Review
Transplantation
Markus Ketteler, Jordi Bover, Sandro Mazzaferro
Summary: This article reviews the management of secondary hyperparathyroidism in non-dialysis chronic kidney disease patients, discussing the strengths and weaknesses of guideline-based and clinical practice approaches, as well as the importance of individualized strategies and calcium-phosphate homeostasis. Additionally, it introduces a new treatment option and a potentially novel understanding of vitamin D saturation in advanced stages of chronic kidney disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Ting Sun, Xijie Yu
Summary: FGF23 is a new endocrine product that has been discovered in the past decade. It is not only related to bone diseases, but also plays a role in kidney and parathyroid metabolism, particularly as a biomarker and key factor in kidney diseases. FGF23 is upregulated in the early stages of chronic kidney disease (CKD), in response to excessive phosphorus levels. However, as kidney function declines, the protective effect of FGF23 weakens and can lead to various complications. Monoclonal antibodies targeting FGF23 are currently used to treat genetic diseases and CKD. This article reviews the role of FGF23 in CKD and discusses the interaction between FGF23 and various organs in CKD conditions, highlighting the importance of studying the effect of hyperphosphatemia on different organs. The potential of FGF23 for therapy is also discussed.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lucio Diaz-Flores, Ricardo Gutierrez, Miriam Gonzalez-Gomez, Maria del Pino Garcia, Jose Luis Carrasco, Juan Francisco Madrid, Lucio Diaz-Flores Jr
Summary: Telocytes/CD34+ stromal cells (TCs/CD34+ SCs) are important cellular components in the human parathyroid stroma, except around vessels within parenchymal nests. They exhibit typical characteristics and play a role in development, as well as various pathological conditions such as hyperplastic and adenomatous parathyroids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Li-Xi Zhang, Ben Zhang, Xu-Yao Liu, Zi-Ming Wang, Peng Qi, Tong-Yue Zhang, Qiang Zhang
Summary: Secondary and tertiary hyperparathyroidism are common and complicated endocrine diseases, and their hyperactivity disorder can cause structural alterations in multiple organs and systems. The current treatment for these diseases remains unclear.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Arslan Y. Pannu, Magdalena R. O'Connor-Manson, Lynda Wyld, Saba P. Balasubramanian
Summary: NIRAF showed potential benefits in aiding parathyroid identification during surgery for primary hyperparathyroidism, however, it did not improve cure rates compared to traditional methods. Further studies on larger patient cohorts and fluorescence patterns are needed to explore the full potential of NIRAF in surgical settings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Louis-Charles Desbiens, Aboubacar Sidibe, Roth-Visal Ung, Fabrice Mac-Way
Summary: This study investigated the association between FGF23, alpha-Klotho, and traditional mineral parameters with fractures. The results showed that cFGF23 was linearly associated with fracture incidence, while alpha-Klotho, PTH, and phosphate levels had a U-shaped association.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Wajid Amjad, Sara P. Ginzberg, Jesse E. Passman, Jonathan Heintz, Rachel R. Kelz, Heather Wachtel
Summary: A scoring system was developed to stratify patients according to their risk of developing hungry bone syndrome (HBS) after parathyroidectomy. Clinical factors such as younger age, renal osteodystrophy, longer duration of dialysis or kidney transplant, and higher Elixhauser score were significantly associated with HBS.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Medicine, General & Internal
Climerio Pereira Nascimento, Sergio Samir Arap, Melani Ribeiro Custodio, Ledo Mazzei Massoni Neto, Marilia D'Elboux Guimaraes Brescia, Rosa Maria Affonso Moyses, Vanda Jorgetti, Fabio Luiz de Menezes Montenegro
Summary: After total parathyroidectomy and autograft, dialysis patients exhibit four distinct patterns of graft function, each requiring varied therapeutic management. These patterns include stable function, early function with later failure, graft recurrence, and complete graft failure. Patterns of parathormone levels become statistically different after 36 months, highlighting the importance of long-term monitoring.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Computer Science, Information Systems
Meidi Chen, Zijin Chen, Yun Xi, Xiaoya Qiao, Xiaonong Chen, Qiu Huang
Summary: In the disease of secondary hyperparathyroidism (SHPT), accurately locating hyperplastic parathyroid glands is crucial before surgery. This study presents a deep learning method with a fusion network to detect these glands in SPECT/CT images. The fusion network integrates anatomical and functional information to improve the detection of low-uptake glands. Experimental results show improved performance compared to current strategies, with an average sensitivity of 0.822.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Takahisa Hiramitsu, Toshihide Tomosugi, Manabu Okada, Kenta Futamura, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Yoshihiro Tominaga, Toshihiro Ichimori
Summary: This study proposes a method utilizing intact PTH ratio to predict the localization of causative parathyroid glands for re-parathyroidectomy, avoiding the risks of pain and nerve damage that traditional methods may pose.
Article
Endocrinology & Metabolism
Takahisa Hiramitsu, Yuki Hasegawa, Kenta Futamura, Manabu Okada, Norihiko Goto, Shunji Narumi, Yoshihiko Watarai, Yoshihiro Tominaga, Toshihiro Ichimori
Summary: The dialysis vintage and maximum diameter of PTG for autograft have been found to be key factors contributing to re-PTx due to autograft-dependent recurrent SHPT. The use of PTGs with a maximum diameter of <14 mm can prevent reoperation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Ozlem Saraydaroglu, Mine Ozsen, Selin Narter, Turkay Kirdak, Erdinc Erturk
Summary: This study retrospectively analyzed the lesions of 638 parathyroidectomy specimens between 2005 and 2016, and identified cases with suspicious histopathological features of carcinoma but not meeting the criteria for parathyroid carcinoma, which were defined as atypical parathyroid adenomas. Close follow-up should be conducted for these borderline cases between adenoma and carcinoma.
MINERVA ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuhua Wang, Ye Liu, Na Li, Wanchun Zhang
Summary: This study investigated the differences in biochemical markers and lesion visualization on Tc-99m-MIBI imaging between PHPT and SHPT. The findings showed that PHPT patients had higher positive results and T/NT ratio on Tc-99m-MIBI SPECT/CT imaging compared to SHPT patients. The volume of parathyroid lesions in SHPT was smaller than in PHPT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pediatrics
Dieter Haffner, Maren Leifheit-Nestler
Summary: Complications of chronic kidney disease-associated mineral and bone disorders are common in pediatric kidney transplant recipients, leading to various adverse outcomes. Treatment should focus on monitoring bone health and mineral metabolism, including physical activity, transplant preservation, immunosuppression, and disease management.
PEDIATRIC NEPHROLOGY
(2021)
Article
Transplantation
Aarti Mathur, JiYoon B. Ahn, Whitney Sutton, Nadia M. Chu, Alden L. Gross, Dorry L. Segev, Mara McAdams-DeMarco
Summary: Receiving treatment for secondary hyperparathyroidism (SHPT) was associated with a lower risk of incident dementia among older patients with end-stage renal disease (ESRD). The beneficial effect of SHPT treatment differed by sex and race, with females and those of Asian or Black race experiencing the greatest reduction in dementia risk.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Endocrinology & Metabolism
Cedric Lavet, Aline Martin, Marie-Therese Linossier, Arnaud Vanden Bossche, Norbert Laroche, Mireille Thomas, Maude Gerbaix, Patrick Ammann, Antoine Fraissenon, Marie-Helene Lafage-Proust, Daniel Courteix, Laurence Vico
JOURNAL OF BONE AND MINERAL RESEARCH
(2016)
Review
Biochemistry & Molecular Biology
Wafa Bouleftour, Laura Juignet, Guenaelle Bouet, Renata Neves Granito, Arnaud Vanden-Bossche, Norbert Laroche, Jane E. Aubin, Marie-Helene Lafage-Proust, Laurence Vico, Luc Malaval
Editorial Material
Rheumatology
Marie-Helene Lafage Proust
Article
Cell Biology
Wafa Bouleftour, Renata Neves Granito, Arnaud Vanden-Bossche, Odile Sabido, Bernard Roche, Mireille Thomas, Marie Therese Linossier, Jane E. Aubin, Marie-Helene Lafage-Proust, Laurence Vico, Luc Malaval
JOURNAL OF CELLULAR PHYSIOLOGY
(2017)
Article
Urology & Nephrology
Martin Jannot, Fabrice Mac-Way, Vanessa Lapierre, Marie-Helene Lafage-Proust
JOURNAL OF NEPHROLOGY
(2017)
Review
Transplantation
Pieter Evenepoel, Patrick D'Haese, Justine Bacchetta, Jorge Cannata-Andia, Anibal Ferreira, Mathias Haarhaus, Sandro Mazzaferro, Marie-Helene Lafage Proust, Syazrah Salam, Goce Spasovski, Mario Cozzolino
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2017)
Article
Multidisciplinary Sciences
Guillaume Jean, Marie Helene Lafage-Proust, Jean Claude Souberbielle, Sylvain Lechevallier, Patrik Deleaval, Christie Lorriaux, Jean Marc Hurot, Brice Mayor, Manolie Mehdi, Charles Chazot
Article
Endocrinology & Metabolism
W. Bouleftour, L. Juignet, L. Verdiere, I. Machuca-Gayet, M. Thomas, N. Laroche, A. Vanden-Bossche, D. Farlay, C. Thomas, E. Gineyts, J. P. Concordet, J. B. Renaud, D. Aubert, M. Teixeira, O. Peyruchaud, L. Vico, M. H. Lafage-Proust, H. Follet, L. Malaval
Review
Rheumatology
Marie-Helene Lafage-Proust, Isabelle Courtois
Article
Endocrinology & Metabolism
Robin Caire, Bernard Roche, Tiphanie Picot, Carmen-Mariana Aanei, Zhiguo He, Lydia Campos, Mireille Thomas, Luc Malayal, Laurence Vico, Marie-Helene Lafage-Proust
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Editorial Material
Urology & Nephrology
Marie Helene Lafage-Proust
KIDNEY INTERNATIONAL
(2019)
Review
Psychiatry
Jean-Claude Souberbielle, Claude Laurent Benhamou, Bernard Cortet, Mickael Rousiere, Christian Roux, Vered Abitbol, Cedric Annweiler, Maurice Audran, Justine Bacchetta, Pierre Bataille, Olivier Beauchet, Remi Bardet, Alexandra Benachi, Francis Berenbaum, Hubert Blain, Francoise Borson-Chazot, Veronique Breuil, Karine Briot, Philippe Brunet, Jean-Claude Carel, Philippe Caron, Olivier Chabre, Philippe Chanson, Roland Chapurlat, Pierre Cochat, Regis Coutant, Sophie Christin-Maitre, Martine Cohen-Solal, Christian Combe, Catherine Cormier, Marie Courbebaisse, Gregory Debrus, Brigitte Delemer, Georges Deschenes, Marc Duquenne, Guillaume Duval, Patrice Fardellone, Denis Fouque, Gerard Friedlander, Jean-Bernard Gauvain, Lionel Groussin, Pascal Guggenbuhl, Pascal Houillier, Thierry Hannedouche, William Jacot, Rose-Marie Javier, Guillaume Jean, Claude Jeandel, Dominique Joly, Peter Kamenicky, Bertrand Knebelmann, Marie-Helene Lafage-Proust, Yves Le bouc, Erick Legrand, Florence Levy-Wei, Agnes Linglart, Laurent Machet, Emmanuel Maheu, Eric Mallet, Christian Marcelli, Pierre Mares, Christophe Mariat, Gerard Maruani, Yves Maugars, France Montagnon, Bruno Moulin, Philippe Orcel, Henri Partouche, Virginie Personne, Charles Pierrot-Deseilligny, Michel Polak, Claire Pouteil-Noble, Dominique Prie, Agathe Raynaud-Simon, Yves Rolland, Jean -Louis Sadoul, Bernard Salle, Corinne Sault, Anne -Marie Schott, Isabelle Sermet-Gaudelus, Martin Soubrier, Ivan Tack, Eric Thervet, Isabelle Tostivint, Philippe Touraine, Florence Tremollieres, Pablo Urena-Torres, Jean-Paul Viard, Jean-Louis Wemeau, Georges Weryha, Norbert Winer, Jacques Young, Thierry Thomas
GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT
(2016)
Article
Medical Laboratory Technology
Dominique Prie
ANNALES DE BIOLOGIE CLINIQUE
(2015)
Article
Medical Laboratory Technology
Lucie Henaut, Romuald Mentaverri, Sophie Liabeuf, Anne-Sophie Bargnoux, Pierre Delanaye, Etienne Cavalier, Jean-Paul Cristol, Ziad Massy, Said Kamel
ANNALES DE BIOLOGIE CLINIQUE
(2015)
Article
Medical Laboratory Technology
Sophie Liabeuf, Pierre Delanaye, Etienne Cavalier, Alain Guerin, Said Kamel, Ziad A. Massy
ANNALES DE BIOLOGIE CLINIQUE
(2015)
