Review
Immunology
Edmund Y. M. Chung, Yuan M. Wang, Karen Keung, Min Hu, Hugh McCarthy, Germaine Wong, Lukas Kairaitis, Bhadran Bose, David C. H. Harris, Stephen Alexander
Summary: Primary membranous nephropathy is a common cause of adult-onset nephrotic syndrome, characterized by autoimmune reactions in the kidneys. Although understanding of the disease mechanisms has advanced, treatments are still non-specific and often ineffective or toxic.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Shuang Gao, Zhao Cui, Ming-hui Zhao
Summary: This study investigates the role of C3a and C3a receptor (C3aR) in the pathogenesis of primary membranous nephropathy (MN). It demonstrates that C3a anaphylatoxin is a crucial effector of complement-mediated podocyte damage in MN, and blocking C3aR may be a potentially viable treatment for this disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Sanjeev Sethi, Benjamin Madden, Hanna Debiec, Johann Morelle, M. Cristine Charlesworth, LouAnn Gross, Vivian Negron, David Buob, Sidharth Chaudhry, Michel Jadoul, Fernando C. Fervenza, Pierre Ronco
Summary: Membranous nephropathy (MN) can be caused by antibodies targeting different antigens in the glomerular basement membrane (GBM), such as PLA2R, THSD7A, NELL1, SEMA3B, and now, the novel protein PCHD7. PCHD7 appears to define a distinct type of MN with specific characteristics in terms of staining pattern and antibody reactivity.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Gabriel B. Lerner, Samarth Virmani, Joel M. Henderson, Jean M. Francis, Laurence H. Beck
Summary: Primary membranous nephropathy is a leading cause of adult nephrotic syndrome. The identification of PLA2R as a target antigen and the ability to measure circulating autoantibodies has provided new insights into the humoral aspect of the disease. Additionally, the detection and monitoring of autoantibody levels are crucial for guiding disease management.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Hongyan Liu, Hong Cheng, Hongyun Wang, Qiong Wang, Jun Yuan
Summary: In this study, the biological functions and mechanisms of crocin in membranous nephropathy (MN) were investigated. It was found that crocin can alleviate the pathological damage of MN by inhibiting immune injury and podocyte damage through activating the Sirt1/Nrf2/HO-1 pathways.
Article
Urology & Nephrology
Janina Mueller-Deile, Nina Sopel, Alexandra Ohs, Victoria Rose, Marwin Groener, Christoph Wrede, Jan Hegermann, Christoph Daniel, Kerstin Amann, Gunther Zahner, Mario Schiffer
Summary: This study demonstrates that miR-192-5p and miR-378a-3p are upregulated in the glomeruli of iMGN patients, while NPNT is reduced. Using zebrafish and mouse models, it was shown that overexpression of miR-192-5p and knockdown of npnt induced edema, proteinuria, and podocyte damage. GEC downregulates podocyte NPNT via exosomes containing miR-192-5p.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Tiffany N. Caza, Samar I. Hassen, Michael Kuperman, Shree G. Sharma, Zeljko Dvanajscak, John Arthur, Rick Edmondson, Aaron Storey, Christian Herzog, Daniel J. Kenan, Christopher P. Larsen
Summary: Research has identified neural cell adhesion molecule 1 (NCAM1) as a target antigen in some cases of membranous lupus nephritis and rare cases of primary membranous nephropathy, colocalizing with IgG in glomerular immune deposits. Circulating antibodies to NCAM1 have been detected in serum of patients with NCAM1-associated membranous nephropathy, suggesting diagnostic significance. Future studies are needed to determine whether anti-NCAM1 antibody levels correlate with disease activity or response to therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Andrew J. B. Watts, Keith H. Keller, Gabriel Lerner, Ivy Rosales, A. Bernard Collins, Miroslav Sekulic, Sushrut S. Waikar, Anil Chandraker, Leonardo V. Riella, Mariam P. Alexander, Jonathan P. Troost, Junbo Chen, Damian Fermin, Jennifer L. Yee, Matthew G. Sampson, Laurence H. H. Beck Jr, Joel M. Henderson, Anna Greka, Helmut G. Rennke, Astrid Weins
Summary: In a subset of patients with minimal change disease, circulating nephrin autoantibodies were detected during active disease but significantly reduced or absent during treatment response. These autoantibodies were correlated with podocyte-associated punctate IgG in renal biopsies. A steroid-dependent patient with childhood minimal change disease developed end stage kidney disease, with high pretransplant circulating nephrin autoantibodies associated with massive post-transplant recurrence of proteinuria.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Sanjeev Sethi, Benjamin Madden, Marta Casal Moura, Raman Deep Singh, Samih H. Nasr, Jean Hou, Alok Sharma, Karl A. Nath, Ulrich Specks, Fernando C. Fervenza, Mark Haas
Summary: Syphilis is a common sexually transmitted infection that can cause proteinuria. This study reveals a novel target antigen, NDNF, associated with membranous nephropathy in syphilis. NDNF-associated MN in syphilis has distinct clinical and pathological features, and NDNF appears to be the target antigen in syphilis-associated MN.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Elenjickal Elias John, Athul Thomas, Jeethu Joseph Eapen, Sabina Yusuf, Sanjeet Roy, Anna T. Valson, Vinoi George David, Santosh Varughese, Suceena Alexander
Summary: This study followed up 501 adult patients diagnosed with bacterial infection-related glomerulonephritis over a period of 12 years, showing that parainfectious GN caused predominantly by nonstreptococcal and drug-resistant bacterial infections was associated with poor kidney prognosis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Wei-Bo Le, Jing-Song Shi, Yang Fan, Si-Wen Gong
Summary: The study found that carrying specific HLA alleles (DRB1*13:01/DQB1*06:03, DRB1*04:05, DQB1*03:02) was independently associated with poor prognosis in Chinese patients with PLA2R-related membranous nephropathy.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Marc Fila, Hanna Debiec, Helene Perrochia, Nabila Djouadi, Marie-Christine Verpont, David Buob, Pierre Ronco
Summary: This study reports the first case of early recurrence after transplantation of membranous nephropathy associated with antibodies directed at semaphorin 3B. The findings provide strong evidence that anti-semaphorin 3B antibodies are pathogenic and should be carefully monitored in patients with membranous nephropathy. Furthermore, the study supports the efficacy of rituximab in treating the disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Daoyuan Lv, Song Jiang, Mingchao Zhang, Xiaodong Zhu, Fan Yang, Hui Wang, Shen Li, Feng Liu, Caihong Zeng, Weisong Qin, Limin Li, Zhihong Liu
Summary: 《》This article introduces the research progress in the treatment of membranous nephropathy (MN). Recent studies have shown that pyroptosis is the cause of podocyte injury in MN. The study found that disulfiram (DSF) has a therapeutic effect on MN by inhibiting pyroptosis and podocyte injury.
Article
Pharmacology & Pharmacy
Wei Qu, Nan Liu, Tianhua Xu, Binyao Tian, Meng Wang, Yanqiu Li, Jianfei Ma, Li Yao
Summary: The coexistence of anti-GBM disease, idiopathic membranous nephropathy, and IgA nephropathy in one patient is very rare. Treatment including high-dose steroids, plasma exchange, and intravenous infusion led to improvement in the patient's condition.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiujie Shi, Qi Zhang, Meiying Chang, Yifan Zhang, Mingming Zhao, Bin Yang, Peng Li, Yu Zhang
Summary: This study reveals the involvement of ferroptosis in the pathological damage of membranous nephropathy, accompanied by the activation of ferritinophagy.
Article
Urology & Nephrology
Elion Hoxha, Laurence H. Beck, Thorsten Wiech, Nicola M. Tomas, Christian Probst, Swantje Mindorf, Catherine Meyer-Schwesinger, Gunther Zahner, Phillip R. Stahl, Ruth Schoepper, Ulf Panzer, Sigrid Harendza, Udo Helmchen, David J. Salant, Rolf A. K. Stahl
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2017)
Article
Urology & Nephrology
Christopher P. Larsen, Claire Trivin-Avillach, Paige Coles, A. Bernard Collins, Michael Merchant, Hong Ma, Daniel W. Wilkey, Josephine M. Ambruzs, Nidia C. Messias, L. Nicholas Cossey, Ivy A. Rosales, Thomas Wooldridge, Patrick D. Walker, Robert B. Colvin, Jon Klein, David J. Salant, Laurence H. Beck
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2018)
Review
Urology & Nephrology
David J. Salant
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2019)
Editorial Material
Urology & Nephrology
Laurence H. Beck, David J. Salant
KIDNEY INTERNATIONAL
(2018)
Article
Urology & Nephrology
Vivek Kasinath, Osman A. Yilmam, Mayuko Uehara, Liwei Jiang, Farideh Ordikhani, Xiaofei Li, David J. Salant, Reza Abdi
KIDNEY INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Mostafa E. Belghasem, Ousama A'amar, Daniel Roth, Joshua Walker, Nkiruka Arinze, Sean M. Richards, Jean M. Francis, David J. Salant, Vipul C. Chitalia, Irving J. Bigio
SCIENTIFIC REPORTS
(2019)
Editorial Material
Urology & Nephrology
Laurence H. Beck, David J. Salant
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2020)
Article
Multidisciplinary Sciences
Jesse A. Pace, Robert Bronstein, Yiqing Guo, Yaqi Yang, Chelsea C. Estrada, Nehaben Gujarati, David J. Salant, John Haley, Agnieszka B. Bialkowska, Vincent W. Yang, John C. He, Sandeep K. Mallipattu
Summary: This study revealed that regulating factors such as KLF4, STAT3 signaling pathway, FN1, and ITGB6 can control podocyte loss and PEC activation in mice. Targeting the communication between podocytes and PECs might be a critical therapeutic strategy in proliferative glomerulopathies.
Article
Medicine, Research & Experimental
Sudhir Kumar, Xueping Fan, Hila Milo Rasouly, Richa Sharma, David J. Salant, Weining Lu
Summary: This study identifies the key role of ZEB2 in maintaining the cell fate of FOXD1(+) stromal progenitors during kidney development. Loss of ZEB2 leads to differentiation of FOXD1(+) stromal progenitors into myofibroblasts and kidney fibrosis.
Review
Urology & Nephrology
Robert Bronstein, Jesse Pace, Yogesh Gowthaman, David J. Salant, Sandeep K. Mallipattu
Summary: Podocytes and parietal epithelial cells (PECs) are principal cell types within the kidney glomerulus, with the former serving as a crucial part of the kidney filtration barrier and the latter representing a supporting epithelial layer. They share a developmental lineage and a conserved gene expression program. In addition to their homeostatic functions, podocytes and PECs also play roles in kidney pathogenesis, with PEC proliferation and migration being closely associated with podocyte loss in certain diseases.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Physiology
Dawn J. Caster, Erik A. Korte, Min Tan, Michelle T. Barati, Shweta Tandon, T. Michael Creed, David J. Salant, Jessica L. Hata, Paul N. Epstein, Hui Huang, David W. Powell, Kenneth R. McLeish
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2018)
Article
Medicine, Research & Experimental
Chelsea C. Estrada, Praharshasai Paladugu, Yiqing Guo, Jesse Pace, Monica P. Revelo, David J. Salant, Stuart J. Shankland, Vivette D. D'Agati, Anita Mehrotra, Stephanie Cardona, Agnieszka B. Bialkowska, Vincent W. Yang, John C. He, Sandeep K. Mallipattu
Article
Urology & Nephrology
Vijaya B. Kolachalama, Priyamvada Singh, Christopher Q. Lin, Dan Mun, Mostafa E. Belghasem, Joel M. Henderson, Jean M. Francis, David J. Salant, Vipul C. Chitalia
KIDNEY INTERNATIONAL REPORTS
(2018)
Article
Pathology
Erik A. Korte, Dawn J. Caster, Michelle T. Barati, Min Tan, Shirong Zheng, Celine C. Berthier, Frank C. Brosius, Mark B. Vieyra, Ryan M. Sheehan, Michele Kosiewicz, Marcin Wysoczynski, Patrick M. Gaffney, David J. Salant, Kenneth R. McLeish, David W. Powell
AMERICAN JOURNAL OF PATHOLOGY
(2017)
Article
Urology & Nephrology
Craig E. Gordon, Vipul C. Chitalia, J. Mark Sloan, David J. Salant, David L. Coleman, Karen Quillen, Katya Ravid, Jean M. Francis
AMERICAN JOURNAL OF KIDNEY DISEASES
(2017)