4.5 Article

Coordinated Analysis of Age, Sex, and Education Effects on Change in MMSE Scores

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/geronb/gbs077

关键词

Cognitive; Coordinated Analysis; Education; Longitudinal; Mental Status Exam; Meta-analysis; Mixed Model

资金

  1. National Institute on Aging at the National Institutes of Health [AG026453, AG08861]
  2. National Institute on Aging [AG04563, AG10175]
  3. MacArthur Foundation Research Network on Successful Aging
  4. Swedish Council for Social Research [97:0147:1B]
  5. Swedish Research Council [2007-2722]
  6. Australian National Health and Medical Research Council
  7. Swedish Council for Working Life and Social Research
  8. Adlerbertska Foundation
  9. Hjalmar Svensson Foundation
  10. Knut and Alice Wallenberg Foundation
  11. Wenner-Gren Foundations
  12. Wilhelm and Martina Lundgrens Foundation
  13. Swedish Research Council
  14. Swedish Brain Power
  15. Epilife
  16. Canadian Institutes for Health Research [CUK-103284]
  17. U.S. Department of Veterans Affairs
  18. MRC [MC_U123092720, G0700704] Funding Source: UKRI
  19. Medical Research Council [MC_U123092720, MR/K026992/1, G0700704] Funding Source: researchfish

向作者/读者索取更多资源

We describe and compare the expected performance trajectories of older adults on the Mini-Mental Status Examination (MMSE) across six independent studies from four countries in the context of a collaborative network of longitudinal studies of aging. A coordinated analysis approach is used to compare patterns of change conditional on sample composition differences related to age, sex, and education. Such coordination accelerates evaluation of particular hypotheses. In particular, we focus on the effect of educational attainment on cognitive decline. Regular and Tobit mixed models were fit to MMSE scores from each study separately. The effects of age, sex, and education were examined based on more than one centering point. Findings were relatively consistent across studies. On average, MMSE scores were lower for older individuals and declined over time. Education predicted MMSE score, but, with two exceptions, was not associated with decline in MMSE over time. A straightforward association between educational attainment and rate of cognitive decline was not supported. Thoughtful consideration is needed when synthesizing evidence across studies, as methodologies adopted and sample characteristics, such as educational attainment, invariably differ.

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