Article
Geriatrics & Gerontology
Katie M. Jajtner, Debra L. Brucker, Sophie Mitra
Summary: This study explores the relationship between midlife work limitations and aging outcomes, finding that midlife work limitations are associated with lower likelihood of desirable aging outcomes, emphasizing the need for further research to understand the mechanisms linking work limitations and aging outcomes.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Ligia J. Dominguez, Nicola Veronese, Eleonora Baiamonte, Martina Guarrera, Angela Parisi, Chiara Ruffolo, Federica Tagliaferri, Mario Barbagallo
Summary: Multiple factors, including genetics, behavior, environment, and diet, contribute to the complex process of aging. Nutritional factors have a significant impact on age-related chronic diseases and mortality. Recent nutrition research has shifted from focusing on single nutrients to considering food combinations and overall dietary patterns.
Article
Medicine, General & Internal
Sofia Pavanello, Manuela Campisi, Alberto Grassi, Giuseppe Mastrangelo, Elisabetta Durante, Arianna Veronesi, Maurizio Gallucci
Summary: Research on elderly individuals has shown that longer leukocyte telomere length (LTL) can predict a longer life and better health. The study found a positive relationship between LTL and survival, with factors like Short Physical Performance Battery (SPPB) scores and years of education affecting LTL elongation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Jennifer C. Lai, Amy M. Shui, Andres Duarte-Rojo, Robert S. Rahimi, Daniel R. Ganger, Elizabeth C. Verna, Michael L. Volk, Matthew Kappus, Daniela P. Ladner, Brian Boyarsky, Dorry L. Segev, Ying Gao, Chiung-Yu Huang, Jonathan P. Singer
Summary: This study evaluated the association between pre-LT and post-LT frailty with post-LT global functional health. The results showed that pre-LT frailty was associated with worse global functional health after LT, while post-LT frailty was associated with worse physical health. These data suggest that interventions targeting frailty before and/or early after LT may improve the health and well-being of LT recipients.
Article
Medicine, General & Internal
Daria A. Kashtanova, Veronika V. Erema, Maria S. Gusakova, Ekaterina R. Sutulova, Anna Yu. Yakovchik, Mikhail V. Ivanov, Anastasiia N. Taraskina, Mikhail V. Terekhov, Lorena R. Matkava, Antonina M. Rumyantseva, Vladimir S. Yudin, Anna A. Akopyan, Irina D. Strazhesko, Irina S. Kordiukova, Alexandra I. Akinshina, Valentin V. Makarov, Olga N. Tkacheva, Sergey A. Kraevoy, Sergey M. Yudin
Summary: This study aimed to identify predictors of overall one-year mortality in long-living individuals and risk factors for COVID-19-related mortality. The most reliable predictors of overall mortality were cognitive impairment, malnutrition, frailty, aging-associated diseases, and specific blood markers. In post-COVID 19 participants, depression, frontal lobe dysfunction, frailty, and specific blood biomarkers were significant mortality predictors.
FRONTIERS IN MEDICINE
(2023)
Article
Geriatrics & Gerontology
Raoping Tu, Huihui He, Suhang Wang, Jiali Ding, Qingping Zeng, Lu Guo, Yueping Li, Tianwei Xu, Guangyu Lu
Summary: This study found that the Healthy Aging Index (HAI) is closely related to disability progression among adults aged over 60 years old. Older adults with higher HAI scores tend to have slower disability progression.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Cell Biology
Andrew P. K. Wodrich, Andrew W. Scott, Edward Giniger
Summary: By asking questions about the nature of aging and examining data from Drosophila melanogaster, this study explores the complex interactions among age-related phenotypes at different biological levels. The differing perspectives on aging shed light on its properties and mechanisms, offering potential paths for understanding the nature of aging.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Panagiota Pietri, Christodoulos Stefanadis
Summary: Cardiovascular aging and longevity are interconnected through various pathophysiological mechanisms, with factors like cardiometabolic disorders and genetic modulators playing significant roles. Understanding the genetic, molecular, and biochemical pathways of aging may lead to interventions that delay cardiovascular aging, potentially contributing to achieving longevity goals. Research on long-living populations helps translate these mechanisms into clinical data for further study.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cell Biology
Valentina Siino, Ashfaq Ali, Giulia Accardi, Anna Aiello, Mattia E. Ligotti, Sergio Mosquim Junior, Giuseppina Candore, Calogero Caruso, Fredrik Levander, Sonya Vasto
Summary: The study of healthy human aging is crucial for understanding the molecular mechanisms behind aging and preventing age-related disorders. In this study, an unbiased mass spectrometry-based approach was used to investigate age-related protein changes in a healthy Sicilian plasma cohort. The findings confirmed previously known proteins associated with age and discovered novel proteins that could be a unique signature for healthy aging.
Article
Medicine, General & Internal
R. C. Oude Voshaar, H. W. Jeuring, M. K. Borges, R. H. S. van den Brink, R. M. Marijnissen, E. O. Hoogendijk, B. van Munster, I. Aprahamian
Summary: The frailty index (FI) independently predicted mortality, with the highest impact in individuals with endocrine, lung, or heart diseases. Both multimorbidity and specific chronic disease clusters were associated with an accelerated increase in frailty over time, highlighting the importance of initiating frailty prevention in middle age.
Article
Geriatrics & Gerontology
Yi-Chin Lin, Hung-Yu Lin, Liang-Kung Chen, Fei-Yuan Hsiao
Summary: This study examines the associations between subjective aging and the psychological and behavioral responses of older individuals, specifically focusing on the longitudinal changes in biological age. The results indicate that there are no significant associations between changes in biological age and subjective aging across different chronological age groups.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Tomiko Yoneda, Nathan A. Lewis, Jamie E. Knight, Jonathan Rush, Rebecca Vendittelli, Luca Kleineidam, Jinshil Hyun, Andrea M. Piccinin, Scott M. Hofer, Emiel O. Hoogendijk, Carol A. Derby, Martin Scherer, Steffi Riedel-Heller, Michael Wagner, Ardo van den Hout, Wenyu Wang, David A. Bennett, Graciela Muniz-Terrera
Summary: The study found that engaging in physical activity, especially before the onset of cognitive impairment, significantly reduces the risk of transitioning from nonimpaired to mildly impaired cognitive functioning and extends life expectancy. Additionally, physical activity also has a protective effect after the onset of cognitive impairment, although there is some heterogeneity between study results.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Nutrition & Dietetics
Ligia J. Dominguez, Giovanna Di Bella, Nicola Veronese, Mario Barbagallo
Summary: In the past 150 years, the average life expectancy of the world population has significantly increased, with a focus on food combination patterns in nutrition research. The Mediterranean diet has been associated with numerous health benefits and is considered ecologically sustainable.
Article
Multidisciplinary Sciences
Hannah Froy, Sarah L. Underwood, Jennifer Dorrens, Luise A. Seeker, Kathryn Watt, Rachael V. Wilbourn, Jill G. Pilkington, Lea Harrington, Josephine M. Pemberton, Daniel H. Nussey
Summary: The study found that in wild Soay sheep, there was no significant association between telomere length and subsequent survival, suggesting that telomere length is not an important marker of biological aging or exposure to environmental stress in this study system. Instead, individual differences in average telomere length were associated with increased lifespan, indicating a genetic basis for this correlation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Wei Zhang, Yunshuang Ye, Yinan Sun, Yongxuan Li, Mingxia Ge, Kangning Chen, Liping Yang, Guijun Chen, Jumin Zhou
Summary: Aging is associated with weakened immune function, but dietary restriction can improve health and lifespan. Halving amino acid components in the HUNTaa diet further extends lifespan and improves resistance. In aged fruit flies, stress-related genes are downregulated and immune function is enhanced, reducing immune senescence.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jaime L. Speiser, Kathryn E. Callahan, Edward H. Ip, Michael E. Miller, Janet A. Tooze, Stephen B. Kritchevsky, Denise K. Houston
Summary: Mobility limitation is common in older adults and can lead to poor health outcomes. This study developed machine learning models using repeated measures data to predict future mobility limitation, with predictors such as ease of getting up from a chair, gait speed, self-reported health status, body mass index, and depression being the most important factors. The models showed good performance in identifying at-risk older adults, highlighting the potential utility of such prediction models in clinical settings for interventions to prevent or delay mobility limitation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Psychiatry
Ilja M. J. Saris, Moji Aghajani, Lianne M. Reus, Pieter-Jelle Visser, Yolande Pijnenburg, Nic J. A. van der Wee, Amy C. Bilderbeck, Andreea Raslescu, Asad Malik, Maarten Mennes, Sanne Koops, Celso Arrango, Jose Luis Ayuso-Mateos, Gerard R. Dawson, Hugh Marston, Martien J. Kas, Brenda W. J. H. Penninx
Summary: The study found a correlation between social dysfunction and reduced DMN connectivity, with the combined effect of both being more pronounced, independent of diagnostic status and not confounded by key clinical or sociodemographic effects.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Mark A. Espeland, Jamie Nicole Justice, Judy Bahnson, Joni K. Evans, Medha Munshi, Kathleen M. Hayden, Felicia R. Simpson, Karen C. Johnson, Craig Johnston, Stephen R. Kritchevsky
Summary: Multimorbidity and frailty indices can predict subsequent decline in cognitive and physical function, as well as increased risk of mortality. Accelerated biological aging is captured by these indices. Whether intensive lifestyle interventions targeting these indices can reduce risks for downstream outcomes remains to be seen.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Clinical Neurology
Alejandro De la Torre-Luque, Alba Viera-Campos, Amy C. Bilderbeck, Maria Teresa Carreras, Jose Vivancos, Covadonga M. Diaz-Caneja, Moji Aghajani, Ilja M. J. Saris, Andreea Raslescu, Asad Malik, Jenna Clark, Brenda W. J. H. Penninx, Nic van der Wee, Inge Winter-van Rossum, Bernd Sommer, Hugh Marston, Gerard R. Dawson, Martien J. Kas, Jose Luis Ayuso-Mateos, Celso Arango
Summary: This study investigated the role of social withdrawal in neuropsychiatric patients and found that they showed poorer performance in detecting facial emotions compared to healthy individuals. Social withdrawal was associated with higher accuracy in negative emotion detection and lower misclassification of positive emotions. These findings suggest that social withdrawal may lead to heightened sensitivity to negative emotions and impact social functioning in people with severe mental illness.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
Nathaly Rius Ottenheim, Kuan-Yu Pan, Almar A. L. Kok, Frederike Jorg, Merijn Eikelenboom, Melany Horsfall, Rob A. Luteijn, Patricia van Oppen, Didi Rhebergen, Robert A. Schoevers, Brenda W. J. H. Penninx, Erik J. Giltay
Summary: The study found neuroticism to be a robust predictor of adverse changes in mental health, and identified additional sociodemographic and COVID-19-related predictors that explain longitudinal variability in mental health during the COVID-19 pandemic.
Article
Geriatrics & Gerontology
A. R. M. Saifuddin Ekram, Joanne Ryan, Sara E. Espinoza, Anne B. B. Newman, Anne M. M. Murray, Suzanne G. Orchard, Sharyn M. Fitzgerald, John J. J. McNeil, Michael E. Ernst, Robyn L. Woods
Summary: This study examined the relationship between physical frailty and healthy community-dwelling older adults and explored the impact of frailty on disability-free survival. The results showed that frailty is common among older adults and is associated with factors such as age, waist circumference, education, and ethnicity. Frailty significantly reduces disability-free survival and addressing modifiable correlates such as depression and polypharmacy may help mitigate its adverse effects.
Article
Geriatrics & Gerontology
Kyle D. Moored, Yujia (Susanna) Qiao, Andrea L. Rosso, Frederico G. S. Toledo, Peggy M. Cawthon, Steven R. Cummings, Bret H. Goodpaster, Stephen B. Kritchevsky, Nancy W. Glynn
Summary: Cardiorespiratory fitness and perceived fatigability are associated with life-space mobility in older adults. Higher fitness levels are associated with greater life-space, but the association plateaus at higher fitness levels. Individuals with higher fatigability are more likely to have lower life-space mobility, especially due to physical fatigability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Anne B. Newman, Sheena Patel, Jorge R. Kizer, Se-Jin Lee, Shalinder Bhasin, Peggy Cawthon, Nathan LeBrasseur, Russel P. Tracy, Peter Ganz, Steven R. Cummings
Summary: Studies using heterochronic parabiosis have found that circulating factors play a role in brain aging in animal models. In this study, the levels of GDF-11, GDF-8, and follistatin were evaluated and their associations with cognitive function, brain MRI findings, and incident dementia were assessed. The results showed that these factors were not significantly correlated with cognitive outcomes or dementia in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Gerontology
Jaime M. Hughes, Rebecca T. Brown, Jason Fanning, Minakshi Raj, Alycia N. S. Bisson, Mira Ghneim, Stephen B. Kritchevsky
Summary: Modifying unhealthy behaviors and/or environments can improve or maintain the health of older adults, but achieving and sustaining behavior change is challenging and involves various domains such as clinical, social, psychological, and political factors. The National Institute on Ageing (NIA) Research Centers Collaborative Network (RCCN) organized a two-day workshop to emphasize the multidisciplinary nature of behavior change in older adults. The workshop focused on the individual, community, and systems-level determinants of behavior change and discussed future research, education, and training opportunities for the six NIA research centers.
Article
Biochemistry & Molecular Biology
Tina Drincic, Jens H. van Dalfsen, Jeanine Kamphuis, Mike C. Jentsch, Sjoerd M. van Belkum, Marcus J. M. Meddens, Brenda W. J. H. Penninx, Robert A. Schoevers
Summary: Insomnia has a clinically relevant relationship with major depressive disorder (MDD), as it is associated with neurobiological alterations similar to the pathophysiology of MDD. This study aimed to investigate the relationship between insomnia and the main mechanisms of MDD in a clinical sample of MDD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Atalie C. Thompson, Haiying Chen, Michael E. Miller, Christopher C. Webb, Jeff D. Williamson, Anthony P. Marsh, Christina E. Hugenschmidt, Laura D. Baker, Paul J. Laurienti, Stephen B. Kritchevsky
Summary: This study found that contrast sensitivity is associated with lower extremity physical function in cognitively intact older adults. Lower contrast sensitivity is significantly related to worse performance on physical performance tests, such as gait speed, narrow walking speed, and balance. The relationship between contrast sensitivity and postural sway is influenced by the surface condition, and the effect of contrast sensitivity on gait velocity is greater during fast pace compared to usual pace.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Brendan L. McNeish, Iva Miljkovic, Xiaonan Zhu, Peggy M. Cawthon, Anne B. Newman, Bret Goodpaster, Kristine Yaffe, Caterina Rosano
Summary: This study found a positive association between serum myostatin levels and the amyloid burden in Alzheimer's disease. The association was significant in white men and women, but not in black men or women. Further investigation is needed to understand the role of myostatin in AD pathogenesis and its influence on different racial groups.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Peggy M. Cawthon, Sheena Patel, Anne B. Newman, Shalender Bhasin, Liming Peng, Russell P. Tracy, Jorge R. Kizer, Se-Jin Lee, Luigi Ferrucci, Peter Ganz, Nathan K. LeBrasseur, Steven R. Cummings
Summary: Based on studies from animal models, growth differentiation factor-11 (GDF-11) may have rejuvenating effects in humans. GDF-11 has high sequence homology with GDF-8, and follistatin and follistatin-like protein-3 (FSTL-3) are inhibitory proteins of both GDF-8 and GDF-11. In two prospective cohort studies of older adults, it was found that GDF-8 levels were positively associated with muscle size and strength, while GDF-11 was not significantly associated with strength or performance. This suggests that GDF-8 and its binding proteins may play a role in counteracting age-related loss of muscle mass and strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Shivani Sahni, Alyssa B. Dufour, Na Wang, Douglas P. Kiel, Marian T. Hannan, Paul F. Jacques, Emelia J. Benjamin, Ramachandran S. Vasan, Joanne M. Murabito, Anne B. Newman, Roger A. Fielding, Gary F. Mitchell, Naomi M. Hamburg
Summary: This study examined the association between vascular health measures and grip strength and gait speed. The cross-sectional analysis showed a positive association between resting brachial artery diameter and grip strength, as well as between mean arterial pressure (MAP) and grip strength. The longitudinal analysis revealed a significant association between brachial pulse pressure and slower gait speed, but no association with grip strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jamie N. Justice, Xiaoyan Leng, Nathan K. Lebrasseur, Tamara Tchkonia, James L. Kirkland, Natalia Mitin, Yongmei Liu, Stephen B. Kritchevsky, Barbara J. Nicklas, Jingzhong Ding
Summary: Cellular senescence is an aging process exacerbated by obesity and linked to inflammation and chronic diseases. Caloric restriction may improve metabolism by reducing cellular senescence and inflammation. This randomized controlled trial showed that caloric restriction intervention altered specific circulating biomarkers of cellular senescence in middle-aged and older adults with obesity and prediabetes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)