Article
Health Care Sciences & Services
Peter Johannes Schulz, Annalisa Pessina, Uwe Hartung, Serena Petrocchi
Summary: The study investigated the association between objective and subjective health literacy through an online survey on depression and its treatments. It found that high objective health literacy levels are linked to beneficial health behaviors and the ability to recognize low-quality information on health websites. Only objective health literacy appears to have the potential to prevent individuals from falling victim to health misinformation.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Stacie J. Shropshire, Matteo Fabbri, Sheila M. Manemann, Veronique L. Roger, Jill M. Killian, Susan A. Weston, Alanna M. Chamberlain
Summary: This study examined the self-awareness of heart failure (HF) diagnosis among residents in southeast Minnesota. The findings showed that only 37% of patients with HF were aware of their diagnosis. Factors such as being a woman, having HF with reduced ejection fraction, attending the HF clinic, and having coronary artery disease were associated with increased awareness, while having diabetes was associated with decreased awareness of an HF diagnosis.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Jung-Won Ahn, Sun Mi Lee, Yon Hee Seo
Summary: This study aimed to evaluate the characteristics, physiological indices, and health literacy affecting self-care behavior in patients with chronic kidney disease in South Korea. The results showed significant differences in self-care behavior based on age, cohabitation status, employment, smoking status, dialysis, comorbidities, and certain physiological indices. Factors such as not currently working, being a non-smoker, having end-stage kidney disease, and a positive response to health literacy significantly affected self-care behavior.
Article
Public, Environmental & Occupational Health
Marit Helen Andersen, Kristin Hjorthaug Urstad, Marie Hamilton Larsen, Eivind Engebretsen, John Odemark, Anne Eriksen, Astrid Klopstad Wahl
Summary: The study identified processes of knowing in patients awaiting kidney transplantation, including meaning-making, acquiring confidence, and accessing professional knowledge. Active interactions between patients and healthcare providers were found to be crucial in knowledge translation, requiring both parties to engage in self-consciousness and critical questioning.
PATIENT EDUCATION AND COUNSELING
(2021)
Article
Health Care Sciences & Services
Ping-Shaou Yu, Yi-Chun Tsai, Yi-Wen Chiu, Pei-Ni Hsiao, Ming-Yen Lin, Tzu-Hui Chen, Shu-Li Wang, Lan-Fang Kung, Shih-Ming Hsiao, Shang-Jyh Hwang, Mei-Chuan Kuo
Summary: This study showed that health literacy was significantly and positively correlated with self-care behavior in patients with CKD. Patients with sufficient or excellent health literacy demonstrated better diet, exercise, and home blood pressure monitoring scores compared to those with inadequate or limited/problematic health literacy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Shu-Li Wang, Tiffany Wan-Hua Shien, Tzu-Hui Chen, Pei-Ni Hsiao, Shih-Ming Hsiao, Lan-Fang Kung, Shang-Jyh Hwang, Yi-Wen Chiu, Yi-Chun Tsai, Jer-Ming Chang
Summary: Chronic kidney diseases (CKD) is a major public health issue worldwide, primarily caused by diabetes mellitus. Having sufficient disease knowledge and good self-care behavior can help prevent the progression of diabetes mellitus and CKD. This study found that high disease knowledge scores were associated with good glycemic control and higher self-care behavior scores.
Article
Transplantation
Mayra L. Estrella, Paula Allen-Meares, Ana C. Ricardo, Michael J. Fischer, Elisa J. Gordon, Eunice Carmona-Powell, James Sondheimer, Jing Chen, Edward Horwitz, Xue Wang, Jesse Y. Hsu, James P. Lash, Claudia Lora
Summary: In patients with chronic kidney disease, limited health literacy is associated with increased risk of CKD progression, cardiovascular events, hospitalization, and mortality.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Transplantation
Marco D. Boonstra, Sijmen A. Reijneveld, Elisabeth M. Foitzik, Ralf Westerhuis, Gerjan Navis, Andrea F. de Winter
Summary: This systematic review identified potential targets and strategies for improving limited health literacy in chronic kidney disease patients. Strong evidence was found for the association of limited health literacy with smoking and suboptimal transplantation process, while weak evidence was found for other factors related to self-care management, care utilization, patient-provider interaction, and social context. Interventions aimed at improving knowledge, decision-making, and health behaviors showed weak effectiveness, emphasizing the need for more and higher quality studies in earlier CKD stages. Healthcare organizations should focus on supporting limited health literacy patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Stacy Loeb, Joseph E. Ravenell, Scarlett Lin Gomez, Hala T. Borno, Katherine Siu, Tatiana Sanchez Nolasco, Nataliya Byrne, Godfrey Wilson, Derek M. Griffith, Rob Crocker, Robert Sherman, Samuel L. Washington, Aisha T. Langford
Summary: Black men have a higher risk of prostate cancer compared with White men, but they are underrepresented in online content about prostate cancer. Trust in the content is influenced by racial representation and patients have more medical mistrust than physicians.
Article
Psychology, Clinical
In Ju Yoon, Su Jung Lee
Summary: The aim of this study was to investigate anxiety levels among hemodialysis patients during the COVID-19 pandemic and explore the relationship between health literacy and anxiety. The results showed that health literacy increased with decreasing age and increasing educational level. Patients with comorbidities had higher levels of general anxiety. Patients who spent more time searching for health information had higher levels of coronavirus disease-related anxiety. This study highlights the need for further research on the effectiveness of health literacy programs in reducing anxiety levels and the importance of social support for patients with comorbidities.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2023)
Review
Urology & Nephrology
Roseanne E. E. Billany, Ashnee Thopte, Sherna F. F. Adenwalla, Daniel S. S. March, James O. O. Burton, Matthew P. M. Graham-Brown
Summary: Low health literacy is common in patients with chronic kidney disease and is associated with reduced disease self-management, poor health outcomes, increased mortality and poorer quality of life. However, the exact nature of these associations is still not well understood.
JOURNAL OF NEPHROLOGY
(2023)
Article
Immunology
En-Jung Shon, Lena Lee
Summary: Physicians emphasize the importance of flu vaccination, especially during the COVID-19 pandemic. Low coverage among younger groups may be due to a lack of vaccine literacy and negative perceptions towards vaccination. This study examined the relationship between flu vaccine literacy, health beliefs, and vaccination, and found that vaccine literacy directly affected health beliefs and vaccination, while susceptibility belief directly influenced perceived health status. The study underscores the need for healthcare providers and governments to improve vaccine literacy and address negative perceptions towards vaccination among younger populations, in order to increase flu vaccination rates and protect public health.
Article
Public, Environmental & Occupational Health
Jennifer M. Silva, Elizabeth Durden, Annemarie Hirsch
Summary: Current policy efforts aim to address health disparities by integrating social determinants of health into electronic health records. However, clinician documentation and engagement with patients' social characteristics may contribute to these disparities.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Urology & Nephrology
M. S. Gurgel do Amaral, S. A. Reijneveld, L. M. G. Meems, J. Almansa, G. J. Navis, A. F. de Winter
Summary: This study found that low health literacy is associated with more multimorbidity in CKD patients. Health literacy is not associated with patterns of multimorbidity in younger patients, but it is slightly in older ones.
JOURNAL OF NEPHROLOGY
(2022)
Article
Psychology, Clinical
Allison E. Gaffey, Sally G. Haskell, Cynthia A. Brandt, Lori A. Bastian, Judith L. Meadows, Matthew M. Burg
Summary: The study found that veterans have a higher risk of heart disease, with female veterans having slightly higher knowledge compared to male veterans, but there were no significant differences in prevention behaviors. Therefore, improved education on heart disease risk and personalized prevention strategies may benefit veterans and their healthcare providers.
Article
Urology & Nephrology
Sandeep Brar, Kathleen D. Liu, Alan S. Go, Raymond K. Hsu, Vernon M. Chinchilli, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, T. Alp Ikizler, James Kaufman, Paul L. Kimmel, Chirag R. Parikh, Edward D. Siew, Lorraine B. Ware, Hui Zeng, Chi-yuan Hsu
Summary: The study found that the use of ACEI/ARB after hospital discharge did not increase the risk of recurrent AKI in patients with or without previous AKI during hospitalization. Additionally, there were no significant differences in the risks of death, kidney disease progression, and adjudicated heart-failure events between patients who did and did not experience AKI during hospitalization.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, Research & Experimental
Jeremy Puthumana, Heather Thiessen-Philbrook, Leyuan Xu, Steven G. Coca, Amit X. Garg, Jonathan Himmelfarb, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Lorraine B. Ware, Kathleen D. Liu, Alan S. Go, James S. Kaufman, Paul L. Kimmel, Vernon M. Chinchilli, Lloyd G. Cantley, Chirag R. Parikh
Summary: The study found that levels of MCP-1 and YKL-40 measured at 3 months after hospitalization were associated with long-term risk of kidney failure, while UMOD levels were linked with decreased risk of kidney injury. Using a multimarker score provided better accuracy in predicting patients' risk of kidney disease progression compared to traditional clinical variables.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Editorial Material
Urology & Nephrology
T. Alp Ikizler
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Editorial Material
Urology & Nephrology
T. Alp Ikizler, Jonathan Himmelfarb
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Sherry G. Mansour, Pavan K. Bhatraju, Steven G. Coca, Wassim Obeid, Francis P. Wilson, Ian B. Stanaway, Yaqi Jia, Heather Thiessen-Philbrook, Alan S. Go, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Chi-yuan Hsu, Amit X. Garg, W. Brian Reeves, Kathleen D. Liu, Paul L. Kimmel, James S. Kaufman, Mark M. Wurfel, Jonathan Himmelfarb, Samir M. Parikh, Chirag R. Parikh, ASSESS-AKI Consortium
Summary: A higher Angpt-1:Angpt-2 ratio is strongly associated with reduced risk of CKD progression, heart failure, and mortality in patients with AKI.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Hematology
Melis Sahinoz, James M. Luther, Mona Mashayekhi, Dae Kwang Jung, T. Alp Ikizler, Brian G. Engelhardt
Summary: Cancer survivors have an increased risk of developing type 2 diabetes, and the interaction between cancer and body mass index (BMI) can affect insulin sensitivity and glucose regulation.
Editorial Material
Nutrition & Dietetics
T. Alp Ikizler
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Editorial Material
Urology & Nephrology
Osama El Shamy, T. Alp Ikizler
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Nan Guan, Hanako Kobayashi, Ken Ishii, Olena Davidoff, Feng Sha, Talat A. Ikizler, Chuan-Ming Hao, Navdeep S. Chandel, Volker H. Haase
Summary: This study investigates the role of mitochondrial electron transport in kidney homeostasis by inactivating a subunit of mitochondrial complex III in kidney progenitor cells. The results show that mitochondrial oxidative metabolism is critical for kidney development, and inactivation of specific proteins can lead to severe kidney dysplasia or smaller functional kidneys.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Rengin Elsurer Afsar, Talat Alp Ikizler
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Steven Menez, Yumeng Wen, Leyuan Xu, Dennis G. Moledina, Heather Thiessen-Philbrook, David Hu, Wassim Obeid, Pavan K. Bhatraju, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Amit X. Garg, Alan S. Go, Kathleen D. Liu, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb, Steven G. Coca, Lloyd G. Cantley, Chirag R. Parikh
Summary: Urinary epidermal growth factor (EGF) may serve as a biomarker for tubular function and can be used to assess the risk of chronic kidney disease (CKD) after hospitalization. Higher urinary EGF concentrations three months post-discharge are associated with a reduced risk of major adverse kidney events (MAKE), such as CKD incidence, progression, or kidney failure.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Finnian R. Mc Causland, Jesse Y. Hsu, Jonathan Himmelfarb, Talat Alp Ikizler, Dominic S. Raj, Rajnish Mehrotra, Sushrut S. Waikar, Paul L. Kimmel, Alan S. Kliger, Laura M. Dember, David M. Charytan
Summary: In a post hoc analysis, it was found that spironolactone treatment resulted in a higher frequency of bradycardia and conduction blocks in patients receiving maintenance hemodialysis. Close monitoring is necessary for these patients while awaiting definitive trial results.
Review
Urology & Nephrology
Lale Ertuglu, Abdulmecit Yildiz, Jorge Gamboa, T. Alp Ikizler
Summary: Sarcopenia, characterized by decreased muscle function and mass, is common in patients with moderate to advanced chronic kidney disease (CKD) and is associated with poor clinical outcomes. Mitochondrial dysfunction is proposed as one of the underlying mechanisms, which is noticeable from the early stages and correlated with disease severity. Uremic toxins, oxidative stress, and systemic inflammation play a role in the development of mitochondrial dysfunction. Therapeutic interventions targeting mitochondrial function, such as coenzyme Q and cardiolipin-targeted peptides, have been tested in early studies. Aerobic exercise, although effective in healthy adults, is not as effective in advanced CKD patients, potentially due to impaired activation of mitochondrial biogenesis. Further research is needed to better understand the pathogenesis of mitochondrial dysfunction and develop targeted therapies for sarcopenia in CKD patients.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Urology & Nephrology
Juan Pablo Arroyo, Elvis A. Akwo, Andrew S. Terker, Aseel Alsouqi, Gautam Bhave, Raymond C. Harris, Adriana M. Hung, T. Alp Ikizler
Summary: The study found a significant correlation between peripheral insulin resistance and elevated copeptin levels in patients with CKD, with a 39% increase in copeptin levels for every 1 SD decrease in insulin sensitivity. Further research into how peripheral insulin resistance and elevated vasopressin affect CKD progression could provide valuable insights.
Article
Urology & Nephrology
Dominic S. Raj, Michael B. Sohn, David M. Charytan, Jonathan Himmelfarb, T. Alp Ikizler, Rajnish Mehrotra, Ali Ramezani, Renu Regunathan-Shenk, Jesse Y. Hsu, J. Richard Landis, Hongzhe Li, Paul L. Kimmel, Alan S. Kliger, Laura M. Dember
Summary: The study found that there is greater variability in gut microbiome and metabolomic composition between individuals with ESKD than within individuals. Treatment with p-inulin was well tolerated and showed signs of increasing microbiome diversity.