期刊
KIDNEY INTERNATIONAL
卷 79, 期 9, 页码 933-934出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/ki.2011.8
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资金
- NHLBI NIH HHS [K08 HL092958] Funding Source: Medline
- NIDDK NIH HHS [R37 DK037175-28, R37 DK037175] Funding Source: Medline
The mechanisms underlying beneficial influences of low-protein diets on the progressive nature of chronic kidney disease are incompletely understood. Gao et al. identify a downregulation of Kruppel-like factor-15 (KLF15) associated with increased renal fibrosis. The KLF15 downregulation and renal fibrosis are reversed with dietary protein restriction, especially when ketoacids are added. The results suggest that KLF15 may play a role in suppressing renal fibrosis and could contribute to the benefits of dietary protein restriction. Kidney International (2011) 79, 933-934. doi:10.1038/ki.2011.8
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