Review
Biochemistry & Molecular Biology
Dimitrios Kotsos, Konstantinos Tziomalos
Summary: Nonalcoholic fatty liver disease (NAFLD) is common in the general population and even more prevalent in obese and diabetic patients. NAFLD, especially nonalcoholic steatohepatitis (NASH), increases the risk for liver-related and cardiovascular morbidity. The development and progression of NAFLD involve complex and multifactorial pathogenesis, with potential involvement of microsomal prostaglandin E synthase-1 and -2. Targeting these enzymes may offer a novel therapeutic approach for NAFLD. This review discusses the association between microsomal prostaglandin E synthase-1 and -2 and NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Fumiaki Kojima, Hiroki Sekiya, Yuka Hioki, Hitoshi Kashiwagi, Makoto Kubo, Masaki Nakamura, Shotaro Maehana, Yoshitaka Imamichi, Koh-Ichi Yuhki, Fumitaka Ushikubi, Hidero Kitasato, Takafumi Ichikawa
Summary: mPGES-1 is a key enzyme in the production of colonic PGE(2) and its deficiency can exacerbate colitis by affecting colonic T cell-mediated immunity. This suggests that mPGES-1 may impact both intestinal inflammation and T cell-mediated immunity associated with IBD.
INFLAMMATION AND REGENERATION
(2022)
Article
Oncology
Rosangela Mayer Goncalves, Marina Delgobo, Jonathan Paulo Agnes, Raquel Nascimento das Neves, Marcelo Falchetti, Tuany Casagrande, Ana Paula Vargas Garcia, Thaynan Cunha Vieira, Nauana Somensi, Maciel Alencar Bruxel, Daniel Augusto Gasparin Bueno Mendes, Alex Rafacho, Andre Bafica, Daniel Pens Gelain, Jose Claudio Fonseca Moreira, Geovanni Dantas Cassali, Alexander James Roy Bishop, Alfeu Zanotto-Filho
Summary: Obesity is a major risk factor for breast cancer, especially in post-menopausal women. An obesogenic diet has been shown to promote mammary tissue inflammation and local estrogen production, accelerating mammary tumor formation in a COX-2-dependent manner. Treatment with a COX-2 inhibitor was found to decrease inflammation, estrogen levels, and mammary tumor formation, leading to prolonged animal survival.
Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Hiroshi Kuwata, Yoshihito Nakatani, Chieko Yokoyama, Shuntaro Hara
Summary: The study investigated the roles of mPGES-1 and PGIS in cutaneous immune responses using a contact hypersensitivity (CHS) model. The results indicated that these PG terminal synthases play critical roles in acquired cutaneous immune responses.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yuze Zhang, Julia Steinmetz-Spah, Helena Idborg, Liyuan Zhu, Huihui Li, Haojie Rao, Zengrong Chen, Ziyi Guo, Lejia Hu, Chuansheng Xu, Hong Chen, Marina Korotkova, Per-Johan Jakobsson, Miao Wang
Summary: Inhibition of mPGES-1 can prevent chronic adverse cardiac remodeling after myocardial infarction, which may serve as a potential therapeutic strategy for HFrEF.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Nelufar Yasmen, Madison N. N. Sluter, Lexiao Li, Ying Yu, Jianxiong Jiang
Summary: Status epilepticus (SE) is a condition characterized by prolonged convulsive seizures that are difficult to control. Current antiseizure drugs (ASDs) aim to quickly stop seizures to prevent brain inflammation, injury, and long-term consequences. However, relying solely on acute therapies may not always be possible. The inhibition of microsomal prostaglandin E synthase-1 (mPGES-1) has shown neuroprotective effects and reduces inflammation in SE, suggesting it as a potential target for adjunctive treatment after SE.
Article
Medicine, Research & Experimental
Sandra Georgy Chafik, Haidy E. Michel, Ebtehal El-Demerdash
Summary: This study aimed to investigate the potential protective effects of a selective CB2 receptor agonist, 1-phenylisatin, on acute nephrotoxicity induced by cisplatin. The results showed that 1-phenylisatin significantly mitigated the damage to the kidneys caused by cisplatin through its anti-apoptotic, anti-inflammatory, and antioxidant effects. These effects were mainly mediated through the CB2 receptor.
Article
Immunology
Wenfei Wang, Yuping Ning, Yejun Wang, Guofang Deng, Simona Pace, Stefanie A. Barth, Christian Menge, Kehong Zhang, Youchao Dai, Yi Cai, Xinchun Chen, Oliver Werz
Summary: This study found that infection of human macrophages by M.tb significantly increases the expression of COX-2 and mPGES-1, leading to the formation of a large amount of PGE(2). However, the anti-inflammatory drug SASP can reduce the expression of COX-2 and the release of PGE(2).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Qian Wang, Yuanyuan Li, Mengying Wu, Songming Huang, Aihua Zhang, Yue Zhang, Zhanjun Jia
Summary: mPGES-1 inhibitors show promise in blocking the production of PGE2 with better specificity compared to NSAIDs, making them crucial in treating inflammatory diseases. Two inhibitors are undergoing clinical trials, with more novel inhibitors in development.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Yuka Sasaki, Hiroshi Kuwata, Eri Aida, Tsubasa Ochiai, Daisuke Kamei, Yoshihito Nakatani, Shuntaro Hara
Summary: The study indicates that mPGES-1 plays an important role in skin carcinogenesis, with mPGES-1 deficiency suppressing DMBA/TPA-induced skin carcinogenesis and inhibiting the induction of inflammatory cytokines by TPA.
ANTICANCER RESEARCH
(2021)
Article
Immunology
Ali Attiq, Juriyati Jalil, Khairana Husain, Jamia Azdina Jamal, Elysha Nur Ismail
Summary: The study isolated two new compounds with anti-inflammatory activities from Cyathocalyx pruniferus, where 2-octaprenyl-1,4-benzoquinone (5) showed potent inhibition of inflammatory mediators without cytotoxicity, indicating potential applications in acute and chronic inflammation.
INFLAMMOPHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Madison N. Sluter, Qianqian Li, Nelufar Yasmen, Yu Chen, Lexiao Li, Ruida Hou, Ying Yu, Chao-Yie Yang, Bernd Meibohm, Jianxiong Jiang
Summary: The COX/PGE(2) signaling pathway is a critical target for anti-inflammatory therapeutic development in neurological diseases, but its medical use is limited due to cardiovascular and cerebrovascular complications. Modulating the mPGES-1 enzyme may provide a more specific approach to inhibit PGE(2)-elicited neuroinflammation in epilepsy, stroke, and glioma.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Multidisciplinary Sciences
X. Jiang, H. Renkema, B. Pennings, S. Pecheritsyna, J. C. Schoeman, T. Hankemeier, J. Smeitink, J. Beyrath
Summary: Increased levels of PGE(2) were detected in patient cells with mitochondrial disease, but were normalized by exposure to KH176m. This redox-modulator also selectively inhibited PGE(2) production in control skin fibroblasts, suggesting potential therapeutic applications for mitochondrial disease and beyond.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Nada F. Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H. Eisa
Summary: The study demonstrates that quinacrine alleviates cisplatin-induced renal toxicity by upregulating SIRT-1, downregulating inflammatory markers (ICAM-1 and TNF-alpha), reducing oxidative stress, and inhibiting apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tarique Anwer, Saeed Alshahrani, Ahmad M. H. Somaili, Abdullah H. Khubrani, Rayan A. Ahmed, Abdulmajeed M. Jali, Ayed Alshamrani, Hina Rashid, Yousra Nomeir, Mohammad Khalid, Mohammad Firoz Alam
Summary: This study aimed to investigate the nephroprotective effect of diosmin, a flavonoid glycoside, against cisplatin-induced kidney damage. The results demonstrated that diosmin can reduce kidney structural damage, lower kidney function markers, and alleviate oxidative stress. Therefore, diosmin may serve as a supplement in the management of nephrotoxicity associated with cisplatin treatments.