pregnancy, and parental CAKUT. However, previous associations with diabetes and obesity were not replicated. Folic acid supplement use and younger maternal age seemed to reduce the risk of CSFK.
PEDIATRIC NEPHROLOGY
(2023)
Letter
Pediatrics
Nori J. L. Smeets, Michiel F. Schreuder, Saskia N. de Wildt
EUROPEAN JOURNAL OF PEDIATRICS
(2022)