期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 63, 期 1, 页码 12-20出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/63.1.12
关键词
rat; hippocampus; growth hormone; capillary density; angiogenesis
资金
- NIA NIH HHS [R01 AG026607, P01 AG11370, P01 AG011370] Funding Source: Medline
- NINDS NIH HHS [R01 NS056218] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS056218] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG026607, P01AG011370] Funding Source: NIH RePORTER
The effect of aging on microvascular density and plasticity in the rodent hippocampus, a brain region critically important for learning and memory, was investigated in F344XBN rats. Capillary density and angiogenesis were measured in three regions of the hippocampus in young and old rats and in old rats administered growth hormone. a treatment that improves cognitive function in older animals. Animals were housed under control conditions or in hypoxic conditions (11 % ambient oxygen levels) to stimulate vascular growth. Our results indicate that aging is not associated with a reduction in hippocampal capillary density. However, aged animals demonstrate a significant impairment in hypoxia-induced capillary angiogenesis compared to young animals. Growth hormone treatment to, aged animals for 6 weeks did not alter hippocampal capillary density and did not ameliorate the age-related deficit in angiogenesis. We conclude that aging significantly reduces hippocampal microvascular plasticity, which is not improved with growth hormone therapy.
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