Article
Cell Biology
Ekaterina Kiseleva, Olesya Serbina, Anna Karpukhina, Vincent Mouly, Yegor S. Vassetzky
Summary: Facioscapulohumeral muscular dystrophy (FSHD) is a genetic disease caused by the ectopic expression of the DUX4 gene in skeletal muscle, leading to muscle degeneration and replacement by fat and connective tissue. This study demonstrates that the interaction between FSHD myoblasts and MSCs plays a crucial role in the pathophysiology of FSHD, including stimulation of MSC migration, proliferation, and collagen secretion.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell & Tissue Engineering
Sung-Tai Wei, Yen-Chih Huang, Jung-Ying Chiang, Chia-Ching Lin, Yu-Jung Lin, Woei-Cherng Shyu, Hui-Chen Chen, Chia-Hung Hsieh
Summary: The study revealed that CXCR7 promotes the osteogenic and chondrogenic differentiation of MSCs and MSC-mediated immunomodulation by regulating multiple signaling pathways and anti-inflammatory soluble factors. MSCs with enhanced CXCR7 function significantly improved arthritic symptoms in a collagen-induced arthritis model.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Genetics & Heredity
Ameng Shi, Ting Wang, Miao Jia, Lei Dong, Haitao Shi
Summary: The study revealed that the SDF-1/CXCR7 axis is crucial in promoting migration, invasion, and EMT in gastric cancer cells, suggesting that targeting CXCR7 suppression could be a potential strategy for inhibiting gastric cancer metastasis.
FRONTIERS IN GENETICS
(2021)
Article
Pharmacology & Pharmacy
Isabel Hamshaw, Marco M. D. Cominetti, Wing-Yee Lai, Mark Searcey, Anja Mueller
Summary: Cancer metastasis is a major cause of cancer-related death. The CXCR4 receptor and its ligand CXCL12 play important roles in promoting metastasis, making them attractive therapeutic targets. In this study, a novel CXCR4 antagonist was developed and used for CXCR4-based imaging. The results showed that these antagonists were non-toxic and effectively inhibited cancer cell migration and calcium release.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Li Ling, Jiying Hou, Dandan Liu, Dongyuan Tang, Yanqin Zhang, Qianru Zeng, Heng Pan, Ling Fan
Summary: The SDF-1/CXCR4 axis partially mediates the migration and homing of systemically transplanted hAD-MSCs to the ovaries of rats with chemotherapy-induced POI, and the PI3K/Akt signaling pathway might be involved in the migration and homing of hAD-MSCs mediated by the SDF-1/CXCR4 axis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Zheng-Yu Liu, Qiu-Xia Yang, Yan Cao, Hong-Wei Pan, Jing-Jing Rong, Jing Ling, Yi Tang, Jin He, Chang-Lu Wang, Xiang Peng, Qiong-Chao Zou, Le Zhang, Jiao Zheng, Jia Wang, Yu Zhang, Jian-Qiang Peng, Lan-Bing Xiong, Feng Liu, Zi-Hui Ying, Zhao-Fen Zheng, Bai-Ling Zhang
Summary: The study investigates the regulatory mechanism of CXCR4 on BM-EPCs under hypoxic conditions through the PI3K/Akt signaling pathway. CXCR4 promotes proliferation and migration, and inhibits apoptosis in BM-EPCs, while upregulating the expression of PI3K and Akt. Inhibitors of PI3K and CXCR4 effectively suppress the proliferation, migration, and resistance to apoptosis of CXCR4-mediated BM-EPCs under hypoxia.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Nataliya Petinati, Irina Shipounova, Natalia Sats, Alena Dorofeeva, Alexandra Sadovskaya, Nikolay Kapranov, Yulia Tkachuk, Anatoliy Bondarenko, Margarita Muravskaya, Michail Kotsky, Irina Kaplanskaya, Tamara Vasilieva, Nina Drize
Summary: This article investigates the properties of BM-MSCs before and after implantation under the renal capsule in a mini pig model. It is found that the implants formed ectopic foci containing bones, ectopic hematopoiesis, bone marrow stromal cells, and muscle cells. The cells that migrated out from these implants meet the criteria for MSCs and are designated as IM-MSCs.
Article
Cell & Tissue Engineering
Songjiao Zhao, Xichen Wan, Yiqin Dai, Lan Gong, Qihua Le
Summary: This study found that WNT16B enhances the proliferation and self-renewal of LECs through the CXCR4/MEK/ERK signaling pathway and promotes corneal epithelial wound healing.
Article
Multidisciplinary Sciences
Eva M. Garcia-Cuesta, Jose Miguel Rodriguez-Frade, Sofia R. Gardeta, Gianluca D'Agostino, Pablo Martinez, Blanca Soler Palacios, Graciela Cascio, Tobias Wolf, Nicolas Mateos, Rosa Ayala-Bueno, Cesar A. Santiago, Pilar Lucas, Lucia Llorente, Luis M. Allende, Luis Ignacio Gonzalez-Granado, Noa Martin-Cofreces, Pedro Roda-Navarro, Federica Sallusto, Francisco Sanchez-Madrid, Maria F. Garcia-Parajo, Laura Martinez-Munoz, Mario Mellado
Summary: This study reveals that the truncated mutant chemokine receptor CXCR4(R334X) associated with WHIM syndrome fails to nanoclusterize after CXCL12 stimulation, affecting cell spatial organization and mobility, and causing multiple phalloidin-positive protrusions in cells. The inappropriate activation of beta-arrestin1 by CXCR4(R334X) leads to inadequate actin cytoskeleton remodeling, disrupting the balance between activated and deactivated cofilin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera
Summary: The role of the chemokine SDF-1 and its receptor CXCR4 in pituitary gland development was investigated. The expression patterns of CXCR4, SDF-1, and CXCR7 were characterized, and it was found that SDF-1 is expressed in progenitor-rich regions of the pituitary gland. Conditional deletion of CXCR4 in embryonic pituitary progenitors did not lead to observable defects, suggesting that CXCR4 expression in HESX1+ cells and their descendants is not essential for normal pituitary development in mice.
Article
Cell & Tissue Engineering
Rosario Hervas-Salcedo, Maria Fernandez-Garcia, Miriam Hernando-Rodriguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano Garcia-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodriguez de Alba, Damian Garcia-Olmo, Carmen Ayuso, Maria Luisa Lamana, Juan A. Bueren, Rosa Maria Yanez
Summary: The transient co-expression of CXCR4 and IL10 enhances the therapeutic potential of MSCs in a local inflammation mouse model, indicating that mRNA-modified cells may be a new step towards more efficient cell therapies for inflammatory diseases.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Shlomo Elias, Rahul Sharma, Michael Schizas, Izabella Valdez, Sham Rampersaud, Sun-Mi Park, Paula Gonzalez-Figueroa, Quan-Zhen Li, Beatrice Hoyos, Alexander Y. Rudensky
Summary: Regulatory T cells control autoreactive B cells in the bone marrow in a CXCR4-dependent manner, affecting their ability to produce antibodies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Shreya Udani, Justin Langerman, Doyeon Koo, Sevana Baghdasarian, Brian Cheng, Simran Kang, Citradewi Soemardy, Joseph de Rutte, Kathrin Plath, Dino Di Carlo
Summary: By developing secretion-encoded single-cell sequencing (SEC-seq) method, the authors simultaneously measured the secretion and transcriptome for thousands of cells, and found heterogeneity in the secretion of vascular endothelial growth factor A (VEGF-A) within the cell population, which is poorly correlated with the VEGFA transcript level. Enrichment of a specific cell subpopulation characterized by a unique gene expression signature enabled the identification of gene signatures linked to specific secretory states. SEC-seq facilitates mechanistic studies and the development of means to modulate cellular secretion.
NATURE NANOTECHNOLOGY
(2023)
Article
Polymer Science
Xing-Ran Yan, Juan Li, Xiang-Ming Na, Tong Li, Yu-Fei Xia, Wei-Qing Zhou, Guang-Hui Ma
Summary: Mesenchymal stem cells (MSCs) are an important source of cells for regenerative medicine, but their clinical application is influenced by the rigidity of microcarriers. This study achieved rapid proliferation and good differentiation potential maintenance of MSCs by regulating the rigidity of Konjac glucomannan (KGM) microcarriers.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Oncology
Xianxian Wu, Hongdian Zhang, Zhilin Sui, Yongyin Gao, Lei Gong, Chuangui Chen, Zhao Ma, Peng Tang, Zhentao Yu
Summary: CXCR4, a member of the CXC chemokine receptor family, plays a crucial role in esophageal squamous cell carcinoma (ESCC) by promoting cancer cell proliferation, migration, invasion, and survival. HIF-1α transcriptionally regulates CXCR4 expression, indicating the potential of CXCR4 as a therapeutic target for ESCC.
Article
Pharmacology & Pharmacy
Rulin Xu, Anping Cai, Dongdan Zheng, Ruofeng Qiu, Liwen Li, Yingling Zhou, Yingqing Feng, Weiyi Mai
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2016)
Article
Biochemistry & Molecular Biology
Dongdan Zheng, Qing Liang, FanFang Zeng, Zhuocheng Mai, Anping Cai, Ruofeng Qiu, Rulin Xu, Dongjuan Li, Weiyi Mai
LIPIDS IN HEALTH AND DISEASE
(2015)
Article
Biochemical Research Methods
Zhongping Huang, Ruofeng Qiu, Tingfei Liu, Yilei Huang, Zuoyi Zhu, Lili Wang
JOURNAL OF CHROMATOGRAPHY A
(2016)
Article
Engineering, Civil
Yi Pan, Cuiping Kuang, Jiabo Zhang, Yongping Chen, Xiaodan Mao, Yue Ma, Yu Zhang, Yanxiong Yang, Ruofeng Qiu
JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
(2017)
Article
Engineering, Civil
Yi Pan, Cuiping Kuang, Jiabo Zhang, Yongping Chen, Xiaodan Mao, Yue Ma, Yu Zhang, Yanxiong Yang, Ruofeng Qiu
JOURNAL OF WATERWAY PORT COASTAL AND OCEAN ENGINEERING
(2017)
Article
Biochemical Research Methods
Zhongping Huang, Ruofeng Qiu, Yilei Huang, Huijun Liu, Zaifa Pan, Lili Wang
Article
Biotechnology & Applied Microbiology
Anping Cai, Dongdan Zheng, Ruofeng Qiu, Weiyi Mai, Yingling Zhou
Article
Environmental Sciences
Yi Pan, Cuiping Kuang, Jie Gu, Lulu He, Yu Zhang, Yanxiong Yang, Ruofeng Qiu, Jiabo Zhang
JOURNAL OF COASTAL RESEARCH
(2014)
Article
Environmental Sciences
Cuiping Kuang, Lulu He, Jie Gu, Yi Pan, Yu Zhang, Yanxiong Yang, Ruofeng Qiu, Jiabo Zhang
JOURNAL OF COASTAL RESEARCH
(2014)
Article
Biochemistry & Molecular Biology
Dongdan Zheng, FanFang Zeng, Anping Cai, Huocheng Liao, Ling Liu, Ruofeng Qiu, Rulin Xu, Chun Xiao, Weiyi Mai
LIPIDS IN HEALTH AND DISEASE
(2014)
Article
Multidisciplinary Sciences
Anping Cai, Ruofeng Qiu, Liwen Li, Dongdan Zheng, Yugang Dong, Danqing Yu, Yuli Huang, Shaoqi Rao, Yingling Zhou, Weiyi Mai
Article
Oceanography
Cuiping Kuang, Xiaodan Mao, Jie Gu, Haibo Niu, Yue Ma, Yanxiong Yang, Ruofeng Qiu, Jiabo Zhang
OCEAN & COASTAL MANAGEMENT
(2019)
Article
Engineering, Chemical
Tao Liu, Kaiwen Xia, Yuanjin Zheng, Yanxiong Yang, Ruofeng Qiu, Yunfei Qi, Chao Liu
Summary: This paper investigates the constrained inverse problem based on the nonlinear convection-diffusion equation in multiphase porous media flow, introducing a widely convergent homotopy method to solve it. Two numerical examples demonstrate the method's wide convergence region and strong anti-noise ability.
Article
Cell Biology
Ruofeng Qiu, Anping Cai, Yugang Dong, Yingling Zhou, Danqing Yu, Yuli Huang, Dongdan Zheng, Shaoqi Rao, Yingqing Feng, Weiyi Mai
JOURNAL OF BIOMEDICAL SCIENCE
(2012)