Review
Biochemistry & Molecular Biology
Gabriel Ichim, Benjamin Gibert, Sahil Adriouch, Catherine Brenner, Nathalie Davoust, Solange Desagher, David Devos, Svetlana Dokudovskaya, Laurence Dubrez, Jerome Estaquier, Germain Gillet, Isabelle Guenal, Philippe P. Juin, Guido Kroemer, Patrick Legembre, Romain Levayer, Stephen Manon, Patrick Mehlen, Olivier Meurette, Olivier Micheau, Bernar Mignotte, Florence Nguyen-Khac, Nikolay Popgeorgiev, Jean-Lu Poyet, Muriel Priault, Jean-Ehrlan Ricci, Franck B. Riquet, Santos A. Susin, Magal Suzanne, Pierre Vacher, Ludivine Walter, Bertran Mollereau
Summary: Since the Nobel Prize was awarded more than twenty years ago for discovering the core apoptotic pathway in C. elegans, researchers around the world have conducted extensive research on apoptosis and various other forms of regulated cell death. Although there are still many aspects of regulated cell death that need to be clarified in specific cell subtypes and disease conditions, the last decade has seen the description of multiple cell death modalities, some of which have been successfully used in clinical therapy. To keep research into cell death alive, francophone researchers from several institutions in France and Belgium established the French Cell Death Research Network (FCDRN), which is at the forefront of emerging topics in cell death research. These research efforts will enhance our mechanistic knowledge of regulated cell death and its therapeutic applications in the coming years.
Article
Immunology
Wenhao Xu, Hai-Jia Tang, Aihetaimujiang Anwaier, Wangrui Liu, Xi Tian, Jiaqi Su, Shiyin Wei, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Summary: This study evaluated the transcriptomic profile of cell death pathways in bladder cancer patients and found that patients with high cell-death index (CDI) had a higher risk of mortality. These high-risk patients also exhibited an immunoevasive tumor microenvironment characterized by increased tumor-associated macrophage infiltration and expression of immune checkpoints. These findings provide important clinical and immunological insights for the management of bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tapan Behl, Rashita Makkar, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Gokhan Zengin, Simona Bungau, Felicia Liana Andronie-Cioara, Mihai Alexandru Munteanu, Mihaela Cristina Brisc, Diana Uivarosan, Ciprian Brisc
Summary: The human body is complex and comprises various living cells and extracellular material forming tissues, organs, and organ systems. While most human cells turnover regularly, postmitotic nerve cells have the exceptional ability to regenerate and sustain throughout an individual's life to safeguard the central nervous system's functioning. Neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, result from factors like oxidative stress, cell death, and neuroinflammation, causing neuronal degradation and impacting the quality of life for millions worldwide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Minggang Tian, Baoli Dong, Zheming Zhang, Junling Yin, Weiying Lin
Summary: A new fluorescent probe mPTP-F has been successfully designed to monitor the opening of mPTP in cellular native status. This probe can serve as an important tool for studying areas such as ischemia-reperfusion injury and cell apoptosis.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Juan A. Montero, Carlos Ignacio Lorda-Diez, Juan M. Hurle
Summary: This paper proposes a new perspective on the regulation of programmed cell death (PCD) in developing systems based on epigenetics. It challenges the traditional view that PCD is solely controlled by specific gene-encoded signals, arguing that the signals and local tissue interactions responsible for embryonic tissue growth and differentiation play a significant role in PCD. The study suggests that cells retain an epigenetic profile sensitive to DNA damage, resulting in their subsequent elimination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Jia-Heng Zhang, Shi-Yu Ni, Ya-Ting Tan, Jia Luo, Shu-Chao Wang
Summary: By conducting bibliometric analyses, this study explores the research trends and hotspots of Pin1 and cell death. The results indicate that the research on Pin1 and cell death has been increasing annually since 2001, but growth after 2014 appears to be stagnant. The cooperation between core institutions needs to be strengthened, and recently, Fujian Medical University in China has emerged as the institution with the highest citation count. Further research is required to understand the role of Pin1 in cell death and to identify new research hotspots. Future studies are likely to focus on disease treatment using Pin1 inhibitors, before breakthroughs are made in understanding the molecular mechanisms or signaling pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Virology
Shannic-Le Kerr, Cynthia Mathew, Reena Ghildyal
Summary: Rhinoviruses are common causes of the common cold and can lead to more severe diseases in lower respiratory tract infections. These viruses hijack host cell pathways to suppress antiviral responses, and the mechanism of how they exit infected cells remains unclear.
Review
Neurosciences
Yan Zhang, Suliman Khan, Yang Liu, Ruiyi Zhang, Hongmin Li, Guofeng Wu, Zhouping Tang, Mengzhou Xue, V. Wee Yong
Summary: This review summarizes the knowledge of cell death induced by intracerebral hemorrhage (ICH), with a focus on apoptosis and necrosis. It also discusses the involvement of recently described modes of cell death including necroptosis, pyroptosis, ferroptosis, autophagy, and parthanatos in ICH. Treatment strategies to mitigate brain injury based on specific cell death pathways after ICH are also summarized.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Leo Razakamanantsoa, Neeraj R. Rajagopalan, Yasushi Kimura, Michele Sabbah, Isabelle Thomassin-Naggara, Francois H. Cornelis, Govindarajan Srimathveeravalli
Summary: Irreversible electroporation (IRE) can cause apoptosis, necrosis, oncosis, or pyroptosis. The mode of cell death following IRE is determined by intracellular ATP levels. Cell death after IRE is insensitive to caspase inhibition and is correlated with ATP loss, which cannot be rescued by ATP supplementation.
BIOELECTROCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Sweata Hanson, Aiswarya Dharan, P. V. Jinsha, Sanjay Pal, Bipin G. Nair, Rekha Kar, Nandita Mishra
Summary: Programmed cell death (PCD) is a universal process that regulates cellular homeostasis and plays a crucial role in disease conditions, including cancer. Apoptosis is a major PCD, but cancer cells develop resistance to it, necessitating the search for alternative forms of programmed cell death such as paraptosis. Paraptosis is characterized by vacuolation and damage to cellular structures and has potential therapeutic implications in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Cell Biology
Lawrence M. Schwartz
Summary: Cell death is a normal and essential component of development and homeostasis, but dysregulation of this process underlies most human diseases. Autophagy is a process mediated by the formation of double membrane vesicles, which allows cells to survive stresses and may also mediate cell death during development and pathogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Pankaj Ahluwalia, Meenakshi Ahluwalia, Ashis K. Mondal, Nikhil Sahajpal, Vamsi Kota, Mumtaz Rojiani, Amyn M. Rojiani, Ravindra Kolhe
Summary: This study identified a novel 21-gene cell death signature in lung cancer patients, which significantly correlates with patient survival. Patients with higher expression of this genomic signature were found to have increased risk of early mortality. Additionally, the study revealed perturbations in cytokine expression, immune cell infiltration, and immune checkpoint molecule expression in high-risk patients, suggesting a potential for personalized immunotherapies targeting these pathways.
Review
Biochemistry & Molecular Biology
Dimakatso R. Mokoena, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer, originating from ducts or lobules, ranks as the second most common cancer globally. Risk factors include age, mutations in BRCA1 or BRCA2 genes, and dense breast tissue. Photodynamic therapy (PDT) has shown promise as a less invasive treatment option with reduced harm to normal cells and tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bartosz Wiernicki, Sophia Maschalidi, Jonathan Pinney, Sandy Adjemian, Tom Vanden Berghe, Kodi S. Ravichandran, Peter Vandenabeele
Summary: Ferroptosis, a form of cell death characterized by iron accumulation and lipid peroxidation, has lower immunogenicity compared to other cell death modalities, inhibiting the maturation and antigen cross-presentation of immune cells and hence weakening the anti-tumor immune response.
NATURE COMMUNICATIONS
(2022)
Article
Geriatrics & Gerontology
Maryam Farhang, Claudia Miranda-Castillo, Maria Isabel Behrens, Eduardo Castillo, Sandra Mosquera Amar, Graciela Rojas
Summary: The study found that older adults with mild cognitive impairment (MCI) were mainly psychologically and socially affected by social distancing and isolation during the COVID-19 outbreak, especially those who were alone. They experienced negative emotions such as anger, fear of contracting the virus or passing it to their families, worries, sadness, and emotional loneliness. It is notable that the majority of participants used various coping strategies during this challenging time.
AGING & MENTAL HEALTH
(2022)
Article
Engineering, Biomedical
Daniela Martinez, Rodrigo Diaz, Jorge Rufs, Christian Fajardo, Cristian Valverde, Felipe Salech
Review
Psychiatry
Bravo Maximiliano, Bustos Sebastian, Acuna Estefania, Cisternas Irma, Pedro Gutierrez, Ponce de la Vega Daniela P, Castro Roberta, Tobar Eduardo, Maldonado Jose, Salech Felipe
Summary: This study aimed to conduct a systematic analysis of the published data on the epidemiology of delirium in hospitalized patients in Latin America. The study found that delirium occurs frequently in different clinical scenarios, and the occurrence rate varies. The Confusion Assessment Method is the most commonly used delirium assessment tool. However, the implementation of non-pharmacological interventions to prevent delirium is not universal.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Article
Cell Biology
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe Garcia, Lorena Abarzua-Catalan, Sebastian Oyarce-Pezoa, Maria Fernanda Hernandez, Bastian Cortes, Markus Uhrig, Daniela P. Ponce, Claudia Duran-Aniotz, Claudio Hetz, Carol D. SanMartin, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, Rene L. Vidal, Ute Woehlbier, Melissa Nassif
Summary: This study investigated the cell-specific expression of Rubicon in postmortem brain samples from AD patients and 5xFAD mice and its impact on amyloid beta burden. Increased Rubicon levels were found in AD-hiPSCs and postmortem samples. In AD transgenic mice lacking Rubicon, intensified amyloid beta burden was observed. In neuroblastoma cells, the absence of Rubicon led to increased APP/amyloid beta secretion.
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge and funding, as well as inadequate infrastructure, present significant barriers to dementia biomarker research in Latin American and Caribbean countries. However, the region shows great potential for advancements in this field.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Felipe Salech, Carol D. SanMartin, Jorge Concha-Cerda, Esteban Romero-Hernandez, Daniela P. Ponce, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Barbara Bruna, Jamileth More, Maria I. Behrens
Summary: Recent studies have shown that cellular senescence is involved in the development of Alzheimer's Disease (AD). By measuring senescence markers in peripheral blood mononuclear cells (PBMCs) of AD patients, this study found that several markers of cellular senescence can be measured in PBMCs of both aMCI and AD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Maryam Farhang, Graciela Rojas, Pablo Martinez, Maria Isabel Behrens, Alvaro Langer, Marcela Diaz, Claudia Miranda-Castillo
Summary: This study aims to evaluate the effectiveness of a yoga-based mindfulness intervention for older adults with MCI and has designed a two-arm individually randomized controlled trial. The results of this study will have significant implications for providing an acceptable and effective non-pharmacological option for MCI in Chile.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Evelyn A. Alvarez, Veronica A. Rojas, Lorena I. Caipo, Melany M. Galaz, Daniela P. Ponce, Rodrigo G. Gutierrez, Felipe Salech, Eduardo Tobar, Fernando I. Reyes, Rodrigo C. Vergara, Jose I. Egana, Constanza A. Briceno, Antonello Penna
Summary: Patients who develop postoperative delirium (POD) have several clinical complications, such as increased morbidity, increased hospital stays, higher hospital costs, cognitive and functional impairment, and higher mortality. A prospective clinical study was conducted to determine whether patients undergoing intervention by an Occupational Therapy (OT) team have a lower incidence of POD compared to the group treated only with standard measures.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Jorge J. Llibre-Guerra, Anika Heavener, Sonia Maria Dozzi Brucki, Juan Pablo Diaz Marante, Maritza Pintado-Caipa, Yaohua Chen, Maria Isabel Behrens, Angela Hardi, Arianna Admirall-Sanchez, Rufus Akinyemi, Suvarna Alladi, Karen A. Dorsman, Ana M. Rodriguez-Salgado, Joel Solorzano, Ganesh M. Babulal
Summary: The burden of Alzheimer's disease and related dementia (ADRD) is projected to be disproportionally higher in low-middle-income countries (LMICs). However, there is a lack of representation of LMICs in ADRD clinical trial platforms. This study found that only 11.6% of ADRD clinical trials were conducted in emerging economies (upper-middle income [9.6%] and low-middle income [2.0%]). The limitations for trial implementation in LMICs include limited financial resources, low industry presence, regulatory obstacles, and operational barriers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Ivan Plaza-Rosales, Enzo Brunetti, Rodrigo Montefusco-Siegmund, Samuel Madariaga, Rodrigo Hafelin, Daniela P. Ponce, Maria Isabel Behrens, Pedro E. Maldonado, Andrea Paula-Lima
Summary: This study evaluated the manifestations and mechanisms of visual-spatial deficits in early stages of Alzheimer's disease (AD) using behavioral, electroencephalography (EEG), and eye movement recordings. The results showed impaired spatial learning and altered visual exploration in AD patients, suggesting early and specific features for understanding functional connectivity loss. These findings are clinically promising for early diagnosis and improving quality of life of AD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Carol D. SanMartin, Felipe Salech, Daniela Paz Ponce, Jorge Concha-Cerda, Esteban Romero-Hernandez, Gianella Liabeuf, Nicole K. Rogers, Paola Murgas, Barbara Bruna, Jamileth More, Maria I. Behrens
Summary: Epidemiological studies find that having a history of cancer or Alzheimer's Disease (AD) can protect against the development of the other. The underlying mechanism for this mutual protection is unknown. However, research suggests that PBMCs of individuals with aMCI and AD have increased susceptibility to oxidative cell death, while a history of cancer is associated with increased resistance to cell death caused by oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Marcelo Adrian Maito, Hernando Santamaria-Garcia, Sebastian Moguilner, Katherine L. Possin, Maria E. Godoy, Jose Alberto Avila-Funes, Maria Behrens, Ignacio L. Brusco, Martin A. Bruno, Juan F. Cardona, Nilton Custodio, Adolfo M. Garcia, Shireen Javandel, Francisco Lopera, Diana L. Matallana, Bruce Miller, Maira Okada de Oliveira, Stefanie D. Pina-Escudero, Andrea Slachevsky, Ana L. Sosa Ortiz, Leonel T. Takada, Enzo Tagliazuchi, Victor Valcour, Jennifer S. Yokoyama, Agustin Ibanez
Summary: This study aimed to discriminate between Alzheimer's disease (AD) and frontotemporal dementia (FTD) using demographic, clinical, and cognitive data. Results showed that a machine learning model achieved accurate classification of patients, indicating that data-driven techniques can enhance diagnostic procedures in resource-limited regions. The study also highlighted the potential of specific cognitive and behavioral measures for the diagnosis of AD and FTD in Latin American countries.
LANCET REGIONAL HEALTH-AMERICAS
(2023)
Article
Clinical Neurology
Mario A. Parra, Paulina Orellana, Tomas Leon, Cabello G. Victoria, Fernando Henriquez, Rodrigo Gomez, Constanza Avalos, Andres Damian, Andrea Slachevsky, Agustin Ibanez, Henrik Zetterberg, Betty M. Tijms, Jennifer S. Yokoyama, Stefanie D. Pina-Escudero, J. Nicholas Cochran, Diana L. Matallana, Daisy Acosta, Ricardo Allegri, Bianca P. Arias-Suarez, Bernardo Barra, Maria Isabel Behrens, SoniaM. D. Brucki, Geraldo Busatto, Paulo Caramelli, Sheila Castro-Suarez, Valeria Contreras, Nilton Custodio, Sergio Dansilio, Myriam De la Cruz-Puebla, Leonardo Cruz de Souza, Monica M. Diaz, Lissette Duque, Gonzalo A. Farias, Sergio T. Ferreira, Nahuel Magrath Guimet, Ana Kmaid, David Lira, Francisco Lopera, Beatriz Mar Meza, Eliane C. Miotto, Ricardo Nitrini, Alberto Nunez, Santiago O'Neill, John Ochoa, Maritza Pintado-Caipa, Elisa de Paula Franca Resende, Shannon Risacher, Luz Angela Rojas, Valentina Sabaj, Lucas Schilling, Allis F. Sellek, Ana Sosa, Leonel T. Takada, Antonio L. Teixeira, Martha Unaucho-Pilalumbo, Claudia Duran-Aniotz
Summary: Limited knowledge on dementia biomarkers in Latin American and Caribbean countries due to lack of funding, infrastructure, and training. However, the region holds great potential to advance dementia biomarkers research and it is crucial to expand research in this field.
ALZHEIMERS & DEMENTIA
(2023)
Review
Geriatrics & Gerontology
Hong Lin, Felipe Salech, Anthony Lim, Sara Vogrin, Gustavo Duque
Summary: This systematic review evaluated the efficacy of rapalogues in age-related musculoskeletal disorders (MSKD) in humans. While some studies have assessed the effects of rapamycin and rapalogues on bone, muscle, and joints, there is considerable variability in subjects' age, inclusion criteria, and drug administration protocols. The evidence supporting their use is still limited, and further research is needed to explore the clinical implications on osteoporosis, sarcopenia, or osteosarcopenia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
