期刊
KIDNEY INTERNATIONAL
卷 80, 期 8, 页码 851-860出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2011.224
关键词
albuminuria; cholecalciferol; diabetic nephropathy; MCP-1; TGF-beta 1; vitamin D
资金
- Swiss National Science Foundation
- Novartis Foundation
- Imperial College Healthcare Charity
- National Institute for Health Research (NIHR) Biomedical Research Centre
- Roche Palo Alto
- AstraZeneca Limited
- Baxter Biosciences
- Cyclacel
- UCB Celltech
- GlaxoSmithKline
The anti-inflammatory, antifibrotic, and antiproteinuric properties of vitamin D have been defined in studies using active vitamin D analogs. In this prospective observational study we determined whether nutritional vitamin D repletion can have additional beneficial effects in patients with type 2 diabetic nephropathy already established on renin-angiotensin-aldosterone system inhibition. During a 7-month period, 63 patients were enrolled and those with low levels of 25(OH) D were treated with oral cholecalciferol for 4 months. Baseline serum 25(OH) D and 1,25(OH)(2)D showed no significant correlation with baseline urinary MCP-1, TGF-beta 1, or albuminuria measured as the urinary albumin-to-creatinine ratio. Of the 63 patients, 54 had insufficient or deficient levels of serum 25(OH) D and 49 complied with cholecalciferol therapy and follow-up. Both 25(OH) D and 1,25(OH)(2)D were significantly increased at 2 and 4 months of treatment. Albuminuria and urinary TGF-beta 1 decreased significantly at both time points compared to their baseline values, while urinary MCP-1 did not change. Thus, in the short term, dietary vitamin D repletion with cholecalciferol had a beneficial effect in delaying the progression of diabetic nephropathy above that due to established renin-angiotensin-aldosterone system inhibition. Kidney International (2011) 80, 851-860; doi:10.1038/ki.2011.224; published online 10 August 2011
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