期刊
PROTEOMICS CLINICAL APPLICATIONS
卷 10, 期 4, 页码 516-531出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.201500081
关键词
Biomarkers; Cancer; Mass spectrometry; Oncoproteomics; Personalized medicine; Protein micropurification
资金
- National 973 Basic Research Program of China [2013CB911300]
- Chinese NSFC [81225015, 81430071, 31201045]
- Sichuan Science-Technology Innovative Research Team for Young Scientist [2013TD0001]
Oncoproteomics is the study of cancer-associated proteins and their interactions using proteomic technologies. It is expected to play a crucial role in the detection and surveillance of cancer, as well as in the development of personalized medicine for oncology. In this review, we will outline the current status, advantages, and limitations of oncoproteomics. Further, we will discuss available strategies arising from a better understanding of oncoproteomics, including integrated omics approaches, to overcome current problems in the discovery and validation of biomarkers, identification of novel drug targets, and management of personalized medicine.
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