Review
Medicine, General & Internal
Raisa Thielemans, Reinhart Speeckaert, Charlotte Delrue, Sander De Bruyne, Matthijs Oyaert, Marijn M. Speeckaert
Summary: Uromodulin, also known as Tamm-Horsfall protein, is the predominant urinary protein in healthy individuals. It has been found to be associated with various parameters such as kidney function, graft survival, cardiovascular disease, glucose metabolism, and overall mortality. Reduced levels of urinary uromodulin have been linked to an increased risk of acute kidney injury (AKI) and decreased levels of urinary uromodulin are strongly correlated with variations in estimated glomerular filtration rate in chronic kidney disease (CKD). Serum levels of uromodulin, due to leakage in the thick ascending limb, are closely associated with kidney function and disease severity. The UMOD gene has been identified as being linked to kidney function parameters, CKD risk, hypertension, and kidney stones. Uromodulin holds great promise as a biomarker for understanding kidney function and disease progression.
Article
Physiology
Kaice A. LaFavers, Chadi A. Hage, Varun Gaur, Radmila Micanovic, Takashi Hato, Shehnaz Khan, Seth Winfree, Simit Doshi, Ranjani N. Moorthi, Homer Twigg, Xue-Ru Wu, Pierre C. Dagher, Edward F. Srour, Tarek M. El-Achkar
Summary: The kidney modulates the immune response in sepsis by enhancing mononuclear phagocyte function through the release of Tamm-Horsfall protein, suggesting potential therapeutic applications in sepsis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Stephan Kemmner, Christopher Holzmann-Littig, Helene Sandberger, Quirin Bachmann, Flora Haberfellner, Carlos Torrez, Christoph Schmaderer, Uwe Heemann, Lutz Renders, Volker Assfalg, Tarek M. El-Achkar, Pranav S. Garimella, Juergen Scherberich, Dominik Steubl
Summary: Higher pretransplant serum uromodulin (sUMOD) levels were independently associated with lower odds of delayed graft function (DGF) following kidney transplantation, potentially serving as a non-invasive marker for stratifying patients based on their risk for developing DGF early on.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Christine Y. Bakhoum, Matthew B. Matheson, Jason H. Greenberg, Susan L. Furth, Joachim H. Ix, Pranav S. Garimella
Summary: The study found no association between urine uromodulin levels and blood pressure in children with chronic kidney disease. Further research is needed to confirm this finding in healthy pediatric cohorts.
Article
Medical Laboratory Technology
Dietmar Enko, Andreas Meinitzer, Jurgen E. Scherberich, Winfried Maerz, Markus Herrmann, Katharina Artinger, Alexander R. Rosenkranz, Sabine Zitta
Summary: The study found that there is no correlation between serum uromodulin concentrations and GFR in healthy individuals, in contrast to CKD patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Urology & Nephrology
Belen Ponte, Marie C. Sadler, Eric Olinger, Peter Vollenweider, Murielle Bochud, Sandosh Padmanabhan, Caroline Hayward, Zoltan Kutalik, Olivier Devuyst
Summary: UMOD variants associated with higher levels of urinary uromodulin increase the risk of chronic kidney disease (CKD) and hypertension. Mendelian randomization studies showed that higher uUMOD levels have a direct adverse effect on kidney function outcome, not mediated by blood pressure.
KIDNEY INTERNATIONAL
(2021)
Article
Urology & Nephrology
Christina B. Joseph, Marta Mariniello, Ayumi Yoshifuji, Guglielmo Schiano, Jennifer Lake, Jonathan Marten, Anne Richmond, Jennifer E. Huffman, Archie Campbell, Sarah E. Harris, Stephan Troyanov, Massimiliano Cocca, Antonietta Robino, Sebastien Theriault, Kai-Uwe Eckardt, Matthias Wuttke, Yurong Cheng, Tanguy Corre, Ivana Kolcic, Corrinda Black, Vanessa Bruat, Maria Pina Concas, Cinzia Sala, Stefanie Aeschbacher, Franz Schaefer, Sven Bergmann, Harry Campbell, Matthias Olden, Ozren Polasek, David J. Porteous, Ian J. Deary, Francois Madore, Philip Awadalla, Giorgia Girotto, Sheila Ulivi, David Conen, Elke Wuehl, Eric Olinger, James F. Wilson, Murielle Bochud, Anna Koettgen, Caroline Hayward, Olivier Devuyst
Summary: This study identifies novel gene loci, KRT40 and WDR72, associated with urinary uromodulin. Functional studies show that KRT40 affects the processing and excretion of uromodulin in kidney cells. This research provides new insights into the biology of uromodulin, keratins, and the UMOD-PDILT locus's influence on kidney function.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Kaice LaFavers, Pranav S. Garimella
Summary: Although initially thought to be limited to the kidney and genitourinary tract, recent studies have shown that uromodulin plays a broader role in human health. It has the potential to prevent infection, promote kidney repair, reduce calcification risk, and may be a therapeutic target.
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
(2023)
Article
Pediatrics
Sophia C. Faulkner, Matthew B. Matheson, Jason H. Greenberg, Pranav S. Garimella, Susan L. Furth, Joachim H. Ix, Christine Y. Bakhoum
Summary: In this study, the relationship between age and kidney function with urine uromodulin levels in children with chronic kidney disease (CKD) was examined. It was found that older age was associated with lower Umod/Cr levels, independent of eGFR. More research is needed to fully understand the age-specific reference ranges and longitudinal relationship between uromodulin, age, and eGFR in children with CKD.
PEDIATRIC NEPHROLOGY
(2023)
Review
Physiology
Celine Schaeffer, Olivier Devuyst, Luca Rampoldi
Summary: Uromodulin, a kidney-specific protein, plays crucial roles in kidney physiology and overall health, with its genetic mutations causing renal disease and common polymorphisms associated with various disorders such as chronic kidney disease, hypertension, and cardiovascular diseases. Variations in uromodulin levels in urine and blood can serve as prognostic markers for kidney function, cardiovascular events, and mortality.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.
Article
Cardiac & Cardiovascular Systems
Faiez Zannad, Joao Pedro Ferreira, Stuart J. Pocock, Cordula Zeller, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Sibylle Jenny Hauske, Martina Brueckmann, Egon Pfarr, Janet Schnee, Christoph Wanner, Milton Packer
Summary: In the EMPEROR-Reduced trial, empagliflozin treatment had beneficial effects on key efficacy outcomes and slowed the rate of kidney function decline in patients with and without chronic kidney disease, regardless of the severity of kidney impairment at baseline.
Article
Medicine, General & Internal
Babak Yazdani, Graciela E. Delgado, Hubert Scharnagl, Bernhard K. Kraemer, Heinz Drexel, Winfried Maerz, Juergen E. Scherberich, Andreas Leiherer, Marcus E. Kleber
Summary: Serum uromodulin is directly correlated with eGFR in patients with kidney function impairment and inversely associated with mortality. Discordance between the two markers can impact mortality risk, highlighting the importance of assessing both for more precise risk modeling.
FRONTIERS IN MEDICINE
(2021)
