Article
Urology & Nephrology
Felix S. Seibert, Maximilian Sitz, Juergen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Benjamin Rohn, Nina Babel, Timm H. Westhoff
Summary: The study showed that urinary calprotectin and NGAL concentrations significantly differed between CKD patients and healthy controls, but these biomarkers did not have diagnostic value in differentiating primarily inflammatory from non-inflammatory etiologies of CKD.
Article
Medicine, General & Internal
Guadalupe Tabernero, Moises Pescador, Elena Ruiz Ferreras, Ana I. Morales, Marta Prieto
Summary: Kidney transplantation is the most effective treatment for end-stage chronic kidney disease. The study focused on early kidney damage biomarkers (NAG, NGAL, and KIM-1) to predict complications and improve graft survival rates. Urinary NAG, NGAL, and KIM-1 levels were analyzed in 70 kidney transplant patients over the first week post-transplantation. The study found correlations between these biomarkers and delayed graft function, as well as renal function stabilisation time.
Article
Medicine, General & Internal
Yuping Wang, Yang Gu, Xin Gu, Danielle B. Cooper, David F. Lewis
Summary: This study found that there is tubular injury in preeclampsia, which is indicated by increased levels of NGAL and KIM-1. The higher postpartum levels of NGAL and KIM-1 in preeclamptic pregnancies suggest that proper follow-up and management of kidney function is necessary to reduce chronic kidney diseases in these women later in life.
FRONTIERS IN MEDICINE
(2023)
Article
Pediatrics
P. Mangala C. S. De Silva, T. D. K. S. C. Gunasekara, S. D. Gunarathna, P. M. M. A. Sandamini, R. A. Pinipa, E. M. D. Ekanayake, W. A. K. G. Thakshila, S. S. Jayasinghe, E. P. S. Chandana, Nishad Jayasundara
Summary: This study aimed to determine reference intervals for KIM-1 and NGAL in a pediatric population in Sri Lanka affected by CKDu. The findings provide valuable information for screening and detecting early renal damage in rural communities impacted by CKDu.
Article
Medicine, General & Internal
Frank Bienaime, Mordi Muorah, Marie Metzger, Melanie Broeuilh, Pascal Houiller, Martin Flamant, Jean-Philippe Haymann, Jacky Vonderscher, Gerard Friedlander, Jacques Mizrahi, Benedicte Stengel, Fabiola Terzi
Summary: This study rigorously validates multiple assays for relevant urinary biomarkers of CKD progression and identifies a combination of five biomarkers that can improve the prediction of CKD progression.
Article
Cell Biology
Ana Amaya-Garrido, Manon Brunet, Benedicte Buffin-Meyer, Alexis Piedrafita, Lucile Grzesiak, Ezechiel Agbegbo, Arnaud Del Bello, Ines Ferrandiz, Serban Ardeleanu, Marcelino Bermudez-Lopez, Camille Fedou, Mylene Camus, Odile Burlet-Schiltz, Jean Massines, Marie Buleon, Guylene Feuillet, Melinda Alves, Eric Neau, Audrey Casemayou, Benjamin Breuil, Jean-Sebastien Saulnier-Blache, Colette Denis, Jakob Voelkl, Griet Glorieux, Sam Hobson, Samsul Arefin, Awahan Rahman, Karolina Kublickiene, Peter Stenvinkel, Jean-Loup Bascands, Stanislas Faguer, Jose M. Valdivielso, Joost P. Schanstra, Julie Klein
Summary: Vascular calcification is a significant risk factor for cardiovascular mortality in patients with chronic kidney disease. A study found that circulating calprotectin is independently associated with calcification, cardiovascular outcomes, and mortality in CKD patients. Inhibition of calprotectin may be a promising strategy to prevent vascular calcification in these patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Amaal E. Abdulle, Martin F. Bourgonje, Lyanne M. Kieneker, Sacha la Bastide-van Gemert, Sanne J. Gordijn, Clara Hidden, Tom Nilsen, Ron T. Gansevoort, Douwe J. Mulder, Robin P. F. Dullaart, Martin H. de Borst, Stephan J. L. Bakker, Harry van Goor
Summary: Circulating levels of NGAL are associated with acute kidney injury, severity and progression of CKD. This study investigated NGAL as a potential biomarker for new-onset CKD and found that higher plasma NGAL concentrations are associated with an increased risk of developing CKD in the general population, mainly driven by renal function decline.
Article
Cell & Tissue Engineering
Hala M. F. El Miniawy, Haithem A. Farghali, Marwa S. Khattab, Ibrahim A. Emam, Essam M. Ibrahem, Dina Sabry, Tahany A. Ismail
Summary: This study demonstrates the therapeutic potential of Camel Wharton jelly-mesenchymal stem cells (CWJ-MSCs) in chronic kidney disease (CKD) model induced in dogs. The results show that CWJ-MSCs can significantly decrease serum urea and creatinine levels, improve renal tissue pathology, and promote renal tissue repair.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Ahmet Ufuk Komuruglu, Yildiray Basbugan, Okan Arihan, Seda Karaoz Arihan
Summary: This study found that exposure to fluoride may lead to an increase in serum inflammation markers (NGAL, KIM-1) which could be influenced by dosage and exposure period differences. Further long term studies are needed to understand the impact of chronic fluoride exposure on the renal system.
Review
Endocrinology & Metabolism
Jiayi Yan, Jue Wang, John Cijiang He, Yifei Zhong
Summary: The incidence and prevalence of chronic kidney disease (CKD) are increasing worldwide and pose a significant public health burden. SIRT1, a NAD+-dependent deacetylase, has protective effects on the kidney by regulating fibrosis, apoptosis, senescence, oxidative stress, inflammation, and aging. This narrative review provides an overview of the recent progress on the role of SIRT1 and its downstream pathways in CKD and discusses potential therapeutic approaches by activating the SIRT1-related pathway in CKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Romejko, Magdalena Markowska, Stanislaw Niemczyk
Summary: Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa protein secreted by immune cells in response to inflammation. It serves as a biomarker for acute kidney injury and is also elevated in chronic kidney disease and cardiovascular diseases. NGAL is involved in the progression of renal function decrease and is associated with complications and mortality due to kidney failure. It is also useful in the diagnostic processes of cardiovascular diseases and plays a role in inflammatory states, hypertension, obesity, diabetes, and carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Merve Vural Yalman, Yusuf Madendag, Erdem Sahin, Ilknur Col Madendag, Mefkure Eraslan Sahin, Gokhan Acmaz, Fatma Ozdemir, Sabahattin Muhtaroglu, Iptisam Ipek Muderris
Summary: The study revealed that as the severity of preeclampsia increases, kidney damage assessed using NGAL levels continues for a long period of time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Urology & Nephrology
Ian E. McCoy, Jesse Y. Hsu, Joseph Bonventre, Chirag R. Parikh, Alan S. Go, Kathleen D. Liu, Ana C. Ricardo, Anand Srivastava, Debbie L. Cohen, Jiang He, Jing Chen, Panduranga S. Rao, Chi-Yuan Hsu
Summary: Hospitalized acute kidney injury (AKI) is associated with long-term changes in kidney injury markers TNFR1, TNFR2, and KIM-1.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
Francisca Ugarte, Daniela Santapau, Vivian Gallardo, Carolina Garfias, Anahi Yizmeyian, Soledad Villanueva, Carolina Sepulveda, Jocelyn Rocco, Consuelo Pasten, Cinthya Urquidi, Gabriel Cavada, Pamela San Martin, Francisco Cano, Carlos E. Irarrazabal
Summary: This study evaluated early tubulointerstitial damage biomarkers in pediatric patients with T1DM and their correlation with classical DKD parameters. The findings suggest that urinary exosome-like extracellular vesicles can serve as a new source for early detection of tubular injury biomarkers of DKD in T1DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Sukhanshi Khandpur, Medha Srivastava, Rajni Sharma, Shafaque Asif, Dharmendra S. Bhadauria, Prabhaker Mishra, Anil J. Purty, Swasti Tiwari
Summary: This study found that Wilms tumor-1 (WT1) protein in urine could serve as an early indication of kidney injury in individuals without chronic kidney disease (CKD). Compared to other markers of glomerular and kidney tubule injury, WT1 protein in urine was better able to explain the variability of urine albumin-to-creatinine ratio (ACR).
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Lisa Pilgram, Lukas Eberwein, Bjoern-Erik O. Jensen, Carolin E. M. Jakob, Felix C. Koehler, Martin Hower, Jan T. Kielstein, Melanie Stecher, Bernd Hohenstein, Fabian Prasser, Timm Westhoff, Susana M. Nunes de Miranda, Maria J. G. T. Vehreschild, Julia Lanznaster, Sebastian Dolff
Summary: This multicentre cohort study aimed to evaluate the situation of CKD5D patients during the COVID-19 pandemic and investigate the association between dialysis dependency and mortality. The results showed that dialysis dependency was not related to mortality, but the mortality rate of CKD patients was high.
Letter
Urology & Nephrology
Moritz Anft, Krystallenia Paniskaki, Tina Giglio, Jacqueline Wellenkoetter, Arturo Blazquez-Navarro, Toni L. Meister, Toral Roch, Claudia Giesecke-Thiel, Timm H. Westhoff, Ulrik Stervbo, Stephanie Pfaender, Okan Cinkilic, Nina Babel
KIDNEY INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
Maximilian Hogeweg, Adrian Doevelaar, Sonja Rieckmann, Felix Seibert, David Scholten, Monika Segelmacher, Ulrik Stervbo, Nina Babel, Timm H. Westhoff
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Immunology
Carla Ferrandiz-Pulido, Ulrike Leiter, Catherine Harwood, Charlotte M. Proby, Martina Guthoff, Christina H. Scheel, Timm H. Westhoff, Jan Nico Bouwes Bavinck, Thomas Meyer, Mirjam C. Naegeli, Veronique del Marmol, Celeste Lebbe, Alexandra Geusau
Summary: The use of ICIs in solid organ transplant recipients with advanced skin cancers is a clinical challenge. While kidney transplant recipients can benefit from ICIs as a first-line treatment, for other transplant recipients the use of ICIs should be carefully considered on a case-by-case basis, weighing the benefits against the risk of allograft rejection.
Letter
Immunology
Toralf Roch, Patrizia Wehler, Arturo Blazquez-Navarro, Friederike Bachmann, Isabel E. Neumann, Sviatlana Kaliszczyk, Constantin J. Thieme, Moritz Anft, Ulrik Stervbo, Timm H. Westhoff, Nina Babel, Mira Choi
Article
Cardiac & Cardiovascular Systems
Nikolaos Pagonas, Felix S. Seibert, Gerhard Liebisch, Maximillian Seidel, Theodoros Giannakopoulos, Benjamin Sasko, Oliver Ritter, Nina Babel, Timm H. Westhoff
Summary: This study found an association between low levels of propionate, a short-chain fatty acid, and coronary artery disease (CAD).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Urology & Nephrology
Moritz Anft, Sarah Skrzypczyk, Michael Frahnert, Lutz Fricke, Jan Zapka, Daniel Kuehn, Bjoern Koos, Michael Adamzik, Stephanie Pfaender, Ulrik Stervbo, Timm H. Westhoff, Nina Babel
KIDNEY INTERNATIONAL REPORTS
(2023)
Letter
Urology & Nephrology
Moritz Anft, Sarah Skrzypczyk, Michael Frahnert, Lutz Fricke, Jan Zapka, Daniel Kuehn, Bjoern Koos, Michael Adamzik, Stephanie Pfaender, Ulrik Stervbo, Timm H. Westhoff, Nina Babel
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Infectious Diseases
Uwe Koppe, Julia Schilling, Melanie Stecher, Maria Madeleine Ruethrich, Adine Marquis, Michaela Diercke, Martina Haselberger, Carolin E. M. Koll, Michaela Niebank, Bettina Ruehe, Stefan Borgmann, Linus Grabenhenrich, Kerstin Hellwig, Lisa Pilgram, Christoph Spinner, Thomas Paerisch
Summary: This study investigated factors associated with severe COVID-19 and compared the representativeness of the dataset to the general population. The results showed that patients above 76 years old were less likely represented in the LEOSS dataset, and they also had lower mortality. Factors associated with severe COVID-19 in LEOSS included increasing age, male sex, prior stem cell transplantation, and an elevated C-reactive protein at the time of diagnosis.
BMC INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Veit Busch, Joachim Streis, Sandra Muller, Niklas Mueller, Felix S. Seibert, Thomas Felderhoff, Timm H. Westhoff
Summary: Convenient oscillometric devices can be used to detect blood flow below 500 ml/min in a real-life clinical setting. Among the parameters measured by these devices, the relative volumetric change (AMP) showed the highest diagnostic accuracy.
Article
Microbiology
Krystallenia Paniskaki, Margarethe J. Konik, Moritz Anft, Harald Heidecke, Toni L. Meister, Stephanie Pfaender, Adalbert Krawczyk, Markus Zettler, Jasmin Jaeger, Anja Gaeckler, Sebastian Dolff, Timm H. Westhoff, Hana Rohn, Ulrik Stervbo, Carmen Scheibenbogen, Oliver Witzke, Nina Babel
Summary: Although the role of adaptive SARS-CoV-2 specific immunity in post-acute sequelae of COVID-19 (PASC) is not well explored, this study found that PASC patients have a stronger CD8+ T cell response and comparable neutralizing capacity compared to controls. The persistent inflammatory response triggered by low avidity SARS-CoV-2 reactive CD8+ T cells may be responsible for the observed sequelae in PASC patients. Further studies are needed for a better understanding of the underlying immunopathogenesis.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Ulrik Stervbo, Marc Van Bracht, Stathis Philippou, Nina Babel, Timm H. Westhoff
Summary: This study utilized adaptive immune receptor repertoire sequencing (AIRR-Seq) to assess the specificity of tissue infiltrating immune cells in myocarditis induced by vaccination of SARS-CoV-2 with BNT162b2 or mRNA-1273. It was found that both vaccines had a low incidence of myocarditis.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Adrian A. N. Doevelaar, Martin Bachmann, Bodo Hoelzer, Felix S. Seibert, Benjamin J. Rohn, Panagiota Zgoura, Oliver Witzke, Ulf Dittmer, Thorsten Brenner, Krystallenia Paniskaki, Serap Yilmaz, Rita Dittmer, Sonja Schneppenheim, Jochen Wilhelm, Ulrik Stervbo, Nina Babel, Ulrich Budde, Timm H. Westhoff
Summary: Recent research has shown that von Willebrand factor (VWF) multimers play a role in immunothrombosis in Coronavirus disease 2019 (COVID-19). This study investigates whether the generation of autoantibodies to ADAMTS13 contributes to this finding. The study collected blood samples and clinical data from patients hospitalized for COVID-19. The results showed that ADAMTS13 antibodies occurred more frequently in severely ill COVID-19 patients and were associated with lower ADAMTS13 activity and increased risk of adverse disease progression.
SCIENTIFIC REPORTS
(2023)
Letter
Urology & Nephrology
Arturo Blazquez-Navarro, Lisa Mittmann, Constantin Joachim Thieme, Moritz Anft, Krystallenia Paniskaki, Adrian Doevelaar, Felix Sebastian Seibert, Bodo Hoelzer, Margarete Justine Konik, Marc Moritz Berger, Thorsten Brenner, Clemens Tempfer, Carsten Watzl, Toni Luise Meister, Stephanie Pfaender, Eike Steinmann, Sebastian Dolff, Ulf Dittmer, Oliver Witzke, Ulrik Stervbo, Toralf Roch, Michal Or-Guil, Timm Henning Westhoff, Nina Babel
JOURNAL OF NEPHROLOGY
(2023)