期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 9, 期 9, 页码 701-706出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B0820090
关键词
arylamine N-acetyltransferases (NATs); apoptosis; HepG2; camptothecin (CAM)
类别
资金
- National Natural Science Foundation of China [30400591]
- Science Foundation of Heilongjiang Province, China [D2004-13, D200505]
- Young Scientist Fund of Harbin City, China [2004AFQXJ035]
Objective: To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis. Methods: NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry. Results: NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells. Conclusion: NAT can inhibit apoptosis in HepG2 cells.
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