Article
Urology & Nephrology
Karin Bergling, Giedre Martus, Carl M. M. Oberg
Summary: Blocking glucose channels can reduce glucose absorption and improve ultrafiltration efficiency in PD.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Johann Morelle, Mark Lambie, Carl M. Oberg, Simon Davies
Summary: A healthy peritoneal membrane is crucial for effective peritoneal dialysis treatment. Variability and dysfunction of the membrane can lead to fluid overload and complications. This review provides an overview of the structure, function, and pathophysiology of the peritoneal membrane and discusses their clinical implications for patient-centered care.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Olof Heimburger, Jorgen Hegbrant, Giedre Martus, Martin Wilkie, Charlotte De Leon, Ola Carlsson, Ann-Cathrine Johansson
Summary: Steady concentration peritoneal dialysis (PD) performed with the Carry Life UF device resulted in higher ultrafiltration rates, more efficient use of glucose, and greater sodium removal compared with a standard continuous ambulatory PD (CAPD) dwell.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Qianhui Song, Xiaoxiao Yang, Yuanyuan Shi, Hao Yan, Zanzhe Yu, Zhenyuan Li, Jiangzi Yuan, Zhaohui Ni, Leyi Gu, Wei Fang
Summary: The study investigates the efficacy of the intraperitoneal inflammation marker, IL-6 level, as a predictor of UF insufficiency in patients undergoing peritoneal dialysis. Results suggest that higher baseline dialysate IL-6 AR is associated with an increased risk of UF insufficiency, and IL-6 AR could be a potential predictor of UF insufficiency in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
David A. Jaques, Andrew Davenport
Summary: The study found that factors such as fast transport type, serum sodium levels, and diabetes were positively associated with sodium to water clearance, while PD mode and the use of 2.27% glucose dialysate were negatively associated. This indicates that CAPD, fast transport, and high serum sodium levels may allow more sodium to be removed compared to water.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Physiology
Raymond T. Krediet
Summary: This review summarizes the structural and functional alterations of the peritoneal dialysis membrane caused by long-term peritoneal dialysis, and discusses the pseudohypoxia hypothesis and glucose-induced conditions as explanations for these alterations. The upregulation of GLUT-1 in interstitial fibroblasts is highlighted as a key factor in ultrafiltration failure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Bartosova, Conghui Zhang, Betti Schaefer, Rebecca Herzog, David Ridinger, Ivan Damgov, Eszter Levai, Iva Marinovic, Christoph Eckert, Philipp Romero, Peter Sallay, Akos Ujszaszi, Markus Unterwurzacher, Anja Wagner, Georg Hildenbrand, Bradley A. Warady, Franz Schaefer, Sotirios G. Zarogiannis, Klaus Kratochwill, Claus Peter Schmitt
Summary: This study investigated the impact of glucose degradation products (GDP) found in peritoneal dialysis fluids on accelerated vasculopathy development in chronic kidney disease (CKD) patients. The results indicated that high-GDP exposure led to increased cell death/apoptosis genes and decreased cell viability/survival genes in omental arterioles. Additionally, high-GDP exposure was associated with disrupted endothelial cell junction and cytoskeleton, leading to apoptosis in patients with CKD and on peritoneal dialysis.
CIRCULATION RESEARCH
(2021)
Review
Urology & Nephrology
Raymond T. Krediet
Summary: Ultrafiltration in peritoneal dialysis is crucial for maintaining optimal blood volume, but long-term treatment can lead to complex issues with ultrafiltration failure. This failure is primarily attributed to the increased perfusion of peritoneal microvessels, resulting in a decline in the osmotic gradient. The contribution of peritoneal interstitial tissue becomes more significant in long-term PD due to the development of fibrosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Andrew Davenport
Summary: The study reviewed the calcium balance in peritoneal dialysis patients and found that over 40% of the patients had a positive peritoneal calcium balance. The use of calcium-containing phosphate binders had a significant impact on calcium balance, and excessive prescribing may increase the risk of vascular calcification, especially for anuric patients.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Monika Misian, Ewa Baum, Andrzej Breborowicz
Summary: Serum and dialysate from patients undergoing peritoneal dialysis can induce inflammatory and prothrombotic reactions in coronary artery endothelial cells, and Sulodexide can reduce these effects.
Article
Medicine, General & Internal
Fen Zhang, Tingting Zhang, Sisi Yang, Di Wang, Qianqian Zhuo, Xianhui Qin, Nirong Gong, Jun Ai
Summary: This study suggested that sacubitril-valsartan is associated with an increase in short-term peritoneal ultrafiltration and total output in PD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Johann Morelle, Celine Marechal, Zanzhe Yu, Huguette Debaix, Tanguy Corre, Mark Lambie, Marion Verduijn, Friedo Dekker, Philippe Bovy, Pieter Evenepoel, Bert Bammens, Rafael Selgas, Maria A. Bajo, Annemieke M. Coester, Amadou Sow, Nicolas Hautem, Dirk G. Struijk, Raymond T. Krediet, Jean-Luc Balligand, Eric Goffin, Ralph Crott, Pierre Ripoche, Simon Davies, Olivier Devuyst
Summary: A common variant in AQP1 is associated with decreased ultrafiltration and an increased risk of death or technique failure among patients treated with peritoneal dialysis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Urology & Nephrology
Lifen Liu, Bei Zhang, Jing Luo, Zhengyan Li, Dong Liu, Yanna Dou, Lin Yang, Jing Xiao, Zhanzheng Zhao
Summary: This study investigates the role of the segmental bioelectrical impedance technique in assessing intraperitoneal ultrafiltration volume with peritoneal dialysis patients. The results show that this technique can effectively evaluate the intraperitoneal ultrafiltration volume and guide the retention time and maximum volume of dialysis fluid for peritoneal dialysis patients.
Article
Urology & Nephrology
Marios Papasotiriou, Vassilios Liakopoulos, Ioannis Kehagias, Georgia Vareta, Theodoros Ntrinias, Evangelos Papachristou, Dimitrios S. Goumenos
Summary: Peritoneal dialysis (PD) has shown to be an effective treatment option for patients with refractory heart failure (HF), leading to reduced hospitalization rate and improved cardiac functional status. The study found that PD significantly improved patients' quality of life and reduced hospital stay.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Hematology
Theerasak Tangwonglert, Andrew Davenport
Summary: Research showed that sodium losses in peritoneal dialysis patients are influenced by glucose absorption, which in turn is affected by the type of dialysate and treatment modality used.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Urology & Nephrology
Olivier Devuyst, Krzysztof Kiryluk
KIDNEY INTERNATIONAL
(2023)
Article
Transplantation
Ines P. D. Costa, Nicolas Hautem, Gugliemo Schiano, Shinichi Uchida, Tomoya Nishino, Olivier Devuyst
Summary: The study reveals that AQP1 and AQP7 are abundantly expressed in the peritoneal membrane. While AQP1 facilitates water transport during peritoneal dialysis, the role of AQP7 in glycerol transport during fasting is unknown. The findings show that fasting increases the expression of AQP1 and AQP7 in the peritoneum, leading to structural and functional changes that improve fluid removal.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Konstantinos Efthymakis, Giuseppina Bologna, Pasquale Simeone, Laura Pierdomenico, Giulia Catitti, Simone Vespa, Angelo Milano, Domenico De Bellis, Francesco Laterza, Assunta Pandolfi, Caterina Pipino, Michele Sallese, Marco Marchisio, Sebastiano Miscia, Matteo Neri, Paola Lanuti
Summary: Extracellular vesicles (EVs) play important roles in intercellular communication, homeostasis maintenance, and diseases. This study aimed to assess and characterize circulating EVs in celiac disease patients and patients on a gluten-free diet (GFD) using a novel flow cytometry technique. The results showed significantly increased total EV counts in both newly diagnosed celiac disease patients and patients on GFD, while endothelial-derived and epithelial-derived EV counts were significantly decreased in subjects on gluten exclusion. These findings indicate that EVs could serve as potential disease-specific biomarkers in celiac disease.
Article
Engineering, Biomedical
Luca Comuzzi, Margherita Tumedei, Tea Romasco, Morena Petrini, Kelvin I. Afrashtehfar, Francesco Inchingolo, Adriano Piattelli, Natalia Di Pietro
Summary: Short implants were introduced to reduce morbidity, treatment duration, and complex bone regeneration interventions in atrophic jaws and to improve patient-reported outcomes. This study aimed to determine the insertion torque (IT), removal torque (RT), and resonance frequency analysis (RFA) values of ultrashort (3 mm length), short (7 mm length), and standard implants (10 mm length) inserted in 1-, 2-, 3-, and 4-mm thickness polyurethane sheets with densities of 10, 20, and 30 pounds per cubic foot (PCF). The results showed that short-length implants had comparable or higher IT values compared to the standard-length implants in most experimental conditions. Ultrashort-length implants demonstrated similar primary stability to standard implants in lower thicknesses. These findings suggest the potential application of short and ultrashort implants in critical atrophy of the posterior jaws.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Emira D'Amico, Tania Vanessa Pierfelice, Rosa Amoroso, Ivana Cacciatore, Camillo D'Arcangelo, Stefania Lepore, Simonetta D'Ercole, Natalia Di Pietro, Annalisa Di Rienzo, Morena Petrini, Adriano Piattelli, Alessia Ricci, Susi Zara, Antonio Di Stefano, Giovanna Iezzi, Barbara De Filippis
Summary: Recently, research has focused on finding new approaches to manage oral wound healing. The use of resveratrol (RSV) as a drug is limited due to its poor bioavailability. This study aimed to investigate a series of RSV derivatives (1a-j) with better pharmacokinetic profiles. Among them, derivatives 1d and 1h showed increased cell viability compared to RSV. Further studies demonstrated that both 1d and 1h exhibited positive effects on cell viability, proliferation, and gene expression in various cells involved in oral wound healing. Additionally, 1d and 1h showed promising physicochemical properties and stability, indicating their potential as RSV-based agents for oral tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Valeria Schiavone, Tea Romasco, Nadia Di Pietrantonio, Stefania Garzoli, Carola Palmerini, Pamela Di Tomo, Caterina Pipino, Domitilla Mandatori, Rossella Fioravanti, Elena Butturini, Manuela Sabatino, Maria Pompea Antonia Baldassarre, Rino Ragno, Assunta Pandolfi, Natalia Di Pietro
Summary: Essential oils derived from aromatic plants have been found to improve the lipid and glycemic profile of patients with diabetes mellitus. This study investigated the potential anti-inflammatory effect of anise and laurel essential oils on endothelial cells isolated from females with gestational diabetes mellitus. The results showed that both essential oils significantly reduced monocyte adhesion, VCAM-1 expression, and NF-κB p65 nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Luca Comuzzi, Margherita Tumedei, Ugo Covani, Tea Romasco, Morena Petrini, Lorenzo Montesani, Adriano Piattelli, Natalia Di Pietro
Summary: Bone characteristics, implant macrogeometry, and drilling technique are important factors for implant primary stability. This in vitro study evaluated the effects of under-preparation on insertion torque, removal torque, and resonance frequency analysis of conical implants. Results showed that proper site preparation can improve implant primary stability.
APPLIED SCIENCES-BASEL
(2023)
Review
Oncology
Sara Pagotto, Pasquale Simeone, Davide Brocco, Giulia Catitti, Domenico De Bellis, Simone Vespa, Natalia Di Pietro, Lisa Marinelli, Antonio Di Stefano, Serena Veschi, Laura De Lellis, Fabio Verginelli, Francesco Kaitsas, Manuela Iezzi, Assunta Pandolfi, Rosa Visone, Nicola Tinari, Ignazio Caruana, Mauro Di Ianni, Alessandro Cama, Paola Lanuti, Rosalba Florio
Summary: This review highlights the potential of CAR-T-derived extracellular vesicles (EVs) as therapeutic agents in tumors. CAR-T lymphocytes have shown potential effectiveness in immunotherapy against refractory neoplastic diseases. However, physical barriers, hostile microenvironment, and tumor heterogeneity limit their efficacy against solid tumors. The use of CAR-T-derived EVs as therapeutic agents may enhance CAR-T homing and overcome some adverse effects.
Review
Pharmacology & Pharmacy
Letizia Pelusi, Domitilla Mandatori, Leonardo Mastropasqua, Luca Agnifili, Marcello Allegretti, Mario Nubile, Assunta Pandolfi
Summary: Ocular drug delivery remains a challenge due to the limitations of conventional dosage forms and the anatomical complexity of the eye. Recent developments in materials and technologies have led to the creation of various ocular drug delivery systems, such as inserts, contacts, and intraocular lenses, which show promise for future clinical applications.
Article
Biochemistry & Molecular Biology
Tea Romasco, Pier Michele Mandrillo, Erica Morsut, Margherita Tumedei, Domitilla Mandatori, Morena Petrini, Maria Cristina Curia, Francesco De Angelis, Camillo D'Arcangelo, Adriano Piattelli, Natalia Di Pietro
Summary: Maintaining the health of periodontal and peri-implant soft tissues is crucial. Collagen-based medical products have shown to be safe and effective in preventing connective tissue alterations and related diseases. This study evaluated the effects of Dental SKIN BioRegulation, an injectable medical device composed of collagen, on human gingival fibroblasts.
Article
Chemistry, Physical
Luca Comuzzi, Margherita Tumedei, Natalia Di Pietro, Tea Romasco, Hamid Heydari Sheikh Hossein, Lorenzo Montesani, Francesco Inchingolo, Adriano Piattelli, Ugo Covani
Summary: This study aimed to compare the stability of three different types of implants in different densities of polyurethane blocks. The results showed that TAC conical implants demonstrated better primary stability in low-density models.
Article
Chemistry, Multidisciplinary
Natalia Di Pietro, Mario Ceddia, Tea Romasco, Nilton De Bortoli Jr, Bruno Freitas Mello, Margherita Tumedei, Alessandro Specchiulli, Adriano Piattelli, Bartolomeo Trentadue
Summary: The reason for peri-implant bone resorption is still unknown, but it may be related to bacterial contamination at the micro-gap level between the implant and abutment. Placement of subcrestal implants can provide aesthetic advantages, but there are conflicting results on bone resorption in the literature. Finite Element Analysis showed that subcrestally placed implants had lower stresses in the cortical bone compared to equicrestally placed implants.
APPLIED SCIENCES-BASEL
(2023)
Article
Engineering, Biomedical
Ugo Covani, Enrica Giammarinaro, Natalia Di Pietro, Simona Boncompagni, Giorgia Rastelli, Tea Romasco, Eugenio Velasco-Ortega, Alvaro Jimenez-Guerra, Giovanna Iezzi, Adriano Piattelli, Simone Marconcini
Summary: This study compared two implants with different healing abutment geometries and quantified the three-dimensional topography and morphological properties of collagen using transmission electron microscopy. The results showed that a concave abutment design promotes the formation of a well-organized peri-implant collagen structure.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Multidisciplinary
Alessandro Cipollina, Mario Ceddia, Natalia Di Pietro, Francesco Inchingolo, Margherita Tumedei, Tea Romasco, Adriano Piattelli, Alessandro Specchiulli, Bartolomeo Trentadue
Summary: Extreme atrophy of the maxilla remains a challenge for clinicians. The premaxillary device (PD) technique offers a simpler approach to reconstruct severely atrophic maxillae, aiming to avoid more complicated and risky surgical procedures. Finite element analysis (FEA) demonstrated that using a PD allows for an optimal distribution of stresses on the basal bone, reducing the risk of bone resorption or implant failure.
Article
Biochemistry & Molecular Biology
Luca Comuzzi, Mario Ceddia, Natalia Di Pietro, Francesco Inchingolo, Angelo Michele Inchingolo, Tea Romasco, Margherita Tumedei, Alessandro Specchiulli, Adriano Piattelli, Bartolomeo Trentadue
Summary: This study used three-dimensional finite element analysis to investigate the biomechanical effects of different positions of dental implants relative to the alveolar crest. The findings suggest that placing the implant subcrestally (-1 to -2 mm) can help reduce peri-implant bone resorption and improve long-term implant success.