Article
Cell Biology
Elvina Valatkaite, Raminta Bausyte, Aida Vitkeviciene, Diana Ramasauskaite, Ruta Navakauskiene
Summary: Our study investigated the characteristics and decidualization potential of hEndSCs isolated from endometrium and menstrual blood. The expression of mesenchymal stromal cell markers remained stable after long-term cultivation, and decidualization markers were upregulated in induced hEndSCs. These findings suggest that endometrium and menstrual blood derived stem cells have potential for tissue regeneration and therapy for reproductive system disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giedre Skliute, Raminta Bausyte, Veronika Borutinskaite, Giedre Valiuliene, Algirdas Kaupinis, Mindaugas Valius, Diana Ramasauskaite, Ruta Navakauskiene
Summary: The study found that menstrual blood stem cells have good proliferation and regenerative abilities, can perform decidualization through differentiation into epithelial cells, and express genes related to decidualization and angiogenesis, demonstrating the potential for treating reproductive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lingrui Shang, Ruiyun Zhang, Jiaxing Yan, Yilin Lu, Shenghui Zhang, Yuliang Sun, Hongbin Cheng, Yanli Liu, Juntang Lin
Summary: This study explores the suitable period for sustainable MenSC-CM preparation and confirms the improvement of MenSC-CM on promoting cell viability and skin wound healing.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Han Li, Jinghui Wei, Zhigang Zhang, Junyao Li, Yaokai Ma, Ping Zhang, Juntang Lin
Summary: This study aimed to investigate the inhibitory effect of MenSCs on neuroinflammation in PD rats by regulating M1/M2 polarization and to explore the underlying mechanisms. The results showed that MenSCs could suppress microglia cell activation and decrease inflammation in vitro. After transplantation into PD rats, MenSCs improved motor function, reduced dopaminergic neuron loss, and down-regulated pro-inflammatory factors. Moreover, protein array and bioinformatic analysis revealed the biological processes and signal pathways involved in the factors secreted by MenSCs.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Endocrinology & Metabolism
Rongli Wang, Wei Wang, Lijun Wang, Linnan Yuan, Feiyan Cheng, Xin Guan, Nini Zheng, Xinyuan Yang
Summary: The study demonstrates that MenSCs can improve the function of injured granulosa cells by increasing the expression of FTO, and the expression level of FTO in the ovaries of POF mice can affect the proliferation and apoptosis of injured cells by either overexpressing or down-regulating FTO.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Cell & Tissue Engineering
Colleen M. Miller, Elizabeth Ann L. Enninga, Skylar A. Rizzo, Jordan Phillipps, Hugo Guerrero-Cazares, Christopher C. Destephano, Timothy E. Peterson, Paul G. Stalboerger, Atta Behfar, Zaraq Khan
Summary: The study found that a platelet-derived purified exosome product (PEP) can be absorbed by various types of endometrial cells. PEP treatment can increase cell proliferation and wound healing capacity.
REGENERATIVE MEDICINE
(2022)
Article
Immunology
Fen Zhang, Linxiao Fan, Qiuhong Liu, Shima Tang, Sainan Zhang, Lanlan Xiao, Lingjian Zhang, Qian Li, Nueraili Maihemuti, Lanjuan Li
Summary: MenSCs treatment can alleviate autoimmune hepatitis by inhibiting macrophages and M1 polarization in the liver tissue.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
Yaping Shi, Yunfei Liu, Bichao Zhang, Xiaoying Li, Juntang Lin, Ciqing Yang
Summary: Spinal cord injury (SCI) is a challenging condition to repair due to the difficulty of regenerating damaged neurons. However, recent studies have shown that stem cell therapy, specifically using human menstrual blood-derived endometrial stem cells (MenSCs), can improve functional recovery after SCI. This study demonstrated that MenSC transplantation accelerated neuronal recovery, inhibited glial cell and microglial activation, reduced inflammatory factor expression, and improved the inflammatory microenvironment, leading to functional recovery of SCI.
CELL TRANSPLANTATION
(2023)
Review
Health Care Sciences & Services
David M. Z. B. Hennes, Anna Rosamilia, Jerome A. Werkmeister, Caroline E. Gargett, Shayanti Mukherjee
Summary: Endometrial mesenchymal stem/progenitor cells (eMSC) show potential for applications in treating chronic and degenerative human diseases, with less invasive extraction methods and improved potency and proliferative capacity. They are particularly useful for pelvic organ prolapse treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell & Tissue Engineering
Nouri Arezoo, Hajian Mohammad, Monsefi Malihezaman
Summary: This study demonstrates the potential of uterine decellularized scaffolds as a natural niche for MenSCs differentiation. The preserved ECM and successful differentiation of MenSCs to epithelial and smooth muscle tissues in the decellularized uterus show promise for cell transplantation and tissue engineering. The use of MenSCs in uterine tissue engineering is a promising approach for curing female infertility.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Medicinal
Antonia Navarro, Maria Victoria Bariani, Hang-Soo Park, Ami R. Zota, Ayman Al-Hendy
Summary: Uterine leiomyomas are common pelvic tumors in women of reproductive age and their pathophysiology is not well understood. This study found that exosomes derived from uterine leiomyoma tumor cells can promote proliferation and angiogenesis of endometrial microvascular endothelial cells. These findings may contribute to the identification of novel biomarkers for the treatment of uterine leiomyomas.
Article
Cell Biology
Pandi Saranya, Madhu Shekhar, Aravind Haripriya, Veerappan Muthukkaruppan, Chidambaranathan Gowri Priya
Summary: This study identified and functionally characterized adult stem cells in the human lens epithelium, and revealed their potential association with cataract development.
Article
Reproductive Biology
Ali Sarhadi Roodbari, Somayeh Solhjoo, Maria Grazia Palmerini, Mahna Mansouri, Massood Ezzatabadipour
Summary: This study aimed to investigate the effects of human menstrual blood-derived stem cells (MenSCs) on the ovarian histology of a polycystic ovary syndrome (PCOS) model of Wistar rats. The results showed that MenSCs treatment improved folliculogenesis in PCOS rats and ameliorated PCOS symptoms by improving fibrosis, angiogenesis, and weight gain.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Mariana Robalo Cordeiro, Carlota Anjinho Carvalhos, Margarida Figueiredo-Dias
Summary: The human endometrium contains stem cells called menstrual blood-derived stem cells (MenSC) that have the potential to play a critical role in the development and maintenance of endometriosis. These cells have been studied as biomarkers for the early diagnosis of endometriosis and for the development of targeted therapies. However, further research is needed to ensure their long-term safety and effectiveness before they can be widely implemented in the management of this complex disease.
Article
Health Care Sciences & Services
Alisa Domnina, Larisa Alekseenko, Irina Kozhukharova, Olga Lyublinskaya, Mariia Shorokhova, Valeriy Zenin, Irina Fridlyanskaya, Nikolay Nikolsky
Summary: Formation of multicellular aggregates known as spheroids from eMSCs enhances tissue repair capabilities, showing higher therapeutic potency compared to monolayer eMSC culture.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
