Article
Geriatrics & Gerontology
Wen Hao, Wenjing Zhao, Takashi Kimura, Shigekazu Ukawa, Ken Kadoya, Katsunori Kondo, Akiko Tamakoshi
Summary: This study comprehensively explored the association of gait with global cognitive function and cognitive domains using wearable sensors, finding that the general cycle of gait is strongly associated with global cognitive function and executive function. Further longitudinal studies are needed to examine the relationships in more depth.
Article
Clinical Neurology
Emmeline Ayers, Cuiling Wang, Joe Verghese
Summary: This study examined the validity of subjective cognitive and motoric complaints for motoric cognitive risk syndrome (MCR) and developed a score to define subjective MCR. The results showed that subjective MCR can serve as a remote screening assessment for MCR and help identify individuals at high risk for dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Tobin J. Ehrlich, Hanjoo Kim, Kelly A. Ryan, Scott A. Langenecker, Elizabeth R. Duval, Anastasia K. Yocum, Claudia Diaz-Byrd, Anna L. Wrobel, Olivia M. Dean, Sue M. Cotton, Michael Berk, Melvin G. McInnis, David F. Marshall
Summary: This study evaluated the relationship between childhood trauma and cognition in individuals diagnosed with bipolar disorder. It found that higher childhood trauma was associated with worse memory functioning in bipolar disorder patients. The study emphasizes the importance of understanding the long-term cognitive outcomes of childhood trauma in bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Bernice J. A. Gulpers, Frans R. J. Verhey, Simone J. P. M. Eussen, Miranda T. Schram, Bastiaan E. de Galan, Martin P. J. van Boxtel, Coen D. A. Stehouwer, S. Kohler
Summary: This study investigates the relationship between individual anxiety disorders, generalized anxiety symptoms, and multiple cognitive domains. The results show that agoraphobia is associated with worse scores on all cognitive domains and higher odds of cognitive impairment. High scores on the Generalized Anxiety Disorder 7-item scale (GAD-7) are associated with worse scores on processing speed and higher odds of cognitive impairment. Panic disorder is significantly associated with worse scores on memory tasks. These associations are stronger in younger participants and in those with type 2 diabetes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
J. Matthijs Biesbroek, Jae-Sung Lim, Nick A. Weaver, Gozdem Arikan, Yeonwook Kang, Beom Joon Kim, Hugo J. Kuijf, Albert Postma, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee-Joon Bae, Geert Jan Biessels
Summary: The study identified anatomical correlates for semantic and phonemic fluency, with lower performance associated with left hemispheric frontotemporal and parietal cortical regions, and subcortical regions centered on the left thalamus. Phonemic fluency was linked to a more extensive frontoparietal white matter network, while semantic fluency was associated with disconnection of specific white matter tracts.
Article
Clinical Neurology
Frederico Pieruccini-Faria, Sandra E. Black, Mario Masellis, Eric E. Smith, Quincy J. Almeida, Karen Z. H. Li, Louis Bherer, Richard Camicioli, Manuel Montero-Odasso
Summary: The study demonstrates that high gait variability is a marker of cognitive-cortical dysfunction, particularly in Alzheimer's disease dementia, and can help to accurately discriminate AD from other neurodegenerative and cognitive conditions.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Eileen E. Moran, Susan B. Bressman, Roberto A. Ortega, Deborah Raymond, William C. Nichols, Christina A. Palmese, Sonya Elango, Matthew Swan, Vicki Shanker, Imali Perera, Cuiling Wang, Molly E. Zimmerman, Rachel Saunders-Pullman
Summary: Mutations and variants in the glucocerebrosidase (GBA) gene are common genetic risk factors for Parkinson's disease (PD), but carriers without PD show poorer performance in executive functioning while no significant differences are observed in other domains. This suggests that most GBA mutation carriers may not present pre-manifest non-motor or motor features associated with PD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Ying Xu, Canru Geng, Tong Tang, Juanying Huang, Ying Hou
Summary: This study aimed to identify the influence of cognitive overload on the walking and auditory addition and subtraction dual-task performance of patients with Parkinson's disease. The results showed that patients with Parkinson's disease experienced cognitive overload, which was reflected in gait control failure and calculation errors.
Article
Psychology, Multidisciplinary
Martino Ceroni, Stefania Rossi, Giorgia Zerboni, Elena Biglia, Emiliano Soldini, Alessia Izzo, Lucia Morellini, Leonardo Sacco
Summary: This study analyzed the neuropsychological performance of adults with ADHD and found that attention and executive deficits may be influenced by age and education level. Gender did not show statistically significant differences in cognitive performance.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Wen Hao, Yi-fan Shan, Takashi Kimura, Shigekazu Ukawa, Hideki Ohira, Satoe Okabayashi, Kenji Wakai, Masahiko Ando, Akiko Tamakoshi
Summary: The study found that dual decline in gait speed and cognition is associated with a higher risk of late-life dementia, particularly in older Japanese men. These findings highlight the importance of early screening for dual decline.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Geriatrics & Gerontology
Linhui Ni, Wen Lv, Di Sun, Yi Sun, Yu Sun, Xinxin Xu, Mengyue Chang, Xing Han, Shuai Tao, Xingyue Hu, Huaying Cai
Summary: Given the limitations of neuropsychological tests, researchers have sought to identify a simple and reliable means, such as gait, to differentiate mild dementia subtypes. This study described distinct gait signatures in post-stroke dementia (PSD) and Alzheimer's disease (AD) patients and found certain gait parameters that could distinguish PSD from post-stroke non-dementia and AD. Specific gait characteristics could potentially aid in the early identification of PSD and facilitate non-invasive discrimination between PSD and AD or other subtypes of dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Psychology, Multidisciplinary
Rachel E. Warsaw, Andrew Jones, Abigail K. Rose, Alice Newton-Fenner, Sophie Alshukri, Suzanne H. Gage
Summary: This study found that smartphone use has a negative impact on inhibition and decision-making, while increased engagement in video games and refraining from smartphone use before bedtime can improve working memory performance. However, there is a high risk of methodological biases and low quality of evidence in determining the relationship between technology use and executive functioning.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Pediatrics
Emily A. Beckmann, Kristen E. Jastrowski Mano
Summary: Youth with chronic pain frequently experience executive functioning difficulties, but this area remains understudied. Existing measurement methods lack consistency, highlighting the need for enhanced validation efforts to better guide research in this area.
Article
Immunology
Naoise Mac Giollabhui, Lauren B. Alloy, Lizanne J. S. Schweren, Catharina A. Hartman
Summary: Many depressed individuals experience difficulties in executive functioning, especially those with chronic inflammation. This study found that depression and higher CRP levels are associated with worse executive functioning, with this association being more pronounced in older adults.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychology, Multidisciplinary
Judit Catalan-Aguilar, Esperanza Gonzalez-Bono, Alejandro Lozano-Garcia, Paula Tormos-Pons, Kevin G. Hampel, Vicente Villanueva, Irene Cano-Lopez
Summary: This study aims to establish phenotypes according to how patients face a stressful condition (epilepsy) and examine differences in cognition and quality of life depending on these phenotypes. The results suggest that dealing with stress in patients with epilepsy is related to cognitive performance and quality of life. These findings underline the relevance of considering comorbidities in epilepsy and may be useful for detecting vulnerable or resilient profiles as risk or protective factors for cognitive and quality of life decline.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Deborah A. Levine, Kenneth M. Langa, Angela Fagerlin, Lewis B. Morgenstern, Brahmajee K. Nallamothu, Jane Forman, Andrzej Galecki, Mohammed U. Kabeto, Colleen D. Kollman, Tolu Olorode, Bruno Giordani, Lynda D. Lisabeth, Darin B. Zahuranec
Article
Multidisciplinary Sciences
Rok Pozar, Bruno Giordani, Voyko Kavcic
Article
Clinical Neurology
Deborah A. Levine, Alden L. Gross, Emily M. Briceno, Nicholas Tilton, Mohammed U. Kabeto, Stephanie M. Hingtgen, Bruno J. Giordani, Jeremy B. Sussman, Rodney A. Hayward, James F. Burke, Mitchell S. Elkind, Jennifer J. Manly, Andrew E. Moran, Erin R. Kulick, Rebecca F. Gottesman, Keenan A. Walker, Yuichiro Yano, Darrell J. Gaskin, Stephen Sidney, Kristine Yaffe, Ralph L. Sacco, Clinton B. Wright, Veronique L. Roger, Norrina Bai Allen, Andrzej T. Galecki
Article
Nursing
An-Yun Yeh, Susan J. Pressler, Donna Algase, Laura M. Struble, Bunny J. Pozehl, Ann M. Berger, Bruno J. Giordani
Summary: The relationship between sleep-wake disturbances and episodic memory differed depending on the type of measure used – objective measurement was associated with poorer memory while perceived daytime sleepiness was associated with better memory. Cognitive reserve and depressive symptoms did not moderate this relationship.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Correction
Biophysics
John Stratton, Allison Sylvia, Flora Hoodin, Sung Won Choi, Attaphol Pawarode, Bruno Giordani, Kristen Votruba
Summary: The paper has been amended and a link to the updated version is available at the top of the original paper.
BONE MARROW TRANSPLANTATION
(2021)
Article
Biophysics
John Stratton, Allison Sylvia, Flora Hoodin, Sung Won Choi, Attaphol Pawarode, Bruno Giordani, Kristen Votruba
Summary: The study found that age did not have a significant impact on cognition one year after hematopoietic cell transplantation (HCT), but there may be differences between different types of transplant recipients. These results suggest that advanced age may not be a risk factor for worse cognitive outcomes post-HCT, while younger allogeneic transplant recipients may be at risk for worse cognitive outcomes compared to younger autologous recipient counterparts.
BONE MARROW TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Cynthia Arslanian-Engoren, Bruno Giordani, Kinnothan Nelson, Debra K. Moser
Summary: This study evaluated the feasibility and acceptability of a nurse-led, virtual home-based cognitive training and self-care education intervention for patients with heart failure. Improvements in self-care were found to be related to cognitive changes, and the intervention also showed potential in reducing 30-day hospital readmission rates. Further testing of the modified intervention is recommended.
JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Surgery
Kyler Mulhauser, Evan L. Reynolds, Brian C. Callaghan, Cassandra Fierro, Bruno Giordani, Kristen Votruba
Summary: Extreme obesity is associated with cognitive deficits, particularly in executive functioning, processing speed, and learning. Abdominal obesity is linked to executive functioning deficits independently of common medical and psychiatric factors.
Article
Environmental Sciences
Allan K. Nkwata, Ming Zhang, Xiao Song, Bruno Giordani, Amara E. Ezeamama
Summary: The study found that discrimination, chronic stress, and low mastery were associated with worse cognition. The persistent cognitive disadvantage for African American individuals compared to White/Other races was only present among adults with high mastery, suggesting that adverse social experiences may counteract the cognitive benefits associated with mastery among African American populations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Deborah A. Levine, Alden L. Gross, Emily M. Briceno, Nicholas Tilton, Bruno J. Giordani, Jeremy B. Sussman, Rodney A. Hayward, James F. Burke, Stephanie Hingtgen, Mitchell S. V. Elkind, Jennifer J. Manly, Rebecca F. Gottesman, Darrell J. Gaskin, Stephen Sidney, Ralph L. Sacco, Sarah E. Tom, Clinton B. Wright, Kristine Yaffe, Andrzej T. Galecki
Summary: This study suggests that women may have better cognitive reserve but faster cognitive decline than men in global cognition, executive function, and memory, which could contribute to sex differences in late-life dementia.
Article
Infectious Diseases
A. E. Ezeamama, S. K. Zalwango, A. Sikorskii, R. Tuke, P. M. Musoke, B. Giordani, M. J. Boivin
Summary: The study aimed to quantify the association between in utero/peripartum antiretroviral (IPA) exposure and cognition, executive function (EF), and socioemotional adjustment (SEA) in school-aged Ugandan children. Different types of IPA exposure may have varying effects on cognitive development in children, with adjustments for caregiver sociodemographic and contextual factors based on the study findings.
Article
Health Care Sciences & Services
Deborah A. Levine, Andrzej T. Galecki, Brenda L. Plassman, Angela Fagerlin, Lauren P. Wallner, Kenneth M. Langa, Rachael T. Whitney, Brahmajee K. Nallamothu, Lewis B. Morgenstern, Bailey K. Reale, Emilie M. Blair, Bruno Giordani, Kathleen Anne Welsh-Bohmer, Mohammed U. Kabeto, Darin B. Zahuranec
Summary: The study found that patients with MCI do not have significantly different treatment preferences compared to patients with NC. Most MCI and NC patients desire life-sustaining treatment in their current health. After adjusting for factors, the difference in rejected treatments between MCI and NC patients was not statistically significant.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Pediatrics
Joseph Ikekwere, Valentine Ucheagwu, Itziar Familiar-Lopez, Alla Sikorskii, Jorem Awadu, Julius Caesar Ojuka, Deborah Givon, Cilly Shohet, Bruno Giordani, Michael J. Boivin
Summary: The study showed that early childhood development caregiver training improved attention in perinatally HIV-exposed/uninfected preschool-age children in rural Uganda. Both intervention groups made significant gains in sustained attention over the year-long intervention, with the MISC arm showing better results at 6 months.
JOURNAL OF PEDIATRICS
(2021)
Article
Clinical Neurology
Anson Kairys, Ana Daugherty, Voyko Kavcic, Sarah Shair, Carol Persad, Judith Heidebrink, Arijit Bhaumik, Bruno Giordani
Summary: This study examines the validity of computerized cognitive assessments in characterizing Alzheimer's disease in black adults. The results suggest that NIH Toolbox crystallized abilities may be more sensitive to diagnostic group differences, while deficits in memory and executive functioning tests also contribute to prediction.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Clinical Neurology
Deborah A. Levine, Andrzej T. Galecki, Lewis B. Morgenstern, Darin B. Zahuranec, Kenneth M. Langa, Mohammed U. Kabeto, Dolorence Okullo, Brahmajee K. Nallamothu, Bruno Giordani, Bailey K. Reale, Morgan Campbell, Lynda D. Lisabeth
Summary: Patients with preexisting mild cognitive impairment and dementia may receive less frequent certain treatments and procedures after acute ischemic stroke, but there is no significant difference in the composite quality measure compared to cognitively normal patients.