期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 67, 期 12, 页码 1352-1357出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/gls128
关键词
Vasopressin; Aquaporin; Water channels; Urea transporters; sodium transport
资金
- National Institutes of Health [R01-DK41707, R01-DK89828, R21-DK91147]
Urine concentrating ability is reduced during normal aging in people and rats. The abundance of many of the key transport proteins that contribute to urine concentrating ability is reduced in the kidney medulla of aged rats. The reductions in water, sodium, and urea transport protein abundances, and their reduced response to water restriction, contribute to the reduced ability of aged rats to concentrate their urine and conserve water. If similar mechanisms occur in human kidneys, it would provide a molecular explanation for the reduced urine concentrating ability in aging and may provide opportunities for novel therapeutic approaches to improve urine concentrating ability and/or nocturnal polyuria.
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