Article
Cell & Tissue Engineering
Yusheng Cai, Si Wang, Jing Qu, Juan Carlos Izpisua Belmonte, Guang-Hui Liu
Summary: Stem cell therapies offer promising approaches for treating various diseases by addressing stem cell exhaustion and dysfunction. Recent advances in understanding the mechanisms of stem cell regeneration and rejuvenation strategies utilizing intrinsic and extrinsic factors may pave the way for interventions to delay aging and treat age-associated diseases.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Review
Physiology
Fengjiao Huo, Qing Liu, Hailiang Liu
Summary: This review focuses on the etiology, assessment, and treatment of sarcopenia, as well as the functional and regulatory mechanisms of muscle satellite cells. Patients with sarcopenia often exhibit dysregulation of muscle satellite cell homeostasis, highlighting the importance of improving muscle satellite cell function in the treatment of sarcopenia.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaofeng Wang, Fanyuan Yu, Ling Ye
Summary: Recent studies have shown that MSCs play a vital role in bone regeneration, including osteogenic differentiation and providing seed cells. However, factors like drug intake and body senescence can affect MSCs' functions in bone regeneration. Epigenetic regulation has received attention for its heritable nature and involvement in bone metabolism disorders. This review focuses on the effects of epigenetic regulation on osteogenic differentiation, proliferation, and cellular senescence in MSCs and its role in bone regeneration.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell & Tissue Engineering
Novella Guidi, Gina Marka, Vadim Sakk, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Summary: The study found that an aged niche restrains the function of ex vivo rejuvenated old HSCs, with a low level of the cytokine osteopontin being a contributing factor. Sustainable rejuvenation of the function of aged HSCs in vivo will need to address the influence of an aged niche on rejuvenated HSCs.
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Geriatrics & Gerontology
Lucas Paulo de Lima Camillo, Robert B. A. Quinlan
Summary: This review explores the interplay between epigenetics and aging, with a focus on the potential of epigenetic reprogramming for age reversal. While in vivo partial reprogramming holds promise as a therapy, there are several limitations that need to be addressed. Reprogramming for rejuvenation is a young but rapidly expanding subfield in the biology of aging.
Review
Biochemistry & Molecular Biology
Emilia Manole, Cristina Niculite, Ioana Maria Lambrescu, Gisela Gaina, Octavian Ioghen, Laura Cristina Ceafalan, Mihail Eugen Hinescu
Summary: Macrophages play a crucial role in maintaining tissue homeostasis and repair, displaying heterogeneity in response to environmental cues. Their diverse functions as M1 and M2 phenotypes contribute to tissue damage and wound healing, emphasizing the importance of understanding their intervention in stem cell behavior and niche regulation for developing novel therapeutic strategies in different diseases.
Review
Cell Biology
Wasco Wruck, Nina Graffmann, Lucas-Sebastian Spitzhorn, James Adjaye
Summary: Heterogeneity exists in human mesenchymal stem cells (MSCs) due to distinct tissue origins, genetic backgrounds, and age differences. Transcriptome data from various tissues reveal markers characterizing this heterogeneity. Environmental factors and epigenetics drive MSC heterogeneity, with epigenetic alterations affecting differentiation capabilities and disease phenotypes. Rejuvenated induced MSCs offer a solution to bypass age- and tissue-related heterogeneity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Summary: Advanced age is a shared risk factor for chronic skeletal diseases. The senescence of mesenchymal stem cells (MSCs) exacerbates inflammatory microenvironment and disrupts bone remodeling, contributing to age-related bone diseases. Understanding the molecular and epigenetic mechanisms of MSC senescence, such as oxidative stress and mitochondrial dysfunction, could present rejuvenation strategies for skeletal aging restoration.
Review
Biochemistry & Molecular Biology
Hantae Jo, Sofia Brito, Byeong Mun Kwak, Sangkyu Park, Mi-Gi Lee, Bum-Ho Bin
Summary: MSCs play a key role in promoting repair of damaged and aging skin by increasing cell proliferation, neovascularization, collagen and elastic fiber production. iPSC-derived MSCs are considered advanced MSCs for cell therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao, Qing Niu, Fengping Wu, Liyun Zhang
Summary: This review discusses the characteristics of MSCs, their interaction with the microenvironment, and the importance of the microenvironment in maintaining cell function and disease progression.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Peripheral Vascular Disease
Shota Shimizu, Tomohiro Iba, Hisamichi Naito, Fitriana Nur Rahmawati, Hirotaka Konishi, Weizhen Jia, Fumitaka Muramatsu, Nobuyuki Takakura
Summary: This study found that the number of tissue-resident vascular endothelial stem cells (VESCs) was lower in aged mice and their potential to differentiate into endothelial cells was impaired. The study also discovered that inflammatory signaling was more activated in aged mice, suggesting the possible involvement of age-associated inflammation in the functional decline of VESCs.
Review
Cell Biology
Yauhen Statsenko, Nik V. Kuznetsov, Daria Morozova, Katsiaryna Liaonchyk, Gillian Lylian Simiyu, Darya Smetanina, Aidar Kashapov, Sarah Meribout, Klaus Neidl-Van Gorkom, Rifat Hamoudi, Fatima Ismail, Suraiya Anjum Ansari, Bright Starling Emerald, Milos Ljubisavljevic
Summary: Although accelerated aging is a commonly recognized theory, it still has many shortcomings and limitations that require an updated concept.
Review
Cell Biology
Xiaotong Hong, Silvia Campanario, Ignacio Ramirez-Pardo, Mercedes Grima-Terren, Joan Isern, Pura Munoz-Canoves
Summary: This article discusses the reasons for the functional failure of satellite cells during aging, including intrinsic changes and external factors, as well as the applications of single-cell sequencing technologies in the study of skeletal muscle aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Cell & Tissue Engineering
Zhaohua Wang, Si Wen, Meiqi Zhong, Ziming Yang, Wei Xiong, Kuo Zhang, Shude Yang, Huizheng Li, Shu Guo
Summary: Bone has limited capacity to repair critical-sized bone defects, but stem cells, particularly mesenchymal stem cells (MSCs), show promise in enhancing bone regeneration. Epigenetic modification, including nucleic acids methylation, histone modification, and non-coding RNAs, plays a crucial role in determining MSCs fate and differentiation. Understanding the epigenetic mechanisms of MSCs can improve stem cell activity and function. This review highlights the potential of harnessing epigenetic modification of MSCs for treating bone defects and promoting bone regeneration, providing therapeutic targets for bone-related diseases.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Cell Biology
Anne Brunet, Margaret A. Goodell, Thomas A. Rando
Summary: Stem cell function declines during ageing, resulting in the loss of tissue integrity and health deterioration. This Review discusses the mechanisms underlying ageing in stem cells and their niches, and potential rejuvenation strategies.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Virology
Clara Duran-Castells, Anuska Llano, Ai Kawana-Tachikawa, Anna Prats, Ignacio Martinez-Zalacain, Mie Kobayashi-Ishihara, Bruna Oriol-Tordera, Ruth Pena, Cristina Galvez, Sandra Silva-Arrieta, Bonaventura Clotet, Eva Riveira-Munoz, Esther Ballana, Julia. G. Prado, Javier Martinez-Picado, Jorge Sanchez, Beatriz Mothe, Dennis Hartigan-O'Connor, Tony Wyss-Coray, Andreas Meyerhans, Magnus Gisslen, Richard. W. Price, Carles Soriano-Mas, Jose Antonio Munoz-Moreno, Christian Brander, Marta Ruiz-Riol
Summary: High levels of SIRT2 are associated with uncontrolled HIV infection, plasma viral load, and proviral levels. SIRT2 levels are also linked to markers of neurological damage and brain involution, especially in individuals who initiate cART later. Inhibition of SIRT2 could potentially be a therapeutic target for HIV infections and their associated neurological dysfunction.
JOURNAL OF VIROLOGY
(2023)
Correction
Multidisciplinary Sciences
Tal Iram, Fabian Kern, Achint Kaur, Saket Myneni, Allison R. Morningstar, Heather Shin, Miguel A. Garcia, Lakshmi Yerra, Robert Palovics, Andrew C. Yang, Oliver Hahn, Nannan Lu, Steven R. Shuken, Michael S. Haney, Benoit Lehallier, Manasi Iyer, Jian Luo, Henrik Zetterberg, Andreas Keller, J. Bradley Zuchero, Tony Wyss-Coray
Editorial Material
Multidisciplinary Sciences
Ian H. Guldner, Tony Wyss-Coray
Summary: An analysis of mice with tau protein, a key feature of Alzheimer's disease, demonstrates that immune cells work together to cause tau-mediated neurodegeneration, and that existing clinic drugs can combat this decline.
Article
Biotechnology & Applied Microbiology
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Summary: By studying the expression of noncoding RNA (ncRNA) in aging and rejuvenated mice, we found that the molecular aging trajectories are mostly tissue-specific, except for eight broadly deregulated microRNAs (miRNAs). These miRNAs were also found in circulating plasma and extracellular vesicles (EVs), while tissue-specific ncRNAs were less present. MiR-29c-3p had the strongest correlation with aging in solid organs, plasma, and EVs. In mice rejuvenated by heterochronic parabiosis, the level of miR-29c-3p was restored to a similar level as in young liver. MiR-29c-3p targets pathways related to the extracellular matrix and secretion, which are known to be involved in aging.
NATURE BIOTECHNOLOGY
(2023)
Review
Cell Biology
Antoine de Morree, Thomas A. Rando
Summary: Adult stem cells are crucial for maintaining and regenerating mammalian tissues. The quiescent state of stem cells, controlled by various post-transcriptional mechanisms, plays a vital role in their long-term maintenance and ability to respond to injuries. Understanding these mechanisms has important implications for regenerative medicine.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Article
Immunology
Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang, Nicole Hajicek, Adam J. Carr, Emma K. Lendy, Oliver Hahn, Micaiah Atkins, Aulden G. Foltz, Jheel Patel, Guixiang Xu, Miguel Moutinho, John Sondek, Qisheng Zhang, Andrew D. Mesecar, Yunlong Liu, Brady K. Atwood, Tony Wyss-Coray, Kwangsik Nho, Stephanie J. Bissel, Bruce T. Lamb, Gary E. Landreth
Summary: Genetic association studies have shown the critical role of microglial immune response in Alzheimer's disease pathogenesis. Two genetic variants of the PLCG2 gene, PLCG2P522R and PLCG2M28L, have been identified to be associated with AD risk. PLCG2P522R reduces the risk while PLCG2M28L increases the risk of AD. These variants modulate microglial responses and contribute to the development of AD.
Article
Biochemistry & Molecular Biology
Fabian Kern, Thomas Kuhn, Nicole Ludwig, Martin Simon, Laura Groeger, Natalie Fabis, Ernesto Aparicio-Puerta, Abdulrahman Salhab, Tobias Fehlmann, Oliver Hahn, Annika Engel, Viktoria Wagner, Marcus Koch, Katarzyna Winek, Hermona Soreq, Irina Nazarenko, Gregor Fuhrmann, Tony Wyss-Coray, Eckart Meese, Verena Keller, Matthias W. Laschke, Andreas Keller
Summary: Previous studies have shown that RNA molecules exhibit global and tissue-specific ageing patterns in both murine models and humans. In this study, we focused on extracellular vesicles (EVs), which are membrane vesicles that mediate the transfer of genetic information between tissues. We sequenced small regulatory RNAs (sncRNAs) in two fractions of mouse plasma at different time points, and observed unique ageing patterns in different sncRNA classes between the free-circulating (fc-RNA) and EV-bound (EV-RNA) fractions. Furthermore, we found that miR-29 family in adipose tissues, particularly in the EV-RNA fraction, was strongly associated with ageing.
Article
Cell Biology
Yun Ju Sung, Chengran Yang, Joanne Norton, Matt Johnson, Anne Fagan, Randall J. Bateman, Richard J. Perrin, John C. Morris, Martin R. Farlow, Jasmeer P. Chhatwal, Peter R. Schofield, Helena Chui, Fengxian Wang, Brenna Novotny, Abdallah Eteleeb, Celeste Karch, Suzanne E. Schindler, Herve Rhinn, Erik C. B. Johnson, Hamilton Se-Hwee Oh, Jarod Evert Rutledge, Eric B. Dammer, Nicholas T. Seyfried, Tony Wyss-Coray, Oscar Harari, Carlos Cruchaga
Summary: This study identified altered proteins associated with Alzheimer's disease (AD) in brain tissue, cerebrospinal fluid (CSF), and plasma samples, and replicated these findings in external datasets. Additionally, a proteomic signature that distinguished genetically defined AD from sporadic AD was identified. The study suggests that combined proteomics across multiple tissues can be used to identify markers for both sporadic and genetically defined AD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Cana Park, Oliver Hahn, Shweta Gupta, Arturo J. Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A. Villeda, Tony Wyss-Coray, Dena B. Dubal
Summary: Platelet factors regulate wound healing and can signal from the blood to the brain. This study shows that the platelet factor 4 (PF4) can permeate the brain and enhance cognition. Systemic administration of klotho, a protein that enhances longevity and cognition, increases the levels of platelet factors, including PF4, in mice. PF4 treatment improves synaptic plasticity and cognition in young mice, and decreases cognitive deficits and restores aging-induced changes in hippocampal factors in old mice.
Article
Cell Biology
Matthew T. Buckley, Eric D. D. Sun, Benson M. George, Ling Liu, Nicholas Schaum, Lucy Xu, Jaime M. Reyes, Margaret A. Goodell, Irving L. Weissman, Tony Wyss-Coray, Thomas A. Rando, Anne Brunet
Summary: This study develops aging clocks based on single-cell transcriptomics to quantify the diversity of cell types in aging and rejuvenation. The clocks are applicable to different species and can predict chronological and biological age. The study demonstrates that heterochronic parabiosis and exercise have distinct effects on transcriptomic rejuvenation in specific neural cell types.
Article
Cell Biology
Afroditi Tsitsou-Kampeli, Stefano Suzzi, Mor Kenigsbuch, Akisawa Satomi, Romano Strobelt, Oded Singer, Ester Feldmesser, Maitreyee Purnapatre, Sarah Phoebeluc Colaiuta, Eyal David, Liora Cahalon, Oliver Hahn, Tony Wyss-Coray, Yosef Shaul, Ido Amit, Michal Schwartz
Summary: The expression of CYP46A1 in choroid plexus plays a role in regulating brain function and immune homeostasis. Decreased levels of CYP46A1 are observed in various brain conditions, including amyloidosis, aging, and SARS-CoV-2 infection. The enzymatic product of CYP46A1, 24(S)-hydroxycholesterol, can reduce inflammatory responses in the choroid plexus. TNF-α downregulates CYP46A1 expression, while overexpression or pharmacological activation of CYP46A1 can enhance resilience to TNF-α and improve cognitive performance in transgenic mice with amyloidosis.
CELL REPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Matthias Flotho, Jeremy Amand, Pascal Hirsch, Friederike Grandke, Tony Wyss-Coray, Andreas Keller, Fabian Kern
Summary: The molecular causes and mechanisms of neurodegenerative diseases are still not well understood. This study introduces ZEBRA, a large single-cell and single-nucleus RNA-seq database, which integrates gene expression and metadata from multiple studies to enhance our understanding of mammalian brain function during aging and disease.
NUCLEIC ACIDS RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
K. Robertson, O. Hahn, A. Faruk, R. Hall, T. Wyss-Coray, L. Becker, J. Kaltschmidt
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Meeting Abstract
Hematology
Adam Wilkinson, Michael Haney, Archana Shankar, Ian Hsu, Masashi Miyauchi, Robert Palovics, Leonid Olender, Hwei Minn Khoo, Kyomi Igarashi, Joydeep Bhadury, Christy Munson, Paul Mack, Tze-Kai Tan, Hiromitsu Nakauchi, Tony Wyss-Coray
EXPERIMENTAL HEMATOLOGY
(2023)
