期刊
PROGRESS IN POLYMER SCIENCE
卷 48, 期 -, 页码 111-121出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2015.03.001
关键词
Thermosensitivity; LCST; Non-fouling; Bio-conjugate; PEGylation; pOEGMA
资金
- Chinese Scholarship Council (CSC)
- Sassella foundation
Poly(oligo(ethylene glycol) methyl ether methacrylate) (pOEGMA) is a highly versatile polymer because manipulation of the dimensions of its comb-type structure has a predictable effect on the conformation of its main-chain and side-chains which can, together or independently, be either extended or collapsed. This control, and the distinctive physical-chemical characteristics of pOEGMA, are the common driving forces behind its tunable thermosensitivity properties, supramolecular assembly characteristics, and efficient protein repellency. Because of these interesting properties, pOEGMA is increasingly being used within functional coatings, biosensors, drug delivery systems, biomaterials, etc. This Trend article highlights the how to control (and factors influencing) pOEGMA main/side-chain conformations, and consequently exploit this polymer in several emerging areas of importance. This discussion integrates all current areas of application (i.e., in solution, within complex (bio)conjugates, and grafted to solids), in order to provide a common and general perspective on how this polymer can be most efficiently used in future applications. (C) 2015 Elsevier Ltd. All rights reserved.
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