期刊
KIDNEY INTERNATIONAL
卷 80, 期 2, 页码 200-208出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2011.103
关键词
chronic inflammation; chronic kidney disease; fibroblast; fibrosis
资金
- Talecis
- Wellcome Clinical Training fellowship
- Academy of Medical Sciences (AMS) [AMS-SGCL8-Smith] Funding Source: researchfish
- Medical Research Council [G9818340B] Funding Source: researchfish
Stromal fibroblasts are the primary cells of the kidney that produce fibrotic matrix. CD248 is a stromal marker expressed on fibroblasts and pericytes within the human kidney. Here, we tested whether CD248 expression in the kidney colocalizes with fibrosis and if it is associated with known determinants of chronic kidney disease (CKD). CD248 expression was located and quantified in situ by immunohistochemistry in kidney biopsies from 93 patients with IgA nephropathy and compared with 22 archived biopsies encompassing normal kidney tissue as control. In normal kidney tissue, CD248 was expressed by resident pericytes, stromal fibroblasts, and was upregulated in human CKD. The expression was linked to known determinants of renal progression. This relationship was maintained in a multivariate analysis with CD248 expression linked to renal survival. CD248 was expressed by a population of alpha-smooth muscle actin (SMA)(+) myofibroblasts and alpha-SMA(-) stromal cells but not expressed on CD45(+) leukocytes. Thus, CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD. Kidney International (2011) 80, 199-207; doi:10.1038/ki.2011.103; published online 13 April 2011
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