期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 67, 期 5, 页码 456-464出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glr196
关键词
Growth rate; ROS; Telomere length; Skin fibroblasts; Mitochondria
资金
- Netherlands Genomics Initiative [NCHA 050-060-810]
- Innovation Oriented Research Program on Genomics (SenterNovem) [IGE01014, IGE5007]
- Netherlands Genomics Initiative/Netherlands Organization for Scientific Research [05040202, 050-060-810]
- EU [FP6 036894]
Respiratory chain function becomes less efficient with age resulting in increased levels of damaging reactive oxygen species. We compared rotenone-exposed fibroblast strains from young and old subjects and from offspring of nonagenarian siblings and the partners of the offspring. Rotenone increased reactive oxygen species levels, inhibited growth rate, and increased telomere shortening (all p < .05). Non-stressed strains from young subjects showed lower reactive oxygen species levels (p = .031) and higher growth rates (p = .002) than strains from old subjects. Stressed strains from young subjects showed smaller increases in reactive oxygen species levels (p = .014) and larger decreases in growth rate (p < .001) than strains from old subjects. Telomere-shortening rates were not different between groups. Stress-induced decreases in growth rate were larger in strains from offspring than from partners (p = .05). Strains from young and old subjects are differentially affected by chronic inhibition of the respiratory chain. Changed growth rates in strains from offspring resemble those from strains from young subjects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据