Article
Medicine, General & Internal
C. Hsu, Wei Yang, Rishi V. Parikh, Amanda H. Anderson, Teresa K. Chen, Debbie L. Cohen, Jiang He, Madhumita J. Mohanty, James P. Lash, Katherine T. Mills, Anthony N. Muiru, Afshin Parsa, Milda R. Saunders, Tariq Shafi, Raymond R. Townsend, Sushrut S. Waikar, J. Wang, Myles Wolf, Thida C. Tan, Harold I. Feldman, Alan S. Go
Summary: The study found that using serum creatinine levels to estimate GFR without taking race (or genetic ancestry) into account led to systematic misclassification. Estimating GFR with cystatin C produced similar results while eliminating negative consequences of race-based approaches.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Maurice Laville
Summary: Nephroprotective treatments may lead to a drop in glomerular filtration rate, which could be related to the intensity of baseline glomerular anomalies and potential treatment benefits. The study by Oshima et al. further confirms this relationship in diabetic patients with chronic kidney disease under sodium-glucose cotransporter 2 inhibition.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Maggie Wang, Samson S. Peter, Chi D. Chu, Delphine S. Tuot, Jonathan H. Chen
Summary: The findings of this study suggest that nearly half of patients with CKD at high risk of progressing to kidney failure do not have a nephrologist visit within 1 year of established risk.
Article
Multidisciplinary Sciences
Sam O. Kleeman, Mattia Cordioli, Paul R. H. J. Timmers, Atlas Khan, Pinkus Tober-Lau, Florian Kurth, Vadim Demichev, Hannah Meyer, James F. Wilson, Markus Ralser, Krzysztof Kiryluk, Andrea Ganna, Kenneth Baillie, Tobias Janowitz
Summary: This study found a significant association between cystatin C production and the severity and mortality of COVID-19 in patients, suggesting its potential use in stratifying patients and its functional role in the host response to COVID-19.
Article
Pharmacology & Pharmacy
Yifei Zhang, Catherine M. Sherwin, Daniel Gonzalez, Qunshu Zhang, Mona Khurana, Jeffrey Fisher, Gilbert J. Burckart, Yanin Wang, Lynne P. Yao, Charles J. Ganley, Jian Wang
Summary: The study evaluated the performance of eGFR equations in estimating drug clearance in pediatric patients, finding that Schwartz equations led to an overestimation of drug clearance. The bedside Schwartz equation showed a higher eGFR/CL ratio in subjects with lower SCR or CL.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Urology & Nephrology
James A. Diao, Gloria J. Wu, Jason K. Wang, Isaac S. Kohane, Herman A. Taylor, Hocine Tighiouart, Andrew S. Levey, Lesley A. Inker, Neil R. Powe, Arjun K. Manrai
Summary: The newly recommended 2021 CKD-EPI creatinine-based eGFR equation may result in substantial changes to recommended care for US patients of all racial and ethnic groups.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Lucas M. Wiggenhauser, Lena Metzger, Katrin Bennewitz, Silas Soleymani, Mike Boger, Christoph T. Tabler, Ingrid Hausser, Carsten Sticht, Paulus Wohlfart, Nadine Volk, Elena Heidenreich, Michael Buettner, Hans-Peter Hammes, Jens Kroll
Summary: This study identified the pdx1 mutant as a novel model for the study of DKD, showing signs of the early disease progression already in the larval stage and several selective features of later DKD in adult mutants.
Article
Medicine, General & Internal
H. Pottel, J. Bjork, A. D. Rule, N. Ebert, B. O. Eriksen, L. Dubourg, E. Vidal-Petiot, A. Grubb, M. Hansson, E. J. Lamb, K. Littmann, C. Mariat, T. Melsom, E. Schaeffner, P. -O. Sundin, A. Akesson, A. Larsson, E. Cavalier, J. B. Bukabau, E. K. Sumaili, E. Yayo, D. Monnet, M. Flamant, U. Nyman, P. Delanaye
Summary: The study developed a cystatin C-based equation (EKFC eGFRcys) to estimate glomerular filtration rate (GFR). This equation had similar accuracy to a creatinine-based equation (EKFC eGFRcr) and outperformed other commonly used equations. Furthermore, taking the arithmetic mean of EKFC eGFRcr and EKFC eGFRcys further improved the accuracy of GFR estimation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Urology & Nephrology
Lesley A. Inker, Andrew S. Levey
Summary: Developing and validating equations for estimating glomerular filtration rate in diverse populations, including different age groups, races, and clinical conditions, is essential. Two newly developed equations for children and young adults showed better performance than recommended equations, but require further evaluation for generalizability in diverse populations.
KIDNEY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Jane Ha, Cheol Woong Jung, Sunkyu Choi, Myung-Gyu Kim, Jun Gyo Gwon, Joong Kyung Kim, Chan-Duck Kim, Ji Won Min, Jaeseok Yang, Curie Ahn
Summary: Comparing kidney transplantations from donors with acute kidney injury to those from non-AKI donors through matching, it was found that although transplantations from AKI donors had a higher incidence of delayed graft function, the overall graft function was comparable.
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Transplantation
Edouard L. Fu, Josef Coresh, Morgan E. Grams, Catherine M. Clase, Carl-Gustaf Elinder, Julie Paik, Chava Ramspek, Lesley A. Inker, Andrew S. Levey, Friedo W. Dekker, Juan J. Carrero
Summary: Implementing the 2021 CKD-EPI equation in predominantly White European populations would slightly increase eGFR and reclassify a significant proportion of CKD patients to a higher eGFR category. eGFR by both equations strongly predicted outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Bridget M. Lin, Ying Zhang, Bing Yu, Eric Boerwinkle, Bharat Thygarajan, Milagros Yunes, Martha L. Daviglus, Qibin Qi, Robert Kaplan, James Lash, Jianwen Cai, Tamar Sofer, Nora Franceschini
Summary: This study aimed to identify the source of variability in the association of metabolites with estimated glomerular filtration rate (eGFR) in Hispanics/Latinos with low chronic kidney disease prevalence. The results suggest that complex mechanisms contribute to the association of eGFR with metabolites and provide new insights into these associations.
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Andrea R. V. R. Horimoto, Nora Franceschini
CIRCULATION-GENOMIC AND PRECISION MEDICINE
(2022)
Article
Urology & Nephrology
Bryan Kestenbaum, Alexander G. Bick, Caitlyn Vlasschaert, Michael J. Rauh, Matthew B. Lanktree, Nora Franceschini, Moore B. Shoemaker, Raymond C. Harris Jr, Bruce M. Psaty, Anna Koettgen, Pradeep Natarajan, Cassianne Robinson-Cohen
Summary: This study found an association between clonal hematopoiesis and kidney function decline in the general population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Multidisciplinary Sciences
Usman A. Tahir, Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, Jeremy M. Robbins, Zhi Yu, Zsu-Zsu Chen, Mark D. Benson, Daniel E. Cruz, Debby Ngo, Shuliang Deng, Xu Shi, Shuning Zheng, Aaron S. Eisman, Laurie Farrell, Michael E. Hall, Adolfo Correa, Russell P. Tracy, Peter Durda, Kent D. Taylor, Yongmei Liu, W. Craig Johnson, Xiuqing Guo, Jie Yao, Yii-Der Ida Chen, Ani W. Manichaikul, Frederick L. Ruberg, William S. Blaner, Deepti Jain, Claude Bouchard, Mark A. Sarzynski, Stephen S. Rich, Jerome Rotter, Thomas J. Wang, James G. Wilson, Clary B. Clish, Pradeep Natarajan, Robert E. Gerszten
Summary: Integrating genetic information with metabolomics provides new insights into genes affecting human metabolism. This study integrates genomic and metabolomic data in Black individuals, highlighting the value of whole genome sequencing in diverse populations and linking circulating metabolites to human disease.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Margaret Sunitha Selvaraj, Xihao Li, Zilin Li, Akhil Pampana, David Y. Zhang, Joseph Park, Stella Aslibekyan, Joshua C. Bis, Jennifer A. Brody, Brian E. Cade, Lee-Ming Chuang, Ren-Hua Chung, Joanne E. Curran, Lisa de Las Fuentes, Paul S. de Vries, Ravindranath Duggirala, Barry Freedman, Mariaelisa Graff, Xiuqing Guo, Nancy Heard-Costa, Bertha Hidalgo, Chii-Min Hwu, Marguerite R. Irvin, Tanika N. Kelly, Brian G. Kral, Leslie Lange, Xiaohui Li, Martin Lisa, Steven A. Lubitz, Ani W. Manichaikul, Preuss Michael, May E. Montasser, Alanna C. Morrison, Take Naseri, Jeffrey R. O'Connell, Nicholette D. Palmer, Patricia A. Peyser, Muagututia S. Reupena, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Russell P. Tracy, Michael Y. Tsai, Zhe Wang, Yuxuan Wang, Wei Bao, John T. Wilkins, Lisa R. Yanek, Wei Zhao, Donna K. Arnett, John Blangero, Eric Boerwinkle, Donald W. Bowden, Yii-Der Ida Chen, Adolfo Correa, L. Adrienne Cupples, Susan K. Dutcher, Patrick T. Ellinor, Myriam Fornage, Stacey Gabriel, Soren Germer, Richard Gibbs, Jiang He, Robert C. Kaplan, Sharon L. R. Kardia, Ryan Kim, Charles Kooperberg, Ruth J. F. Loos, Karine A. Viaud-Martinez, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Deborah Nickerson, Kari E. North, Bruce M. Psaty, Susan Redline, Alexander P. Reiner, Ramachandran S. Vasan, Stephen S. Rich, Cristen Willer, Jerome Rotter, Daniel J. Rader, Xihong Lin, Gina M. Peloso, Pradeep Natarajan
Summary: This study used whole genome sequencing to expand the range of genetic variations associated with blood lipids and identified multiple genes related to blood lipids, including both common and rare coding and non-coding variants. The study also found a correlation between rare LDLR intronic variants and increased LDL-C.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Yang Pan, Xiao Sun, Xuenan Mi, Zhijie Huang, Yenchih Hsu, James E. Hixson, Donna Munzy, Ginger Metcalf, Nora Franceschini, Adrienne Tin, Anna Koettgen, Michael Francis, Jennifer A. Brody, Bryan Kestenbaum, Colleen M. Sitlani, Josyf C. Mychaleckyj, Holly Kramer, Leslie A. Lange, Xiuqing Guo, Shih-Jen Hwang, Marguerite R. Irvin, Jennifer A. Smith, Lisa R. Yanek, Dhananjay Vaidya, Yii-Der Ida Chen, Myriam Fornage, Donald M. Lloyd-Jones, Lifang Hou, Rasika A. Mathias, Braxton D. Mitchell, Patricia A. Peyser, Sharon L. R. Kardia, Donna K. Arnett, Adolfo Correa, Laura M. Raffield, Ramachandran S. Vasan, L. Adrienne Cupple, Daniel Levy, Robert C. Kaplan, Kari E. North, Jerome Rotter, Charles Kooperberg, Alexander P. Reiner, Bruce M. Psaty, Russell P. Tracy, Richard A. Gibbs, Alanna C. Morrison, Harold Feldman, Eric Boerwinkle, Jiang He, Tanika N. Kelly
Summary: This study conducted a whole-exome sequencing to identify rare variants for diabetic kidney disease (DKD) and discovered four novel exome-wide significant DKD-related loci. The findings provide new insights into the molecular mechanisms underlying DKD.
HUMAN MOLECULAR GENETICS
(2023)
Editorial Material
Urology & Nephrology
Nora Franceschini, Jonathan S. Berg
KIDNEY INTERNATIONAL
(2023)
Article
Health Policy & Services
Molly Remch, Nora Franceschini, Thibaut Davy-Mendez, Michelle Floris-Moore, Sonia Napravnik
Summary: The management outcomes of hypertension in people with HIV have not been well studied. This study found a high burden of hypertension among HIV patients, with a low proportion initiating antihypertensive treatment and achieving blood pressure control.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)
Article
Endocrinology & Metabolism
Ryan P. Brady, Elizabeth T. Jensen, Joseph Rigdon, Nancy A. Crimmins, Daniel Mallon, Lawrence M. Dolan, Giuseppina Imperatore, Anna R. Kahkoska, Amy K. Mottl, Ann Honor, David J. Pettitt, Lina Merjaneh, Dana Dabelea, Amy S. Shah
Summary: Undiagnosed celiac disease is likely present in youth with type 1 diabetes, and potentially undiagnosed CD is associated with a higher risk of diabetic retinopathy. These findings indicate the importance of routine screening for CD in type 1 diabetes in youth.
PEDIATRIC DIABETES
(2023)
Article
Gastroenterology & Hepatology
Brandilyn A. Peters, Qibin Qi, Mykhaylo Usyk, Martha L. Daviglus, Jianwen Cai, Nora Franceschini, James P. Lash, Marc D. Gellman, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D. Burk, Robert C. Kaplan
Summary: This study found that there is an association between kidney function and the gut microbiome. The relationship between kidney damage and the gut microbiome depends on whether the individual has diabetes. The metabolites produced by the gut microbiome may contribute to the progression of chronic kidney disease.
Article
Genetics & Heredity
Laura Y. Zhou, Tamar Sofer, Andrea R. V. R. Horimoto, Gregory A. Talavera, James P. Lash, Jianwen Cai, Nora Franceschini
Summary: Estimated glomerular filtration rate (eGFR) is used to evaluate kidney function and determine the presence of chronic kidney disease (CKD). Polygenic risk score (PRS) is a popular method that uses large genome-wide association studies (GWASs) to estimate disease risk. However, PRS calculations for Hispanic/Latino individuals rely on different ancestry GWASs due to limited availability of summary statistics. This study compared different PRS constructions for eGFR prediction in Hispanic/Latino individuals and found that all eGFR PRSs were highly associated with eGFR and significantly associated with lower risk of CKD, with the combined PRSs performing the best.
HUMAN GENETICS AND GENOMICS ADVANCES
(2023)
Article
Urology & Nephrology
Dorota Marchel, Howard Trachtman, Maria Larkina, Margaret Helmuth, Jennifer Y. Lai Yee, Damian Fermin, Andrew S. Bomback, Pietro A. Canetta, Debbie S. Gipson, Amy K. Mottl, Rulan S. Parekh, Manish K. Saha, Matthew G. Sampson, Richard A. Lafayette, Laura H. Mariani
Summary: Hematuria is prevalent among participants with podocytopathies and is significantly associated with worse kidney-related outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Young Ho Kim, Manish K. Saha, Yichun Hu, Srikar Kumar, Caroline J. Poulton, Susan L. Hogan, Patrick Nachman, J. Charles Jennette, Cynthia C. Nast, Amy K. Mottl
Summary: This study aimed to evaluate the impact of concomitant diabetic glomerulosclerosis (DGS) and its severity on the treatment and outcomes of primary glomerular diseases (GDs) with comorbid diabetes. The results indicated that the severity of diabetic glomerular lesions was associated with an increased risk of end-stage kidney disease (ESKD) and death.
Article
Medicine, Research & Experimental
Amand F. Schmidt, Roshni Joshi, Maria Gordillo-Maranon, Fotios Drenos, Pimphen Charoen, Claudia Giambartolomei, Joshua C. Bis, Tom R. Gaunt, Alun D. Hughes, Deborah A. Lawlor, Andrew Wong, Jackie F. Price, Nishi Chaturvedi, Goya Wannamethee, Nora Franceschini, Mika Kivimaki, Aroon D. Hingorani, Chris Finan
Summary: Schmidt et al. assessed the effects of elevated levels of cholesterol-containing lipoproteins and apolipoproteins on various health outcomes. They found that these lipoproteins and apolipoproteins were associated with atherosclerosis, coronary heart disease, Alzheimer's disease, and other diseases, independent of traditional lipid fractions like LDL-C and HDL-C.
COMMUNICATIONS MEDICINE
(2023)
Article
Physiology
Pei-Lun Chu, Joseph C. Gigliotti, Sylvia Cechova, Gabor Bodonyi-Kovacs, Yves T. Wang, Luojing Chen, Sylvi Wasserthil Smoller, Jianwen Cai, Brant E. Isakson, Nora Franceschini, Thu H. Le
Summary: Collectrin is a chaperone of amino acid transporters in the kidney and endothelium and its knockout leads to hypertension and renal dysfunction. PT-specific collectrin knockout mice show hypertension and altered expression of NHE3, but not increased salt sensitivity or reduced renal blood flow. In HCHS/SOL participants, there are sex-specific associations between TMEM27 polymorphisms and diastolic blood pressure. Loss of collectrin in the PT can induce hypertension through activation of NHE3 and altered renal blood flow may be a determining factor for salt sensitivity.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)