期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 64, 期 11, 页码 1107-1113出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glp101
关键词
Calorie restriction; T cell; Immune response; Aging; Obesity
资金
- National Institute on Aging [NGA-3U01-AG20478]
- United States Department of Agriculture [58-1950-9-001]
- International Nutrition Foundation-Ellison Medical Foundation
Calorie restriction (CR) enhances immune response and prolongs life span in animals. However, information on the applicability of these results to humans is limited. T-cell function declines with age, We examined effects of CR on T-cell function in humans. Forty-six overweight, nonobese participants aged 20-42 years were randomly assigned to 30% or 10% CR group for 6 months. Delayed-type hypersensitivity (DTH), T-cell proliferation (TP), and prostaglandin E-2 (PGE(2)) productions were determined before and after CR. DTH and TP to T cell mitogens were increased in both groups over baseline (p <=.019). However, number of positive responses to DTH antigens (p=.016) and TP to anti-CD3 reached statistical significance only after 30% CR (p=.001). Lipopolysaccharide-stimulated PGE(2) was reduced in both groups but reached statistical significance after 30% CR (p <=.029). These results, for the first time, show that 6-month CR in humans improves T-cell function.
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