Article
Cardiac & Cardiovascular Systems
Roopinder K. Sandhu, Jacqueline S. Dron, Yunxian Liu, M. Vinayaga Moorthy, Neal A. Chatterjee, Patrick T. Ellinor, Daniel I. Chasman, Nancy R. Cook, Amit V. Khera, Christine M. Albert
Summary: This study investigated the genetic basis of familial predisposition to sudden and/or arrhythmic death (SAD) in the context of coronary artery disease (CAD). The results showed that a genome-wide polygenic score for CAD (GPSC(CAD)) can predict the risk of SAD in CAD patients without severe systolic dysfunction, identifying a population that might benefit from defibrillator therapy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Kyu-Beck Lee, Seung Hyeok Han, Suah Sung, Seong Kwon Ma, Soo Wan Kim
Summary: This study found that high body weight variability is independently associated with rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biology
Yue Huang, YingBo Ren, Hai Yang, YiJie Ding, Yan Liu, YunChun Yang, AnQiong Mao, Tan Yang, YingZi Wang, Feng Xiao, QiZhou He, Ying Zhang
Summary: This study investigates the relationship between coronary artery calcification score (CACS) and the occurrence of coronary heart disease (CHD) using machine learning analysis. Among the models used, the random forest model performs the best, indicating a significant advancement in medical analysis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Georgios Sofidis, Nikolaos Otountzidis, Nikolaos Stalikas, Efstratios Karagiannidis, Andreas S. Papazoglou, Dimitrios V. Moysidis, Eleftherios Panteris, Olga Deda, Anastasios Kartas, Thomas Zegkos, Paraskevi Daskalaki, Niki Theodoridou, Leandros Stefanopoulos, Haralambos Karvounis, Helen Gika, Georgios Theodoridis, Georgios Sianos
Summary: The study showed a significant positive correlation between the GRACE and SYNTAX scores in ACS patients. The GRACE score moderately predicted the severity of CAD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Amira Assaf, Marisa van der Graaf, Nick van Boven, Maarten J. B. van Ettinger, Roberto Diletti, Mark G. Hoogendijk, Tamas Szili-Torok, Dominic A. M. J. Theuns, Sing-Chien Yap
Summary: In patients with untreated CTO, a larger scar is an independent factor associated with an increased risk of ventricular arrhythmias.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Min-Tser Liao, Chia-Ter Chao, Chung-Kuan Wu
Summary: The study demonstrated that among adult chronic hemodialysis patients, higher grades of aortic arch calcification were associated with increased risks of major adverse cardiovascular events and cardiovascular and overall mortality. The presence of aortic valve calcification further increased the cardiovascular risk associated with aortic arch calcification in patients on maintenance hemodialysis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark M. Hammer, Suzanne C. Byrne, Ron Blankstein
Summary: This study retrospectively evaluated the accuracy of reporting coronary calcification on lung cancer screening CTs in real-world scenarios, as well as the subsequent testing and prescribing of statins. The results showed that 65% of patients had concordant coronary calcification scores in paired cardiac CTs, while in 34% of patients, the calcifications were not mentioned or underestimated. Reporting coronary artery calcification led to new statin prescriptions, with a higher odds ratio for calcifications with significant incidental findings. Radiologists should consider reporting coronary calcifications to facilitate risk-benefit discussions with physicians.
ACADEMIC RADIOLOGY
(2023)
Article
Medicine, General & Internal
Yves Cottin, Rany Issa, Mourad Benalia, Basile Mouhat, Alexandre Meloux, Laura Tribouillard, Florence Bichat, Luc Rochette, Catherine Vergely, Marianne Zeller
Summary: The study found an association between serum OPG levels and coronary lesion complexity in patients with acute myocardial infarction, which was not influenced by factors such as hypercholesterolemia, cardiovascular history, and reduced glomerular filtration rate.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jiayu Wang, Xianwei Huang, Caihua Fu, Qiping Sheng, Ping Liu
Summary: This study aimed to compare and analyze the predictive ability of TyG index and CACS for multi-vascular disease and MACEs in ACS patients. The results showed that TyG index, as a reliable and independent indicator, could replace CACS for predicting the severity and prognosis of MVCD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
Tzyy-Ling Chuang, Yuh-Feng Wang, Malcolm Koo, Mei-Hua Chuang
Summary: The trabecular bone score (TBS) was found to be significantly associated with moderate coronary artery calcification (CAC). This study further explored the association between TBS-adjusted Fracture Risk Assessment Tool (FRAX) and CAC score in women. The results showed a significant association between CAC score and an increase in major osteoporotic fracture (MOF) and hip fracture (HF) risk as measured by TBS-adjusted FRAX. This suggests that clinicians should be aware of the potential increased risk of coronary events among women with increased TBS-adjusted FRAX for MOF and HF.
Review
Medicine, General & Internal
David Bauer, Petr Tousek
Summary: This review evaluates known outcome predictors supported by clinical data in light of the development of new treatment strategies for ACS patients during the last three decades.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Samel Park, Min Hong, HwaMin Lee, Nam-jun Cho, Eun-Young Lee, Won-Young Lee, Eun-Jung Rhee, Hyo-Wook Gil
Summary: The study aimed to predict the presence of CAC and evaluate the performance of the models, using multiple models that performed well in practice and could potentially be applied in clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Christopher B. Fordyce, Robert P. Giugliano, Christopher P. Cannon, Matthew T. Roe, Abhinav Sharma, Courtney Page, Jennifer A. White, Yuliya Lokhnygina, Eugene Braunwald, Michael A. Blazing
Summary: This study examines the long-term incidence and influence of cardiovascular events before sudden death among stabilized patients after an acute coronary syndrome (ACS). The results show that patients stabilized within 10 days of ACS remain at long-term risk of sudden death, with the greatest risk in those with an additional cardiovascular event.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Simon Winther, Samuel E. Schmidt, Borek Foldyna, Thomas Mayrhofer, Laust D. Rasmussen, Jonathan N. Dahl, Udo Hoffmann, Pamela S. Douglas, Juhani Knuuti, Morten Bottcher
Summary: The risk factor-weighted clinical likelihood (RF-CL) model and the coronary artery calcium score-weighted clinical likelihood (CACS-CL) model improve the identification of obstructive coronary artery disease (CAD) compared with basic pretest probability (PTP) models. These new models provide improved risk stratification for myocardial infarction and death.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gorav Batra, Johan Lindback, Richard C. Becker, Robert A. Harrington, Claes Held, Stefan K. James, Tibor Kempf, Renato D. Lopes, Kenneth W. Mahaffey, Philippe Gabriel Steg, Robert F. Storey, Eva Swahn, Kai C. Wollert, Agneta Siegbahn, Lars Wallentin
Summary: This study developed a biomarker-based prediction model for predicting the 1-year risk of cardiovascular death and myocardial infarction in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). The model showed good calibration and discrimination in both the development cohort and the validation cohort.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
