Article
Multidisciplinary Sciences
Elizabeth B. Draganova, Ekaterina E. Heldwein
Summary: Herpesviruses infect a majority of the human population, establishing lifelong latent infections with no cure, and periodic viral reactivation spreads infection while causing disease states that are particularly harmful in the immunocompromised. The viral replication and spread of infection rely on the nuclear egress complex (NEC), which helps translocate viral capsids and mature them into infectious virions. Peptides derived from the UL25 capsid protein have been shown to inhibit the membrane-budding activity of the NEC, providing a potential new avenue for developing inhibitors against herpesvirus replication.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Xueqi Li, Jianbin Wang, Tangwei Mou, Yang Gao, Lichun Wang, Shengtao Fan, Xingli Xu, Guorun Jiang, Pingfang Cui, Xiangxiong Xu, Suqin Duan, Jingjing Zhang, Dandan Li, Yun Liao, Li Yu, Heng Zhao, Ming Lu, Hailian Zhu, Ran Gu, Ying Zhang, Wei Dong, Qihan Li
Summary: Convalescent serum from HSV2-infected patients predominantly recognized the ICP35 protein encoded by gene UL26.5, which could be used to design an integrated antigen with other viral glycoproteins.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Neurosciences
Francisca Acuna-Hinrichsen, Adriana Covarrubias-Pinto, Yuta Ishizuka, Maria Francisca Stolzenbach, Carolina Martin, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth
Summary: HSV-1 infection may induce structural disassembly and functional deregulation in early stages, leading to altered glutamate response, increased accumulation of Arc protein within somata, and decreased expression of dendritic spine scaffolding proteins.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Virology
Marianne Graninger, Hannes Vietzen, Elisabeth Puchhammer-Stoeckl
Summary: Herpes simplex virus encephalitis (HSE) is a rare complication of herpes simplex virus type 1 (HSV-1) infection or reactivation. Certain genetic variants associated with the host NK cell response, such as HLA-E*0101 and rs9916629C, are significantly associated with HSE. These genetic variations could potentially be used as clinical markers to predict HSE prognosis and guide personalized treatment.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Jiaofeng Huang, Yinlian Wu, Mingfang Wang, Su Lin
Summary: This study aimed to evaluate the association between serum 25-hydroxyvitamin D levels and herpes simplex virus (HSV) infection. The results showed a negative correlation between vitamin D levels and HSV-1 and HSV-2 infection, suggesting that vitamin D deficiency is an independent risk factor for HSV infection.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Virology
Bangxing Hong, Upasana Sahu, Matthew P. Mullarkey, Balveen Kaur
Summary: Oncolytic herpes simplex virus (oHSV) shows promise as a treatment for solid tumors, but there are still barriers that limit its efficacy. This review focuses on the essential viral genes that allow for virus replication and spread, with the aim of enhancing oHSV infection and replication among tumor cells.
Article
Clinical Neurology
Junjie Lu, Jingyang Liang, Jiarui Yang, David Mischoulon, Maren Nyer
Summary: This study used data from National Health and Nutrition Examination Survey 2009-2014 to investigate the relationship between HSV-2 infection and depression, considering gender and sexual orientation as potential modifiers. The results showed that sexual minority status did not have a significant effect on the association, while biological sex assigned at birth did. Females with HSV-2 infection had a higher risk for depressive symptoms. Further longitudinal investigations are needed to validate these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biotechnology & Applied Microbiology
Yeu-Yang Tseng, Anjali Gowripalan, Sarah N. Croft, Stewart A. Smith, Karla J. Helbig, Si Ming Man, David C. Tscharke
Summary: Studies have shown that the upregulation of viperin during HSV-1 infection is cell-type specific in mouse and human cells, with mouse viperin exhibiting inhibitory effects against HSV-1. The anti-HSV-1 activity of viperin is dependent on viral gene transcription and the N-terminal domain of the protein. Furthermore, the HSV-1 virion host shutoff protein is identified as a key viral factor that counters the effects of viperin in mouse cells.
JOURNAL OF GENERAL VIROLOGY
(2021)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Biology
Manutea C. Serrero, Virginie Girault, Sebastian Weigang, Todd M. Greco, Ana Ramos-Nascimento, Fenja Anderson, Antonio Piras, Ana Hickford Martinez, Jonny Hertzog, Anne Binz, Anja Pohlmann, Ute Prank, Jan Rehwinkel, Rudolf Bauerfeind, Ileana M. Cristea, Andreas Pichlmair, Georg Kochs, Beate Sodeik, Adam P. Geballe
Summary: This study identifies an interferon-inducible protein, MxB, that can sense herpesviral capsids and disassemble them, thereby restricting viral nuclear targeting and progeny capsid assembly, leading to enhanced innate immune responses.