Article
Biochemistry & Molecular Biology
Dominic Robles, De-Huang Guo, Noah Watson, Diana Asante, Sangeetha Sukumari-Ramesh
Summary: Stroke is a common disease that often leads to brain injury and mortality, with intracerebral hemorrhage (ICH) being the most severe subtype. However, the effect of aging on ICH pathophysiology is not well studied, and there is no effective treatment for ICH. Recent studies have shown that circulating microRNAs can be potential diagnostic and prognostic biomarkers in various conditions, but their functions in ICH are not well understood. This study aims to identify potential blood biomarkers for acute ICH in the elderly by analyzing dysregulated microRNAs in aged mice.
Article
Geriatrics & Gerontology
Ying Zhao, Xiangli Bai, Xiong Jia, Yajing Lu, Wenzhuo Cheng, Meng Shu, Yan Zhu, Lin Zhu, Li Wang, Yan Shu, Yi Song, Si Jin
Summary: Aging is a natural process accompanied by diseases. By investigating the levels of Sirt6 and telomerase in serum, a negative correlation with age was found, suggesting that serum Sirt6 level may serve as a potential sex-specific aging marker.
Article
Biotechnology & Applied Microbiology
Lin Li, Andre Gorgens, Veronika Mussack, Elena Pepeldjiyska, Anne Sophie Hartz, Andreas Rank, Jorg Schmohl, Doris Kra''mer, Samir El Andaloussi, Michael W. Pfaffl, Helga Schmetzer
Summary: Extracellular Vesicles (EVs) play a crucial role in hematological malignancies, affecting bone marrow environment, immune system, drug resistance, and therapies. EVs collected from serum of leukemia samples have potential as biomarkers for disease pattern distinctions. This study aims to investigate the potential role and methodology of serum-derived EVs as biomarkers in leukemic versus healthy samples.
CANCER GENE THERAPY
(2022)
Article
Immunology
Sonya Krishnan, Artur T. L. Queiroz, Amita Gupta, Nikhil Gupte, Gregory P. Bisson, Johnstone Kumwenda, Kogieleum Naidoo, Lerato Mohapi, Vidya Mave, Rosie Mngqibisa, Javier R. Lama, Mina C. Hosseinipour, Bruno B. Andrade, Petros C. Karakousis
Summary: Novel high-throughput approaches may improve the recognition of tuberculosis in HIV-infected individuals, especially in those with severely suppressed immune systems.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Jose D. Debes, Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Late diagnosis and limited treatment options contribute to the low survival rate of patients with HCC. Currently, combining ultrasound with the biomarker AFP is a commonly used screening method, but its clinical utility and operator-dependence are controversial.
Article
Medicine, General & Internal
Andrew D. Nguyen, Theodore K. Malmstrom, Geetika Aggarwal, Douglas K. Miller, Bruno Vellas, John E. Morley
Summary: This study found a positive association between serum NfL levels and mortality in late middle-aged and older individuals, with higher serum NfL levels associated with reduced survival. The results suggest that serum NfL levels may be a useful biomarker for all-cause mortality, but further studies are needed to understand the biological mechanisms underlying this association.
Article
Biotechnology & Applied Microbiology
Hongdong Li, Liyuan Ma, Fengyuan Luo, Wenkai Liu, Na Li, Tao Hu, Haijian Zhong, You Guo, Guini Hong
Summary: This study utilized a large miRNA-profiled serum samples repository to identify two miRNA pairs that can accurately diagnose glioma and differentiate it from other brain diseases. These findings provide potential population screening and cancer-specific biomarkers for glioma clinical practice.
Article
Biochemistry & Molecular Biology
Jaehoon Lee, Hee Seung Lee, Soo Been Park, Chanyang Kim, Kahee Kim, Dawoon E. Jung, Si Young Song
Summary: The study aimed to identify non-invasive miRNA markers for early pancreatic cancer diagnosis. A total of 39 miRNA markers were selected from blood serum samples to build a PC diagnosis model, which showed excellent performance in independent sample validation and differential expression in samples from PC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maia Segura-Wang, Bertrand Grenier, Suzana Ilic, Ursula Ruczizka, Maximiliane Dippel, Moritz Buenger, Matthias Hackl, Veronika Nagl
Summary: This study investigated the changes in miRNA expression induced by DON in porcine liver, jejunum, and serum. The serum miRNA response to DON increased over time and declined after removal of contaminated diets. Receiver operating curve analyses for individual miRNAs were significant, and a combination of four miRNAs increased the predictive capacity for DON exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Nikoleta M. Kouri, Maria Stangou, George Lioulios, Zoi Mitsoglou, Grazia Serino, Samantha Chiurlia, Sharon Natasha Cox, Persia Stropou, Francesco P. Schena, Aikaterini Papagianni
Summary: Serum levels of let-7b and miR-148b may serve as predictors for long-term renal function outcomes, particularly in patients treated with corticosteroids.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Liu Chen Geng, Meng Shuang, Li Ying, Lu Yao, Zhao Yue, Wang Pei Chang
Summary: This study explores the diagnostic value of ABCA1-labeled exosomal miR-135a for Alzheimer's disease, especially in early stages. Results indicate that the levels of ABCA1 exosomes from HT-22 cells and neuron culture medium were significantly higher compared to RBCs and WBCs, showing promise for early AD diagnosis.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bo Yu, Mengran Xiao, Fuhua Yang, Jing Xiao, Hui Zhang, Lin Su, Xiaomin Zhang, Xiaorong Li
Summary: Early diagnosis and precise monitoring of PDR are crucial for improving therapeutic strategies and reducing blindness. EVs, especially sEVs, are potential sources for novel biomarkers, with miR-431-5p showing promise as a biomarker for PDR.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Clinical Neurology
Matthew Shew, Helena Wichova, Madeleine St Peter, Athanasia Warnecke, Hinrich Staecker
Summary: Meniere's disease patients exhibit unique miRNA expression profiles in both perilymph and serum, with miRNA-1299 being validated as downregulated in both serum and perilymph of Meniere's patients.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Tim Nestler, Justine Schoch, Gazanfer Belge, Klaus-Peter Dieckmann
Summary: miR371 is a more sensitive and specific biomarker for testicular germ cell cancer than conventional serum markers. It shows potential for initial diagnosis, treatment monitoring, and follow-up. However, miR371 is not expressed in teratoma. Further studies are needed to determine its importance in detecting testicular tumor recurrences and residual tumors after chemotherapy.
Article
Genetics & Heredity
Rongkang Li, Chong Lu, Xinji Li, Xuan Chen, Guocheng Huang, Zhenyu Wen, Hang Li, Lingzhi Tao, Yimin Hu, Zhengping Zhao, Zebo Chen, Yongqing Lai
Summary: In this study, six miRNAs were found to be significantly dysregulated in the serum of RCC patients compared to normal controls, and a four-miRNA panel was established to enhance diagnostic value.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Qun Chen, Fan Zhang, Lei Dong, Huimin Wu, Jie Xu, Hanqin Li, Jin Wang, Zhen Zhou, Chunyan Liu, Yanbo Wang, Yuyan Liu, Liangsheng Lu, Chen Wang, Minghui Liu, Xi Chen, Cheng Wang, Chunni Zhang, Dangsheng Li, Ke Zen, Fangyu Wang, Qipeng Zhang, Chen-Yu Zhang
Summary: The study reveals that SIDT1 expressed on gastric pit cells is necessary for the absorption of dietary microRNAs, and deficiency in SIDT1 leads to reduced absorption. The stomach is identified as the primary site for dietary microRNA absorption, and the process relies on SIDT1 and low pH. Oral administration of plant-derived miR2911 can delay liver fibrosis, but this effect is nullified in SIDT1-deficient mice.
Article
Oncology
Yujie Zhong, Xiaoyu Ding, Yuying Bian, Jing Wang, Wanqing Zhou, Xiangdong Wang, Pumin Li, Yi Shen, Jun-Jun Wang, Jing Li, Chunni Zhang, Cheng Wang
Summary: miR-520c-3p and miR-1274b were found to be significantly increased in NSCLC patients and decreased after tumor resection, showing potential as biomarkers for early diagnosis of NSCLC with high AUCs in ROC curve analysis. Logistic regression analysis confirmed the two-miRNA panel as an independent risk factor for NSCLC.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Zhiying Gao, Likun Zhou, Jing Bai, Meng Ding, Deshui Liu, Shaohai Zheng, Yuewen Li, Xiulan Li, Xiaojuan Wang, Ming Jin, Huizi Shangting, Changchun Qiu, Cheng Wang, Xiaojie Zhang, Chenyu Zhang, Xi Chen
Summary: This study identified three HCMV-encoded miRNAs that were significantly increased in the plasma of pregnant women with APOs, with hcmv-miR-US25-1-5p showing the highest sensitivity and specificity. These miRNAs could serve as potential noninvasive biomarkers for predicting and monitoring APOs during HCMV infection.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Pediatrics
Cheng Tan, Xiuying Yi, Ying Chen, Shuangshuang Wang, Qing Ji, Fang Li, Yuwen Wang, Runmei Zou, Cheng Wang
Summary: The study aims to explore the ECG changes of children with dilated cardiomyopathy (DCM) when their posture changes, and found that differences in T-wave amplitude and QT interval may have value in diagnosing and predicting the prognosis of DCM. Changes in these parameters before and after treatment could also potentially predict disease response and therapeutic efficacy.
FRONTIERS IN PEDIATRICS
(2021)
Article
Orthopedics
Yu Kang, Chao Liu, Ming Wang, Cheng Wang, Yi-Guo Yan, Wen-Jun Wang
Summary: In this study, a novel rat model of interbody fusion was developed based on anterior lumbar corpectomy and fusion, which more closely resembles clinical surgery. The surgeries were successfully completed with 3D-printed titanium cages, and Micro-CT results showed higher fusion rates, BV/TV, and Tb.N in group B compared to group A.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Physiology
Dandan Li, Pingping Wang, Wenyan Wei, Cheng Wang, Yong Zhong, Lei Lv, Junjun Wang
Summary: The dynamic changes of circulating miRNAs during a 5-km run test at 51-52% maximum oxygen uptake contribute to the adaptive regulation of cardiovascular function. Some specific miRNAs showed significant increases post-exercise and correlated with traditional cardiovascular-related indicators, highlighting their potential role in cardiovascular adaptation during exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ping Liu, Jin Huang, Wanzhen Mei, Xingfang Zeng, Cheng Wang, Chuan Wen, Jing Xu
Summary: The study investigated the protective effect of EGCG on H/R-stimulated cardiomyocytes, showing that EGCG can alleviate cell damage by increasing ATG4C expression. Moreover, overexpression of ATG4C can further enhance the protective effect of EGCG and reduce cell autophagy induced by H/R stimulation.
Article
Immunology
Chao Xia, Wei Huang, Yun-Liang Chen, Hai-Bin Fu, Ming Tang, Tao-Lan Zhang, Jing Li, Guo-Hua Lv, Yi-Guo Yan, Zhi-Hua Ouyang, Nvzhao Yao, Cheng Wang, Ming-Xiang Zou
Summary: This study investigated the expression of PD-L1, HHLA2, B7H3, IDO-1, and Galectin-9 in spinal chordoma and their association with tumor infiltrating lymphocytes, clinicopathological characteristics, and patient survival. The results showed that HHLA2 and PD-L1 were commonly expressed in spinal chordoma and their coexpression independently predicted worse local recurrence-free survival and overall survival. In contrast, stromal levels of PD-L1 and Galectin-9 were associated with better prognosis. This study provides insights into the immunosuppressive mechanism in chordoma and may contribute to the development of improved immunotherapy approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xuemei Luo, Jie Xiong, Hong Cai, Runmei Zou, Fang Li, Yuwen Wang, Cheng Wang
Summary: This study evaluated the mechanism of VD deficiency on the function of cardiac autonomic nervous system (ANS) in rats. The results showed that VD deficiency leads to imbalance in heart rate variability, impaired release and secretion of neurotransmitters and local plasma hormones in the heart, and downregulation of potassium channel protein expression.
CARDIOVASCULAR THERAPEUTICS
(2022)
Article
Clinical Neurology
Ze-Peng Li, Lu-Lu Liu, Hao Liu, Jing-Hua Tan, Xue-Lin Li, Zhun Xu, Zhi-Hua Ouyang, Cheng Wang, Yi-Guo Yan, Jing-Bo Xue
Summary: This study aimed to analyze the factors influencing early recurrence after transforaminal endoscopy lumbar discectomy (TELD) in the treatment of lumbar disc herniation. The study found that postoperative annulus-fibrosus tear size, disc height index (DHI), and location of the herniation were associated with early recurrence. Increased base width of the herniation, severe disc degeneration, decreased cross-sectional area of the foramen (CSAF), and Modic change were identified as risk factors for early recurrence after TELD.
GLOBAL SPINE JOURNAL
(2022)
Article
Engineering, Biomedical
Yijia Liao, Yiguo Yan, Yu Kang, Wenjun Wang, Xizheng Song, Wen Peng, Haibin Fu, Huarong Chen, Cheng Wang
Summary: This study compared the biomechanical characteristics of external spinal fixation and internal fixation system for treating lumbar fracture through finite element analysis. The results showed that the external fixation system had a better stress distribution and overall mobility compared to the internal fixation system.
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
(2022)
Review
Cardiac & Cardiovascular Systems
Ting Zhao, Shuo Wang, Miao Wang, Hong Cai, Yuwen Wang, Yi Xu, Runmei Zou, Cheng Wang
Summary: This article reviews the value of electrocardiographic indicators in the diagnosis and prognosis of children with vasovagal syncope (VVS).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Cheng Wang, Cuiping Zhang, Quan Fu, Nan Zhang, Meng Ding, Zhen Zhou, Xi Chen, Fengmin Zhang, Chunni Zhang, Chen-Yu Zhang, Jun-Jun Wang
Summary: This study identified three piRNAs with significantly increased levels in the serum of patients with brucellosis. The combination of these three piRNAs could serve as a novel blood-based auxiliary tool for detecting brucellosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Clinical Neurology
Jiahuan Wu, Ying Meng, Fei Xu, Qian Wu, Cheng Wang
Summary: This study investigated the genome-wide biological significance of circulating miRNA markers in adult epileptic seizures patients. The results identified potential biomarkers for adult epilepsy and revealed their functions in cell regulating pathways.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Cheng Wang, Yunhua Zhu, Penglu Chen, Chen Wang, Wanqing Zhou, Cuiping Zhang, Jing Wang, Xi Chen, Meng Ding, Chunni Zhang, Jun-Jun Wang, Chen-Yu Zhang
Summary: The majority of HCMV miRNAs were significantly upregulated in the serum of fever patients, suggesting their potential role in monitoring HCMV activation status in patients with immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)