期刊
KIDNEY INTERNATIONAL
卷 77, 期 9, 页码 760-764出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ki.2010.35
关键词
dosage; nephrotoxicity; S. aureus; vancomycin
Vancomycin is a key tool in the treatment of serious Gram-positive infections. A progressive increase in vancomycin resistance with consequent treatment failure has been observed in staphylococci. Therefore, new dosing guidelines advocating much higher vancomycin doses have been issued. Target trough levels of 15-20 mu g/ml are proposed. Whether and how these targets can be achieved in patients with chronic kidney disease or those on dialysis are still under evaluation. The higher vancomycin doses to achieve these treatment targets carry a substantial risk for nephrotoxicity. This risk is incremental with higher trough levels and longer duration of vancomycin use. Critically ill patients, patients receiving concomitant nephrotoxic agents, and patients with already compromised renal function are particularly at risk for vancomycin-induced nephrotoxicity. Kidney International (2010) 77, 760-764; doi: 10.1038/ki.2010.35; published online 24 February 2010
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据