期刊
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
卷 9, 期 2, 页码 90-92出版社
ZHEJIANG UNIV
DOI: 10.1631/jzus.B0710621
关键词
mitochondria; mitochondrial disorder; mutation
The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.
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