期刊
JOURNAL OF VIROLOGY
卷 89, 期 1, 页码 857-862出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02328-14
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资金
- Public Health Service [P01CA050661, RO1CA93804, R01CA63113, R0137667, 5T32AI007245, F31CA177274]
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) [DK 63829, 63861, 63821, 63865, 63863, 63836, 63790, UC4DK095300, HHSN267200700014C]
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institute of Child Health and Human Development (NICHD)
- National Institute of Environmental Health Sciences (NIEHS)
- Juvenile Diabetes Research Foundation (JDRF)
- Centers for Disease Control and Prevention (CDC)
Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.
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