Article
Oncology
Katie M. O'Brien, Quaker E. Harmon, Chandra L. Jackson, Mary Diaz-Santana, Jack A. Taylor, Clarice R. Weinberg, Dale P. Sandler
Summary: This study found that women with higher circulating 25-hydroxyvitamin D (25(OH)D) concentrations had a lower risk of breast cancer, especially among Hispanic/Latina women. The association was weaker among Black/African American women. There was no clear association between 24,25-dihydroxyvitamin D (24,25(OH)2D) and breast cancer risk.
Article
Nutrition & Dietetics
Nirmala Sannappa G. Gowda, Varsha D. Shiragannavar, Lakshana D. Puttahanumantharayappa, Ashwini Tumkur Shivakumar, Siva Dallavalasa, Chaithanya G. Basavaraju, Smitha S. Bhat, Shashanka K. Prasad, Ravishankar M. Vamadevaiah, SubbaRao V. Madhunapantula, Prasanna K. Santhekadur
Summary: This study aimed to explore the hepatoprotective role of quercetin on breast cancer associated hepatic inflammation and fibrosis through the activation of Vitamin D receptor (VDR). In vivo experiments using mouse mammary carcinoma model and in vitro assays using human breast cancer cell lines were conducted. Results demonstrated that quercetin reduced tumor volume, liver enzymes activity, hepatic inflammation, and fibrosis. Furthermore, docking study confirmed the interaction between quercetin and VDR, and in vitro assays revealed the Vitamin D mimicking effect of quercetin. Therefore, quercetin could be a promising therapeutic drug for breast cancer treatment.
FRONTIERS IN NUTRITION
(2023)
Article
Oncology
Gary Hardiman, Stephen J. Savage, E. Starr Hazard, Willian A. da Silveira, Rebecca Morgan, Adam Harris, Melanie S. Jefferson, Robert C. Wilson, Susan Caulder, Linda Ambrose, Lewis Frey, Bethany Wolf, Sebastiano Gattoni-Celli, Chanita Hughes Halbert
Summary: Men of African origin have a higher likelihood of developing and dying from prostate cancer compared to men of European origin, with specific gene expression differences and clinical characteristics. This study identified a gene expression signature that separates African American men with the most severe clinical features, linking to elevated Gleason scores and vitamin D deficiency. Protein-protein interaction network analysis revealed a high degree of connectivity within genes associated with racial differences.
Article
Biochemistry & Molecular Biology
Anindita Ravindran, Danthasinghe Waduge Badrajee Piyarathna, Jie Gohlke, Vasanta Putluri, Tanu Soni, Stacy Lloyd, Patricia Castro, Subramaniam Pennathur, Jeffrey A. Jones, Michael Ittmann, Nagireddy Putluri, George Michailidis, Thekkelnaycke M. Rajendiran, Arun Sreekumar
Summary: African-American men are more likely to die of prostate cancer than European American men. This study reveals the association between lipid metabolic pathway alterations and prostate cancer disparities, as well as specific lipid changes associated with early biochemical recurrence.
Review
Oncology
Claire Stevens, Alexandria Hightower, Sarah G. Buxbaum, Sara M. Falzarano, Suhn K. Rhie
Summary: Prostate cancer is the second most common cancer in men in the United States, and racial disparities are greatly observed in the disease. In order to narrow the gap between clinical outcomes for African American and European American prostate cancer patients, genetic and molecular signatures contributing to this disparity have been characterized.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Farnaz Aghazadeh Shabestari, Saba Vaezi, Atefe Abak, Hamed Shoorei, Arash Karimi, Mohammad Taheri, Abbas Basiri
Summary: Quercetin is a flavonoid agent found in fruits and vegetables, known for its anti-inflammatory, antioxidant, and anticancer effects, specifically targeting prostate cancer. It can inhibit cell cycle transition and induce apoptosis in neoplastic cells, showing differential cytotoxic effects on cancerous cells compared to normal prostate cells. Moreover, quercetin may enhance the effects of other therapeutic options against prostate cancer, such as in combination with TRAIL as a novel modality for treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Margaret S. Pichardo, Tsion Zewdu Minas, Catherine M. Pichardo, Maeve Bailey-Whyte, Wei Tang, Tiffany H. Dorsey, William Wooten, Brid M. Ryan, Christopher A. Loffredo, Stefan Ambs
Summary: This study found that African American men living in deprived neighborhoods have a higher risk of prostate cancer and related mortality, potentially due to their systemic immune function and inflammation levels.
Article
Oncology
Fei Ye, Xiaoxia Han, Yonzhao Shao, Jingzhi Lo, Fengxia Zhang, Jinhua Wang, Jonathan Melamed, Fang-Ming Deng, Karen S. Sfanos, Angelo De Marzo, Guoping Ren, Dongwen Wang, David Zhang, Peng Lee
Summary: This study identifies differential expression of Aurora, Cyclin D1, and HNF-3a proteins between African American and Caucasian prostate cancer tissue. These proteins may be involved in different pathways leading to aggressive prostate cancer behavior in African American patients and could potentially serve as biomarkers for prostate cancer racial disparity.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin Kensler, Amparo Serna, Adriana Vidal, Sungyong You, Michael R. Freeman, Elai Davicioni, Yang Liu, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Bruce J. Trock, Joshua D. Campbell, David J. Einstein, Raavi Gupta, Steven Balk, Priti Lal, Jong Y. Park, John L. Cleveland, Timothy R. Rebbeck, Stephen J. Freedland, Kosj Yamoah
Summary: Prostate tumors in African American men exhibit a unique immune profile with significant enrichment in proinflammatory immune pathways. The tumor microenvironment of African American men shows higher immune content compared to European American men, as well as lower DNA damage repair and increased genomic radiosensitivity. Overexpression of proinflammatory genes in African American men, such as IFITM3, is associated with higher risk of biochemical recurrence and poorer outcomes.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Hein Vincent Stroomberg, Fie Juhl Vojdeman, Christian Medom Madsen, John Thomas Helgstrand, Peter Schwarz, Anne-Marie Heegaard, Anja Olsen, Anne Tjonneland, Bent Struer Lind, Klaus Brasso, Henrik Lovendahl Jorgensen, Martin Andreas Roder
Summary: The study found no association between serum vitamin D levels and the risk of PCa diagnosis, but men with PCa and serum vitamin D deficiency had higher overall and PCa-specific mortality rates compared to those with sufficient levels of serum vitamin D.
Article
Biology
Walter Rayford, Alp Tuna Beksac, Jordan Alger, Mohammed Alshalalfa, Mohsen Ahmed, Irtaza Khan, Ugo G. Falagario, Yang Liu, Elai Davicioni, Daniel E. Spratt, Edward M. Schaeffer, Felix Y. Feng, Brandon Mahal, Paul L. Nguyen, Robert B. Den, Mark D. Greenberger, Randy Bradley, Justin M. Watson, Matthew Beamer, Lambros Stamatakis, Darrell J. Carmen, Shivanshu Awasthi, Jonathan Hwang, Rachel Weil, Harri Merisaari, Nihal Mohamed, Leslie A. Deane, Dimple Chakravarty, Kamlesh K. Yadav, Kosj Yamoah, Sujit S. Nair, Ashutosh K. Tewari
Summary: Racial disparities in prostate cancer were investigated in a multi-institutional retrospective analysis of African-American and European-American men who underwent radical prostatectomy. Differences were found in gene expression with African-American men showing higher expression of inflammation genes and lower expression of mismatch repair genes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Xiaoyin Li, Siddhartha Roy, Jennifer Damonte, Hyun Y. Park, Aasha I. Hoogland, Kala Jamison, Khaled R. Komrokji, Chang Dong Yeo, Youngchul Kim, Jasreman Dhillon, Lisa M. Gudenkauf, Laura B. Oswald, Heather S. L. Jim, Kosj Yamoah, Julio M. Pow-Sang, Peter A. Kanetsky, Clement K. Gwede, Jong Y. Park, Brian D. Gonzalez
Summary: This study aimed to establish a state-wide biobank of African American prostate cancer survivors in Florida to identify biological bases for health disparities. African American men diagnosed with prostate cancer between 2013 and 2017 were identified through the State of Florida's cancer registry. Of the eligible and reachable individuals, a low overall consent rate of 10% was observed. Existing challenges limit the consent and participation in biospecimen research.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Multidisciplinary Sciences
Weerachai Jaratlerdsiri, Jue Jiang, Tingting Gong, Sean M. Patrick, Cali Willet, Tracy Chew, Ruth J. Lyons, Anne-Maree Haynes, Gabriela Pasqualim, Melanie Louw, James G. Kench, Raymond Campbell, Lisa G. Horvath, Eva K. F. Chan, David C. Wedge, Rosemarie Sadsad, Ilma Simoni Brum, Shingai B. A. Mutambirwa, Phillip D. Stricker, M. S. Riana Bornman, Vanessa M. Hayes
Summary: Prostate cancer shows significant geo-ethnic disparity, with African ancestry being a major risk factor. Whole-genome sequencing revealed specific somatic variants and mutational subtypes associated with African ancestry, providing insights into the differences in evolutionary trajectories and mutational processes between ethnic groups.
Article
Oncology
P. Travis Courtney, Rishi Deka, Nikhil Kotha, Daniel R. Cherry, Mia A. Salans, Tyler J. Nelson, Abhishek Kumar, Elaine Luterstein, Anthony T. Yip, Vinit Nalawade, J. Kellogg Parsons, A. Karim Kader, Tyler F. Stewart, Brent S. Rose
Summary: Outcomes were similar for African American and White men treated for low-intermediate-risk prostate cancer with active surveillance in the Veterans Affairs Health System.
Article
Oncology
Ravi B. Parikh, Joseph J. Gallo, Yu-Ning Wong, Kyle W. Robinson, John P. Cashy, Vivek Narayan, Ravishankar Jayadevappa, Sumedha Chhatre
Summary: The study examined the incidence and management of depression among African American and White veterans diagnosed with localized prostate cancer, finding that incident depression is associated with higher mortality rates, especially among African American men. African American veterans were more likely to be diagnosed with depression and less likely to be prescribed antidepressants compared to White veterans, highlighting disparities in outcomes.
Article
Materials Science, Multidisciplinary
Kun-Li Wang, I-Hao Shih, Sheng-Tung Huang, Hsin-Luen Tsai
ORGANIC ELECTRONICS
(2015)
Article
Thermodynamics
Huan-Liang Tsai, Phuong Truong Le
ENERGY CONVERSION AND MANAGEMENT
(2016)
Article
Energy & Fuels
Phuong Truong Le, Huan-Liang Tsai, Thanh Hien Lam
Article
Materials Science, Multidisciplinary
A. K. Chu, W. C. Tien, S. W. Lai, H. L. Tsai, R. Y. Bai, X. Z. Lin, L. Y. Chen
ORGANIC ELECTRONICS
(2017)
Article
Energy & Fuels
Le Phuong Truong, Hoang An Quoc, Huan-Liang Tsai, Do Van Dung
Article
Chemistry, Analytical
Jen-Yung Lin, Huan-Liang Tsai, Wen-Chi Sang
Article
Chemistry, Analytical
Jen-Yung Lin, Huan-Liang Tsai, Wei-Hong Lyu
Summary: Water temperature, pH, dissolved oxygen (DO), electrical conductivity (EC), and salinity levels are critical factors for freshwater aquaculture. This study proposed a wireless multi-sensor system integrating sensors with an ESP32 Wi-Fi module to monitor water quality and display information on the ThingSpeak IoT platform. The system showed sufficient accuracy, reliability and tolerance for water quality monitoring.
Article
Energy & Fuels
Huan-Liang Tsai, Le Phuong Truong, Wei-Hung Hsieh
Summary: This paper presents the development of a wireless AC power monitoring module for the proposed AC power monitoring IoT system. The module integrates voltage and current sensors, an analog-to-digital converter, and a Wi-Fi module for data transmission. The AC power parameters are calculated and sent to the ThingSpeak IoT platform for visualization. The module is cost-effective and has shown close agreement and confidence with commercial AC power meters.
Article
Chemistry, Analytical
Phuong-Truong Le, Huan-Liang Tsai, Phuong-Long Le
Summary: This paper presents a photovoltaic (PV) evaluation and fault detection (PVEFD) system for PV applications based on IoT technology. The system utilizes an STM32F103C8T6 chip with a 32-bit Arm Cortex-M3 RISC and 12-bit resolution ADC for measuring important parameters of PV applications. The measured data is then fed into a PV model for HIL simulation and transmitted to a cloud server for remote monitoring and automatic warning. The study demonstrates the system's high accuracy and validation of fault detection in PV systems.
Proceedings Paper
Automation & Control Systems
Yu-Lung Hsu, Huan-Liang Tsai, Guan-Hua Lu
Summary: This paper presents a wireless multi-sensor module for monitoring the environment of smart manufacturing workplace. The module integrates various sensors and a WiFi module, and transmits the sensor observations to an IoT platform via a WiFi network.
2022 61ST ANNUAL CONFERENCE OF THE SOCIETY OF INSTRUMENT AND CONTROL ENGINEERS (SICE)
(2022)
Article
Communication
Hsin-Luen Tsai, Jia-Fen Wu
Proceedings Paper
Automation & Control Systems
Phuong Truong Le, Hoang An Quoc, Ngo Van Thuyen, Huan-Liang Tsai
PROCEEDINGS OF 2019 INTERNATIONAL CONFERENCE ON SYSTEM SCIENCE AND ENGINEERING (ICSSE)
(2019)
Proceedings Paper
Green & Sustainable Science & Technology
Jen-Yung Lin, Chia-Chung Hsu, Huan-Liang Tsai
2018 4TH INTERNATIONAL CONFERENCE ON GREEN MATERIALS AND ENVIRONMENTAL ENGINEERING (GMEE 2018)
(2018)
Proceedings Paper
Automation & Control Systems
Jen-Yung Lin, Chia-Chung Hsu, Huan-Liang Tsai
2018 INTERNATIONAL AUTOMATIC CONTROL CONFERENCE (CACS)
(2018)