Article
Biochemistry & Molecular Biology
Taiga Seki, Yui Shimizu, Kyota Ishii, Yuzuki Takahama, Kazunori Kato, Tomohiro Yano
Summary: The study showed that NK cells can selectively target androgen-dependent prostate cancer stem-like cells via the TRAIL/DR5 pathway, providing a basis for developing strategies to eliminate prostate cancer stem cells.
Review
Pharmacology & Pharmacy
Daniel Westaby, Maria de Los Dolores Fenor de La Maza, Alec Paschalis, Juan M. Jimenez-Vacas, Jon Welti, Johann de Bono, Adam Sharp
Summary: In the last two decades, there has been significant progress in the treatment of advanced prostate cancer by targeting androgen and the androgen receptor (AR). However, drug resistance remains a challenge that needs to be addressed for the development of future therapeutic strategies.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ulrich Sommer, Tiziana Siciliano, Celina Ebersbach, Alicia-Marie K. Beier, Matthias B. Stope, Korinna Joehrens, Gustavo B. Baretton, Angelika Borkowetz, Christian Thomas, Holger H. H. Erb
Summary: PSMA protein plays an important role in the diagnosis and treatment of prostate cancer, and the activation and inhibition of androgen receptor (AR) can affect PSMA protein levels. This study found that AR activation and inhibition affect PSMA protein levels through a possible non-canonical mechanism, and low PSMA expression rates may be necessary to increase PSMA protein through androgen deprivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abilash Valsala Gopalakrishnan, Reshma Murali, Abhijit Dey, Balachandar Vellingiri, Raja Ganesan
Summary: Prostate cancer (PCa) is the leading cause of mortality in men, with unclear pathophysiological factors. PCa cells adopt abnormal lipid signaling and metabolism to gain protection. They modify metabolism in response to excessive nutrient intake, facilitating disease progression. Metabolic syndrome (MetS) is closely linked to carcinogenesis in PCa, exacerbating disease severity. Changes in mitochondrial metabolism are hypothesized to contribute to PCa onset. Examining the metabolome of prostate tissue can help study specific alterations in PCa progression. Additional epidemiological research is needed to determine the relationship between MetS and PCa due to inconsistent initial findings. Multiple risk factors, including MetS, are correlated with PCa progression. This review focuses on analyzing and evaluating metabolic changes in PCa, assessing the impact of metabolic abnormalities on disease aggressiveness and metabolism.
Article
Multidisciplinary Sciences
Lin Lei, Lijuan Yu, Weixiao Fan, Xiaoke Hao
Summary: This study reveals the significant role of small extracellular vesicles (sEVs) in the androgen-independent transformation of prostate cancer. By transferring the key sEVs molecule Let-7a-5p and activating the androgen receptor (AR) and PI3K/Akt signaling pathways, sEVs regulate the process. This finding provides new perspectives for targeted treatment approaches for AIPC patients.
Article
Biochemistry & Molecular Biology
Viviana M. Bimonte, Francesco Marampon, Ambra Antonioni, Simona Fittipaldi, Elisabetta Ferretti, Richard G. Pestell, Mariaignazia Curreli, Andrea Lenzi, Giovanni Vitale, Antonio Brunetti, Silvia Migliaccio, Antonio Aversa
Summary: The study demonstrates that TAD can significantly modulate AR expression and activity, Cyp19a1 and ER beta expression in PCa cells. In addition, TAD potentiates the antiproliferative activity of BCT, opening a new clinical scenario in the treatment of PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Katharina Wissmiller, Sara Bilekova, Andras Franko, Stefan Z. Lutz, Miriam Katsburg, Sebastian Gulde, Natalia S. Pellegata, Arnulf Stenzl, Martin Heni, Lucia Berti, Hans-Ulrich Haering, Heiko Lickert
Summary: The novel insulin/IGF1 signaling modulator inceptor has been found to play a crucial role in prostate cancer progression, with its expression positively correlated with certain genes involved in androgen signaling. In vitro experiments showed that inceptor expression was associated with androgen status, increased cell migration, and IGF1R signaling. These findings provide a basis for further investigation of inceptor in the context of prostate cancer.
MOLECULAR METABOLISM
(2023)
Review
Oncology
Marzieh Ehsani, Faith Oluwakemi David, Aria Baniahmad
Summary: Prostate cancer can develop resistance to hormone treatment and chemotherapy, mainly due to the androgen receptor (AR). There are genomic and non-genomic signaling bypass mechanisms that tumor cells may develop to escape therapy. As resistance progresses, tumors may evolve further adaptive pathways which lead to increased aggressiveness and metastatic ability.
Article
Pharmacology & Pharmacy
Lang Guo, Xiaowei Luo, Ping Yang, Yanting Zhang, Jialuo Huang, Hong Wang, Yinfeng Guo, Weifeng Huang, Zhiqiang Chen, Shusheng Wang, Junjian Wang, Jinping Lei, Songtao Xiang, Yonghong Liu
Summary: The Polycomb protein enhancer EZH2 plays a critical role in prostate cancer progression and drug resistance, making it a major obstacle in treatment. Enzalutamide is a common drug used for metastatic castration-resistant prostate cancer, but many tumors eventually develop resistance to it. Ilicicolin A (Ili-A) has shown potential to overcome resistance and enhance the anticancer activity of enzalutamide in CRPC cancer models.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Qin-Shu Li, Peng-Sheng Zheng
Summary: The ESRRB/SMAD7/MYC-positive feedback loop inhibits TGF beta signaling to activate cell-cycle progression and promote proliferation in cervical cancer, thereby driving tumor growth.
Review
Cell Biology
Qianyao Tang, Bo Cheng, Rongyang Dai, Ronghao Wang
Summary: Prostate cancer (PCa) is the second most lethal cancer for men in western countries, with androgen receptor (AR) playing a central role in its initiation and progression. The interactions between stromal cells and PCa epithelial cells, mediated by AR signaling, impact the growth and invasiveness of PCa cells. Androgen deprivation therapy (ADT) treatment can enhance the reciprocal interaction between stromal and epithelial cells, promoting cell invasion of PCa cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Bo Chen, Tianjiao Mao, Xiuni Qin, Wenqi Zhang, Nobumoto Watanabe, Jiang Li
Summary: This study identified novel biomarkers affecting the prognosis of DLBCL and identified STAT and KRAS pathways as potential growth regulatory pathways. These findings provide new avenues for the treatment of DLBCL patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Hiroki Ide, Hiroshi Miyamoto
Summary: This article summarizes the involvement of sex hormone receptors, such as androgen receptor, estrogen receptor-alpha, and estrogen receptor-beta, in the progression of urothelial cancer, focusing on their modulation for the efficacy of conventional therapy and discusses their potential to overcome therapeutic resistance.
Article
Biotechnology & Applied Microbiology
Jianjun Li, Chuan Xiong, Pan Xu, Qiang Luo, Ronggui Zhang
Summary: The study showed that Puerarin has significant inhibitory effects on androgen-independent prostate cancer cells, primarily through inducing apoptosis, increasing ROS and LDH production, and altering the levels of inflammatory cytokines. This antitumor activity is achieved by inactivating the Keap1/Nrf2/ARE signaling pathway.
Review
Endocrinology & Metabolism
Franck Mauvais-Jarvis, Carol A. Lange, Ellis R. Levin
Summary: Steroid hormones regulate physiological and disease processes through binding to receptors on the cell membrane and collaboration with receptors in the nucleus.
Article
Biochemistry & Molecular Biology
Joana Silva, Joana Santiago, Barbara Matos, Magda C. Henriques, Daniela Patricio, Ana D. Martins, Jose A. Duarte, Rita Ferreira, Marco G. Alves, Paula Oliveira, Pedro F. Oliveira, Margarida Fardilha
Summary: This study examined the effects of age and lifelong moderate-intensity exercise on rat testis. The results showed that aging is associated with testicular atrophy and alterations in stress response and mitochondrial biogenesis and function. Exercise did not protect against age-induced testicular atrophy and led to deleterious effects on sperm morphology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ana E. F. Ferreira, Joana Santiago, Joana V. V. Silva, Pedro E. F. Oliveira, Margarida Fardilha
Summary: This review provides an overview of the protein phosphorylation-dependent biochemical pathways underlying sperm motility acquisition and hyperactivation, as well as the research advances in PP inhibitors. Further research in this area, particularly using other PP inhibitors, is necessary due to the increasing cases of male infertility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Tania Lima, Joao Eduardo Rodrigues, Bruno Manadas, Rui Henrique, Margarida Fardilha, Rui Vitorino
Summary: This study reanalyzed a urine proteome dataset from prostate cancer patients and controls using a peptide-centric approach. Compared to the conventional protein-centric approach, the peptide analysis revealed more relevant information related to prostate cancer, highlighting the importance of peptide analysis in proteomics research.
JOURNAL OF PROTEOMICS
(2023)
Article
Obstetrics & Gynecology
Noemia A. P. Mariani, Joana Silva, Margarida Fardilha, Erick J. R. Silva
Summary: The high rates of unintended pregnancy and the growing world population pose significant challenges to countries. Expanding male contraceptive options is urgently needed to address these global challenges. Understanding the molecules involved in sperm motility can lead to the development of safe and effective male contraceptives. However, there are challenges in translating preclinical findings into clinical candidates.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Pharmacology & Pharmacy
Sarah Jones, Barbara Matos, Sarah Dennison, Margarida Fardilha, John Howl
Summary: The objective of this study was to bioengineer analogues of Djeya1 that can reduce the ability of stem cells to regenerate in decapitated planarian. Aib-substituted Djeya1 analogues showed delay in planarian head regeneration, indicating the potential use of bioportide technologies to manipulate stem cells in situ.
Article
Biochemistry & Molecular Biology
Magda Carvalho Henriques, Joana Santiago, Antonio Patricio, Maria Teresa Herdeiro, Susana Loureiro, Margarida Fardilha
Summary: Lifestyle choices significantly affect male fertility, as evidenced by the association between tobacco consumption, decreased semen quality, and increased levels of stress-related proteins in sperm cells.
Article
Biochemistry & Molecular Biology
Joana Santiago, Joana V. Silva, Manuel A. S. Santos, Margarida Fardilha
Summary: The trend of delaying parenthood is increasing, which has an impact on fertility and reproductive outcomes. Advanced paternal age (APA) has been linked to impaired testicular function, abnormal semen parameters, and poor reproductive and birth outcomes. This study aimed to investigate the effects of men's age on semen parameters and sperm microRNA profiles. The results suggest that although conventional semen parameters were not affected by men's age, alterations in microRNA regulation may occur and be responsible for poor fertility and reproductive outcomes associated with APA.
Review
Veterinary Sciences
Patricia Pinto-Pinho, Ana F. Ferreira, Rosario Pinto-Leite, Margarida Fardilha, Bruno Colaco, Inmaculada Parrilla Riera, Athina Basioura, Junwei Li
Summary: This review article provides an overview of current and future developments in rabbit sperm sexing technologies, as well as the implications and challenges of implementing these methods in the cuniculture industry.
VETERINARY SCIENCES
(2023)
Review
Veterinary Sciences
Patricia Pinto-Pinho, Maria de Lurdes Pinto, Jose Monteiro, Margarida Fardilha, Rosario Pinto-Leite, Bruno Colaco
Summary: Rabbit production is important in modern agriculture due to its potential as a sustainable source of high-quality protein. However, studies on feto-maternal monitoring in rabbits are uncommon. This review gathers research on factors affecting rabbit gestation and provides insights into the potential impacts on reproduction and maternal and fetal health.
VETERINARY SCIENCES
(2023)
Article
Education & Educational Research
Patricia Pinto-Pinho, Ana Ferreira, Barbara Matos, Joana Santiago, Magda Carvalho Henriques, Pedro Oliveira Corda, Tania Lima, Mario Rodrigues, Maria de Lourdes Pereira, Margarida Fardilha
Summary: The World Cafe method can enhance student engagement, foster knowledge-sharing, and improve collaborative work skills in biomedical education. Students prefer this method over traditional lectures, and the availability of modern facilities can increase their motivation to learn.
INNOVATIONS IN EDUCATION AND TEACHING INTERNATIONAL
(2023)
Review
Andrology
Pedro O. Corda, Jessica Moreira, John Howl, Pedro F. Oliveira, Margarida Fardilha, Joana Vieira Silva
Summary: Proteomics provides new opportunities for investigating the molecular mechanisms of male infertility. This study systematically compared the sperm proteome of normozoospermic and infertile men to identify potential protein markers for evaluating sperm quality. Several proteins related to male reproductive tissues, infertility phenotypes, or specific sperm functions were highlighted as potential targets for further research.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Oncology
Tania Lima, Catarina Macedo-Silva, Diana Felizardo, Joao Fraga, Isa Carneiro, Carmen Jeronimo, Rui Henrique, Margarida Fardilha, Rui Vitorino
Summary: Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. This study evaluated Gal-3 protein expression in tumor and normal prostate tissues and found decreased staining in tumor tissues compared with normal tissues. Furthermore, Gal-3 had no significant effect on survival and relapse in these PCa patients. This work confirms Gal-3 as a promising marker for PCa diagnosis.
Review
Medicine, Research & Experimental
Daniela Patricio, Joana Santiago, Joao F. Mano, Margarida Fardilha
Summary: This article provides an overview of organoid technology and its applications in healthcare and research, with a focus on male reproductive system organoids and other biomaterials. The article also discusses current applications and highlights the research gaps, challenges, and opportunities in the field.
WIRES MECHANISMS OF DISEASE
(2023)
Meeting Abstract
Obstetrics & Gynecology
J. Santiago, J. V. Silva, M. A. S. Santos, M. Fardilha
HUMAN REPRODUCTION
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
J. Santiago, J. V. Silva, M. A. S. Santos, M. Fardilha