Article
Virology
Jiangwei Song, Yitong Guo, Dan Wang, Rong Quan, Jing Wang, Jue Liu
Summary: The Seneca Valley virus (SVV) inhibits the type I interferon (IFN) response by degrading STAT1, STAT2, and IRF9, and cleaving STAT2, which leads to impaired IFN-stimulated gene activity. Additionally, SVV blocks the nuclear import of STAT1 and STAT2 by degrading karyopherin 1, thereby evading the host immune response.
JOURNAL OF VIROLOGY
(2023)
Article
Cell Biology
Yuxin Wang, Qiaoling Song, Wei Huang, Yuxi Lin, Xin Wang, Chenyao Wang, Belinda Willard, Chenyang Zhao, Jing Nan, Elise Holvey-Bates, Zhuoya Wang, Derek Taylor, Jinbo Yang, George R. Stark
Summary: Type I interferons (IFN-I) play a crucial role in protecting against viral infections, with STAT2 being a key component in driving gene expression in response to IFN-I. The phosphorylation of STAT2 at T404 acts as a critical conformational switch, disrupting an inactive STAT1-STAT2 dimer and enhancing the antiviral defense response to IFN-I. Additionally, virus infection-induced activation of IKK-epsilon can directly phosphorylate T404, further facilitating the antiviral defense mechanism.
Review
Microbiology
Xin-yu Zhang, Yu-ying Li, Hai-xin Huang, Chen-chen Zhao, Xiao-xiao Lei, Bao-peng Zhao, Jing-yi Lu, Tian Lan, Wen-chao Sun
Summary: This article reviews the functions of Seneca Valley virus 3C protease, including promotion of viral replication, modulation of cell apoptosis, and evasion of host immune response, providing a theoretical basis for preventing and controlling SVV infection.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Virology
Elisa Fanunza, Nicole Grandi, Marina Quartu, Fabrizio Carletti, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito, Enzo Tramontano
Summary: The study revealed that Zika virus NS4B protein acts as an antagonist of interferon signaling cascade by suppressing IFN-stimulated response element and transcription, as well as by reducing the expression levels of interferon-stimulated genes. This viral protein also inhibits STAT1 phosphorylation, blocking the nuclear transport of both STAT1 and STAT2.
Article
Immunology
Elisa Fanunza, Fabrizio Carletti, Marina Quartu, Nicole Grandi, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito, Enzo Tramontano
Summary: The viral protein NS2A suppresses the IFN signaling and promotes degradation of STAT1 and STAT2 to evade the innate immune system, helping Zika Virus escape host immune responses. Antagonism against IFN plays a crucial role in flavivirus virulence, and understanding how Zika Virus evades IFN response can pave the way for new strategies to attenuate the pathogenesis.
Article
Immunology
Junhong Hao, Chaochao Shen, Nannan Wei, Minghao Yan, Xuegang Zhang, Guowei Xu, Dajun Zhang, Jing Hou, Weijun Cao, Ye Jin, Keshan Zhang, Haixue Zheng, Xiangtao Liu
Summary: Foot-and-mouth disease virus antagonizes the activation of the IRF3/IFN-β signaling pathway via TPL2 for immune escape and enhanced virus replication. TPL2 deficiency leads to reduced expression of interferon-stimulated genes and interferon regulatory factors, resulting in increased virus replication.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Sirin Theerawatanasirikul, Varanya Lueangaramkul, Nattarat Thangthamniyom, Penpitcha Chankeeree, Ploypailin Semkum, Porntippa Lekcharoensuk
Summary: Foot-and-Mouth Disease (FMD) caused by the FMD Virus (FMDV) is a globally significant infectious disease affecting livestock, particularly in tropical regions. Control measures for FMD include a combination of strategies such as vaccination and the use of antiviral plant-based products like andrographolides. These substances have shown inhibitory effects on FMDV replication and protease activities, offering potential as adjunct therapies for FMD control.
Article
Virology
Xujiao Ren, Mengge Yin, Qiongqiong Zhao, Zixuan Zheng, Haoyuan Wang, Zengjun Lu, Xiangmin Li, Ping Qian
Summary: This study demonstrates for the first time that FMDV infection can induce pyroptosis through GSDME-mediated cell death. This finding provides new insights into the pathogenesis of FMDV and the design of antiviral drugs.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Zhou Huang, Hejun Liu, Jay Nix, Rui Xu, Catherine R. Knoverek, Gregory R. Bowman, Gaya K. Amarasinghe, L. David Sibley
Summary: The study revealed that the protein TgIST from Toxoplasma gondii blocks interferon-induced gene expression by binding to the STAT1 dimer interface, thus inhibiting the expression of immunity genes.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
XuSheng Ma, ZhiKuan Luo, Rui Song, XiaoFeng Nian, Sk Mohiuddin Choudhury, Yi Ru, Fan Yang, YuXia Zhang, ZongBo Zeng, WeiJun Cao, JingJing Pei, XiangTao Liu, HaiXue Zheng
Summary: This study uncovered a novel mechanism of viral immune evasion by FMDV's Lb leader protease (Lbpro), which inhibits IFN-13-induced JAK-STAT signaling by cleaving STAT1/2 proteins.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Zhihai Zhou, Yuan Sun, Jingya Xu, Xiaoyu Tang, Ling Zhou, Qianniu Li, Tian Lan, Jingyun Ma
Summary: The study shows that the SADS-CoV N protein can interfere with host antiviral immune responses by inhibiting interferon production and related signaling pathways' activity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Priyanka Rajeev Menon, Julia Staab, Anke Gregus, Oliver Wirths, Thomas Meyer
Summary: U-STAT1 affects the signal transduction mediated by P-STAT1 and alters the nucleo-cytoplasmic distribution of P-STAT1. U-STAT1 maintains high levels of cytoplasmic STAT1 by inhibiting the nuclear accumulation of P-STAT1, while preserving IFN γ-induced gene expression.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Tingting Ren, Haotai Chen, Xinsheng Liu, Yanxue Wang, Aixia Fan, Linlin Qi, Li Pan, Wenlong Bai, Yongguang Zhang, Yuefeng Sun
Summary: The ID1 protein promotes the degradation of FOXO1, suppresses interferon production, and inhibits HDAC4, ultimately suppressing the replication of FDMV and potentially other viruses.
Article
Microbiology
Jidong Xu, Qin Gao, Weiwu Zhang, Jingyou Zheng, Rong Chen, Xiao Han, Junyong Mao, Ying Shan, Fushan Shi, Fang He, Weihuan Fang, Xiaoliang Li
Summary: Porcine epidemic diarrhea virus (PEDV) downregulates histone deacetylase 1 (HDAC1) expression to enhance acetylation of STAT1 and inhibit its activation and interferon-stimulated gene (ISG) expression.
Article
Immunology
Yimei Cao, Kun Li, Xiangchuan Xing, Huifang Bao, Nana Huang, Guoqiang Zhu, Xingwen Bai, Pu Sun, Yuanfang Fu, Pinghua Li, Jing Zhang, Xueqing Ma, Dong Li, Zaixin Liu, Zengjun Lu
Summary: The study selected O/XJ/CHA/2017 as a promising vaccine strain candidate for foot-and-mouth disease, showing the highest immunogenicity in pigs, cattle, and sheep by NA-ELISA and VNT. Cross-neutralization analysis indicated its broad antigen spectrum and antigenic match with other strains, with a significant correlation between NA-ELISA and VNT results.
Article
Virology
Hanzhong Ke, Mingyuan Han, Jineui Kim, Kurt E. Gusting, Dongwan Yoo
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Yixuan Hou, Hanzhong Ke, Jineui Kim, Dongwan Yoo, Yunfang Su, Patricia Boley, Juliet Chepngeno, Anastasia N. Vlasova, Linda J. Saif, Qiuhong Wang
JOURNAL OF VIROLOGY
(2019)
Article
Infectious Diseases
Leyi Wang, Saraswathi Lanka, Debbie Cassout, Nohra E. Mateus-Pinilla, Ganwu Li, William C. Wilson, Dongwan Yoo, Paul Shelton, Richard L. Fredrickson
TRANSBOUNDARY AND EMERGING DISEASES
(2019)
Review
Virology
Tong-Qing An, Jiang-Nan Li, Chia-Ming Su, Dongwan Yoo
Review
Infectious Diseases
Guangzhi Zhang, Bin Li, Dongwan Yoo, Tong Qin, Xiaodong Zhang, Yaxiong Jia, Shangjin Cui
Summary: COVID-19, caused by SARS-CoV-2, is a highly contagious disease that has rapidly spread worldwide. Despite bats being suggested as the natural host of SARS-CoV-2, uncertainties remain regarding transmission chains, the role of animals in cross-species transmission, and future concerns.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Multidisciplinary Sciences
Wan Liang, Danna Zhou, Chao Geng, Keli Yang, Zhengying Duan, Rui Guo, Wei Liu, Fangyan Yuan, Zewen Liu, Ting Gao, Ling Zhao, Dongwan Yoo, Yongxiang Tian
Article
Virology
Chao Sui, Dandan Jiang, Xiangju Wu, Sidang Liu, Feng Li, Li Pan, Xiaoyan Cong, Juntong Li, Dongwan Yoo, Daniel L. Rock, Laura C. Miller, Changhee Lee, Yijun Du, Jing Qi
Summary: The leader protease (Lpro) of foot-and-mouth disease virus (FMDV) promotes viral replication by antagonizing the OAS/RNase L pathway and interfering with the host's innate immune response. This virus-host interaction is species-specific, only detected in swine cells, not in human, monkey, or canine cells. Additionally, Lpro inhibits apoptosis to promote cell survival.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Chia-Ming Su, Raymond Robert Richard Rowland, Dongwan Yoo
Summary: This review discusses recent advances and understanding of PRRSV entry into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
Article
Multidisciplinary Sciences
Chia-Ming Su, Leyi Wang, Dongwan Yoo
Summary: SARS-CoV-2 proteins activate NF-kappa B, leading to the production of proinflammatory cytokines, which may contribute to acute respiratory distress syndrome in COVID-19 patients. Among these proteins, ORF7a plays a significant role in inducing inflammatory cytokines and chemokines expression.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Xiangju Wu, Yue Hu, Chao Sui, Li Pan, Dongwan Yoo, Laura C. Miller, Changhee Lee, Xiaoyan Cong, Juntong Li, Yijun Du, Jing Qi
Summary: This study investigated the role of SUMOylation in FMDV infection. The findings showed that SUMOylation suppressed FMDV replication and identified four lysine residues that mediated SUMOylation of FMDV 3C protease. Moreover, SUMOylation attenuated the function of FMDV 3C through multiple mechanisms. These results describe a novel cellular regulatory event that restricts FMDV replication through SUMOylation of 3C protease.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Chia-Ming Su, Yijun Du, Raymond R. R. Rowland, Qiuhong Wang, Dongwan Yoo
Summary: Type I interferons (IFNs-alpha/beta) are antiviral cytokines that play a crucial role in innate immunity against viral infections. However, viruses have evolved strategies to evade the IFN response, leading to inefficient innate immunity and delayed adaptive responses that negatively impact vaccine efficacy. Understanding these evasion strategies offers the potential to develop next-generation vaccines that induce robust immune responses against various pathogens by generating IFN antagonism-deficient viruses through reverse genetics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Julie A. Hicks, Dongwan Yoo, Hsiao-Ching Liu
Article
Veterinary Sciences
Han Sang Yoo, Dongwan Yoo
JOURNAL OF VETERINARY SCIENCE
(2020)
Review
Veterinary Sciences
Dongwan Yoo, Hyunil Kim, Joo Young Lee, Han Sang Yoo
JOURNAL OF VETERINARY SCIENCE
(2020)
Meeting Abstract
Immunology
D. Yoo, H. Ke, S. Lee, J. Kim, H. -C Liu
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)