期刊
KIDNEY & BLOOD PRESSURE RESEARCH
卷 31, 期 5, 页码 322-329出版社
KARGER
DOI: 10.1159/000157177
关键词
Vitamin D deficiency; Cholecalciferol; Calcidiol; Calcitriol; Parathyroid hormone; Chronic kidney disease
Background: Data on the efficacy and safety of long-term vitamin D supplementation in chronic kidney disease (CKD) are scarce. We assessed the effects of the 12-month vitamin D 3 treatment on mineral metabolism and calciotropic hormones in patients with CKD stages 2-4. Methods: Eighty-seven patients (mean age 66 years, men/women 33/54) were randomized to cholecalciferol treatment with either 5,000 or 20,000 IU/week. Serum calcium, phosphate, 25(OH)D-3, 1,25(OH)(2)D-3, PTH and urinary mineral concentrations were obtained at baseline and after 4, 8 and 12 months. Results: The median serum mineral concentrations were normal and not changed throughout the study. The number of hypercalciuric patients slightly increased with higher dose, but no sustained rise in calciuria was present. Vitamin D insufficiency/deficiency was revealed in 72 (83%) patients at baseline and 37 (43%) at month 12. The 25(OH)D-3 levels increased more with higher dose; a rise in 1,25(OH)(2)D-3 was less impressive. The parathyroid hormone ( PTH) concentrations were reduced, but the number of subjects with PTH below the lower limit for CKD stage 3 increased equally with both doses. Conclusions: Vitamin D insufficiency/deficiency in CKD significantly improved after the 12-month cholecalciferol treatment, with higher dose being more effective and equally safe. Further studies of vitamin D 3 effects on bone metabolism are warranted. Copyright (C) 2008 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据