Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Aliaa Anter, Al-Shaimaa F. Ahmed, Asmaa S. A. Hammad, Waleed Hassan Almalki, Sara Mohamed Naguib Abdel Hafez, AlShaimaa W. Kasem, Mohamed A. El-Moselhy, Mohammad W. Alrabia, Ahmed R. N. Ibrahim, Mahmoud El-Daly
Summary: The study aimed to evaluate the effect of menthol against sepsis-induced mortality, acute lung injury (ALI), and acute kidney injury (AKI). Menthol improved survival after sepsis and alleviated the development of ALI and AKI. Additionally, menthol also suppressed inflammation and apoptosis markers, showing its protective role in experimental sepsis.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Changnan Wang, Jihong Yuan, Jiankui Du
Summary: The study showed that resveratrol could alleviate sepsis-induced acute lung injury/acute respiratory distress syndrome by regulating mitochondrial function and mitophagy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Raquel Pires Nakama, Aparecida Donizette Malvezi, Maria Isabel Lovo-Martins, Lucas Felipe dos Santos, Ana Paula Canizares Cardoso, Gustavo Scacco, Andressa Mendes Dionisio de Freitas, Marli Cardoso Martins-Pinge, Phileno Pinge-Filho
Summary: The study found that metabolic syndrome can improve survival rates in septic mice, prevent damage to hematological and cardiovascular functions, and reduce the typical feature of increased nitric oxide in sepsis.
Article
Biochemistry & Molecular Biology
Deepa Mathew, Julia Barillas-Cerritos, Ana Nedeljkovic-Kurepa, Mabel Abraham, Matthew D. Taylor, Clifford S. Deutschman
Summary: Cecal ligation and puncture (CLP) attenuates the tyrosine phosphorylation of insulin receptor β-subunit (IRβ) and insulin receptor substrate molecules (IRS)-1 and IRS-2.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Pratsanee Hiengrach, Peerapat Visitchanakun, Pakteema Tongchairawewat, Ponphisudti Tangsirisatian, Thitiphat Jungteerapanich, Patcharee Ritprajak, Dhammika Leshan Wannigama, Pattarin Tangtanatakul, Asada Leelahavanichkul
Summary: BAM15 shows potential as an adjuvant therapy against sepsis hyperinflammation by attenuating multiple aspects of septic conditions, such as survival, organ damage, apoptosis, and brain injury, as well as regulating mitochondrial functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Cheng-Long Ge, Wei Chen, Li-Na Zhang, Yu-Hang Ai, Yu Zou, Qian-Yi Peng
Summary: Our study reveals the important role of the HPC-PFC pathway in improving cognitive dysfunction in a mouse model of CLP sepsis and provides a novel pathogenetic mechanism for SAE.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Physiology
Jose Maria Moreno-Navarrete, Ferran Comas, Vincent de Jager, Jose Manuel Fernandez-Real, Hjalmar R. Bouma
Summary: The study found that sepsis reduces the expression of adipogenesis-related genes in white adipose tissue while promoting inflammation in adipose tissue. In contrast, sepsis increases inflammation in brown adipose tissue without affecting the expression of thermogenic genes.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Plant Sciences
Qian Xie, Yi Wang, Guo-Liang Zou
Summary: The study found that pre-treatment with Lavender oil (Lav) has a protective effect on sepsis-induced acute lung injury (ALI), possibly through the inhibition of the NF-kappa B pathway. This research provides a theoretical basis for the treatment of sepsis-induced ALI.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Masaru Matsui, Kenji Onoue, Yoshihiko Saito
Summary: This review article focuses on the function and regulation of PlGF/Flt-1 signaling in chronic kidney disease (CKD). Elevated levels of circulating sFlt-1 and downregulated sFlt-1 in vascular endothelial cells exacerbate heart failure and atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Immunology
Claudia V. de Araujo, Frederik Denorme, W. Zac Stephens, Qing Li, Mark J. Cody, Jacob L. Crandell, Aaron C. Petrey, Kimberly A. Queisser, John L. Rustad, Judah L. Evangelista, Michael S. Kay, Joshua D. Schiffman, Robert A. Campbell, Christian C. Yost
Summary: Neutrophil extracellular traps (NETs) can contribute to host inflammatory tissue damage during sepsis. This study investigated a novel therapeutic agent, neonatal NET-Inhibitory Factor (nNIF), and found that nNIF inhibited NET formation and improved survival in a mouse model of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Plant Sciences
Xianming Tang, Jiqiang Liu, Shuo Yao, Jianfei Zheng, Xun Gong, Bing Xiao
Summary: Ferulic acid has a protective effect on sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis, reducing lung damage and improving alveolar epithelial barrier function.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Immunology
Takashi Ashino, Yuki Nakamura, Hirokazu Ohtaki, Yoichiro Iwakura, Satoshi Numazawa
Summary: Sepsis affects drug metabolism and the expression of cytochrome P450s. The study shows that cecal ligation and puncture (CLP) induces the expression of proinflammatory cytokines and leads to decreased survival in IL-6(-/-) mice. CLP also downregulates the expression of Cyp2c and Cyp3a11 genes, but this effect is abolished by IL-6 depletion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Urology & Nephrology
Neil A. Hukriede, Danielle E. Soranno, Veronika Sander, Tayla Perreau, Michelle C. Starr, Peter S. T. Yuen, Leah J. Siskind, Michael P. Hutchens, Alan J. Davidson, David M. Burmeister, Sarah Faubel, Mark P. de Caestecker
Summary: Models used in preclinical research often have limitations that result in results inconsistent with clinical practice. In the field of acute kidney injury (AKI), clinical trial failures are mainly attributed to inaccurate modeling in rodents. Currently, emerging research methods such as human kidney organoids, zebrafish, rodent, and large animal models are being applied in preclinical therapeutic research. However, the traditional preclinical research methods often overlook the limitations of model systems, leading to misleading results in the preclinical stage of treatment effectiveness. To address this problem, a more flexible and integrated approach is needed, with investigator teams using different model systems closely collaborating with clinical researchers to develop more targeted treatment methods. This review summarizes the current state of acute kidney injury model development and emphasizes the importance of adopting a multidisciplinary approach to optimize the development of treatment methods for acute kidney injury.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Urology & Nephrology
Rikako Oki, Yoshifumi Hamasaki, Yohei Komaru, Yoshihisa Miyamoto, Ryo Matsuura, Seigo Akari, Takashi Nakamura, Takayo Murase, Kent Doi, Masaomi Nangaku
Summary: Plasma XOR activity is independently associated with atherosclerotic changes in the carotid artery of stable post-KT patients, with age and plasma XOR activity being independent predictors of CCA/ICA plaque or max-CIMT >0.9 mm. The cutoff value of plasma XOR activity for the diagnosis of CCA/ICA plaque or CCA-IMT > 0.9 mm was found to be 16.3 pmol/h/ml through receiver operator characteristic curve analyses.
Article
Urology & Nephrology
Yoshihisa Miyamoto, Masao Iwagami, Shotaro Aso, Kazuaki Uda, Kiyohide Fushimi, Yoshifumi Hamasaki, Masaomi Nangaku, Hideo Yasunaga, Kent Doi
Summary: Patients with kidney failure and dialysis therapy (KFDT) had higher rates of postoperative complications and 30-day mortality in cancer surgery, but the risk differences varied among different types of cancer. The higher rates of postoperative complications in patients with KFDT were mainly attributable to cardiovascular complications.
CLINICAL KIDNEY JOURNAL
(2022)
Letter
Endocrinology & Metabolism
Rajiv Agarwal, Sibylle Jenny Hauske, David C. Wheeler, Kent Doi, Amelie Elsaesser, Ivana Ritter, Dominik Steubl, Christoph Wanner
DIABETES OBESITY & METABOLISM
(2022)
Letter
Urology & Nephrology
Ryo Matsuura, Kenjiro Honda, Rikako Oki, Yoshifumi Hamasaki, Kent Doi, Masaomi Nangaku
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Tetsushi Yamashita, Jonathan M. Street, Brianna C. Halasa, Yoshitaka Naito, Takayuki Tsuji, Naoko Tsuji, Naoki Hayase, Peter S. T. Yuen, Robert A. Star
Summary: This study evaluated the effect of continuous intravenous norepinephrine infusion in a septic mouse model. The results showed that norepinephrine increased arterial blood pressure and heart rate, but did not improve survival rate. Moreover, heart rate may serve as an indicator for severity of sepsis.
Correction
Immunology
Irina N. Baranova, Alexander V. Bocharov, Tatyana G. Vishnyakova, Zhigang Chen, Anna A. Birukova, Yunbo Ke, Xuzhen Hu, Peter S. T. Yuen, Robert A. Star, Konstantin G. Birukov, Amy P. Patterson, Thomas L. Eggerman
INFECTION AND IMMUNITY
(2022)
Article
Multidisciplinary Sciences
Rikako Oki, Yoshifumi Hamasaki, Shiho Tsuji, Kana Suzuki, Sayaka Tsuneishi, Mikie Imafuku, Yohei Komaru, Yoshihisa Miyamoto, Ryo Matsuura, Kent Doi, Masaomi Nangaku
Summary: Frailty as assessed by the clinical frailty scale (CFS) at dialysis initiation was found to be associated with lower survival rates and higher hospitalization rates within 2 years in maintenance dialysis patients. The CFS score was independently associated with the occurrence of adverse outcomes, regardless of age. This suggests that frailty assessment using CFS may predict outcomes in dialysis-initiated patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Makoto Kurano, Koh Okamoto, Daisuke Jubishi, Hideki Hashimoto, Eri Sakai, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya, Yutaka Yatomi
Summary: This study investigated the modulations of sphingolipids and glycerophospholipids in COVID-19 patients, revealing their dynamic changes depending on the time course and severity of the disease. Several species of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin may serve as better biomarkers for predicting severe COVID-19 during the early phase compared to traditional markers such as CRP and D-dimer.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Junjun Luan, Jingqi Fu, Congcong Jiao, Xiangnan Hao, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Guangyu Zhou, Hongyu Li, Wei Yang, Peter S. T. Yuen, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: This study investigated the role of interleukin-18 (IL-18) in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The results showed that IL-18 deficiency can attenuate renal tubular damage, necroptosis, cell transdifferentiation, and fibrosis, and this renoprotective effect may be mediated by reducing the switch from M1 to profibrotic M2 macrophages.
CELL DEATH & DISEASE
(2022)
Article
Urology & Nephrology
Masanori Abe, Hidetoshi Shiga, Hiroomi Tatsumi, Yoshihiro Endo, Yoshihiko Kikuchi, Yasushi Suzuki, Kent Doi, Taka-Aki Nakada, Hiroyuki Nagafuchi, Noriyuki Hattori, Nobuyuki Hirohashi, Takeshi Moriguchi, Osamu Yamaga, Osamu Nishida
Summary: This cohort study examined the current status of blood purification therapy for critically ill patients in Japan. The study found that continuous renal replacement therapy (CRRT) was the most frequently used mode of treatment, and patients with multiple organ failure (MOF) or sepsis had lower survival rates.
RENAL REPLACEMENT THERAPY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Itsuki Osawa, Ichiro Hirayama, Mineji Hayakawa, Yuichi J. Shimada, Kent Doi
Meeting Abstract
Environmental Sciences
Brian N. Chorley, Tatiana Sharapova, Takayuki Tsuji, Peter S. T. Yuen, Prathap K. Mahalingaiah, Constance A. Mitchell, Syril D. Pettit
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Critical Care Medicine
Naoko Ohashi-Fukuda, Tatsuma Fukuda, Kent Doi
Summary: This study found that delayed advanced airway management in pediatric out-of-hospital cardiac arrest patients is associated with a decreased chance of survival.
RESUSCITATION PLUS
(2022)
Meeting Abstract
Critical Care Medicine
Itsuki Osawa, Tadahiro Goto, Daisuke Kudo, Toshikazu Abe, Mineji Hayakawa, Atsushi Shiraishi, Ryo Uchimido, Kazuma Yamakawa, Kent Doi, Shigeki Kushimoto
CRITICAL CARE MEDICINE
(2022)